Search filters

List of works by James W. Paxton

3'-azido-3'-deoxythymidine (AZT) induces apoptosis and alters metabolic enzyme activity in human placenta

scientific article published on October 2003

A difference between the rat and mouse in the pharmacokinetic interaction of 5,6-dimethylxanthenone-4-acetic acid with thalidomide

scientific article published in June 2001

A rapid LC-MS/MS method for the quantitation of a series of benzonaphthyridine derivatives: application to in vivo pharmacokinetic and lipophilicity studies in drug development

scientific article published on 28 January 2012

A rapid, sensitive and specific radioimmunoassay for methotrexate

scientific article published in November 1977

ABC drug transporter expression and functional activity in trophoblast-like cell lines and differentiating primary trophoblast

scientific article published in December 2005

Absence of effect of propoxyphene on antipyrine kinetics in the rabbit

scientific article published on 01 January 1983

Bioavailability of methotrexate: implications for clinical use

scientific article published on 01 January 1979

Bioavailability of metoprolol in young adults and the elderly, with additional studies on the effects of metoclopramide and probanthine

scientific article published on 01 January 1983

Blood-brain barrier penetration of felbamate

scientific article published in September 1992

Blood-brain glucose transfer in the mouse.

scientific article

Carbamazepine determination in saliva of children: enzyme immunoassay (EMIT) versus high pressure liquid chromatography

scientific article published on 01 April 1982

Comparison of a homologous series of benzonaphthyridine anti-cancer agents in mice: divergence between tumour and plasma pharmacokinetics

scientific article published on 3 June 2012

Comparison of the blood-brain barrier and liver penetration of acridine antitumor drugs.

scientific article published in January 1992

Comparison of the pharmacokinetics and protein binding of the anticancer drug, amsacrine and a new analogue, N-5-dimethyl-9-[(2-methoxy-4-methylsulfonylamino)phenyl-amino] -4-acridinecarboxamide in rabbits

scientific article published on 01 January 1986

Conformational and chemical requirements for antibody recognition of diphenylhydantoin derivatives

scientific article published on November 1976

Cytosol mediated metabolism of the experimental antitumor agent acridine carboxamide to the 9-acridone derivative

scientific article published on 01 October 1991

Determination of thalidomide in transport buffer for Caco-2 cell monolayers by high-performance liquid chromatography with ultraviolet detection

scientific article published on February 2003

Determination of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid and its acyl glucuronide in Caco-2 monolayers by liquid chromatography with fluorescence detection: application to transport studies

scientific article published on September 2004

Development and validation of a liquid chromatography-mass spectrometry (LC-MS) assay for the determination of the anti-cancer agent N-[2-(dimethylamino)ethyl]-2,6-dimethyl-1-oxo-1,2-dihydrobenzo[b]-1,6-naphthyridine-4-carboxamide (SN 28049).

scientific article

Development and validation of bioanalytical method for the determination of asulacrine in plasma by liquid chromatography

scientific article published on 2 October 2007

Development of Long-Circulating pH-Sensitive Liposomes to Circumvent Gemcitabine Resistance in Pancreatic Cancer Cells

scientific article published on 10 March 2016

Development of a gradient high performance liquid chromatography assay for simultaneous analysis of hydrophilic gemcitabine and lipophilic curcumin using a central composite design and its application in liposome development

scientific article published on 21 June 2014

Development of high-content gemcitabine PEGylated liposomes and their cytotoxicity on drug-resistant pancreatic tumour cells.

scientific article published on 18 March 2014

Dietary polyacetylenes of the falcarinol type are inhibitors of breast cancer resistance protein (BCRP/ABCG2).

scientific article published on 20 November 2013

Differences in the metabolism of the antitumour agents amsacrine and its derivative CI-921 in rat and mouse

scientific article

Dose-dependent pharmacokinetics of N-5-dimethyl-9-[(2-methoxy-4-methylsulphonylamino)phenylamino]- 4-acridinecarboxamide (CI-921) in rabbits

scientific article published on 01 January 1987

Drug transfer and metabolism by the human placenta.

scientific article published on January 2004

Effects of anticancer drugs on the metabolism of the anticancer drug 5,6-dimethylxanthenone-4-acetic (DMXAA) by human liver microsomes

scientific article

Enhanced pH-Responsiveness, Cellular Trafficking, Cytotoxicity and Long-circulation of PEGylated Liposomes with Post-insertion Technique Using Gemcitabine as a Model Drug

scientific article published on 6 February 2015

Enhancement of the action of the antivascular drug 5,6-dimethylxanthenone-4-acetic acid (DMXAA; ASA404) by non-steroidal anti-inflammatory drugs

scientific article published on 12 August 2008

Enzyme immunoassay of carbamazepine in serum and saliva

scientific article published on 01 June 1980

Expression, localisation and activity of ATP binding cassette (ABC) family of drug transporters in human amnion membranes

scientific article published on 07 May 2007

Formulation and pharmacokinetic evaluation of an asulacrine nanocrystalline suspension for intravenous delivery

scientific article

Gender differences in the metabolism and pharmacokinetics of the experimental anticancer agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA).

scientific article published on 24 October 2001

Hepatic delta-aminolaevulinic acid synthetase in an attack of hereditary coproporphyria and during remission

scientific article published in March 1971

Heterocyclic cyclohexanone monocarbonyl analogs of curcumin can inhibit the activity of ATP-binding cassette transporters in cancer multidrug resistance.

scientific article

High-throughput screening of potential inhibitors for the metabolism of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid.

scientific article published in February 2002

Hop-derived prenylflavonoids are substrates and inhibitors of the efflux transporter breast cancer resistance protein (BCRP/ABCG2)

scientific article published on 06 August 2014

Human placental glucuronidation and transport of 3'azido-3'-deoxythymidine and uridine diphosphate glucuronic acid

scientific article published on August 2004

Identification and reactivity of the major metabolite (beta-1-glucuronide) of the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in humans

scientific article published in May 2001

Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2).

scientific article published on 27 December 2012

Improving the oral bioavailability of beneficial polyphenols through designed synergies.

scientific article

In vitro and in vivo kinetic interactions of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid with thalidomide and diclofenac

scientific article

Independent regulation of apical and basolateral drug transporter expression and function in placental trophoblasts by cytokines, steroids, and growth factors

scientific article published on 19 January 2007

Inhibition of human CYP1A2 oxidation of 5,6-dimethyl-xanthenone-4-acetic acid by acridines: a molecular modelling study

scientific article published in August 2005

Inter-species variation in the metabolism and inhibition of N-[(2'-dimethylamino)ethyl]acridine-4-carboxamide (DACA) by aldehyde oxidase

scientific article published on 01 January 2000

Interaction of probenecid with the protein binding of methotrexate.

scientific article published in January 1984

Interactions of dietary phytochemicals with ABC transporters: possible implications for drug disposition and multidrug resistance in cancer.

scientific article

Intraperitoneal administration of the antitumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in the mouse: bioavailability, pharmacokinetics and toxicity after a single dose

scientific article published in January 1992

Involvement of glutathione in the metabolism of the anilinoacridine antitumour agents CI-921 and amsacrine

scientific article published on 01 January 1988

Metabolism of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in cancer patients undergoing a phase I clinical trial

scientific article published on 01 January 1999

Modulatory effects of curcumin on multi-drug resistance-associated protein 5 in pancreatic cancer cells

scientific article published on 30 November 2010

Multidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane Vesicles

scientific article

Non-specific binding of the experimental anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in liver microsomes from various species

scientific article published in July 2002

Pharmacokinetics and distribution of SN 28049, a novel DNA binding anticancer agent, in mice

scientific article published on 23 September 2009

Pharmacokinetics and pharmacodynamics of chlorambucil delivered in long-circulating nanoemulsion

scientific article published in February 2010

Pharmacokinetics and pharmacodynamics of chlorambucil delivered in parenteral emulsion

scientific article published on 22 April 2008

Pharmacokinetics and toxicity of the antitumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide after i.v. administration in the mouse.

scientific article published in January 1992

Pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (AS1404), a novel vascular disrupting agent, in phase I clinical trial

scientific article published on 23 September 2006

Pharmacokinetics of acridine-4-carboxamide in the rat, with extrapolation to humans.

scientific article published in January 1993

Pharmacokinetics of amsacrine in patients receiving combined chemotherapy for treatment of acute myelogenous leukemia

scientific article published on 01 January 1985

Plasma and biliary disposition of pirenzepine in man

scientific article published on 01 March 1986

Plasma disposition, metabolism and excretion of the experimental antitumour agent 5,6-dimethylxanthenone-4-acetic acid in the mouse, rat and rabbit

scientific article published on 01 January 1999

Plasma pharmacokinetics of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in a phase I trial

scientific article published on 01 January 1999

Plasma protein binding of the experimental antitumour agent acridine-4-carboxamide in man, dog, rat and rabbit

scientific article published on 01 January 1994

Potentiation of the antitumour effect of cyclophosphamide in mice by thalidomide

scientific article published on 6 July 2002

Preclinical factors affecting the interindividual variability in the clearance of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid

scientific article

Preclinical factors influencing the relative contributions of Phase I and II enzymes to the metabolism of the experimental anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid

scientific article published in January 2003

Predicting pharmacokinetics and drug interactions in patients from in vitro and in vivo models: the experience with 5,6-dimethylxanthenone-4-acetic acid (DMXAA), an anti-cancer drug eliminated mainly by conjugation.

scientific article

Prediction of herb-drug metabolic interactions: a simulation study

scientific article published on 01 June 2005

Production and characterisation of antisera to diphenylhydantoin suitable for radioimmunoassay

scientific article published on 01 January 1976

Propranolol binding in serum: comparison of methods and investigation of effects of drug concentration, pH, and temperature

scientific article published on 01 August 1983

Protein binding of methotrexate in sera from normal human beings: effect of drug concentration, pH, temperature, and storage ⬇️

scientific article published on 01 May 1981

Rat hepatocyte-mediated metabolism of the experimental anti-tumour agent N-[2'-(dimethylamino)ethyl]acridine-4-carboxamide

scientific article published on 01 April 1993

Reversible binding of the novel anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid to plasma proteins and its distribution into blood cells in various species

scientific article

Salivary phenytoin radioimmunoassay. A simple method of the assessment of non-protein bound drug concentrations

scientific article published on 01 January 1977

Selective cellular uptake and retention of SN 28049, a new DNA-binding topoisomerase II-directed antitumor agent

scientific article

Species differences in the metabolism of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid in vitro: implications for prediction of metabolic interactions in vivo

scientific article published in February 2002

Strain differences in the liver microsomal metabolism of the experimental anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid in mice

scientific article

Sustained release of a corticosteroid using polymeric implants

scientific article published on 01 November 1986

The ABC transporter BCRP/ABCG2 is a placental survival factor, and its expression is reduced in idiopathic human fetal growth restriction.

scientific article published on 26 June 2007

The binding of amsacrine to human plasma proteins

scientific article published on 01 June 1986

The clinical pharmacokinetics of N-5-dimethyl-9-[(2-methoxy-4-methyl-sulfonylamino)phenylamino]-4 -acridinecarboxamide (CI-921) in a phase 1 trial

scientific article published on 01 January 1988

The effect of buthionine sulphoximine, cimetidine and phenobarbitone on the disposition of amsacrine in the rabbit

scientific article published in January 1986

The effect of cimetidine, phenobarbitone and buthionine sulphoximine on the disposition of N-5-dimethyl-9-[(2-methoxy-4-methyl-sulphonylamino)phenylamino]- 4-acridinecarboxamide (CI-921) in the rabbit

scientific article published on January 1989

The effect of food on the bioavailability and kinetics of the anticancer drug amsacrine and a new analogue, N-5-dimethyl-9-[(2-methoxy-4-methylsulphonylamino)phenylamino]-4 acridinecarboxamide in rabbits

scientific article published in November 1986

The effect of label affinity on the sensitivity and specificity of a hapten radioimmunoassay: a comparison of three [125I]diphenylhydantoin radioligands with the 14C-labelled drug

scientific article published on January 1979

The effects of flavonoids on the ABC transporters: consequences for the pharmacokinetics of substrate drugs ⬇️

scientific article published on 06 January 2013

The evaluation of a radioimmunoassay for diphenylhydantoin using an iodinated tracer

scientific article published in August 1977

The evaluation of a radioimmunoassay for phenothiazines and thioxanthenes using an iodinated tracer

scientific article published on 01 January 1979

The protein binding and elimination of methotrexate after intravenous infusions in cancer patients

scientific article published on 01 May 1982

The xenobiotic transporter ABCG2 plays a novel role in differentiation of trophoblast-like BeWo cells

scientific article published on 31 January 2007

Thiolytic cleavage and binding of the antitumour agent CI-921 in blood

scientific article published on 01 January 1988

Transport of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid and its acyl glucuronide by human intestinal Caco-2 cells

scientific article published in April 2005

Tumour profile of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide after intraperitoneal administration in the mouse.

scientific article published in January 1993

Tumour tissue selectivity in the uptake and retention of SN 28049, a new topoisomerase II-directed anticancer agent

scientific article published on 14 September 2013

UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term

scientific article (publication date: February 2002)

Paulina is supported by:

About Paulina

Help