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List of works by Armando A. Genazzani

(2S,1'R,2'R,3'R)-2-(2,3-dicarboxycyclopropyl) glycine positively modulates metabotropic glutamate receptors coupled to polyphosphoinositide hydrolysis in rat hippocampal slices

scientific article published on 01 October 1994

(2s,1'R,2'R,3'R)-2-(2,3-Dicarboxycyclopropyl) glycine enhances quisqualate-stimulated inositol phospholipid hydrolysis in hippocampal slices.

scientific article published in May 1993

5-hydroxytryptamine1B receptor and triptan response in migraine, lack of association with common polymorphisms

scientific article published on 30 October 2007

A Ca2+ release mechanism gated by the novel pyridine nucleotide, NAADP.

scientific article published on April 1997

A concise entry into nonsymmetrical alkyl polyamines

scientific article

A concise synthesis of pyrazole analogues of combretastatin A1 as potent anti-tubulin agents

scientific article published on 21 February 2013

A luminal EF-hand mutation in STIM1 in mice causes the clinical hallmarks of tubular aggregate myopathy

scientific article published on 03 December 2019

A novel Ca²⁺-mediated cross-talk between endoplasmic reticulum and acidic organelles: implications for NAADP-dependent Ca²⁺ signalling

scientific article published on 21 January 2015

A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry

scientific article

A pivotal role for cADPR-mediated Ca2+ signaling: regulation of endothelin-induced contraction in peritubular smooth muscle cells

scientific article published in May 2002

Activation of TRPV4 channels reduces migration of immortalized neuroendocrine cells

scientific article published on 19 January 2011

Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB.

scientific article published on 25 April 2013

Amyloid beta protein does not interact with tachykinin receptors coupled to inositol phospholipid hydrolysis in human astrocytoma cells.

scientific article published in January 1993

Amyloid-β and Alzheimer's disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions

scientific article published on 9 May 2013

An opposite-direction modulation of the COMT Val158Met polymorphism on the clinical response to intrathecal morphine and triptans

scientific article

Applications of Deuterium in Medicinal Chemistry

scientific article published on 25 January 2019

Association of haplotype combination of serotonin transporter gene polymorphisms with monthly headache days in MOH patients

scientific article published on 18 May 2011

Aβ leads to Ca²⁺ signaling alterations and transcriptional changes in glial cells.

scientific article

CD38/CD19: a lipid raft-dependent signaling complex in human B cells

scientific article published on 27 February 2007

Calcineurin Controls the Expression of Isoform 4CII of the Plasma Membrane Ca2+Pump in Neurons

scientific article published in Journal of Biological Chemistry

Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons.

scientific article

Calcineurin controls the expression of numerous genes in cerebellar granule cells

scientific article

Calcineurin primes immature gonadotropin-releasing hormone-secreting neuroendocrine cells for migration

scientific article published on 21 November 2007

Calcium controls the transcription of its own transporters and channels in developing neurons.

scientific article

Calcium signaling in closely related protozoan groups (Alveolata): non-parasitic ciliates (Paramecium, Tetrahymena) vs. parasitic Apicomplexa (Plasmodium, Toxoplasma)

scientific article published on 03 March 2012

Calcium signalling: calcium goes global

scientific article published in June 2002

Characterization of NAADP(+) binding in sea urchin eggs

scientific article published in September 2000

Characterization of NAD uptake in mammalian cells

scientific article

Characterization of cyclic adenine dinucleotide phosphate ribose levels in human spermatozoa

scientific article published on 09 August 2006

Characterization of metabotropic glutamate receptors negatively linked to adenylyl cyclase in brain slices

scientific article published on 01 September 1993

Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes.

scientific article published on March 2008

Combined effect of common gene variants on response to drug withdrawal therapy in medication overuse headache

scientific article published on 7 August 2014

Common variants of GSTP1, GSTA1, and TGFβ1 are associated with the risk of radiation-induced fibrosis in breast cancer patients

scientific article

Common variants of eNOS and XRCC1 genes may predict acute skin toxicity in breast cancer patients receiving radiotherapy after breast conserving surgery

scientific article published on 14 January 2012

Dasatinib: is it all in the dose?

scientific article published on June 2010

Design, Synthesis, and Biological Evaluation of Combretabenzodiazepines: A Novel Class of Anti-Tubulin Agents

scientific article published on 27 January 2015

Diagnostic accuracy of HLA-B*57:01 screening for the prediction of abacavir hypersensitivity and clinical utility of the test: a meta-analytic review

scientific article

Differential deregulation of astrocytic calcium signalling by amyloid-β, TNFα, IL-1β and LPS.

scientific article

Difficulties in the production of identical drug products from a pharmaceutical technology viewpoint.

scientific article published on January 2008

Effect of luminal and extravesicular Ca2+ on NAADP binding and release properties

scientific article

Effects of RGH 2202 on cognitive and motor behavior of the rat.

scientific article published in January 1996

Effects of cytidine-diphosphocholine on acetylcholine-mediated behaviors in the rat.

scientific article published in January 1993

Effects of risperidone on motor and sexual activity in the rat

scientific article published on 01 September 1990

Essential Medicinal Chemistry of Essential Medicines

scientific article published on 30 April 2020

Estrogenic Analogues Synthesized by Click Chemistry

scientific article published on 01 April 2007

Expression of inositol trisphosphate receptors.

scientific article

Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine

scientific article

Functional polymorphisms in COMT and SLC6A4 genes influence the prognosis of patients with medication overuse headache after withdrawal therapy.

scientific article

Gene regulation in the frontal cortex of rats exposed to the chronic mild stress paradigm, an animal model of human depression

scientific article published on 25 March 2008

Genetic determinants of chronic oxaliplatin-induced peripheral neurotoxicity: a genome-wide study replication and meta-analysis.

scientific article published on March 2015

Glial calcium signalling in Alzheimer's disease.

scientific article

How Much Are Biosimilars Used in Clinical Practice? A Retrospective Italian Population-Based Study of Erythropoiesis-Stimulating Agents in the Years 2009-2013.

scientific article

Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity.

scientific article published on 6 February 2017

Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2.

scientific article

Identification of novel antitubulin agents by using a virtual screening approach based on a 7-point pharmacophore model of the tubulin colchi-site

scientific article

Inhibition of cADPR-Hydrolase by ADP-ribose potentiates cADPR synthesis from beta-NAD+

scientific article published on 01 June 1996

Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells

scientific article published on 3 December 2007

Key concepts and critical issues on epoetin and filgrastim biosimilars. A position paper from the Italian Society of Hematology, Italian Society of Experimental Hematology, and Italian Group for Bone Marrow Transplantation.

scientific article published on July 2011

Kinetic properties of nicotinic acid adenine dinucleotide phosphate-induced Ca2+ release

scientific article published on 01 March 1997

Medicinal chemistry of combretastatin A4: present and future directions.

scientific article

Melittin enhances excitatory amino acid release and AMPA-stimulated 45Ca2+ influx in cultured neurons

scientific article published in July 1992

Metabolic fate of combretastatin A-1: LC-DAD-MS/MS investigation and biological evaluation of its reactive metabolites

scientific article published on 27 February 2013

Multiple roles of protein kinase a in arachidonic acid-mediated Ca2+ entry and tumor-derived human endothelial cell migration

scientific article published on 24 September 2010

N-Arylbenzamides: extremely simple scaffolds for the development of novel estrogen receptor agonists ⬇️

scientific article published on December 14, 2011

NAADP links histamine H1 receptors to secretion of von Willebrand factor in human endothelial cells

scientific article published on March 2011

NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs

scientific article (publication date: 27 November 2002)

NAADP receptors are present and functional in the heart

scientific article published in June 2001

NAADP-induced Ca(2+ signaling in response to endothelin is via the receptor subtype B and requires the integrity of lipid rafts/caveolae

scientific journal article

NAADP: an atypical Ca2+-release messenger?

scientific article

Nicotinamide phosphoribosyltransferase (NAMPT) is over-expressed in melanoma lesions

scientific article

Nicotinic acid adenine dinucleotide phosphate (NAADP) is present at micromolar concentrations in sea urchin spermatozoa

scientific article published in October 2002

Nicotinic acid adenine dinucleotide phosphate triggers Ca2+ release from brain microsomes

scientific article

Nicotinic acid adenine dinucleotide phosphate-induced Ca(2+) release. Interactions among distinct Ca(2+) mobilizing mechanisms in starfish oocytes

scientific article published in March 2000

Novel adenosine and cAMP signalling pathways in migrating glial cells

scientific article published on July 2010

PPADS is a reversible competitive antagonist of the NAADP receptor

scientific article published on 07 November 2006

Pharmacogenomics of episodic migraine: time has come for a step forward.

scientific article published on March 2014

Pharmacological properties of the Ca2+-release mechanism sensitive to NAADP in the sea urchin egg

scientific article

Potentiation of cADPR-induced Ca(2+)-release by methylxanthine analogues

scientific article published on 01 July 1999

Production and characterization of reduced NAADP (nicotinic acid-adenine dinucleotide phosphate).

scientific article published on February 2004

Promoting Better Clinical Trials and Drug Information as Public Health Interventions for the COVID-19 Emergency in Italy

scientific article published on 16 June 2020

Psammechinus miliaris egg homogenate as a model to investigate Ca2+-release mechanisms

article by Armando A. Genazzani et al published April 1999 in Journal of the Marine Biological Association of the United Kingdom

Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling and In Vivo Proof-of-Concept Efficacy in Acute Pancreatitis

scientific article published on 30 October 2018

Rapid synthesis of triazole-modified resveratrol analogues via click chemistry.

scientific article published on January 2006

Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etoposide or cisplatin in neuroblastoma cells

scientific article published on 17 June 2011

Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues

scientific article published on 30 June 2011

Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation

scientific article published on 28 November 2010

Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry

scientific article published on 22 August 2007

Role of 2 common variants of 5HT2A gene in medication overuse headache

scientific article published on 27 August 2010

Role of the nicotinic acid group in NAADP receptor selectivity

scientific article published in January 2005

SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis

scientific article published in August 2005

Searching for new animal models of Alzheimer's disease.

scientific article published on 15 October 2009

Severe acute nephrotoxicity in a kidney transplant patient despite low tacrolimus levels: a possible interaction between donor and recipient genetic polymorphisms

scientific article published on 9 April 2013

Solution-phase parallel synthesis and biological evaluation of combretatriazoles

scientific article

Somatostatin and the somatostatin receptor 2 are reciprocally controlled by calcineurin during cerebellar granule cell maturation

scientific article published on 5 July 2005

Sperm deliver a new second messenger: NAADP

scientific article (publication date: 21 January 2003)

Sphingosine releases Ca2+ from intracellular stores via the ryanodine receptor in sea urchin egg homogenates

scientific article published on 25 October 2005

Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors

scientific article published on 30 November 2020

Store-operated Ca2+ entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients

scientific article

Synthesis and biological activity of mustard derivatives of combretastatins

scientific article published in August 2005

Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage.

scientific article published on May 2008

Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents

scientific article published on August 2006

Synthesis and cytotoxic evaluation of combretafurazans

scientific article

Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids ⬇️

scientific article published on June 13, 2013

Synthesis of 7-oxasphingosine and -ceramide analogues and their evaluation in a model for apoptosis

scientific article published on November 2004

Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases.

scientific article published on May 2009

Synthesis, molecular docking and biological evaluation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition.

scientific article

The NAMPT inhibitor FK866 reverts the damage in spinal cord injury

scientific article published on 10 April 2012

The effect of CYP3A5 6986A>G and ABCB1 3435C>T on tacrolimus dose-adjusted trough levels and acute rejection rates in renal transplant patients: a systematic review and meta-analysis

scientific article published on August 2012

The expression of the PDZ protein MALS-1/velis is regulated by calcium and calcineurin in cerebellar granule cells

scientific article published on 21 October 2002

The interactions of age, sex, body mass index, genetics, and steroid weight-based doses on tacrolimus dosing requirement after adult kidney transplantation

scientific article published on 20 November 2011

The serotonin transporter gene polymorphism STin2 VNTR confers an increased risk of inconsistent response to triptans in migraine patients

scientific article published on 18 May 2010

Transient global amnesia and cerebral infarct: a case report

scientific article published on 01 November 1995

Triazine dyes are agonists of the NAADP receptor.

scientific article

Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery

scientific article

Triptan nonresponders: do they exist and who are they?

scientific article published on 05 April 2013

Triptan use in Italy: Insights from administrative databases.

scientific article published on 22 September 2014

Tropisetron attenuates amyloid-beta-induced inflammatory and apoptotic responses in rats

scientific article

Voltage-gated sodium channel polymorphisms play a pivotal role in the development of oxaliplatin-induced peripheral neurotoxicity: results from a prospective multicenter study

scientific article

Zinc transporter-1: a novel NMDA receptor-binding protein at the postsynaptic density

scientific article published on 4 January 2015

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