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List of works by Ernst Lengyel

A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns

scientific article published on 16 October 2018

A High-Throughput Screening Model of the Tumor Microenvironment for Ovarian Cancer Cell Growth

scientific article published on 31 January 2017

A phase II, single-arm study of the anti-α5β1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer ⬇️

scientific article published on January 26, 2011

A prospective study evaluating diffusion weighted magnetic resonance imaging (DW-MRI) in the detection of peritoneal carcinomatosis in suspected gynecologic malignancies.

scientific article published on 28 April 2016

A special key for unlocking the door to targeted therapies of breast cancer.

scientific article

Acute inflammatory reaction following placement of sodium hyaluronate-carboxymethylcellulose barrier in a young woman undergoing gynecologic surgery: a case report

scientific article published on 01 January 2011

Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis

scientific article

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

scientific article

An activity-dependent proximity ligation platform for spatially resolved quantification of active enzymes in single cells.

scientific article published on 24 November 2017

An orally available small-molecule inhibitor of c-Met, PF-2341066, reduces tumor burden and metastasis in a preclinical model of ovarian cancer metastasis

scientific article

C-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2/neu

scientific article published in February 2005

CD95 promotes tumour growth

scientific article

Cancer as a Matter of Fat: The Crosstalk between Adipose Tissue and Tumors.

scientific article published on 5 April 2018

Clinico-pathologic comparison of type II endometrial cancers based on tamoxifen exposure

scientific article published on 24 July 2012

Combination Analysis of Activator Protein-1 Family Members, Sp1 and an Activator Protein-2 -Related Factor Binding to Different Regions of the Urokinase Receptor Gene in Resected Colorectal Cancers

article

Cytological diagnosis of zosteriform skin metastases in undiagnosed breast carcinoma

scientific article published on 01 September 1996

Differential expression of c-Met, its ligand HGF/SF and HER2/neu in DCIS and adjacent normal breast tissue

scientific article published on 01 July 2007

Dosimetric predictors of acute hematologic toxicity in cervical cancer patients treated with concurrent cisplatin and intensity-modulated pelvic radiotherapy

scientific article

Downregulation of a mitogen-activated protein kinase signaling pathway in the placentas of women with preeclampsia

scientific article published on 01 October 2000

Effects of oral contraceptives or a gonadotropin-releasing hormone agonist on ovarian carcinogenesis in genetically engineered mice.

scientific article published on 08 September 2009

Elevated keratin 18 protein expression indicates a favorable prognosis in patients with breast cancer.

scientific article

Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular signal-regulated kinase-1-dependent signaling cascade

scientific article published on May 1997

Epithelial ovarian cancer experimental models.

scientific article published on 12 August 2013

Exosomes Promote Ovarian Cancer Cell Invasion through Transfer of CD44 to Peritoneal Mesothelial Cells

scientific article published on 06 October 2016

Expression of latent matrix metalloproteinase 9 (MMP-9) predicts survival in advanced ovarian cancer

scientific article published on 01 August 2001

Expression of the homeobox gene HOXA9 in ovarian cancer induces peritoneal macrophages to acquire an M2 tumor-promoting phenotype.

scientific article published on January 2014

FOXL2 and SOX9 distinguish the lineage of the sex cord-stromal cells in gonadoblastomas.

scientific article published on 17 June 2011

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis

scientific article published on 30 August 2018

Foretinib (GSK1363089), an orally available multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces anoikis, and impairs ovarian cancer metastasis.

scientific article

Gastrin induces expression and promoter activity of the vesicular monoamine transporter subtype 2.

scientific article

Genomics of Ovarian Cancer Progression Reveals Diverse Metastatic Trajectories Including Intraepithelial Metastasis to the Fallopian Tube

scientific article

Glucocorticoid receptor activation inhibits chemotherapy-induced cell death in high-grade serous ovarian carcinoma

scientific article

HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts.

scientific article

Healthy food for trainees: a call to action

scientific article published on 20 August 2020

High glucocorticoid receptor expression predicts short progression-free survival in ovarian cancer

scientific article published on 26 April 2017

Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer

scientific article

Induction of M(r) 92,000 type IV collagenase expression in a squamous cell carcinoma cell line by fibroblasts.

scientific article published on February 1995

Induction of Neoantigen-specific Cytotoxic T Cells and Construction of T-cell Receptor-engineered T cells for Ovarian Cancer

scientific article published on 2 May 2018

Inhibition of fascin in cancer and stromal cells blocks ovarian cancer metastasis

scientific article published on 20 February 2019

Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status

scientific article published on 26 August 2016

Integrin alpha(v)beta(3)/vitronectin interaction affects expression of the urokinase system in human ovarian cancer cells

scientific article

Involvement of a mitogen-activated protein kinase signaling pathway in the regulation of urokinase promoter activity by c-Ha-ras.

scientific article

Isolation and characterization of Rac1 pseudogenes (psi1Rac1-psi4Rac1) in the human genome

scientific article

JNK and p38MAPK are activated during graft reperfusion and not during cold storage in rat liver transplantation

scientific article published on 01 February 2001

Keratin expression reveals mosaic differentiation in vaginal epithelium

scientific article published in December 1993

Let-7 expression defines two differentiation stages of cancer

scientific article

Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2

scientific article

Ligand-independent activation of c-Met by fibronectin and α(5)β(1)-integrin regulates ovarian cancer invasion and metastasis

scientific article

Loss of BRCA1 in the Cells of Origin of Ovarian Cancer Induces Glycolysis: A Window of Opportunity for Ovarian Cancer Chemoprevention.

scientific article published on 6 March 2017

Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion.

scientific article

Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers

scientific article published on 12 October 2016

Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel in mouse models.

scientific article

MicroRNAs as mediators and communicators between cancer cells and the tumor microenvironment

scientific article published on 13 April 2015

Microenvironment-induced downregulation of miR-193b drives ovarian cancer metastasis.

scientific article

Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity

scientific article published on 31 December 2015

Molecular pathways: trafficking of metabolic resources in the tumor microenvironment

scientific article

Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer

scientific article published on 01 September 2018

Mutant p53 regulates LPA signaling through lysophosphatidic acid phosphatase type 6

scientific article published on 26 March 2019

Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum

scientific article published on 19 December 2018

Old drug, new trick: repurposing metformin for gynecologic cancers?

scientific article

Organotypic models of metastasis: A three-dimensional culture mimicking the human peritoneum and omentum for the study of the early steps of ovarian cancer metastasis

scientific article published on January 2009

Patterns and utility of routine surveillance in high grade endometrial cancer

scientific article published on 30 March 2015

Prolactin Receptor-Mediated Internalization of Imaging Agents Detects Epithelial Ovarian Cancer with Enhanced Sensitivity and Specificity

scientific article published on 15 February 2017

Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts

scientific article published on 01 May 2019

Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.

scientific article published on 5 February 2015

RFLP Molecular Analysis of the Urokinase-Type Plasminogen Activator Gene

scientific article published on January 2001

Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation

scientific article published on 7 July 2009

Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation

scientific article

Regulation of 92 kDa type IV collagenase expression by the jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signaling cascades

scientific article published on March 1997

Relationship of type II diabetes and metformin use to ovarian cancer progression, survival, and chemosensitivity.

scientific article published on January 2012

Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer

scientific article

Rethinking ovarian cancer: recommendations for improving outcomes

scientific article

Reversal of Chemoresistance in Ovarian Cancer by Co-Delivery of a P-Glycoprotein Inhibitor and Paclitaxel in a Liposomal Platform

scientific article

Reversible posterior leukoencephalopathy syndrome following intravenous paclitaxel and intraperitoneal cisplatin chemotherapy for fallopian tube cancer

scientific article published on 13 June 2008

Serial sectioning of the fallopian tube allows for improved identification of primary fallopian tube carcinoma.

scientific article published on 10 December 2012

Single-agent pulse dactinomycin has only modest activity for methotrexate-resistant gestational trophoblastic neoplasia

scientific article

Src Induces Urokinase Receptor Gene Expression and Invasion/Intravasation via Activator Protein-1/p-c-Jun in Colorectal Cancer

article

Statin therapy is associated with improved survival in patients with non-serous-papillary epithelial ovarian cancer: a retrospective cohort analysis

scientific article

Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences.

scientific article

Stimulation of urokinase expression by TNF-alpha requires the activation of binding sites for the AP-1 and PEA3 transcription factors

scientific article published on July 1995

Summary of the 2013 American Association for Cancer Research (AACR) Annual Meeting

scientific article published in July 2013

Targeting the urokinase plasminogen activator receptor inhibits ovarian cancer metastasis

scientific article

The Müllerian HOXA10 gene promotes growth of ovarian surface epithelial cells by stimulating epithelial-stromal interactions

scientific article

The Ratio of Toxic-to-Nontoxic miRNAs Predicts Platinum Sensitivity in Ovarian Cancer

scientific article published on 15 June 2021

The Tumor Microenvironment Takes Center Stage in Ovarian Cancer Metastasis

scientific article published on 22 June 2018

The clinical importance of keratin 18 in breast cancer

scientific article published in January 1999

The effects of 17β-estradiol and a selective estrogen receptor modulator, bazedoxifene, on ovarian carcinogenesis

scientific article published on 11 October 2011

The expression of hepatocyte growth factor (HGF) and c-Met in uterine serous carcinoma

scientific article published on 17 December 2010

The first line of intra-abdominal metastatic attack: breaching the mesothelial cell layer.

scientific article

The hypoxia-related microRNA miR-199a-3p displays tumor suppressor functions in ovarian carcinoma.

scientific article published on May 2015

The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin.

scientific article

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

scientific article

The road to long-term survival: Surgical approach and longitudinal treatments of long-term survivors of advanced-stage serous ovarian cancer

scientific article published on 22 November 2018

Three-dimensional modeling of ovarian cancer.

scientific article published on 14 July 2014

Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta1-integrin on the cell surface

scientific article

Transient interaction of activated platelets with endothelial cells induces expression of monocyte-chemoattractant protein-1 via a p38 mitogen-activated protein kinase mediated pathway. Implications for atherogenesis

scientific article published in January 2001

Tumor-specific transcription factor binding to an activator protein-2/Sp1 element of the urokinase-type plasminogen activator receptor promoter in a first large series of resected gastrointestinal cancers

scientific article published on 01 June 2003

Tyrosine kinase mutations in human cancer

scientific article published on February 2007

UVB increases urokinase-type plasminogen activator receptor (uPAR) expression

scientific article published on July 1999

Unsaturated Fatty Acids Maintain Cancer Cell Stemness.

scientific article

Up-regulation of alpha5-integrin by E-cadherin loss in hypoxia and its key role in the migration of extravillous trophoblast cells during early implantation

scientific article

Up-regulation of urokinase-type plasminogen activator expression by the HER2/neu proto-oncogene.

scientific article published on July 1995

Urokinase plasminogen activator system-targeted delivery of nanobins as a novel ovarian cancer therapy

scientific article published on 23 September 2013

Use of a novel 3D culture model to elucidate the role of mesothelial cells, fibroblasts and extra-cellular matrices on adhesion and invasion of ovarian cancer cells to the omentum

scientific article published on 01 October 2007

WNT7A/β-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer.

scientific article

Who are the long-term survivors of high grade serous ovarian cancer?

scientific article published on 8 November 2017

Whole-genome characterization of chemoresistant ovarian cancer

scientific article published in May 2015

beta(3)A-integrin downregulates the urokinase-type plasminogen activator receptor (u-PAR) through a PEA3/ets transcriptional silencing element in the u-PAR promoter

scientific article published on March 2001

c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion

scientific article published on 01 February 2007

m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

scientific article published on 27 August 2018

miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin α5 expression

scientific article published on 15 March 2013

{beta}3-integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer.

scientific article published on October 2009

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