List of works - Roberta Palla

A recurrent Gly43Asp substitution in coagulation Factor X rigidifies its catalytic pocket and impairs catalytic activity and intracellular trafficking

scientific article published on 21 December 2013

ADAMTS-13 activity and autoantibodies classes and subclasses as prognostic predictors in acquired thrombotic thrombocytopenic purpura

scientific article

ADAMTS-13 assays in thrombotic thrombocytopenic purpura

scientific article

ADAMTS13 and anti-ADAMTS13 antibodies as markers for recurrence of acquired thrombotic thrombocytopenic purpura during remission

scientific article

ADAMTS13 mutations and polymorphisms in congenital thrombotic thrombocytopenic purpura

scientific article

Active platelet-binding conformation of plasma von Willebrand factor in young women with acute myocardial infarction

scientific article published on 30 April 2010

B and T lymphocytes in acquired Thrombotic Thrombocytopenic Purpura during disease remission

article published in 2011

Choices of factor VIII products in previously untreated patients with haemophilia A: A global survey

scientific article published on 05 June 2018

Coagulation factor activity and clinical bleeding severity in rare bleeding disorders: results from the European Network of Rare Bleeding Disorders.

scientific article published in April 2012

Congenital thrombotic thrombocytopenic purpura with novel mutations in three unrelated Turkish children

scientific article

Diagnostic relevance of ADAMTS13 activity: evaluation of 28 patients with thrombotic thrombocytopenic purpura - hemolytic uremic syndrome clinical diagnosis

scientific article

Different clinical severity of first episodes and recurrences of thrombotic thrombocytopenic purpura

scientific article

Establishment of a bleeding score as a diagnostic tool for patients with rare bleeding disorders

scientific article published on 14 November 2016

Evaluation of assay methods to measure plasma ADAMTS13 activity in thrombotic microangiopathies

scientific article published on 23 November 2010

FRETS-VWF73 rather than CBA assay reflects ADAMTS13 proteolytic activity in acquired thrombotic thrombocytopenic purpura patients

scientific article

Formation of methionine sulfoxide by peroxynitrite at position 1606 of von Willebrand factor inhibits its cleavage by ADAMTS-13: A new prothrombotic mechanism in diseases associated with oxidative stress

scientific article published on 4 December 2009

Genetic diagnosis of haemophilia and other inherited bleeding disorders.

scientific article

Hemostatic alterations in COVID-19

scientific article published on 27 August 2020

IgG subclasses as biomarkers for persistence of factor VIII inhibitors in previously untreated patients with severe haemophilia A

scientific article published on 14 December 2020

Inactivation of ADAMTS13 by plasmin as a potential cause of thrombotic thrombocytopenic purpura.

scientific article

Introduction. Rare bleeding disorders: general aspects of clinical features, diagnosis, and management

scientific article

Measurement of anti-ADAMTS13 neutralizing autoantibodies: a comparison between CBA and FRET assays

scientific article published on 01 July 2012

Mechanisms of the interaction between two ADAMTS13 gene mutations leading to severe deficiency of enzymatic activity.

scientific article published in April 2006

Mechanistic studies on ADAMTS13 catalysis

scientific article published on 23 May 2008

Molecular Mapping of the Chloride-binding Site in von Willebrand Factor (VWF)

scientific article published in Journal of Biological Chemistry

Pathogenesis and treatment of acquired idiopathic thrombotic thrombocytopenic purpura ⬇️

scientific article published on September 1, 2010

Pitfalls in molecular diagnosis in a family with severe factor VII (FVII) deficiency--misdiagnosis by direct sequence analysis using a PCR product

scientific article published in September 2003

Rare bleeding disorders: diagnosis and treatment

scientific article

Rare bleeding disorders: worldwide efforts for classification, diagnosis, and management.

scientific article published on 25 July 2013

Risk factors for inhibitor development in severe hemophilia A

article

Role of chloride ions in modulation of the interaction between von Willebrand factor and ADAMTS-13.

scientific article

Role of the 2 adenine (g.11293_11294insAA) insertion polymorphism in the 3' untranslated region of the factor VII (FVII) gene: molecular characterization of a patient with severe FVII deficiency.

scientific article

SIPPET: methodology, analysis and generalizability

scientific article

Second international collaborative study evaluating performance characteristics of methods measuring the von Willebrand factor cleaving protease (ADAMTS-13).

scientific article published on 26 July 2008

The P303T mutation in the human factor VII (FVII) gene alters the conformational state of the enzyme and causes a severe functional deficiency

scientific article

The first deletion mutation in the TSP1-6 repeat domain of ADAMTS13 in a family with inherited thrombotic thrombocytopenic purpura

scientific article

The genetics of the alternative pathway of complement in the pathogenesis of HELLP syndrome.

scientific article published on 7 June 2012

The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, the overall enzyme's stability and conformational transitions linked to Na+ binding

scientific article published in January 2006

Timing and severity of inhibitor development in recombinant versus plasma-derived factor VIII concentrates: a SIPPET analysis

scientific article published on 28 October 2017

List of works by Roberta Palla

A recurrent Gly43Asp substitution in coagulation Factor X rigidifies its catalytic pocket and impairs catalytic activity and intracellular trafficking

ADAMTS-13 activity and autoantibodies classes and subclasses as prognostic predictors in acquired thrombotic thrombocytopenic purpura

ADAMTS-13 assays in thrombotic thrombocytopenic purpura

ADAMTS13 and anti-ADAMTS13 antibodies as markers for recurrence of acquired thrombotic thrombocytopenic purpura during remission

ADAMTS13 mutations and polymorphisms in congenital thrombotic thrombocytopenic purpura

Active platelet-binding conformation of plasma von Willebrand factor in young women with acute myocardial infarction

B and T lymphocytes in acquired Thrombotic Thrombocytopenic Purpura during disease remission

Choices of factor VIII products in previously untreated patients with haemophilia A: A global survey

Coagulation factor activity and clinical bleeding severity in rare bleeding disorders: results from the European Network of Rare Bleeding Disorders.

Congenital thrombotic thrombocytopenic purpura with novel mutations in three unrelated Turkish children

Diagnostic relevance of ADAMTS13 activity: evaluation of 28 patients with thrombotic thrombocytopenic purpura - hemolytic uremic syndrome clinical diagnosis

Different clinical severity of first episodes and recurrences of thrombotic thrombocytopenic purpura

Establishment of a bleeding score as a diagnostic tool for patients with rare bleeding disorders

Evaluation of assay methods to measure plasma ADAMTS13 activity in thrombotic microangiopathies

FRETS-VWF73 rather than CBA assay reflects ADAMTS13 proteolytic activity in acquired thrombotic thrombocytopenic purpura patients

Formation of methionine sulfoxide by peroxynitrite at position 1606 of von Willebrand factor inhibits its cleavage by ADAMTS-13: A new prothrombotic mechanism in diseases associated with oxidative stress

Genetic diagnosis of haemophilia and other inherited bleeding disorders.

Hemostatic alterations in COVID-19

IgG subclasses as biomarkers for persistence of factor VIII inhibitors in previously untreated patients with severe haemophilia A

Inactivation of ADAMTS13 by plasmin as a potential cause of thrombotic thrombocytopenic purpura.

Introduction. Rare bleeding disorders: general aspects of clinical features, diagnosis, and management

Measurement of anti-ADAMTS13 neutralizing autoantibodies: a comparison between CBA and FRET assays

Mechanisms of the interaction between two ADAMTS13 gene mutations leading to severe deficiency of enzymatic activity.

Mechanistic studies on ADAMTS13 catalysis

Molecular Mapping of the Chloride-binding Site in von Willebrand Factor (VWF)

Pathogenesis and treatment of acquired idiopathic thrombotic thrombocytopenic purpura ⬇️

Pitfalls in molecular diagnosis in a family with severe factor VII (FVII) deficiency--misdiagnosis by direct sequence analysis using a PCR product

Rare bleeding disorders: diagnosis and treatment

Rare bleeding disorders: worldwide efforts for classification, diagnosis, and management.

Risk factors for inhibitor development in severe hemophilia A

Role of chloride ions in modulation of the interaction between von Willebrand factor and ADAMTS-13.

Role of the 2 adenine (g.11293_11294insAA) insertion polymorphism in the 3' untranslated region of the factor VII (FVII) gene: molecular characterization of a patient with severe FVII deficiency.

SIPPET: methodology, analysis and generalizability

Second international collaborative study evaluating performance characteristics of methods measuring the von Willebrand factor cleaving protease (ADAMTS-13).

The P303T mutation in the human factor VII (FVII) gene alters the conformational state of the enzyme and causes a severe functional deficiency

The first deletion mutation in the TSP1-6 repeat domain of ADAMTS13 in a family with inherited thrombotic thrombocytopenic purpura

The genetics of the alternative pathway of complement in the pathogenesis of HELLP syndrome.

The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, the overall enzyme's stability and conformational transitions linked to Na+ binding

Timing and severity of inhibitor development in recombinant versus plasma-derived factor VIII concentrates: a SIPPET analysis