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List of works by Klaus H. Kaestner

5-hydroxymethylcytosine represses the activity of enhancers in embryonic stem cells: a new epigenetic signature for gene regulation

scientific article

A High-Content Screen Identifies MicroRNAs That Regulate Liver Repopulation After Injury in Mice

scientific article published on 20 November 2019

CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells

scientific article

Collapse of the hepatic gene regulatory network in the absence of FoxA factors

scientific article published on 19 June 2020

Combinatorial genetics in liver repopulation and carcinogenesis with a novel in vivo CRISPR activation platform.

scientific article published in November 2017

Emerging diverse roles of telocytes

scientific article published on 16 July 2019

Epigenetic regulation of intestinal stem cells by Tet1-mediated DNA hydroxymethylation.

scientific article published on 17 November 2016

Examining How the MAFB Transcription Factor Affects Islet β-Cell Function Postnatally

scientific article published on 13 November 2018

Fox transcription factors: from development to disease

scientific article published on December 2016

FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer

scientific article published on 26 November 2018

Genetic activation of α-cell glucokinase in mice causes enhanced glucose-suppression of glucagon secretion during normal and diabetic states

scientific article published on 19 February 2021

Insights From the Crypt: Regionalization, Adaptation, and Renewal of the Intestinal Epithelium

scientific article published on 31 March 2017

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

scientific article (publication date: June 2001)

Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes

scientific article published on 11 January 2016

LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells.

scientific article published on 12 December 2016

Metabolic memory of ß-cells controls insulin secretion and is mediated by CaMKII.

scientific article

NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP)

scientific article published on 24 May 2019

Organisation of the human pancreas in health and in diabetes

scientific article published on 07 September 2020

Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice.

scientific article

Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry

scientific article published on 01 November 2021

Sleeve Gastrectomy Improves Glycemia Independent of Weight Loss by Restoring Hepatic Insulin Sensitivity

scientific article published on 23 February 2018

TRAP-seq identifies cystine/glutamate antiporteras a driver of recovery from liver injury.

scientific article published on 8 March 2018

The 'de novo' DNA methyltransferase Dnmt3b compensates the Dnmt1-deficient intestinal epithelium.

scientific article published on 25 January 2016

The Dysregulation of the - Locus in Islets From Patients With Type 2 Diabetes Is Mimicked by Targeted Epimutation of Its Promoter With TALE-DNMT Constructs

scientific article published on 03 July 2018

The RNA polymerase III subunit Polr3b is required for the maintenance of small intestinal crypts in mice

scientific article published on November 2016

β-Cells are not uniform after all-Novel insights into molecular heterogeneity of insulin-secreting cells

scientific article

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