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List of works by Stefan M. Pfister

A Mouse Ependymoma Model Provides Molecular Insights into Tumor Formation

scientific article published on 01 June 2018

A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes

scientific article published on 5 December 2015

A biobank of patient-derived pediatric brain tumor models

scientific article published on 22 October 2018

A cell-based MAPK reporter assay reveals synergistic MAPK pathway activity suppression by MAPK inhibitor combination in BRAF-driven pediatric low-grade glioma cells

scientific article published on 25 May 2020

A cell-based model system links chromothripsis with hyperploidy

scientific article published on 28 September 2015

A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing.

scientific article

A comprehensive multicenter comparison of whole genome sequencing pipelines using a uniform tumor-normal sample pair

A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat

scientific article

A novel method for rapid molecular subgrouping of medulloblastoma.

scientific article

A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR

scientific article published on 01 November 2020

A systematic analysis of genetic interactions and their underlying biology in childhood cancer

scientific article published on 06 October 2021

ACTR-05. THE RANDOMIZED PHASE II ARTE TRIAL: BEVACIZUMAB PLUS HYPOFRACTIONATED RADIOTHERAPY VERSUS RADIOTHERAPY ALONE IN ELDERLY PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA.

scientific article published on 6 November 2017

AI-08SUBGROUP-SPECIFIC DEREGULATION OF COAGULATION AND ANGIOGENIC GENE EXPRESSION PROFILES IN MEDULLOBLASTOMA- EVIDENCE FOR CROSS-TALK BETWEEN GROWTH FACTOR AND COAGULATION PATHWAYS

AKT1E17K mutations cluster with meningothelial and transitional meningiomas and can be detected by SFRP1 immunohistochemistry

scientific article published on 6 October 2013

AT-03ATYPICAL TERATOID/RHABDOID TUMOUR IS A GENETICALLY HOMOGENEOUS BUT EPIGENETICALLY HETEROGENEOUS DISEASE THAT IS DEFINED BY SUBGROUP SPECIFIC SUPER-ENHANCERS.

scientific article published on 21 April 2015

AT-10ATYPICAL TERATOID RHABDOID TUMORS AND POORLY DIFFERENTIATED CHORDOMAS: DISTINCT MOLECULAR ENTITIES WITH SMARCB1/INI1 LOSS AND DISMAL PROGNOSIS.

scientific article published on 30 May 2016

AT-11CRIBRIFORM NEUROEPITHELIAL TUMOR (CRINET): MOLECULAR CHARACTERIZATION OF A SMARCB1-DEFICIENT NON-RHABDOID TUMOR WITH FAVORABLE LONG-TERM OUTCOME.

scientific article published on 30 May 2016

ATRT-07. TARGETING PRIMARY CILIOGENESIS IN ATYPICAL TERATOID/RHABDOID TUMORS

scientific article published on 23 April 2019

ATRT-09. CHROMATIN SEGMENTATION ANALYSES IN ATYPICAL TERATOID/RHABDOID TUMORS REVEAL H3K27ME3-MEDIATED EPIGENETIC SILENCING OF TUMOR SUPPRESSOR GENES AND IDENTIFY A NOVEL ROLE OF EZH2, ASSOCIATED WITH ACTIVE CHROMATIN.

scientific article

ATRT-09. INTEGRATIVE ANALYSES OF GENE REGULATORY LANDSCAPES REVEAL RHABDOID TUMOR SUBGROUPS WITH POSSIBLE IMMUNE MODULATION THROUGH EPIGENETIC DYSREGULATION

scientific article published on 23 April 2019

ATRT-09. WHOLE GENOME AND EPIGENOME CHARACTERIZATION LINKS ATRT-MYC TO A SUBGROUP OF RENAL RHABDOID TUMORS

scientific article published on 22 June 2018

ATRT-24. CHROMATIN SEGMENTATION IN ATRT REVEALS AN IMPORTANT ROLE FOR RESIDUAL SWI/SNF MEMBERS

ATRT-34. TARGETING PRIMARY CILIOGENESIS IN ATYPICAL TERATOID/RHABDOID TUMORS

scientific article published on 22 June 2018

ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma

scientific article published on 27 November 2014

ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis

scientific article

ATYPICAL TERATOID RHABDOID TUMOUR

Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling

scientific article published on 01 September 2018

Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma.

scientific article published on 25 November 2012

Absence of chromosome 19q13.41 amplification in a case of atypical teratoid/rhabdoid tumor with ependymoblastic differentiation

Abstract 3089: (Epi)genetic profiling enables molecular re-classification of CNS-primitive neuroectodermal tumors

Abstract 3094: Epigenetic classification of ependymal brain tumors across age groups

Abstract LB-172: Novel candidate oncogenic drivers in pineoblastoma

Abstract LB-198: Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

Abstracts

article by L. Bie et al published 1 April 2013 in Neuro-Oncology

Abstracts from the 2011 BNOS Conference, June 29 - July 1, 2011, Homerton College, Cambridge

article by S. Ammoun et al published 21 September 2011 in Neuro-Oncology

Abstracts of the 10th Congress of the European Association of NeuroOncology. Marseille, France. September 6-9, 2012

scientific article published in September 2012

Accumulation of genomic aberrations during clinical progression of medulloblastoma

scientific article published on 15 August 2008

Accurate calling of KIAA1549-BRAF fusions from DNA of human brain tumours using methylation array-based copy number and gene panel sequencing data

scientific article published on 17 December 2020

Active medulloblastoma enhancers reveal subgroup-specific cellular origins

scientific article published on 27 January 2016

Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles

scientific article published on 29 February 2016

Adaptor FYB (Fyn-binding protein) regulates integrin-mediated adhesion and mediator release: differential involvement of the FYB SH3 domain

scientific article

Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities

scientific article published on 19 June 2015

Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification

scientific article published on 17 May 2010

Adult medulloblastoma comprises three major molecular variants.

scientific article

Advances and Challenges in Pediatric and Childhood Cancers

scientific article published on 01 October 2020

Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome

scientific article published on 24 February 2021

An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice

scientific article

An animal model of MYC-driven medulloblastoma

scientific article published on February 2012

An essential role for p38 MAPK in cerebellar granule neuron precursor proliferation

scientific article published on April 2012

An extracellular vesicle-related gene expression signature identifies high-risk patients in medulloblastoma

scientific article published on 11 November 2020

An optimized workflow to improve reliability of detection of KIAA1549:BRAF fusions from RNA sequencing data

scientific article published on 31 May 2020

Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma

scientific article published on 29 January 2011

Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations

scientific article published on 21 March 2018

Announcing cIMPACT-NOW: the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy

scientific article

Arhgap36-dependent activation of Gli transcription factors

scientific article

Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information

scientific article published on 23 March 2018

Array-based profiling of reference-independent methylation status (aPRIMES) identifies frequent promoter methylation and consecutive downregulation of ZIC2 in pediatric medulloblastoma

scientific article published on 7 March 2007

Assessing CpG island methylator phenotype, 1p/19q codeletion, and MGMT promoter methylation from epigenome-wide data in the biomarker cohort of the NOA-04 trial

scientific article

Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

scientific article

Author Correction: The landscape of genomic alterations across childhood cancers

scientific article published in Nature

BAF complexes facilitate decatenation of DNA by topoisomerase IIα

scientific article published on 22 May 2013

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1.

scientific article published on 23 June 2013

BI-30 * CHARACTERIZATION OF L1CAM AS A CLINICAL MARKER FOR THE C11orf95-RELA FUSION IN SUPRATENTORIAL EPENDYMOMAS

BRAF V600E Status Alone Is Not Sufficient as a Prognostic Biomarker in Pediatric Low-Grade Glioma

scientific article published on 15 November 2017

BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas

scientific article published on May 2008

Bevacizumab plus hypofractionated radiotherapy versus radiotherapy alone in elderly patients with glioblastoma: the randomized, open-label, phase II ARTE trial.

scientific article

Biological and clinical heterogeneity of MYCN-amplified medulloblastoma.

scientific article

Biological material collection to advance translational research and treatment of children with CNS tumours: position paper from the SIOPE Brain Tumour Group

article

Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience

scientific article published on 22 April 2019

CBMT-05. ROLE OF THE let7-eEF2K AXIS IN MYC-DRIVEN MEDULLOBLASTOMA ADAPTATION TO NUTRIENT DEPRIVATION

CD28 Signaling via VAV/SLP-76 Adaptors

scientific article published on 01 December 2001

CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas

scientific article published on 08 July 2020

CRISPR-mediated Loss of Function Analysis in Cerebellar Granule Cells Using In Utero Electroporation-based Gene Transfer

scientific article published on 09 June 2018

CS-16 * THE eEF2 KINASE IS CRITICAL FOR BRAIN TUMOURS ADAPTATION TO METABOLIC STRESS

CSIG-15. PROTEOMIC AND PHOSPHOPROTEOMIC ANALYSIS OF HUMAN MEDULLOBLASTOMA REVEALS DISTINCT ACTIVATED PATHWAYS BETWEEN SUBGROUPS

Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome

scientific article

Challenges to curing primary brain tumours

scientific article published on 01 August 2019

Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme.

scientific article published on 20 March 2017

Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology

scientific article published on 7 February 2017

Chordoid meningiomas can be sub-stratified into prognostically distinct DNA methylation classes and are enriched for heterozygous deletions of chromosomal arm 2p

scientific article published on 31 October 2018

Clear cell meningiomas are defined by a highly distinct DNA methylation profile and mutations in SMARCE1

scientific article published on 14 December 2020

Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries.

scientific article

Clonal selection drives genetic divergence of metastatic medulloblastoma

scientific article published on 15 February 2012

Coagulation and angiogenic gene expression profiles are defined by molecular subgroups of medulloblastoma: evidence for growth factor-thrombin cross-talk

scientific article published on 26 September 2014

Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma.

scientific article published on 19 June 2009

Comparative integrated molecular analysis of intraocular medulloepitheliomas and central nervous system embryonal tumors with multilayered rosettes confirms that they are distinct nosologic entities

scientific article

Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation

scientific article published on 27 December 2018

Connect four with glioblastoma stem cell factors

scientific article published in April 2014

Correction to: DNA methylation-based reclassification of olfactory neuroblastoma

scientific article published on 01 September 2018

Corrigendum: Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

scientific article published in Nature

Coverage bias and sensitivity of variant calling for four whole-genome sequencing technologies

scientific article

Cribriform neuroepithelial tumor: molecular characterization of a SMARCB1-deficient non-rhabdoid tumor with favorable long-term outcome

scientific article published on 6 July 2016

Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells

scientific article

Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas

scientific article published in 2021

Cytogenetic prognostication within medulloblastoma subgroups

scientific article published on 03 February 2014

DECIPHER pooled shRNA library screen identifies PP2A and FGFR signaling as potential therapeutic targets for diffuse intrinsic pontine gliomas

scientific article published on 01 July 2019

DNA Methylation based glioblastoma subclassification is related to tumoral T cell infiltration and patient survival

scientific article published on 01 November 2020

DNA copy number alterations in central primitive neuroectodermal tumors and tumors of the pineal region: an international individual patient data meta-analysis

scientific article

DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells

scientific article

DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1-NFATc2 fusion from Ewing sarcoma

scientific article published on 20 March 2019

DNA methylation profiling is a method of choice for molecular verification of pediatric WNT-activated medulloblastomas

scientific article published on 01 February 2019

DNA methylation, transcriptome and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and development

DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

scientific article published on 14 March 2017

DNA methylation-based classification of central nervous system tumours

scientific article published on 14 March 2018

DNA methylation-based classification of ependymomas in adulthood: implications for diagnosis and treatment

scientific article published on 01 November 2018

DNA methylation-based profiling for paediatric CNS tumour diagnosis and treatment: a population-based study

scientific article published on 27 November 2019

DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics

scientific article published on 25 November 2019

DNA methylation-based reclassification of olfactory neuroblastoma

scientific article published on 05 May 2018

DNA-methylation profiling discloses significant advantages over NanoString method for molecular classification of medulloblastoma

scientific article published on 13 October 2017

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

scientific article

Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation.

scientific article published on 12 February 2018

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

scientific article published in Nature Communications

Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma

scientific article

Desmoplastic/nodular medulloblastomas (DNMB) and medulloblastomas with extensive nodularity (MBEN) disclose similar epigenetic signatures but different transcriptional profiles

scientific article published on 02 March 2019

Diagnostics of Paediatric Supratentorial RELA Ependymomas: Integration of information from Histopathology, Genetics, DNA Methylation and Imaging

article

Differential expression and methylation of brain developmental genes define location-specific subsets of pilocytic astrocytoma

scientific article published on 10 May 2013

Diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters (DGONC) - a molecularly defined glioneuronal CNS tumour class displaying recurrent monosomy 14

scientific article published on 23 December 2019

Dissecting the genomic complexity underlying medulloblastoma

scientific article

Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma

scientific article published on 05 September 2018

Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system

scientific article published on 24 October 2013

Divergent clonal selection dominates medulloblastoma at recurrence

scientific article published on 13 January 2016

Downregulation of miR-326 and its host gene β-arrestin1 induces pro survival activity of E2F1 and promotes medulloblastoma growth

scientific article published on 13 September 2020

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

scientific article (publication date: 29 January 2012)

Drivers underpinning the malignant transformation of giant cell tumour of bone

scientific article published on 31 August 2020

Duplications of KIAA1549 and BRAF screening by Droplet Digital PCR from formalin-fixed paraffin-embedded DNA is an accurate alternative for KIAA1549-BRAF fusion detection in pilocytic astrocytomas.

scientific article

EANO guidelines for the diagnosis and treatment of ependymal tumors

scientific article published on 29 November 2017

EANO-EURACAN clinical practice guideline for diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma

scientific article published on 01 December 2019

EG-09EPIGENETIC PROFILING REVEALS A CpG HYPERMETHYLATION PHENOTYPE (CIMP) ASSOCIATED WITH WORSE PROGRESSION-FREE SURVIVAL IN MENINGIOMA.

scientific article published in November 2014

EGFL7 enhances surface expression of integrin αβ to promote angiogenesis in malignant brain tumors

scientific article published on 01 September 2018

EMBR-01. MOLECULAR AND CLINICAL HETEROGENEITY IN HISTOLOGICALLY-DIAGNOSED CNS-PNET PATIENTS PROSPECTIVELY TREATED AS A SINGLE ENTITY: A REPORT FROM THE CHILDREN’S ONCOLOGY GROUP ACNS0332 TRIAL.

scientific article

EMBR-02. RECURRENT HOMOZYGOUS DELETION OF DROSHA AND MICRODUPLICATION OF PDE4DIP CONTAINING THE ANCESTRAL DUF1220 DOMAIN IN PINEOBLASTOMA

EMBR-04. WHAT THE FOX SAY? A MOLECULAR ANALYSIS OF FOXR2 IN PEDIATRIC BRAIN TUMORS.

scientific article

EMBR-05. TUMORS OF THE PINEAL REGION CAN BE CLASSIFIED INTO DISTINCT SUBGROUPS BASED ON MOLECULAR CHARACTERISTICS CORRELATING WITH CLINICAL PARAMETERS AND GENETIC ALTERATIONS

EMBR-10. GENOMIC COMPLEXITY AND EVOLUTION OF EMBRYONAL TUMORS WITH MULTILAYERED ROSETTES (ETMR)

EMBR-15. DIAGNOSTIC RE-EVALUATION AND POOLED CLINICAL DATA ANALYSIS OF PATIENTS WITH PREVIOUS DIAGNOSIS OF CNS-PNET

EORTC SPECTA-AYA: A unique molecular profiling platform for adolescents and young adults with cancer in Europe

scientific article published on 29 August 2019

EP-03MOLECULAR CLASSIFICATION OF EPENDYMAL TUMORS ACROSS ALL CNS COMPARTMENTS, HISTOPATHOLOGICAL GRADES AND AGE GROUPS.

scientific article published on 21 April 2015

EPEN-04. CXorf67 MIMICS ONCOGENIC HISTONE H3 K27M MUTATIONS AND FUNCTIONS AS INTRINSIC INHIBITOR OF PRC2 FUNCTION IN AGGRESSIVE POSTERIOR FOSSA EPENDYMOMA

scientific article published on 23 April 2019

EPEN-05. CXorf67 EXPRESSION IS A PUTATIVE DRIVER OF PFA EPENDYMOMA

EPEN-06. YAP1 SUBGROUP SUPRATENTORIAL EPENDYMOMA REQUIRES TEAD AND NUCLEAR FACTOR I-MEDIATED TRANSCRIPTIONAL PROGRAMS FOR TUMORIGENESIS

scientific article published on 23 April 2019

EPEN-07. OVEREXPRESSION AND MUTATIONS OF CXORF67 IN ‘INFANT-TYPE’ POSTERIOR FOSSA TYPE-A (PFA) EPENDYMOMAS

article published in 2018

EPEN-10. ROLE OF DNA METHYLATION ANALYSIS IN RECURRENT PAEDIATRIC EPENDYMOMA.

scientific article published on 22 June 2018

EPEN-23. MOLECULAR HETEROGENEITY AMONG PEDIATRIC POSTERIOR FOSSA EPENDYMOMA

EPEN-24. YAP1 FUSION PROTEINS MEDIATE ONCOGENIC ACTIVITY IN EPENDYMOMA VIA INTERACTION WITH TEAD TRANSCRIPTION FACTORS.

scientific article published on 22 June 2018

EPEN-25. KANSL1 GAIN AND FUSION - A NOVEL ALTERATION IN CHILDHOOD EPENDYMOMA

EPEN-28. HETEROGENEITY WITHIN THE PFB EPENDYMOMA SUBGROUP.

scientific article published on 22 June 2018

EPENDYMOMA

article

EPIG-04THE CHROMATIN LANDSCAPE OF MEDULLOBLASTOMA.

scientific article

EPIGENOME ALTERATIONS DEFINE LETHAL CIMP POSITIVE EPENDYMOMAS OF INFANCY.

scientific article published in July 2014

EPN-07IMPACT OF CHROMOSOMAL ABERRATIONS AND MOLECULAR SUBTYPE ON TELOMERASE ACTIVATION IN PEDIATRIC EPENDYMOMA.

scientific article published on 30 May 2016

EPN-12PEDIATRIC SUPRATENTORIAL EPENDYMOMA: COMPARISON BETWEEN IMMUNOHISTOCHEMISTRY, FISH AND DNA METHYLATION ANALYSIS FOR RELA REARRANGEMENT AND HISTOLOGICAL CORRELATION.

scientific article published on 30 May 2016

EPN-20NEWLY DIAGNOSED METASTATIC INTRACRANIAL EPENDYMOMA IN CHILDREN: FREQUENCY, TREATMENT AND OUTCOME IN THE POPULATION BASED, PROSPECTIVE HIT-SERIES.

scientific article published on 30 May 2016

EPN-30YAP1-MAMLD1 FUSIONS ALONE ARE SUFFICIENT TO FORM SUPRATENTORIAL EPENDYMOMA-LIKE TUMORS IN MICE.

scientific article published on 30 May 2016

EPN-31MOLECULAR REFINEMENT OF PEDIATRIC POSTERIOR FOSSA EPENDYMOMA.

scientific article published on 30 May 2016

EPN-34EPIGENOMIC ANALYSIS OF EPENDYMAL TUMORS IDENTIFIES SUBGROUP SPECIFIC ENHANCERS CONTROLLING DISTINCT REGULATORY CIRCUITRIES.

scientific article published on 30 May 2016

EPND-01. THE ACTIVE REGULATORY LANDSCAPE OF EPENDYMAL TUMORS.

scientific article published on 31 May 2017

EPND-02. GENOMIC COPY NUMBER ALTERATIONS IN EPENDYOMOMA.

scientific article

EPND-07. MOLECULAR HETEROGENEITY AMONG PEDIATRIC POSTERIOR FOSSA EPENDYMOMA.

scientific article published on 31 May 2017

EPND-13. YAP1-MAMLD1 FUSIONS ALONE ARE SUFFICIENT TO FORM SUPRATENTORIAL EPENDYMOMA-LIKE TUMORS IN MICE.

scientific article

ETMR: a tumor entity in its infancy

scientific article published on 29 June 2020

EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma

scientific article published on 01 July 2019

Early phase clinical trials of anticancer agents in children and adolescents - an ITCC perspective

scientific article

Embryonal tumor with abundant neuropil and true rosettes (ETANTR) with loss of morphological but retained genetic key features during progression

scientific article published on 06 November 2011

Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity

scientific article

Emerging insights into the ependymoma epigenome

scientific article published on March 2013

Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis

scientific article published on 13 June 2019

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

scientific article

Epidemiology, molecular classification and WHO grading of ependymoma

scientific article published on 8 September 2017

Epigenetic Silencing of DKK3 in medulloblastoma.

scientific article published on 8 April 2013

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

scientific article

Epithelioid glioblastomas stratify into established diagnostic subsets upon integrated molecular analysis.

scientific article

Erratum to: Gliomatosis cerebri: no evidence for a separate brain tumor entity

scientific article published on 7 January 2016

Erratum: Corrigendum: Signatures of mutational processes in human cancer

scientific article published in Nature

Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing

scientific article published on 17 December 2016

Evaluation of Prognostic Factors and Role of Participation in a Randomized Trial or a Prospective Registry in Pediatric and Adolescent Nonmetastatic Medulloblastoma - A Report From the HIT 2000 Trial

scientific article published on 07 October 2020

Evidence of H3 K27M mutations in posterior fossa ependymomas

scientific article

Extensive Molecular and Clinical Heterogeneity in Patients With Histologically Diagnosed CNS-PNET Treated as a Single Entity: A Report From the Children's Oncology Group Randomized ACNS0332 Trial

scientific article published on 17 October 2018

FAM131B-BRAF Fusion Gene Resulting From 7q34 Deletion Leads to MAPK Pathway Activation in Pilocytic Astrocytoma

FAM131B-BRAF Fusion Gene Resulting From 7q34 Deletion Leads to MAPK Pathway Activation in Pilocytic Astrocytoma

FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma

scientific article

FGFR1:TACC1 fusion is a frequent event in molecularly defined extraventricular neurocytoma.

scientific article

FORETINIB IS EFFECTIVE THERAPY FOR METASTATIC SONIC HEDGEHOG MEDULLOBLASTOMA.

scientific article published in July 2014

FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma

scientific article

Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma

scientific article published on 21 August 2014

Fatal Outcome of European Tick-borne Encephalitis after Vaccine Failure

scientific article published on 03 April 2017

Feasibility of real-time molecular profiling for patients with newly diagnosed glioblastoma without MGMT promoter-hypermethylation - the NCT Neuro Master Match (N2M2) pilot study

scientific article published on 18 November 2017

Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes.

scientific article published on 21 April 2010

Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma.

scientific article

Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations

scientific article

From class waivers to precision medicine in paediatric oncology.

scientific article published in July 2017

From glioblastoma to gangliocytoma: an unforeseen but welcome shift in biological behavior

scientific article published on November 2009

Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma

scientific article published on 25 July 2011

Functional loss of a noncanonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation

scientific article published on 20 August 2020

Functional precision medicine identifies new therapeutic candidates for medulloblastoma

scientific article published on 12 October 2020

GE-07DNA METHYLATION IN MEDULLOBLASTOMA AND MOLECULAR DIAGNOSTICS OF BRAIN TUMORS.

scientific article published on 21 April 2015

GE-21 * DRASTIC GENOMIC DIVERGENCE OF RECURRENT MEDULLOBLASTOMA INVALIDATES TARGETED THERAPIES DISCOVERED AT DIAGNOSIS

GE-23ENHANCER HIJACKING ACTIVATES GFI1 FAMILY ONCOGENES IN MEDULLOBLASTOMA.

scientific article published in November 2014

GE-28INTEGRATED GENOMICS DEMONSTRATE RELATIVE SPATIAL HOMOGENEITY IN PEDIATRIC BRAIN TUMORS.

scientific article published in November 2014

GENE-02. CHROMOSOME CONFORMATION ANALYSIS OF EPENDYMOMA IDENTIFIES PUTATIVE TUMOR DEPENDENCY GENES ACTIVATED BY DISTAL ONCOGENIC ENHANCERS

scientific article published on 23 April 2019

GENE-04. ESTABLISHING A MOLECULAR PROFILING SERVICE FOR CHILDREN’S CENTRAL NERVOUS SYSTEM TUMORS IN AUSTRALASIA – THE AUSTRALIAN AND NEW ZEALAND CHILDREN’S HAEMATOLOGY AND ONCOLOGY GROUP (ANZCHOG) AIM BRAIN PROJECT

scientific article published on 23 April 2019

GENE-06. DISTINCT MOLECULAR SUBGROUPS OF TUMORS OF THE PINEAL REGION CORRELATE WITH CLINICAL PARAMETERS AND GENETIC ALTERATIONS

scientific article published on 23 April 2019

GENE-07. MOLECULAR NEUROPATHOLOGY 2.0 - INCREASING DIAGNOSTIC ACCURACY IN PEDIATRIC NEUROONCOLOGY.

scientific article

GENE-08. THE MNP 2.0 STUDY: PROSPECTIVE INTEGRATION OF DNA METHYLATION PROFILING IN CNS TUMOR DIAGNOSTICS

GENE-12. ANAPLASTIC NEUROEPITHELIAL TUMOR WITH CONDENSED NUCLEI (ANTCON): A NOVEL BRAIN TUMOR ENTITY WITH RECURRENT NTRK FUSION

GENE-13. PEDIATRIC MENINGIOMAS ARE CHARACTERIZED BY DISTINCT METHYLATION PROFILES DIFFERENT FROM ADULT MENINGIOMAS

scientific article published on 23 April 2019

GENO-20NOVEL CANDIDATE ONCOGENIC DRIVERS IN PINEOBLASTOMA.

scientific article

Gain of 12p encompassing CCND2 is associated with gemistocytic histology in IDH mutant astrocytomas

scientific article published on 20 December 2016

Gene-Tailored Treatments for Brain Disorders: Challenges and Opportunities

scientific article published on June 2016

Genetic aberrations leading to MAPK pathway activation mediate oncogene-induced senescence in sporadic pilocytic astrocytomas

scientific article published on 24 May 2011

Genetic and epigenetic characterization of posterior pituitary tumors

scientific article published on 18 October 2021

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

scientific article

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

scientific article

Genome-wide analysis of acute leukemia and clonally related histiocytic sarcoma in a series of three pediatric patients

scientific article published on 18 November 2019

Genome-wide methylation profiling and copy number analysis in atypical fibroxanthomas and pleomorphic dermal sarcomas indicate a similar molecular phenotype

article published in 2019

Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma

scientific article

Genomic and transcriptomic analyses match medulloblastoma mouse models to their human counterparts

scientific article published on 29 May 2014

Genomic profiling of Acute lymphoblastic leukemia in ataxia telangiectasia patients reveals tight link between ATM mutations and chromothripsis

scientific article published on 15 February 2017

Germline Elongator mutations in Sonic Hedgehog medulloblastoma

scientific article published on 01 April 2020

Germline GPR161 Mutations Predispose to Pediatric Medulloblastoma

scientific article published on 14 October 2019

Glioma.

scientific article published on 16 July 2015

Gliomatosis cerebri: no evidence for a separate brain tumor entity

scientific article published on 22 October 2015

Global epigenetic profiling identifies methylation subgroups associated with recurrence-free survival in meningioma.

scientific article

Guanine Nucleotide-Binding Protein a Subunit Hypofunction in Children with Short Stature and Disproportionate Shortening of the 4th and 5th Metacarpals

scientific article published on 25 January 2014

H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers

scientific article published on 11 April 2017

HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment.

scientific article

HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma

scientific article published on March 2016

HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth

scientific article published on 22 April 2010

HG-09INFANTILE GLIOBLASTOMA WITH SARCOMATOUS HISTOLOGY DRIVEN BY ETV6:NTRK3 FUSIONS ARE SENSITIVE TO TRK INHIBITION BY PHA-848125.

scientific article

HG-127ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMAS: A CLINICOPATHOLOGIC AND MOLECULAR PROFILE.

scientific article published on 30 May 2016

HG-68COMBINED ALTERATIONS IN MAPK PATHWAY GENES, CDKN2A/B AND ATRX CHARACTERIZE ANAPLASTIC PILOCYTIC ASTROCYTOMA.

scientific article published on 30 May 2016

HG-75CLINICAL, RADIOLOGICAL, AND HISTO-GENETIC CHARACTERISTICS OF LONG-TERM SURVIVORS OF DIFFUSE INTRINSIC PONTINE GLIOMA: A COLLABORATIVE REPORT FROM THE INTERNATIONAL AND SIOP-E DIPG REGISTRIES.

scientific article published on 30 May 2016

HGG-03. INTEGRATED MOLECULAR AND PATHOLOGICAL CHARACTERISATION OF NON-BRAINSTEM PAEDIATRIC HIGH GRADE GLIOMA FROM THE HERBY PHASE II RANDOMISED TRIAL.

scientific article published on 31 May 2017

HGG-11. THE Β-CATENIN/CBP-ANTAGONIST ICG-001 INHIBITS PEDIATRIC GLIOMA GROWTH IN A WNT-INDEPENDENT MANNER.

scientific article published on 31 May 2017

HGG-24. MOLECULAR, PATHOLOGICAL, RADIOLOGICAL AND IMMUNE PROFILING OF NON-BRAINSTEM PAEDIATRIC HIGH GRADE GLIOMA FROM THE HERBY PHASE II RANDOMISED TRIAL

scientific article published on 22 June 2018

Hedgehog-mediated regulation of PPARγ controls metabolic patterns in neural precursors and shh-driven medulloblastoma

scientific article published on 11 March 2012

Heterogeneity within the PF-EPN-B ependymoma subgroup

article

High Grade Gliomas and DIPG

scholarly article

High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-beta and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response

scientific article published on 30 April 2009

Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity

scientific article published on 19 October 2015

Histology and molecular pathology of pediatric brain tumors

scientific article

Histone 3.3 hotspot mutations in conventional osteosarcomas: a comprehensive clinical and molecular characterization of six H3F3A mutated cases

scientific article

Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation

scientific article published on 19 March 2020

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

scientific article published on 20 November 2020

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma

scientific article published in October 2012

Hypermutation of the inactive X chromosome is a frequent event in cancer

scientific article published on 17 October 2013

ICGC PedBrain - dissecting the genomic complexity underlying medulloblastoma using whole-genome sequencing.

scientific article

INFORM2 NivEnt: The first trial of the INFORM2 biomarker driven phase I/II trial series: the combination of nivolumab and entinostat in children and adolescents with refractory high-risk malignancies

scientific article published on 05 June 2020

INFORMING TREATMENT DECISIONS IN RELAPSED PEDIATRIC MALIGNANCIES USING NEXT-GENERATION DIAGNOSTICS.

scientific article published in July 2014

Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration

scientific article published on 07 November 2019

Identification of CD24 as a marker of Patched1 deleted medulloblastoma-initiating neural progenitor cells

scientific article published in PLoS ONE

Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma

scientific article

Identification of genes involved in the biology of atypical teratoid/rhabdoid tumours using Drosophila melanogaster

scientific article

Imaging Characteristics of Wingless Pathway Subgroup Medulloblastomas: Results from the German HIT/SIOP-Trial Cohort

scientific article published on 24 October 2019

Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome

scientific article

Implementation of mechanism of action biology-driven early drug development for children with cancer.

scientific article published on 31 May 2016

Implications of New Understandings of Gliomas in Children and Adults with NF1: Report of a Consensus Conference

scientific article published on 14 February 2020

InTAD: chromosome conformation guided analysis of enhancer target genes

article

Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes

scientific article published on 01 April 2020

Infection as a cause of childhood leukemia: virus detection employing whole genome sequencing

scientific article published on 2 February 2017

Infratentorial IDH-mutant astrocytoma is a distinct subtype

scientific article published on 10 August 2020

Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma

scientific article published on 10 July 2014

Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma

scientific article published on 26 September 2017

Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers

scientific article published on 10 March 2015

Integrated genomics elucidates relative spatial homogeneity of embryonal brain tumors.

scientific article

Integrated molecular analysis of adult sonic hedgehog (SHH)-activated medulloblastomas reveals two clinically relevant tumor subsets with VEGFA as potent prognostic indicator

scientific article published on 01 September 2021

Integrated molecular characterization of IDH-mutant glioblastomas

scientific article published on 15 November 2018

Integrating Tenascin-C protein expression and 1q25 copy number status in pediatric intracranial ependymoma prognostication: A new model for risk stratification

scientific article

Integrative Genome-Scale Analysis Identifies Epigenetic Mechanisms of Transcriptional Deregulation in Unfavorable Neuroblastomas

scientific article published on 07 September 2016

International network of cancer genome projects

scientific article

Intraocular Medulloepitheliomas and Embryonal Tumors With Multilayered Rosettes of the Brain: Comparative Roles of LIN28A and C19MC.

scientific article

Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course

scientific article published on 28 September 2019

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.

scientific article published on 7 March 2018

K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

scientific article

Key Implications of Data Sharing in Pediatric Genomics

article by Vasiliki Rahimzadeh et al published 1 May 2018 in JAMA Pediatrics

LG-27DKFZ-BT66 - A NOVEL PILOCYTIC ASTROCYTOMA MODEL FOR PRECLINICAL DRUG TESTING.

scientific article published on 30 May 2016

LGG-02. A PHASE II PROSPECTIVE TRIAL OF SELUMETINIB IN CHILDREN WITH RECURRENT/PROGRESSIVE PEDIATRIC LOW-GRADE GLIOMA (PLGG) WITH A FOCUS UPON OPTIC PATHWAY/HYPOTHALAMIC TUMORS AND VISUAL ACUITY OUTCOMES: A PEDIATRIC BRAIN TUMOR CONSORTIUM (PBTC) ST

LGG-04. CHARACTERIZATION OF ONCOGENE-INDUCED SENESCENCE AND THE ROLE OF THE SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE IN PILOCYTIC ASTROCYTOMA.

scientific article published on 31 May 2017

LGG-08. A PHASE II PROSPECTIVE STUDY OF SELUMETINIB IN CHILDREN WITH RECURRENT OR REFRACTORY LOW-GRADE GLIOMA (LGG): A PEDIATRIC BRAIN TUMOR CONSORTIUM (PBTC) STUDY.

scientific article published on 31 May 2017

LGG-11. REGULATION OF ONCOGENE-INDUCED SENESCENCE IN PILOCYTIC ASTROCYTOMA.

scientific article published on 22 June 2018

LGG-13. PAPILLARY GLIONEURONAL TUMOR (PGNT) EXHIBITS A CHARACTERISTIC METHYLATION PROFILE AND MANDATORY FUSIONS INVOLVING PRKCA

LGG-20. MOLECULARLY-DEFINED DIFFUSE LEPTOMENINGEAL GLIONEURONAL TUMOR (DLGNT) COMPRISES TWO SUBGROUPS WITH DISTINCT CLINICAL AND GENETIC FEATURES

LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR)

scientific article published on 16 November 2012

Larotrectinib in patients with TRK fusion-positive solid tumours: a pooled analysis of three phase 1/2 clinical trials

scientific article published on 24 February 2020

Limitations of current models for testing the clinical potential of epigenetic inhibitors for treatment of pediatric ependymoma

Local and Systemic Therapy of Recurrent Ependymoma in Children and Adolescents: Short- and Long-term Results of the E-HIT-REZ 2005 Study

scientific article published on 17 December 2020

Local treatment of abdominal wound reduces tumor implantation ⬇️

scientific article published on September 1, 1998

Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors

scientific article published on 27 April 2020

Long-term survival in a case of ETANTR with histological features of neuronal maturation after therapy

scientific article published on 20 February 2015

Loss of Smarc proteins impairs cerebellar development

scientific article published in October 2014

Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells

scientific article

Low-dose Actinomycin-D treatment re-establishes the tumoursuppressive function of P53 in RELA-positive ependymoma

scientific article published on 20 August 2016

Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma

scientific article published in Nature Communications

MAPK pathway activation in pilocytic astrocytoma

scientific article

MB-08MOLECULAR (RE-)CLASSIFICATION OF CNS-PRIMITIVE NEUROECTODERMAL TUMORS.

scientific article published on 21 April 2015

MB-17NOVEL CANDIDATE ONCOGENIC DRIVERS IN PINEOBLASTOMA.

scientific article

MB-18DYSFUNCTION OF THE CHROMATIN REMODELER Chd7 CAUSES ABNORMAL CEREBELLAR DEVELOPMENT AND ACCELERATES MEDULLOBLASTOMA FORMATION.

scientific article published on 30 May 2016

MB-21INTEGRATED GENOMICS ELUCIDATES RELATIVE SPATIAL HOMOGENEITY OF EMBRYONAL BRAIN TUMORS.

scientific article published on 21 April 2015

MB-25REGULATION OF MEDULLOBLASTOMA FORMATION BY Gfi1 AND Gfi1b.

scientific article published on 21 April 2015

MB-26SHH DESMOPLASTIC/NODULAR MEDULLOBLASTOMA AND GORLIN SYNDROME IN THE SETTING OF DOWN SYNDROME: CASE REPORT WITH MOLECULAR PROFILING.

scientific article published on 30 May 2016

MB-30OUTCOME OF CLINICAL “STANDARD RISK” MEDULLOBLASTOMA WITH CMYC AMPLIFICATION: A CASE REPORT AND ASSESSMENT OF THE LITERATURE.

scientific article published on 30 May 2016

MB-44SUBGROUP-SPECIFIC QUANTITATIVE PROTEOMIC ANALYSIS OF MEDULLOBLASTOMA.

scientific article published on 30 May 2016

MB-46PROGNOSTIC RELEVANCE OF EPIGENETIC/BIOLOGICAL SUBGROUPS AND MYCC/MYCN GENE AMPLIFICATION IN A HOMOGENOUSLY TREATED METASTATIC MEDULLOBLASTOMA HIT2000 COHORT AGED 4-21 YEARS.

scientific article published on 30 May 2016

MB-53hTERT EXPRESSION AND REGULATION IN PEDIATRIC MEDULLOBLASTOMA (MB).

scientific article published on 30 May 2016

MB-57INTERACTION OF HDAC2 AND MYC IN GROUP 3 MEDULLOBLASTOMA - A NOVEL THERAPEUTIC TARGET.

scientific article published on 30 May 2016

MB-92DO ABCB1 EXPRESSING DRUG RESISTANT CANCER STEM CELLS UNDERLIE MEDULLOBLASTOMA METASTASIS?

scientific article published on 30 May 2016

MBCL-21. EARLY CHILDHOOD MEDULLOBLASTOMA: SUBGROUP-SPECIFIC SURVIVAL IN PATIENTS TREATED WITH SYSTEMIC CHEMOTHERAPY AND INTRAVENTRICULAR MTX TO AVOID CRANIOSPINAL RADIOTHERAPY

MBCL-42. SECOND GENERATION MOLECULAR SUBGROUPING OF MEDULLOBLASTOMA: TOWARDS A WORKING CONSENSUS OF GROUP 3/4 SUBTYPES

MBCL-44. THE MOLECULAR AND CLINICAL LANDSCAPE OF INFANT MEDULLOBLASTOMA (iMB): RESULTS AND MOLECULAR ANALYSIS FROM A PROSPECTIVE, MULTICENTER PHASE II TRIAL (SJYC07)

MBCL-45. ROLE OF IRRADIATION IN RELAPSED MEDULLOBLASTOMA: A REPORT OF THE GERMAN MEDULLOBLASTOMA RELAPSE STUDIES.

scientific article published on 22 June 2018

MBRS-07. BCOR LOSS IMPACTS SHH MEDULLOBLASTOMA FORMATION VIA TRANSCRIPTIONAL UP-REGULATION OF

MBRS-12. INTERFERENCE WITH THE FUNCTION OF MYC IN GROUP 3 MEDULLOBLASTOMA.

scientific article published on 22 June 2018

MBRS-33. RNA-SEQUENCING OF MEDULLOBLASTOMA PATIENT-DERIVED ORTHOTOPIC XENOGRAFT (PDOX) MODELS ENABLES IDENTIFICATION OF BOTH TUMOR AND MICROENVIRONMENT SPECIFIC BIOMARKERS

MBRS-34. MOLECULAR CHARACTERIZATION OF RECURRENT MEDULLOBLASTOMA REVEALS AN UNEXPECTEDLY HIGH INCIDENCE OF SECONDARY MALIGNANCY.

scientific article published on 22 June 2018

MBRS-57. TARGETING METABOLIC ADAPTATION IN MYC/MYCN AMPLIFIED PEDIATRIC MEDULLOBLASTOMA AND NEUROBLASTOMA

MBRS-65. CHEMI-GENOMIC ANALYSIS OF PATIENT-DERIVED XENOGRAFTS TO IDENTIFY PERSONALIZED THERAPIES FOR MEDULLOBLASTOMA.

scientific article published on 22 June 2018

MEDU-01. HDACi AND PLK1i ACT SYNERGISTICALLY IN MYC-AMPLIFIED MEDULLOBLASTOMA

scientific article published on 23 April 2019

MEDU-11. MOLECULAR CHARACTERIZATION OF ETMRs REVEALS A ROLE FOR R-LOOP MEDIATED CHROMOSOMAL INSTABILITY

scientific article published on 23 April 2019

MEDU-20. TARGETING OF MYC BY HDAC INHIBITION IN MYC AMPLIFIED GROUP 3 MEDULLOBLASTOMA.

scientific article

MEDU-21. LOSS OF THE TRANSCRIPTIONAL CO-REPRESSOR BCOR LEADS TO OVEREXPRESSION OF THE GROWTH FACTOR IGF2 AND SHH MEDULLOBLASTOMA TUMOR FORMATION

MEDU-38. NEXT GENERATION MOLECULAR CHARACTERIZATION OF LOCALLY RECURRENT WNT PATHWAY MEDULLOBLASTOMA: A CASE REPORT.

scientific article published on 31 May 2017

MEDULLOBLASTOMA

MEDULLOBLASTOMA

MEK and RAF inhibitors: time for a paradigm shift in the treatment of pediatric low-grade gliomas?

scientific article published on 30 March 2017

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin

scientific article published on 25 November 2015

MNGI-13. A DNA METHYLATION-BASED CLASSIFIER FOR ASSESSMENT OF RISK OF RECURRENCE IN MENINGIOMA

MOLECULAR (RE-)CLASSIFICATION OF CNS-PRIMITIVE NEUROECTODERMAL TUMORS.

scientific article published in July 2014

MPTH-15MOLECULAR RECLASSIFICATION OF CNS-PRIMITIVE NEUROECTODERMAL TUMORS INTO WELL-KNOWN AND NOVEL TUMOR ENTITIES.

scientific article

MPTH-26MOLECULAR REFINEMENT OF PEDIATRIC POSTERIOR FOSSA EPENDYMOMA.

scientific article

MPTH-59. ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMAS: A CLINICOPATHOLOGIC AND MOLECULAR PROFILE

MRI Features of Histologically Diagnosed Supratentorial Primitive Neuroectodermal Tumors and Pineoblastomas in Correlation with Molecular Diagnoses and Outcomes: A Report from the Children's Oncology Group ACNS0332 Trial

scientific article published on 10 October 2019

MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma

scientific article published on 3 December 2011

MYCN amplification drives an aggressive form of spinal ependymoma

scientific article published on 14 August 2019

Machine learning workflows to estimate class probabilities for precision cancer diagnostics on DNA methylation microarray data

scientific article published on 13 January 2020

Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis

scientific article published on 11 June 2012

Mechismo: predicting the mechanistic impact of mutations and modifications on molecular interactions.

scientific article

Medulloblastoma

scientific article published on 14 February 2019

Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group.

scientific article published on 22 November 2013

Medulloblastoma comprises four distinct molecular variants

scientific article published on 07 September 2010

Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

scientific article (publication date: 22 July 2012)

Medulloblastoma subgroups remain stable across primary and metastatic compartments

scientific article

Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress

scientific article published on 05 April 2016

Medulloblastoma: a potpourri of distinct entities ⬇️

scientific article published on April 1, 2012

Medulloblastomics revisited: biological and clinical insights from thousands of patients

scientific article published on 09 December 2019

Medulloblastomics: the end of the beginning

scientific article published on December 2012

Medulloepithelioma with peculiar clinical presentation, stem cell phenotype and aberrant DNA-methylation profile

scientific article published on 29 June 2015

Melanotic tumors of the nervous system are characterized by distinct mutational, chromosomal and epigenomic profiles

scientific article published on 15 December 2014

Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein

scientific article published on 11 April 2013

Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature

scientific article published on 4 May 2017

Methylation array profiling of adult brain tumours: diagnostic outcomes in a large, single centre

Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study.

scientific article

Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups

scientific article published on 28 January 2016

Methylation-based classification of benign and malignant peripheral nerve sheath tumors

scientific article published on 8 February 2016

MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma

scientific article published on 2 December 2011

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

scientific article

Molecular Diagnostics in Pediatric Brain Tumors: Impact on Diagnosis and Clinical Decision-Making - A Selected Case Series

scientific article published on 11 July 2018

Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation

scientific article published on 03 February 2021

Molecular approaches to ependymoma: the next step(s).

scientific article published on December 2012

Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours

scientific article published on 12 July 2019

Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups

scientific article published on 21 October 2014

Molecular characterization of medulloblastomas with extensive nodularity (MBEN).

scientific article published on 22 March 2018

Molecular correlates of cerebellar mutism syndrome in medulloblastoma

scientific article published on 01 February 2020

Molecular diagnostics of CNS embryonal tumors

scientific article published on 30 September 2010

Molecular differences in IDH wildtype glioblastoma according to MGMT promoter methylation.

scientific article published on 24 August 2017

Molecular dissection of ependymomas

scientific article published on 20 August 2015

Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas

scientific article published on 16 June 2018

Molecular insights into pediatric brain tumors have the potential to transform therapy

scientific article

Molecular mechanisms and therapeutic targets in pediatric brain tumors.

scientific article published on 14 March 2017

Molecular neuro-oncology in clinical practice: a new horizon

scientific article published on August 2013

Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain

scientific article published on May 2015

Molecular progression of SHH-activated medulloblastomas

scientific article published on 27 April 2019

Molecular staging of intracranial ependymoma in children and adults

scientific article published in June 2010

Molecular stratification of medulloblastoma: comparison of histological and genetic methods to detect Wnt activated tumours

scientific article published on February 2015

Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations

scientific article published on 25 November 2019

Molecular subgroups of medulloblastoma

scientific article

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

scientific article

Molecular subgroups of medulloblastoma: the current consensus

scientific article

Molecular tumor classification using DNA methylome analysis

scientific article published on 13 July 2020

Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial.

scientific article published in May 2018

Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features.

scientific article

Moyamoya-like vasculopathy (moyamoya syndrome) in children

scientific article

Multicenter pilot study of radio-chemotherapy as first-line treatment for adults with medulloblastoma (NOA-07).

scientific article published on 21 August 2017

Mutational patterns and regulatory networks in epigenetic subgroups of meningioma

scientific article published on 08 May 2019

Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas

scientific article published on 16 February 2013

Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer

scientific article published on 09 October 2013

Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors

scientific article published in February 2015

Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile

scientific article published on 13 July 2018

N2M2 (NOA20) phase I/II trial of molecularly matched targeted therapies plus radiotherapy in patients with newly diagnosed non-MGMT hypermethylated glioblastoma

scientific article published on 01 January 2019

NEURO/MEDICAL ONCOLOGY

NEXT-GENERATION NEUROPATHOLOGY - IMPROVING DIAGNOSTIC ACCURACY FOR BRAIN TUMORS USING DNA METHYLATION ARRAY-BASED MOLECULAR PROFILING.

scientific article published in July 2014

NFM-11. PEDIATRIC MENINGIOMAS ARE MOLECULARLY DISTINCT FROM ADULT COUNTERPARTS

article published in 2018

Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression

scientific article published on 24 July 2013

Nestin Mediates Hedgehog Pathway Tumorigenesis

scientific article

Nestin expression identifies ependymoma patients with poor outcome

scientific article published on 30 May 2012

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

scientific article published on 03 June 2019

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

scientific article

Newly Diagnosed Metastatic Intracranial Ependymoma in Children: Frequency, Molecular Characteristics, Treatment, and Outcome in the Prospective HIT Series

scientific article published on 08 March 2019

Next-generation (epi)genetic drivers of childhood brain tumours and the outlook for targeted therapies

scientific article published on 27 May 2015

Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study

scientific article published on 28 July 2016

Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets

scientific article published on 15 December 2015

No Significant Cytotoxic Effect of the EZH2 Inhibitor Tazemetostat (EPZ-6438) on Pediatric Glioma Cells with Wildtype Histone 3 or Mutated Histone 3.3.

scientific article published on April 2016

No correlation between NF1 mutation position and risk of optic pathway glioma in 77 unrelated NF1 patients

scientific article published on 11 March 2016

Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age.

scientific article published on 10 September 2015

Nonmetastatic Medulloblastoma of Early Childhood: Results From the Prospective Clinical Trial HIT-2000 and An Extended Validation Cohort

scientific article published on 24 April 2020

Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells

scientific article published on 15 May 2017

Novel genomic amplification targeting the microRNA cluster at 19q13.42 in a pediatric embryonal tumor with abundant neuropil and true rosettes.

scientific article

Novel oncogene amplifications in tumors from a family with Li-Fraumeni syndrome

scientific article published in July 2009

Novel, improved grading system(s) for IDH-mutant astrocytic gliomas

scientific article published on 23 April 2018

Nuclear relocation of STAT6 reliably predicts NAB2-STAT6 fusion for the diagnosis of solitary fibrous tumour

scientific article

O10.01PROGNOSTIC AND PREDICTIVE BIOMARKER-BASED SUBGROUPS IN THE NOA-04 TRIAL.

scientific article published in September 2014

OMICS AND PROGNSTIC MARKERS

article

OS02.1 Multicenter pilot study of radio-chemotherapy as first-line treatment for adults with medulloblastoma - the NOA-07 trial.

scientific article published on 19 April 2017

OS6.1 Molecular characterization of astroblastoma.

scientific article

OS6.4 Molecular classification of meningiomas across all histological subtypes and grades.

scientific article published on 21 September 2016

Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma

scientific article published on 20 March 2011

Oncolytic effects of parvovirus H-1 in medulloblastoma are associated with repression of master regulators of early neurogenesis

scientific article published on 2 September 2013

Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma

scientific article published on 9 March 2018

Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma.

scientific article published in July 2018

Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci

scientific article (publication date: April 2009)

Outcomes by Clinical and Molecular Features in Children With Medulloblastoma Treated With Risk-Adapted Therapy: Results of an International Phase III Trial (SJMB03)

scientific article published on 06 January 2021

Overcoming multiple drug resistance mechanisms in medulloblastoma.

scientific article

P04.01RELA FUSION DEFINES CLINICOPATHOLOGIC SUBSETS OF SUPRATENTORIAL EPENDYMOMA: A STUDY FROM THE COLLABORATIVE EPENDYMOMA RESEARCH NETWORK.

scientific article published in September 2014

P08.76 Anti-EGFL7 treatment as an add-on for glioma therapy.

scientific article published on 21 September 2016

P09.09 Gain of 12p encompassing CCND2 is associated with gemistocytic histology in IDH mutant astrocytomas.

scientific article

PATH-04. AN ENHANCED AI-DRIVEN PLATFORM FOR PRECISION MOLECULAR BRAIN TUMOR DIANOSTICS

publication published on 01 December 2020

PATH-24. MOLECULAR SUBGROUPS OF ADULT EPENDYMAL TUMORS: AN ANALYSIS OF THE GERMAN GLIOMA NETWORK

PATH-32. MOLECULAR HETEROGENEITY AMONG PEDIATRIC POSTERIOR FOSSA EPENDYMOMA

PATHOLOGY

scholarly article by J.-i. Adachi et al published 1 November 2013 in Neuro-Oncology

PCDH10 is a candidate tumour suppressor gene in medulloblastoma.

scientific article published on 20 May 2011

PCLN-05. A BIOBANK OF PATIENT-DERIVED MOLECULARLY CHARACTERIZED ORTHOTOPIC PEDIATRIC BRAIN TUMOR MODELS FOR PRECLINICAL RESEARCH

PCLN-06. NOVEL TUMOR-DERIVED MODELS OF CNS HGNET-BCOR PROVIDE INSIGHTS INTO UNDERLYING MOLECULAR MECHANISMS AND INNOVATIVE THERAPEUTIC OPTIONS

PCM-15SOMATIC CRISPR/Cas9-MEDIATED TUMOR SUPPRESSOR DISRUPTION ENABLES VERSATILE BRAIN TUMOR MODELING.

scientific article

PCM-16MOLECULAR CHARACTERIZATION OF ORTHOTOPIC PATIENT-DERIVED XENOGRAFT MODELS OF PEDIATRIC BRAIN TUMORS.

scientific article

PCM-20PRE-CLINICAL DRUG SCREEN IN A PDX ETMR MOUSE MODEL.

scientific article

PDCT-05. MOLECULAR DIAGNOSTICS REVEAL 60% HIGHER SURVIVAL FOR MOLECULARLY-VERIFIED VERSUS HISTOPATHOLOGICALLY-DIAGNOSED PEDIATRIC SUPRATENTORIAL CENTRAL NERVOUS SYSTEM EMBRYONAL TUMORS AND PINEOBLASTOMAS; A REPORT FROM THE CHILDREN’S ONCOLOGY GROUP

PDTM-23. THE ACTIVE REGULATORY LANDSCAPE OF EPENDYMAL TUMORS

PDTM-38. PEDIATRIC MENINGIOMAS ARE CHARACTERIZED BY DISTINCT METHYLATION PROFILES DIFFERENT FROM ADULT MENINGIOMAS

PDTM-46. TARGETING METABOLIC ADAPTATION IN MYC DRIVEN PEDIATRIC NEURONAL TUMORS

scientific article published on 6 November 2017

PDTM-47. CHARACTERIZATION OF THE SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE IN PILOCYTIC ASTROCYTOMA AND ITS ROLE IN ONCOGENE-INDUCED SENESCENCE

PDTM-49. GLOBAL REDUCTION IN H3K27me3, SIMILAR TO H3K27M MUTANT GLIOMAS, IS A MOLECULAR SURROGATE FOR PEDIATRIC POSTERIOR FOSSA- GROUP A EPENDYMOMAS

scientific article published on 6 November 2017

PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.

scientific article published in November 2017

PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas

scientific article published on 03 December 2013

PM-09ESTABLISHMENT AND MOLECULAR CHARACTERIZATION OF PATIENT-DERIVED XENOGRAFT MODELS OF PEDIATRIC BRAIN TUMORS.

scientific article published on 21 April 2015

PM-09REGULATION OF MEDULLOBLASTOMA FORMATION BY Gfi1 AND Gfi1B

scientific article published in November 2014

PNR-12GENOME-WIDE PROFILING OF EMBRYONAL TUMORS WITH MULTILAYERED ROSETTES (ETMR).

scientific article published on 30 May 2016

PNR-21FOUR NEW BRAIN TUMOR ENTITIES EMERGE FROM MOLECULAR CLASSIFICATION OF CNS PNETs

scientific article published on 30 May 2016

PNR-33MOLECULAR RE-EVALUATION OF INSTITUTIONALLY DIAGNOSED CNS-PNETS: CLINICAL CONSEQUENCES OF CONFINED DIAGNOSTIC GROUPS.

scientific article published on 30 May 2016

PNR-39DISTINCT GENE FUSIONS SEGREGATE SUB-CLASSES OF CNS-PNETs.

scientific article published on 30 May 2016

PROGNOSTIC AND PREDICTIVE BIOMARKER-BASED SUBGROUPS IN THE NOA-04 TRIAL.

scientific article published in July 2014

PROGNOSTIC SIGNIFICANCE OF CLINICAL, HISTOPATHOLOGICAL, AND MOLECULAR CHARACTERISTICS OF MEDULLOBLASTOMAS IN THE PROSPECTIVE HIT2000 MULTICENTER CLINICAL TRIAL COHORT

PTPS-11ATYPICAL TERATOID/RHABDOID TUMOUR IS AN EPIGENETICALLY HETEROGENEOUS DISEASE CHARACTERIZED BY SUBGROUP SPECIFIC SUPER-ENHANCERS.

scientific article

Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge

scientific article published on February 2014

Paired box gene 8 (PAX8) expression is associated with sonic hedgehog (SHH)/wingless int (WNT) subtypes, desmoplastic histology and patient survival in human medulloblastomas

scientific article published in February 2015

Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking.

scientific article

Papillary Tumor of the Pineal Region: A Distinct Molecular Entity

scientific article

Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA

scientific article published on 13 February 2019

Pediatric Gliomas: Current Concepts on Diagnosis, Biology, and Clinical Management.

scientific article

Pediatric Low-Grade Gliomas: Next Biologically Driven Steps

scientific article published on 2 August 2017

Pediatric Targeted Therapy: Clinical Feasibility of Personalized Diagnostics in Children with Relapsed and Progressive Tumors

scientific article published on 7 October 2015

Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct

scientific article

Pediatric gliomas

scientific article published on January 2009

Pediatric high-grade glioma: biologically and clinically in need of new thinking

scientific article

Pediatric low-grade gliomas: implications of the biologic era.

scientific article published on 28 September 2016

Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia

scientific article published on 10 December 2019

Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas.

scientific article

Pilocytic Astrocytoma demethylation and transcriptional landscapes link bZIP transcription factors to immune response

scientific article published on 13 February 2020

Pleiotropic effects of miR-183~96~182 converge to regulate cell survival, proliferation and migration in medulloblastoma

scientific article

Poorly differentiated chordoma with SMARCB1/INI1 loss: a distinct molecular entity with dismal prognosis

scientific article published on 11 April 2016

Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation

scientific article published on 15 November 2019

Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience.

scientific article

Pre-clinical drug screen reveals topotecan, actinomycin D and volasertib as potential new therapeutic candidates for ETMR brain tumor patients

scientific article published on 08 May 2017

Preliminary experience with personalized and targeted therapy for pediatric brain tumors

scientific article published on 11 December 2011

Primary intracranial sarcomas with DICER1 mutation often contain prominent eosinophilic cytoplasmic globules and can occur in the setting of neurofibromatosis type 1

scientific article published on 16 January 2019

Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations.

scientific article

Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis

scientific article published on 20 November 2020

Probing Medulloblastoma Initiation at the Single-Cell Level

scientific article published on 28 October 2019

Prognostic relevance of miR-124-3p and its target TP53INP1 in pediatric ependymoma

scientific article published on 24 April 2017

Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort

scientific article

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

scientific article published on 11 March 2016

Proteomic analysis of Medulloblastoma reveals functional biology with translational potential.

scientific article published on 7 June 2018

Proteomic profiling of high risk medulloblastoma reveals functional biology

scientific article published on June 2015

Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups

scientific article published on 01 September 2018

Pseudoprogression in children, adolescents and young adults with non-brainstem high grade glioma and diffuse intrinsic pontine glioma

scientific article

Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma

scientific article published on 19 June 2014

RARE-10. MULTICENTER PILOT STUDY OF RADIO-CHEMOTHERAPY AS FIRST-LINE TREATMENT FOR ADULTS WITH MEDULLOBLASTOMA – THE NOA-07 TRIAL

RF_Purify: a novel tool for comprehensive analysis of tumor-purity in methylation array data based on random forest regression

scientific article published on 16 August 2019

Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B

scientific article published on 20 September 2021

Radiogenomics of Glioblastoma: Machine Learning-based Classification of Molecular Characteristics by Using Multiparametric and Multiregional MR Imaging Features

scientific article

Radiomic subtyping improves disease stratification beyond key molecular, clinical and standard imaging characteristics in patients with glioblastoma

scientific article published on 28 September 2017

Rapid and Sensitive Drug Quantification in Tissue Sections Using Matrix Assisted Laser Desorption Ionization-Ion Mobility-Mass Spectrometry Profiling

scientific article published on 23 January 2020

Rapid and Sensitive Quantification of Osimertinib in Human Plasma Using a Fully Validated MALDI-IM-MS/MS Assay

scientific article published on 14 July 2020

Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples

scientific article published on 6 November 2011

Real-time PCR assay based on the differential expression of microRNAs and protein-coding genes for molecular classification of formalin-fixed paraffin embedded medulloblastomas

scientific article

Receptor activator of nuclear factor kappaB ligand plays a nonredundant role in doxorubicin-induced apoptosis

scientific article published on April 2003

Recommendations for Cancer Surveillance in Individuals with RASopathies and Other Rare Genetic Conditions with Increased Cancer Risk

scientific article published on June 2017

Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis

scientific article published on 17 October 2013

Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors

scientific article published on 05 August 2021

Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma

scientific article published in Nature Communications

Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants.

scientific article published on 18 June 2018

Recurrent non-coding U1-snRNA mutations drive cryptic splicing in Shh medulloblastoma

scientific article published on 09 October 2019

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

scientific article

Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma

scientific article

Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas

scientific article

Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma

scientific article published on 21 August 2020

Reliability of molecular tumour markers in children with medulloblastoma--an example from clinical practice ⬇️

scientific article published on August 19, 2011

Replicative senescence of mesenchymal stem cells: a continuous and organized process

scientific article

Reply to 'Assembling the brain trust: the multidisciplinary imperative in neuro-oncology'

scientific article published on 01 August 2019

Reply to J.C. Lindsey et al

Resolving medulloblastoma cellular architecture by single-cell genomics

scientific article published on 24 July 2019

Response in a child with a BRAF V600E mutated desmoplastic infantile astrocytoma upon retreatment with vemurafenib.

scientific article published on 12 December 2017

Response to trametinib treatment in progressive pediatric low-grade glioma patients

scientific article published on 07 October 2020

Revealing the role of SGK1 in the dynamics of medulloblastoma using a mathematical model

scientific article

Risk stratification of childhood medulloblastoma in the molecular era: the current consensus

scientific article published on 4 April 2016

Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial

scientific article published on 16 May 2018

Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays

scientific article published on 14 May 2013

Role of LIM and SH3 protein 1 (LASP1) in the metastatic dissemination of medulloblastoma

scientific article

Rosette-forming glioneuronal tumors share a distinct DNA methylation profile and mutations in FGFR1, with recurrent co-mutation of PIK3CA and NF1

scientific article published on 27 June 2019

Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions

scientific article published on 05 July 2019

SG-04THE eEF2 KINASE, A MEDIATOR OF MEDULLOBLASTOMA ADAPTATION TO METABOLIC STRESS, SUPPORTS FATTY ACID OXIDATION.

scientific article published on 21 April 2015

SHH desmoplastic/nodular medulloblastoma and Gorlin syndrome in the setting of Down syndrome: case report, molecular profiling, and review of the literature

scientific article

SMAD dependent signaling plays a detrimental role in a fly model of SMARCB1-deficiency and the biology of atypical teratoid/rhabdoid tumors

scientific article published on 20 January 2017

STRUCTURAL VARIANTS SHUFFLE CHROMATIN TO ACTIVATE GFI1 FAMILY ONCOGENES IN MEDULLOBLASTOMA.

scientific article published in July 2014

Sarcoma classification by DNA methylation profiling

scientific article published on 21 January 2021

Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes

scientific article published on 10 May 2019

Secretion of angiogenic proteins by human multipotent mesenchymal stromal cells and their clinical potential in the treatment of avascular osteonecrosis

scientific article published on 21 August 2008

Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations

scientific article

Sellar Region Atypical Teratoid/Rhabdoid Tumors (ATRT) in Adults Display DNA Methylation Profiles of the ATRT-MYC Subgroup

scientific article published on 10 January 2018

Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial

scientific article published on 28 May 2019

Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma.

scientific article published on 22 April 2015

Signatures of mutational processes in human cancer

scientific article (publication date: 22 August 2013)

Single cell derived mRNA signals across human kidney tumors

scientific article published on 23 June 2021

Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma

scientific article published on 01 July 2020

Sodium hyaluronate carboxymethylcellulose-based bioresorbable membrane (Seprafilm)--does it affect tumor implantation at abdominal wound sites?

scientific article published in May 1999

Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling

scientific article published on 11 June 2015

Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas.

scientific article

Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem

scientific article published on 21 February 2012

Spatial heterogeneity in medulloblastoma

scientific article published on 10 April 2017

Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas

scientific article

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

scientific article

Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype.

scientific article

Stepwise accumulation of distinct genomic aberrations in a patient with progressively metastasizing ependymoma

scientific article published in March 2009

Subgroup-specific alternative splicing in medulloblastoma

scientific article

Subgroup-specific localization of human medulloblastoma based on pre-operative MRI.

scientific article

Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma

scientific article published on 08 July 2013

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

scientific article

Supratentorial primitive neuroectodermal tumors of the central nervous system frequently harbor deletions of the CDKN2A locus and other genomic aberrations distinct from medulloblastomas

scientific article

Systematic identification of suspected anthelmintic benzimidazole metabolites using LC-MS/MS.

scientific article published on 28 December 2017

Systematic target actionability reviews of preclinical proof-of-concept papers to match targeted drugs to paediatric cancers

scientific article published on 27 March 2020

Systemic chemotherapy of pediatric recurrent ependymomas: results from the German HIT-REZ studies

scientific article published on 16 October 2021

TB-11MOLECULAR NEUROPATHOLOGY 2.0 - INCREASING DIAGNOSTIC ACCURACY IN PEDIATRIC NEUROONCOLOGY.

scientific article

TB-14THE INFORM PERSONALIZED MEDICINE STUDY - NEW MOLECULAR INSIGHTS INTO RELAPSED PEDIATRIC BRAIN TUMORS.

scientific article

TB-16EXPLORATION OF eEF2K AS A NOVEL THERAPEUTIC TARGET IN MEDULLOBLASTOMA AND NEUROBLASTOMA.

scientific article

TB-17A COMPREHENSIVE PAN-CANCER ANALYSIS OF CHILDHOOD MALIGNANCIES.

scientific article published on 30 May 2016

TB-27SUBGROUP-SPECIFIC OUTCOMES OF CHILDREN WITH MALIGNANT CHILDHOOD BRAIN TUMORS TREATED WITH AN IRRADIATION-SPARING PROTOCOL.

scientific article

TBIO-07. ASSESSING THE UTILITY OF DNA METHYLATION PROFILING IN BRAIN TUMOR DIAGNOSTICS—THE PROSPECTIVE MNP2.0 STUDY

TBIO-10. PEDIATRIC TARGETED THERAPY 2.0: DEVELOPMENT OF PERSONALIZED PEDIATRIC ONCOLOGY

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

scientific article published on 31 October 2013

THER-02. TARGETING DNA DAMAGE REPAIR IN MYC-DRIVEN PEDIATRIC BRAIN TUMORS

scientific article published on 23 April 2019

TMOD-01BCOR IS A NOVEL TUMOR SUPPRESSOR GENE IN SHH-DRIVEN MEDULLOBLASTOMA.

scientific article

TMOD-05. MOLECULAR CHARACTERIZATION OF ORTHOTOPIC PATIENT-DERIVED XENOGRAFT MODELS OF PEDIATRIC BRAIN TUMORS AND THEIR USE IN PRECLINICAL EXPERIMENTS.

scientific article

TMOD-11. HUMAN STEM CELL BASED MODEL OF MEDULLOBLASTOMA

TP53 codon 72 polymorphism may predict early tumour progression in paediatric pilocytic astrocytoma.

scientific article published on 25 June 2016

TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma.

scientific article

TRTH-09. PTT2.0: DEVELOPING PERSONALIZED PEDIATRIC ONCOLOGY.

scientific article published on 31 May 2017

TUMOUR BIOLOGY

Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma

scientific article

Telomerase activation in posterior fossa group A ependymomas is associated with dismal prognosis and chromosome 1q gain

scientific article

Telomere dysfunction and chromothripsis

scientific article published on 9 February 2016

TelomereHunter - in silico estimation of telomere content and composition from cancer genomes

scientific article published on 28 May 2019

The AIEOP 2nd series of children and adolescents intracranial Ependymoma. An integrated molecular and clinical characterization with a long-term follow-up

scientific article published on 02 November 2020

The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma

scientific article

The RNA-binding protein Musashi1 affects medulloblastoma growth via a network of cancer-related genes and is an indicator of poor prognosis

scientific article

The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

scientific article published on 07 December 2018

The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors

scientific article published on 25 September 2014

The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants

scientific article

The clinical implications of medulloblastoma subgroups

scientific article published on 08 May 2012

The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants

scientific article

The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation

scientific article

The genetics of pediatric brain tumors

scientific article published on May 2010

The genomic landscape of pediatric renal cell carcinomas

scientific article published on 26 March 2022

The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma

scientific article published in March 2008

The landscape of genomic alterations across childhood cancers

scientific article published on 28 February 2018

The molecular landscape of ETMR at diagnosis and relapse

scientific article published on 04 December 2019

The role of chromatin remodeling in medulloblastoma.

scientific article published on March 2013

The transcription factor evi-1 is overexpressed, promotes proliferation, and is prognostically unfavorable in infratentorial ependymomas

scientific article

The whole-genome landscape of medulloblastoma subtypes

scientific article published in July 2017

The β-catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner

scientific article published on April 2017

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis

scientific article published on 06 June 2016

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

scientific article published on 20 December 2017

Tissue Factor Regulation by miR-520g in Primitive Neuronal Brain Tumor Cells: A Possible Link between Oncomirs and the Vascular Tumor Microenvironment

scientific article published on 11 December 2015

Transcriptional profiling of medulloblastoma with extensive nodularity (MBEN) reveals two clinically relevant tumor subsets with VSNL1 as potent prognostic marker

scientific article published on 28 November 2019

Transcriptomic and epigenetic profiling of 'diffuse midline gliomas, H3 K27M-mutant' discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location

scientific article published on 5 November 2018

Transitioning from genotypes to epigenotypes: why the time has come for medulloblastoma epigenomics

scientific article published on 20 July 2013

Treatment of Children and Adolescents With Metastatic Medulloblastoma and Prognostic Relevance of Clinical and Biologic Parameters

scientific article published on 31 October 2016

Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities

scientific article published on 28 October 2019

Two molecularly distinct atypical teratoid/rhabdoid tumors (or tumor components) occurring in an infant with rhabdoid tumor predisposition syndrome 1

scientific article published on 03 April 2019

Ultra high-risk PFA ependymoma is characterized by loss of chromosome 6q

scientific article published on 01 August 2021

Update on molecular and genetic alterations in adult medulloblastoma

scientific article

Voxel-wise radiogenomic mapping of tumor location with key molecular alterations in patients with glioma

scientific article published on 01 October 2018

WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma

scientific article

Whole exome sequencing reveals that the majority of schwannomatosis cases remain unexplained after excluding SMARCB1 and LZTR1 germline variants

article published in 2014

YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis

scientific article published on 02 September 2019

YAP1-fusions in pediatric NF2-wildtype meningioma

scientific article published on 16 November 2019

cIMPACT-NOW (the consortium to inform molecular and practical approaches to CNS tumor taxonomy): a new initiative in advancing nervous system tumor classification

scientific article published on 20 December 2016

cIMPACT-NOW update 4: diffuse gliomas characterized by MYB, MYBL1, or FGFR1 alterations or BRAFV600E mutation

scientific article published on 08 March 2019

p19-INK4d inhibits neuroblastoma cell growth, induces differentiation and is hypermethylated and downregulated in MYCN-amplified neuroblastomas

scientific article

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