List of works - Marzia Malcangio

1-(2′,4′-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide, a novel CB2 agonist, alleviates neuropathic pain through functional microglial changes in mice

scientific article published on 03 October 2009

A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis

article

Abnormal substance P release from the spinal cord following injury to primary sensory neurons

scientific article published on 01 January 2000

Assessment and treatment of pain in people with dementia

scientific article published on 10 April 2012

Astrocytes--multitaskers in chronic pain

scientific article published on 22 March 2013

BDNF modulates sensory neuron synaptic activity by a facilitation of GABA transmission in the dorsal horn

scientific article published in September 2002

BDNF: a neuromodulator in nociceptive pathways?

article

Basal and activity-induced release of substance P from primary afferent fibres in NK1 receptor knockout mice: evidence for negative feedback

scientific article published in December 2003

Brain-derived neurotrophic factor induces NMDA receptor subunit one phosphorylation via ERK and PKC in the rat spinal cord

scientific article

CB(1) receptor antagonist SR141716A increases capsaicin-evoked release of Substance P from the adult mouse spinal cord

scientific article

Calcitonin gene-related peptide-expressing sensory neurons and spinal microglial reactivity contribute to pain states in collagen-induced arthritis

scientific article published on June 2015

Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor

scientific article published on November 2010

Chemokine mediated neuron-glia communication and aberrant signalling in neuropathic pain states

scientific article

Chemokines and pain mechanisms.

scientific article published on 25 December 2008

Chronic pain: new insights in molecular and cellular mechanisms

scientific article

Current challenges in glia-pain biology

scientific article published on October 2009

Development of monosodium acetate-induced osteoarthritis and inflammatory pain in ageing mice

scientific article published on 14 May 2015

Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons

scientific article

Effect of brain-derived neurotrophic factor on the release of substance P from rat spinal cord

scientific article

Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner

scientific article published on 11 January 2016

Erratum to “Neurotrophin secretion: current facts and future prospects” [Progr. Neurobiol. 69 (2003) 341–374]

scholarly article published in Progress in Neurobiology

Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma.

scientific article published on 24 November 2017

Fractalkine/CX3CR1 signaling during neuropathic pain

scientific article published on 07 May 2014

GABAB receptors and pain

scientific article

GDNF and somatostatin in sensory neurones

scientific article

Gabapentin reverses microglial activation in the spinal cord of streptozotocin-induced diabetic rats

scientific article

Glatiramer acetate attenuates neuropathic allodynia through modulation of adaptive immune cells

scientific article

Hydrogen peroxide is a novel mediator of inflammatory hyperalgesia, acting via transient receptor potential vanilloid 1-dependent and independent mechanisms

scientific article

Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain

scientific journal article

Intrathecally delivered glial cell line-derived neurotrophic factor produces electrically evoked release of somatostatin in the dorsal horn of the spinal cord.

scientific article

Intrathecally injected neurotrophins and the release of substance P from the rat isolated spinal cord

scientific article

MAP kinase and pain

scientific article

Mechanism by which brain-derived neurotrophic factor increases dopamine release from the rabbit retina

scientific article

Microglial signalling mechanisms: Cathepsin S and Fractalkine ⬇️

scientific article published on September 17, 2011

Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain

scientific article published on 17 April 2014

Neuron-immune mechanisms contribute to pain in early stages of arthritis

scientific article published on 29 April 2016

Neuropathic pain and cytokines: current perspectives

scientific article

Neurotrophin secretion: current facts and future prospects

scientific article

Noxious stimulation induces Trk receptor and downstream ERK phosphorylation in spinal dorsal horn

scientific article published in December 2002

P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide

scientific article

Pain related behaviour in two models of osteoarthritis in the rat knee

scientific article published in November 2004

Pain-like behaviour and spinal changes in the monosodium iodoacetate model of osteoarthritis in C57Bl/6 mice

scientific article published on 21 November 2012

Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions

scientific article published on April 2008

Rapid co-release of interleukin 1beta and caspase 1 in spinal cord inflammation

scientific journal article

Rapid isolation and culture of primary microglia from adult mouse spinal cord.

scientific article published on 9 July 2009

Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice

article

Reduced thermal sensitivity and increased opioidergic tone in the TASTPM mouse model of Alzheimer's disease

scientific article published on 09 June 2016

Role of extracellular calcitonin gene-related peptide in spinal cord mechanisms of cancer-induced bone pain

scientific article published on 13 November 2015

Role of spinal microglia in rat models of peripheral nerve injury and inflammation

article

Role of the cysteine protease cathepsin S in neuropathic hyperalgesia

scientific article

Selective activation of microglia facilitates synaptic strength

scientific article published on March 2015

Specific antinociceptive activity of cholest-4-en-3-one, oxime (TRO19622) in experimental models of painful diabetic and chemotherapy-induced neuropathy

scientific article

Spinal cathepsin S and fractalkine contribute to chronic pain in the collagen-induced arthritis model

scientific article published on 27 December 2011

Spinal changes associated with mechanical hypersensitivity in a model of Guillain–Barré syndrome

article

Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats

scientific article published on September 2010

The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse

scientific article

The effect of treatment with BRX-220, a co-inducer of heat shock proteins, on sensory fibers of the rat following peripheral nerve injury

scientific article (publication date: December 2003)

The liberation of fractalkine in the dorsal horn requires microglial cathepsin S.

scientific article published on May 2009

The role of G-protein receptor 84 in experimental neuropathic pain

scientific article published on June 2015

The role of glia in the spinal cord in neuropathic and inflammatory pain

scientific article published on January 2015

The signaling components of sensory fiber transmission involved in the activation of ERK MAP kinase in the mouse dorsal horn

scientific article published in October 2003

The therapeutic potential of targeting chemokine signalling in the treatment of chronic pain

scientific article published on 14 December 2016

microRNAs in nociceptive circuits as predictors of future clinical applications.

scientific article published on 17 October 2013

List of works by Marzia Malcangio

1-(2′,4′-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide, a novel CB2 agonist, alleviates neuropathic pain through functional microglial changes in mice

A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis

Abnormal substance P release from the spinal cord following injury to primary sensory neurons

Assessment and treatment of pain in people with dementia

Astrocytes--multitaskers in chronic pain

BDNF modulates sensory neuron synaptic activity by a facilitation of GABA transmission in the dorsal horn

BDNF: a neuromodulator in nociceptive pathways?

Basal and activity-induced release of substance P from primary afferent fibres in NK1 receptor knockout mice: evidence for negative feedback

Brain-derived neurotrophic factor induces NMDA receptor subunit one phosphorylation via ERK and PKC in the rat spinal cord

CB(1) receptor antagonist SR141716A increases capsaicin-evoked release of Substance P from the adult mouse spinal cord

Calcitonin gene-related peptide-expressing sensory neurons and spinal microglial reactivity contribute to pain states in collagen-induced arthritis

Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor

Chemokine mediated neuron-glia communication and aberrant signalling in neuropathic pain states

Chemokines and pain mechanisms.

Chronic pain: new insights in molecular and cellular mechanisms

Current challenges in glia-pain biology

Development of monosodium acetate-induced osteoarthritis and inflammatory pain in ageing mice

Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons

Effect of brain-derived neurotrophic factor on the release of substance P from rat spinal cord

Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner

Erratum to “Neurotrophin secretion: current facts and future prospects” [Progr. Neurobiol. 69 (2003) 341–374]

Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma.

Fractalkine/CX3CR1 signaling during neuropathic pain

GABAB receptors and pain

GDNF and somatostatin in sensory neurones

Gabapentin reverses microglial activation in the spinal cord of streptozotocin-induced diabetic rats

Glatiramer acetate attenuates neuropathic allodynia through modulation of adaptive immune cells

Hydrogen peroxide is a novel mediator of inflammatory hyperalgesia, acting via transient receptor potential vanilloid 1-dependent and independent mechanisms

Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain

Intrathecally delivered glial cell line-derived neurotrophic factor produces electrically evoked release of somatostatin in the dorsal horn of the spinal cord.

Intrathecally injected neurotrophins and the release of substance P from the rat isolated spinal cord

MAP kinase and pain

Mechanism by which brain-derived neurotrophic factor increases dopamine release from the rabbit retina

Microglial signalling mechanisms: Cathepsin S and Fractalkine ⬇️

Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain

Neuron-immune mechanisms contribute to pain in early stages of arthritis

Neuropathic pain and cytokines: current perspectives

Neurotrophin secretion: current facts and future prospects

Noxious stimulation induces Trk receptor and downstream ERK phosphorylation in spinal dorsal horn

P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide

Pain related behaviour in two models of osteoarthritis in the rat knee

Pain-like behaviour and spinal changes in the monosodium iodoacetate model of osteoarthritis in C57Bl/6 mice

Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions

Rapid co-release of interleukin 1beta and caspase 1 in spinal cord inflammation

Rapid isolation and culture of primary microglia from adult mouse spinal cord.

Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice

Reduced thermal sensitivity and increased opioidergic tone in the TASTPM mouse model of Alzheimer's disease

Role of extracellular calcitonin gene-related peptide in spinal cord mechanisms of cancer-induced bone pain

Role of spinal microglia in rat models of peripheral nerve injury and inflammation

Role of the cysteine protease cathepsin S in neuropathic hyperalgesia

Selective activation of microglia facilitates synaptic strength

Specific antinociceptive activity of cholest-4-en-3-one, oxime (TRO19622) in experimental models of painful diabetic and chemotherapy-induced neuropathy

Spinal cathepsin S and fractalkine contribute to chronic pain in the collagen-induced arthritis model

Spinal changes associated with mechanical hypersensitivity in a model of Guillain–Barré syndrome

Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats

The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse

The effect of treatment with BRX-220, a co-inducer of heat shock proteins, on sensory fibers of the rat following peripheral nerve injury

The liberation of fractalkine in the dorsal horn requires microglial cathepsin S.

The role of G-protein receptor 84 in experimental neuropathic pain

The role of glia in the spinal cord in neuropathic and inflammatory pain

The signaling components of sensory fiber transmission involved in the activation of ERK MAP kinase in the mouse dorsal horn

The therapeutic potential of targeting chemokine signalling in the treatment of chronic pain

microRNAs in nociceptive circuits as predictors of future clinical applications.