List of works - Thomas J Schmidt

(+)-Pinoresinol/(-)-lariciresinol reductase from Linum perenne Himmelszelt involved in the biosynthesis of justicidin B.

scientific article

3-O-galloylated procyanidins from Rumex acetosa L. inhibit the attachment of influenza A virus

scientific article

5D-QSAR for spirocyclic sigma1 receptor ligands by Quasar receptor surface modeling

scientific article published on 03 April 2010

6-methoxypodophyllotoxin-7-O-n-hexanoate, a new aryltetralin lignan ester from seeds of Linum flavum

scientific article published on 3 December 2009

9β-hydroxyparthenolide esters from Inula montbretiana and their antiprotozoal activity

scientific article

A 3D-QSAR Study on the Antitrypanosomal and Cytotoxic Activities of Steroid Alkaloids by Comparative Molecular Field Analysis

scientific article published on 08 May 2018

A Comprehensive QSAR Study on Antileishmanial and Antitrypanosomal Cinnamate Ester Analogues

scientific article published on 28 November 2019

A New Alkamide with an Endoperoxide Structure from Acmella ciliata (Asteraceae) and Its in Vitro Antiplasmodial Activity.

scientific article published on 11 June 2016

A combined HPLC-UV and HPLC-MS method for the identification of lignans and its application to the lignans of Linum usitatissimum L. and L. bienne Mill

scientific article published on 01 September 2006

Accumulation of aryltetralin lactone lignans in cell suspension cultures of Linum nodiflorum

scientific article published on 01 August 1999

An aryldihydronaphthalene lignan with a novel type of ring system and further new lignans from linum perenne L.

scientific article published on 7 December 2007

An isoform-specific C/EBPβ inhibitor targets acute myeloid leukemia cells

scientific article published on 08 February 2016

An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from Eupatoriumperfoliatum

scientific article published on 15 February 2011

Anti-Protozoal Activities of Cembrane-Type Diterpenes from Vietnamese Soft Corals.

scientific article published on 8 July 2015

Antileishmanial activity, cytotoxicity and QSAR analysis of synthetic dihydrobenzofuran lignans and related benzofurans.

scientific article

Antiprotozoal Sesquiterpene Lactones and Other Constituents from Tarchonanthus camphoratus and Schkuhria pinnata.

scientific article published on 15 December 2017

Antiprotozoal activity of Achillea ptarmica (Asteraceae) and its main alkamide constituents. ⬇️

scientific article published on 20 May 2014

Antiprotozoal activity of Buxus sempervirens and activity-guided isolation of O-tigloylcyclovirobuxeine-B as the main constituent active against Plasmodium falciparum.

scientific article published on 15 May 2014

Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies

scientific article

Arnica Tincture Cures Cutaneous Leishmaniasis in Golden Hamsters.

scientific article published on 12 January 2018

Arylnaphthalene lignans from in vitro cultures of Linum austriacum.

scientific article

Chemical Constituents from Ficus sagittifolia Stem Bark and Their Antimicrobial Activities

scientific article published on 28 July 2023

Complementary Quantitative Structure⁻Activity Relationship Models for the Antitrypanosomal Activity of Sesquiterpene Lactones

scientific article published on 22 November 2018

Complete structural assignment of serratol, a cembrane-type diterpene from Boswellia serrata, and evaluation of its antiprotozoal activity

scientific article published on 14 December 2010

Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research

scientific article published on 23 November 2018

Covalent modification of human serum albumin by the natural sesquiterpene lactone parthenolide.

scientific article

Cytotoxicity of flavonoids and sesquiterpene lactones from Arnica species against the GLC4 and the COLO 320 cell lines.

scientific article published on October 1994

Dermal Absorption of Sesquiterpene Lactones from Arnica Tincture

scientific article published on 30 March 2022

Detection of metabolites of fumaric acid esters in human urine: implications for their mode of action

scientific article published on 14 August 2008

Diarylbutyrolactone lignans from Linum corymbulosum in vitro cultures

scientific article published on 18 September 2006

Enantioselective synthesis of encecaline-derived potent antimalarial agents.

scientific article published on November 2013

Encecalol angelate, an unstable chromene from Ageratum conyzoides L.: total synthesis and investigation of its antiprotozoal activity

scientific article published on 17 June 2011

Engineering of a monomeric fluorescent protein AsGFP499 and its applications in a dual translocation and transcription assay

scientific article

Eupatorium perfoliatum L.: Phytochemistry, traditional use and current applications ⬇️

scientific article published on October 6, 2011

Evaluation of ethnomedical claim III: anti-hyperglycemic activities of Gongronema latifolium root and stem

scientific article published on 28 May 2013

Extract from Rumex acetosa L. for prophylaxis of periodontitis: inhibition of bacterial in vitro adhesion and of gingipains of Porphyromonas gingivalis by epicatechin-3-O-(4β→8)-epicatechin-3-O-gallate (procyanidin-B2-Di-gallate)

scientific article

Glutathione adducts of helenalin and 11 alpha,13-dihydrohelenalin acetate inhibit glutathione S-transferase from horse liver

scientific article published on 01 March 2000

Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB

scientific article published on 01 September 1997

Helenanolide type sesquiterpene lactones. Part 5: the role of glutathione addition under physiological conditions

scientific article published on 01 December 1999

Helenanolide-type sesquiterpene lactones--III. Rates and stereochemistry in the reaction of helenalin and related helenanolides with sulfhydryl containing biomolecules

scientific article published on 01 April 1997

High-performance liquid chromatography/mass spectrometric identification of dibenzylbutyrolactone-type lignans: insights into electrospray ionization tandem mass spectrometric fragmentation of lign-7-eno-9,9'-lactones and application to the lignans

scientific article published on 01 November 2008

Hologram QSAR studies of antiprotozoal activities of sesquiterpene lactones.

scientific article published on 18 July 2014

Identification, pharmacological evaluation and binding mode analysis of novel chromene and chromane based σ1 receptor ligands

scientific article published on 26 June 2014

In Silico Identification and in Vitro Activity of Novel Natural Inhibitors of Trypanosoma brucei Glyceraldehyde-3-phosphate-dehydrogenase.

scientific article published on 3 September 2015

In Silico prediction and experimental evaluation of furanoheliangolide sesquiterpene lactones as potent agents against Trypanosoma brucei rhodesiense

scientific article

In Vitro Metabolism of Helenalin Acetate and 11α,13-Dihydrohelenalin Acetate: Natural Sesquiterpene Lactones from Arnica

scientific article published on 18 January 2022

Influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in Jurkat T cells and human peripheral blood cells: anti-inflammatory and cytotoxic effects

scientific article published in December 2003

Inhibition of Myb-dependent gene expression by the sesquiterpene lactone mexicanin-I.

scientific article published on 11 October 2011

Inhibition of transcription factor NF-kappaB by sesquiterpene lactones: a proposed molecular mechanism of action

scientific article published on 01 November 1999

Inhibitory effects of helenalin and related compounds on 5-lipoxygenase and leukotriene C(4) synthase in human blood cells

scientific article

Justicidin B 7-hydroxylase, a cytochrome P450 monooxygenase from cell cultures of Linum perenne Himmelszelt involved in the biosynthesis of diphyllin

scientific article published on 13 November 2007

Kruppel-like factor KLF4 facilitates cutaneous wound healing by promoting fibrocyte generation from myeloid-derived suppressor cells.

scientific article

Larrea tridentata—Absolute configuration of its epoxylignans and investigations on its antiprotozoal activity

Lignans from Arnica species

scientific article published on 01 May 2006

Lignans from Linum species of sections Syllinum and Linum

scientific article published on 01 January 2007

Lignans in flowering aerial parts of Linum species--chemodiversity in the light of systematics and phylogeny

scientific article published on 23 July 2010

Lignans in seeds of Linum species

scientific article published on 31 July 2012

Metabolic profiling of lignan variability in Linum species of section Syllinum native to Bulgaria

scientific article published on 8 February 2008

Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Therapeutics

scientific article published on 25 April 2023

Natural product derived antiprotozoal agents: synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane derivatives.

scientific article published on 9 September 2013

Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: structure-activity relationships

scientific article published on 26 February 2013

New allo-cedrane type sesquiterpene hemiketals and further sesquiterpene lactones from fruits of Illicium floridanum

scientific article published in April 2001

New dihydrobenzofurans and triterpenoids from roots of Microglossa pyrifolia

scientific article published in March 2003

New triterpene esters from flowerheads of Arnica lonchophylla

scientific article published in October 2004

Novel Phenyl-1-benzoxepinols from Butcher's Broom (Rusci rhizoma)

scientific article published on 01 June 2012

Novel seco-prezizaane sesquiterpenes from north american illicium species

scientific article published on 01 May 1999

On the stability of sesquiterpene lactones in the officinal Arnica tincture of the German pharmacopoeia

scientific article published on 01 October 2000

PLS-Prediction and Confirmation of Hydrojuglone Glucoside as the Antitrypanosomal Constituent of Juglans Spp.

scientific article

Pharmacological properties of the extract and some isolated compounds of Clausena lansium stem bark: anti-trichomonal, antidiabetic, anti-inflammatory, hepatoprotective and antioxidant effects

scientific article published on 27 November 2008

Phenolic Constituents of Medicinal Plants with Activity against Trypanosoma brucei.

scientific article

Pinoresinol-lariciresinol reductases with different stereospecificity from Linum album and Linum usitatissimum

scientific article published in June 2005

Pinoresinol-lariciresinol reductases with opposite enantiospecificity determine the enantiomeric composition of lignans in the different organs of Linum usitatissimum L.

scientific article published on 31 May 2010

Potent Antitrypanosomal Activities of 3-Aminosteroids against African Trypanosomes: Investigation of Cellular Effects and of Cross-Resistance with Existing Drugs

scientific article published on 12 January 2019

Potential of 2-hydroxy-3-phenylsulfanylmethyl-[1,4]-naphthoquinones against Leishmania (L.) infantum: biological activity and structure-activity relationships

scientific article

Preparation of Sesquiterpene Lactone-Loaded PLA Nanoparticles and Evaluation of Their Antitrypanosomal Activity

scientific article published on 04 June 2019

Quantitative structure--antiprotozoal activity relationships of sesquiterpene lactones

scientific article published on 8 June 2009

Reactivity of dimethyl fumarate and methylhydrogen fumarate towards glutathione and N-acetyl-L-cysteine--preparation of S-substituted thiosuccinic acid esters.

scientific article

Salvia Species as Sources of Natural Products with Antiprotozoal Activity

scientific article published on 16 January 2018

Search for Antiprotozoal Activity in Herbal Medicinal Preparations; New Natural Leads against Neglected Tropical Diseases.

scientific article published on 4 August 2015

Secondary metabolites from Vietnamese marine invertebrates with activity against Trypanosoma brucei and T. cruzi.

scientific article

Sesquiterpene Lactones from Vernonia cinerascens Sch. Bip. and Their in Vitro Antitrypanosomal Activity

scientific article

Sesquiterpene Lactones with Dual Inhibitory Activity against the Trypanosoma brucei Pteridine Reductase 1 and Dihydrofolate Reductase

scientific article published on 28 December 2021

Sesquiterpene lactone content in leaves of in vitro and field cultivated Arnica montana

scientific article published on 01 April 1998

Sesquiterpene lactone mix as a diagnostic tool for Asteraceae allergic contact dermatitis: chemical explanation for its poor performance and Sesquiterpene lactone mix II as a proposed improvement

scientific article published on 01 May 2012

Sesquiterpene lactones and inositol esters from Arnica angustifolia

scientific article published on 01 December 1995

Structure revision of xanthalongin and further sesquiterpene lactones from flowers of Arnica longifolia

scientific article published on 01 October 1998

Structure-Activity Relationships of Cinnamate Ester Analogues as Potent Antiprotozoal Agents

scientific article published on 12 November 2019

Structure-activity relationships of seco-prezizaane and picrotoxane/picrodendrane terpenoids by Quasar receptor-surface modeling

scientific article published in August 2004

Structure-activity relationships of seco-prezizaane terpenoids in gamma-aminobutyric acid receptors of houseflies and rats

scientific article

Structure-cytotoxicity relationships of some helenanolide-type sesquiterpene lactones

scientific article published on March 1997

Study of chromatographic retention of natural terpenoids by chemoinformatic tools.

scientific article published on 30 December 2014

Target-Guided Isolation of O-tigloylcyclovirobuxeine -B from Buxus sempervirens L. by Centrifugal Partition Chromatography

scientific article published on 19 October 2020

Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction

scientific article published on 2 December 2015

Tetrahydrofuran lignans from Illicium floridanum and their activity in a luminol enhanced chemiluminescence assay

scientific article published on 01 December 2000

The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65

scientific article

The antiprotozoal activity of methylated flavonoids from Ageratum conyzoides L.

scientific article published on 26 February 2010

The antiprotozoal activity of sixteen asteraceae species native to Sudan and bioactivity-guided isolation of xanthanolides from Xanthium brasilicum.

scientific article published on 8 May 2009

The influence of glutathione and cysteine levels on the cytotoxicity of helenanolide type sesquiterpene lactones against KB cells

scientific article

The molecular structure of 2alpha-hydroxyneoanisatin and structure-activity relationships among convulsant sesquiterpenes of the seco-prezizaane and picrotoxane types

scientific article published on 01 December 1999

The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research

article by James B. McAlpine et al published 13 July 2018 in Natural Product Reports

Tirucallic acids are novel pleckstrin homology domain-dependent Akt inhibitors inducing apoptosis in prostate cancer cells

scientific article

Unusual biotransformation products of the sesquiterpene lactone budlein A by Aspergillus species.

scientific article published on 14 October 2013

List of works by Thomas J Schmidt

(+)-Pinoresinol/(-)-lariciresinol reductase from Linum perenne Himmelszelt involved in the biosynthesis of justicidin B.

3-O-galloylated procyanidins from Rumex acetosa L. inhibit the attachment of influenza A virus

5D-QSAR for spirocyclic sigma1 receptor ligands by Quasar receptor surface modeling

6-methoxypodophyllotoxin-7-O-n-hexanoate, a new aryltetralin lignan ester from seeds of Linum flavum

9β-hydroxyparthenolide esters from Inula montbretiana and their antiprotozoal activity

A 3D-QSAR Study on the Antitrypanosomal and Cytotoxic Activities of Steroid Alkaloids by Comparative Molecular Field Analysis

A Comprehensive QSAR Study on Antileishmanial and Antitrypanosomal Cinnamate Ester Analogues

A New Alkamide with an Endoperoxide Structure from Acmella ciliata (Asteraceae) and Its in Vitro Antiplasmodial Activity.

A combined HPLC-UV and HPLC-MS method for the identification of lignans and its application to the lignans of Linum usitatissimum L. and L. bienne Mill

Accumulation of aryltetralin lactone lignans in cell suspension cultures of Linum nodiflorum

An aryldihydronaphthalene lignan with a novel type of ring system and further new lignans from linum perenne L.

An isoform-specific C/EBPβ inhibitor targets acute myeloid leukemia cells

An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from Eupatoriumperfoliatum

Anti-Protozoal Activities of Cembrane-Type Diterpenes from Vietnamese Soft Corals.

Antileishmanial activity, cytotoxicity and QSAR analysis of synthetic dihydrobenzofuran lignans and related benzofurans.

Antiprotozoal Sesquiterpene Lactones and Other Constituents from Tarchonanthus camphoratus and Schkuhria pinnata.

Antiprotozoal activity of Achillea ptarmica (Asteraceae) and its main alkamide constituents. ⬇️

Antiprotozoal activity of Buxus sempervirens and activity-guided isolation of O-tigloylcyclovirobuxeine-B as the main constituent active against Plasmodium falciparum.

Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies

Arnica Tincture Cures Cutaneous Leishmaniasis in Golden Hamsters.

Arylnaphthalene lignans from in vitro cultures of Linum austriacum.

Chemical Constituents from Ficus sagittifolia Stem Bark and Their Antimicrobial Activities

Complementary Quantitative Structure⁻Activity Relationship Models for the Antitrypanosomal Activity of Sesquiterpene Lactones

Complete structural assignment of serratol, a cembrane-type diterpene from Boswellia serrata, and evaluation of its antiprotozoal activity

Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research

Covalent modification of human serum albumin by the natural sesquiterpene lactone parthenolide.

Cytotoxicity of flavonoids and sesquiterpene lactones from Arnica species against the GLC4 and the COLO 320 cell lines.

Dermal Absorption of Sesquiterpene Lactones from Arnica Tincture

Detection of metabolites of fumaric acid esters in human urine: implications for their mode of action

Diarylbutyrolactone lignans from Linum corymbulosum in vitro cultures

Enantioselective synthesis of encecaline-derived potent antimalarial agents.

Encecalol angelate, an unstable chromene from Ageratum conyzoides L.: total synthesis and investigation of its antiprotozoal activity

Engineering of a monomeric fluorescent protein AsGFP499 and its applications in a dual translocation and transcription assay

Eupatorium perfoliatum L.: Phytochemistry, traditional use and current applications ⬇️

Evaluation of ethnomedical claim III: anti-hyperglycemic activities of Gongronema latifolium root and stem

Extract from Rumex acetosa L. for prophylaxis of periodontitis: inhibition of bacterial in vitro adhesion and of gingipains of Porphyromonas gingivalis by epicatechin-3-O-(4β→8)-epicatechin-3-O-gallate (procyanidin-B2-Di-gallate)

Glutathione adducts of helenalin and 11 alpha,13-dihydrohelenalin acetate inhibit glutathione S-transferase from horse liver

Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB

Helenanolide type sesquiterpene lactones. Part 5: the role of glutathione addition under physiological conditions

Helenanolide-type sesquiterpene lactones--III. Rates and stereochemistry in the reaction of helenalin and related helenanolides with sulfhydryl containing biomolecules

High-performance liquid chromatography/mass spectrometric identification of dibenzylbutyrolactone-type lignans: insights into electrospray ionization tandem mass spectrometric fragmentation of lign-7-eno-9,9'-lactones and application to the lignans

Hologram QSAR studies of antiprotozoal activities of sesquiterpene lactones.

Identification, pharmacological evaluation and binding mode analysis of novel chromene and chromane based σ1 receptor ligands

In Silico Identification and in Vitro Activity of Novel Natural Inhibitors of Trypanosoma brucei Glyceraldehyde-3-phosphate-dehydrogenase.

In Silico prediction and experimental evaluation of furanoheliangolide sesquiterpene lactones as potent agents against Trypanosoma brucei rhodesiense

In Vitro Metabolism of Helenalin Acetate and 11α,13-Dihydrohelenalin Acetate: Natural Sesquiterpene Lactones from Arnica

Influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in Jurkat T cells and human peripheral blood cells: anti-inflammatory and cytotoxic effects

Inhibition of Myb-dependent gene expression by the sesquiterpene lactone mexicanin-I.

Inhibition of transcription factor NF-kappaB by sesquiterpene lactones: a proposed molecular mechanism of action

Inhibitory effects of helenalin and related compounds on 5-lipoxygenase and leukotriene C(4) synthase in human blood cells

Justicidin B 7-hydroxylase, a cytochrome P450 monooxygenase from cell cultures of Linum perenne Himmelszelt involved in the biosynthesis of diphyllin

Kruppel-like factor KLF4 facilitates cutaneous wound healing by promoting fibrocyte generation from myeloid-derived suppressor cells.

Larrea tridentata—Absolute configuration of its epoxylignans and investigations on its antiprotozoal activity

Lignans from Arnica species

Lignans from Linum species of sections Syllinum and Linum

Lignans in flowering aerial parts of Linum species--chemodiversity in the light of systematics and phylogeny

Lignans in seeds of Linum species

Metabolic profiling of lignan variability in Linum species of section Syllinum native to Bulgaria

Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Therapeutics

Natural product derived antiprotozoal agents: synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane derivatives.

Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: structure-activity relationships

New allo-cedrane type sesquiterpene hemiketals and further sesquiterpene lactones from fruits of Illicium floridanum

New dihydrobenzofurans and triterpenoids from roots of Microglossa pyrifolia

New triterpene esters from flowerheads of Arnica lonchophylla

Novel Phenyl-1-benzoxepinols from Butcher's Broom (Rusci rhizoma)

Novel seco-prezizaane sesquiterpenes from north american illicium species

On the stability of sesquiterpene lactones in the officinal Arnica tincture of the German pharmacopoeia

PLS-Prediction and Confirmation of Hydrojuglone Glucoside as the Antitrypanosomal Constituent of Juglans Spp.

Pharmacological properties of the extract and some isolated compounds of Clausena lansium stem bark: anti-trichomonal, antidiabetic, anti-inflammatory, hepatoprotective and antioxidant effects

Phenolic Constituents of Medicinal Plants with Activity against Trypanosoma brucei.

Pinoresinol-lariciresinol reductases with different stereospecificity from Linum album and Linum usitatissimum

Pinoresinol-lariciresinol reductases with opposite enantiospecificity determine the enantiomeric composition of lignans in the different organs of Linum usitatissimum L.

Potent Antitrypanosomal Activities of 3-Aminosteroids against African Trypanosomes: Investigation of Cellular Effects and of Cross-Resistance with Existing Drugs

Potential of 2-hydroxy-3-phenylsulfanylmethyl-[1,4]-naphthoquinones against Leishmania (L.) infantum: biological activity and structure-activity relationships

Preparation of Sesquiterpene Lactone-Loaded PLA Nanoparticles and Evaluation of Their Antitrypanosomal Activity

Quantitative structure--antiprotozoal activity relationships of sesquiterpene lactones

Reactivity of dimethyl fumarate and methylhydrogen fumarate towards glutathione and N-acetyl-L-cysteine--preparation of S-substituted thiosuccinic acid esters.

Salvia Species as Sources of Natural Products with Antiprotozoal Activity

Search for Antiprotozoal Activity in Herbal Medicinal Preparations; New Natural Leads against Neglected Tropical Diseases.