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List of works by Sílvia Chaves

1-Oxa-4,8,12-triazacyclotetradecane-4,12-diacetic acid (H2L2): studies on protonation and metal complexation; crystal structure of [CuL2]·5H2O

3-Hydroxypyridinone derivatives as metal-sequestering agents for therapeutic use.

scientific article published on January 2015

A bis(3-hydroxy-4-pyridinone)-EDTA derivative as a strong chelator for M3+ hard metal ions: complexation ability and selectivity.

scientific article published on 9 June 2009

A gallium complex with a new tripodal tris-hydroxypyridinone for potential nuclear diagnostic imaging: solution and in vivo studies of 67Ga-labeled species

scientific article published on 07 October 2010

A new tripodal-3-hydroxy-4-pyridinone for iron and aluminium sequestration: synthesis, complexation and in vivo studies

A novel tripodal tris-hydroxypyrimidinone sequestering agent for trivalent hard metal ions: synthesis, complexation and in vivo studies

scientific article published on 06 December 2012

Alkylaryl-amino derivatives of 3-hydroxy-4-pyridinones as aluminium chelating agents with potential clinical application.

scientific article published in September 2003

Bifunctional 3-hydroxy-4-pyridinone derivatives as potential pharmaceuticals: synthesis, complexation with Fe(III), Al(III) and Ga(III) and in vivo evaluation with 67Ga

scientific article published in August 2005

Bifunctional 3-hydroxy-4-pyridinone derivatives as potential pharmaceuticals: synthesis, complexation with Fe(III), Al(III) and Ga(III) and in vivo evaluation with 67Ga

Biologically relevant O,S-donor compounds. Synthesis, molybdenum complexation and xanthine oxidase inhibition.

scientific article published on 20 February 2008

Combined chelation based on glycosyl-mono- and bis-hydroxypyridinones for aluminium mobilization: solution and biodistribution studies.

scientific article published on 15 August 2009

Complexes of hydroxy(thio)pyrone and hydroxy(thio)pyridinone with Zn(II) and Mo(VI). Thermodynamic stability and insulin-mimetic activity

scientific article published on 9 November 2009

Copper(II) complexation of tacrine hybrids with potential anti-neurodegenerative roles

scientific article published on 10 June 2015

Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease

scientific article published on 22 February 2020

Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer's drug candidates

scientific article published on 01 December 2018

Electron spin resonance studies and crystal structures of copper(II) complexes of some 12-, 13- and 14-membered oxatriaza macrocycles

Hydroxy(thio)pyrone and hydroxy(thio)pyridinone iron chelators: physico-chemical properties and anti-oxidant activity.

scientific article

Hydroxypyridinone derivatives: a fascinating class of chelators with therapeutic applications - an update

scientific article published on 29 March 2017

Hydroxypyridinone-benzofuran hybrids with potential protective roles for Alzheimer´s disease therapy

scientific article published on 21 November 2017

Iminodiacetyl-hydroxamate derivatives as metalloproteinase inhibitors: equilibrium complexation studies with Cu(II), Zn(II) and Ni(II).

scientific article published in December 2003

Multifunctional iron-chelators with protective roles against neurodegenerative diseases.

scientific article published on 13 March 2013

N-Arylamine derivatives of 3-hydroxy-4-pyridinones: solution studies and bioevaluation in view of Al-detoxification roles

scientific article published on 29 September 2004

N-Carboxyalkyl derivatives of 3-hydroxy-4-pyridinones: synthesis, complexation with Fe(III), Al(III) and Ga(III) and in vivo evaluation.

scientific article published in September 2002

Neglect-like visual exploration behaviour after theta burst transcranial magnetic stimulation of the right posterior parietal cortex

scientific article published on 26 March 2008

New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer's Disease

scientific article published on 07 February 2019

New Tacrine Hybrids with Natural-Based Cysteine Derivatives as Multitargeted Drugs for Potential Treatment of Alzheimer's Disease

scientific article published on 8 August 2015

New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy

scientific article published on 16 March 2013

New silica-immobilized hydroxypyrimidinone as sorbent of hard metal ions from aqueous fluids.

scientific article published in September 2005

New strong extrafunctionalizable tris(3,4-HP) and bis(3,4-HP) metal sequestering agents: synthesis, solution and in vivo metal chelation

scientific article published on 02 October 2019

New tris(hydroxypyridinones) as iron and aluminium sequestering agents: synthesis, complexation and in vivo studies

scientific article published on September 2010

New tris-3,4-HOPO lanthanide complexes as potential imaging probes: complex stability and magnetic properties

scientific article published on 07 January 2013

Novel tacrine-benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer's Disease

scientific article published on 01 December 2020

Pure optic ataxia and visual hemiagnosia - extending the dual visual hypothesis.

scientific article

Recent progress in repositioning Alzheimer's disease drugs based on a multitarget strategy.

scientific article published on 24 October 2016

Tacrine-(hydroxybenzoyl-pyridone) hybrids as potential multifunctional anti-Alzheimer's agents: AChE inhibition, antioxidant activity and metal chelating capacity.

scientific article

Tacrine-deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug

scientific article published on 05 September 2018

The stability of the metal complexes of cyclic tetra-aza tetra-acetic acids

scientific article published on 01 March 1992

Theta burst stimulation reduces disability during the activities of daily living in spatial neglect.

scientific article published on 24 July 2012

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