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List of works by James R. Woodgett

A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases.

scientific article published in February 2018

A Low-Therapeutic Dose of Lithium Inhibits GSK3 and Enhances Myoblast Fusion in C2C12 Cells

scientific article published on 29 October 2019

A Saccharomyces cerevisiae protein-serine kinase related to mammalian glycogen synthase kinase-3 and the Drosophila melanogaster gene shaggy product

scientific article published on November 1993

A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition

scientific article published on 18 January 2017

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

scientific article (publication date: 8 December 2005)

A kinase with Ku-dos

scientific article published on 01 July 1993

A molecular compendium of genes expressed in multiple myeloma

scientific article

A multifunctional calmodulin-dependent protein kinase. Similarities between skeletal muscle glycogen synthase kinase and a brain synapsin I kinase

scientific article published in November 1983

A subgroup of microRNAs defines PTEN-deficient, triple-negative breast cancer patients with poorest prognosis and alterations in RB1, MYC, and Wnt signaling

scientific article published on 31 January 2019

Abnormalities in brain structure and behavior in GSK-3alpha mutant mice

scientific article

Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion

scientific article

Activation of PDK-1 maintains mouse embryonic stem cell self-renewal in a PKB-dependent manner

scientific article published on 4 March 2013

Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway

scientific article published on January 1997

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity ⬇️

scientific article published on February 8, 1991

Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase

scientific article published in December 1997

Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation

scientific article

Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression

scientific article

Alzheimer's disease: Mental plaque removal

scientific article published in May 2003

Assessment of social interaction behaviors

scientific article

Basic research: bizarre but essential

scientific article published in Nature

Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts

scientific article published on June 1999

Burning platforms: friending social media's role in #scicomm.

scientific article published on October 2014

CD28 signal transduction pathways. A comparison of B7-1 and B7-2 regulation of the map kinases: ERK2 and Jun kinases

scientific article

CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly.

scientific article

Can a Two-Faced Kinase be Exploited for Osteosarcoma? ⬇️

scientific article published on April 24, 2012

Cardiac fibroblast glycogen synthase kinase-3β regulates ventricular remodeling and dysfunction in ischemic heart

scientific article published on 4 June 2014

Cardiomyocyte-GSK-3α promotes mPTP opening and heart failure in mice with chronic pressure overload

scientific article published on 27 March 2019

Cardiomyocyte-specific deletion of Gsk3α mitigates post-myocardial infarction remodeling, contractile dysfunction, and heart failure

scientific article

Cardioprotective stress response in the human fetal heart

scientific article published on May 2005

Characterization of the sites phosphorylated on tyrosine hydroxylase by Ca2+ and phospholipid-dependent protein kinase, calmodulin-dependent multiprotein kinase and cyclic AMP-dependent protein kinase

scientific article published in March 1985

Chronic activation of protein kinase Bbeta/Akt2 leads to multinucleation and cell fusion in human epithelial kidney cells: events associated with tumorigenesis

scientific article published on August 2005

Clinical uses of microarrays in cancer research

scientific article published on January 2008

Comparison of calmodulin-dependent glycogen synthase kinase from skeletal muscle and calmodulin-dependent protein kinase-II from brain

scientific article published in May 1984

Conditional ablation of Gsk-3β in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice

scientific article

Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway

scientific article

Correction of GSK3β at young age prevents muscle pathology in mice with myotonic dystrophy type 1.

scientific article published on 4 December 2017

CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome

scientific article

Cytosolic alkalinization increases stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK) activity and p38 mitogen-activated protein kinase activity by a calcium-independent mechanism

scientific article published on May 1997

DREAM is a critical transcriptional repressor for pain modulation

scientific article (publication date: 11 January 2002)

Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol.

scientific article published on 23 August 2010

Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation

scientific article published on October 2008

Deletion of glycogen synthase kinase-3β in cartilage results in up-regulation of glycogen synthase kinase-3α protein expression.

scientific article

Differential gene expression profile reveals deregulation of pregnancy specific beta1 glycoprotein 9 early during colorectal carcinogenesis

scientific article

Differential gene expression profiling of short and long term denervated muscle

article

Differential subcellular localisation of two isoforms of p70 S6 protein kinase

scientific article published in January 1994

Does GSK-3 provide a shortcut for PI3K activation of Wnt signalling?

scientific article published on 24 November 2010

Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis

scientific article published on 8 September 2014

Enabling the Next 25 Years of Cell Biology

scientific article published on 29 September 2016

Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth

scientific article

Evidence that amiloride antagonises insulin-stimulated protein phosphorylation by inhibiting protein kinase activity

article

Exploring pluripotency with chemical genetics

scientific article published on February 2009

Expression of I2PP2A, an inhibitor of protein phosphatase 2A, induces c-Jun and AP-1 activity

scientific article published on July 1999

Expression of Wnt-signaling pathway proteins in intraductal papillary mucinous neoplasms of the pancreas: a tissue microarray analysis

scientific article

Finding the stepping stones downstream of ras

scientific article published on 01 July 1992

Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway

scientific article

Frequent accumulation of nuclear E-cadherin and alterations in the Wnt signaling pathway in esophageal squamous cell carcinomas

article

Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration

scientific article published on 25 July 2006

Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines

scientific article published on June 2007

GSK-3 is a master regulator of neural progenitor homeostasis

scientific article published on 04 October 2009

GSK-3: Functional Insights from Cell Biology and Animal Models

scientific article

GSK-3: tricks of the trade for a multi-tasking kinase

scientific article

GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice

scientific journal article

GSK-3beta controls osteogenesis through regulating Runx2 activity

scientific article

GSK-3α and GSK-3β proteins are involved in early stages of chondrocyte differentiation with functional redundancy through RelA protein phosphorylation

scientific article

GSK-3α is a central regulator of age-related pathologies in mice

scientific article

GSK-3α/β kinases and amyloid production in vivo

scientific article

GSK-3β function in bone regulates skeletal development, whole-body metabolism, and male life span

scientific article published on 31 July 2013

GSK3

GSK3: an in-Toll-erant protein kinase?

GSK3beta mediates renal response to vasopressin by modulating adenylate cyclase activity

scientific article

GSK3β mediates muscle pathology in myotonic dystrophy

scientific article

Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3.

scientific article

Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance

scientific article

Genetic inactivation of GSK3α rescues spine deficits in Disc1-L100P mutant mice

scientific article published on 17 April 2011

Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology

scientific article

Glycogen Synthase Kinase 3: A Kinase for All Pathways?

scientific article published on 28 December 2016

Glycogen Synthase Kinase-3

Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation.

scientific article published on 6 November 2017

Glycogen Synthase Kinase-3 in Neurological Diseases

Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium

scientific article published on 12 February 2007

Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism

scientific article published in October 2007

Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase

scientific article published on October 2004

Glycogen synthase kinase 3α regulates urine concentrating mechanism in mice

scientific article

Glycogen synthase kinase-3 and cancer: good cop, bad cop?

scientific article

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase

scientific article published in November 1992

Glycogen synthase kinase-3: functions in oncogenesis and development

scientific article (publication date: 16 December 1992)

Glycogen synthase kinase-3: properties, functions, and regulation

scientific article (publication date: August 2001)

Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium

scientific article

Glycogen synthase kinase-3beta heterozygote knockout mice as a model of findings in postmortem schizophrenia brain or as a model of behaviors mimicking lithium action: negative results

scientific article

Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3.

scientific article published on 21 August 2007

Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy

scientific article

Glycogen synthase kinase-3beta regulates post-myocardial infarction remodeling and stress-induced cardiomyocyte proliferation in vivo

scientific article

Glycogen synthase kinase-3α limits ischemic injury, cardiac rupture, post-myocardial infarction remodeling and death

scientific article

Glycogen synthase kinase-3β promotes cyst expansion in polycystic kidney disease

scientific article published on 28 January 2015

Gsk3 is a metabolic checkpoint regulator in B cells

scientific article published on 23 January 2017

Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts

scholarly article

How to Become a Control Freak

IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins.

scientific article

IL-17 receptor signaling inhibits C/EBPbeta by sequential phosphorylation of the regulatory 2 domain

scientific article published on 24 February 2009

Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer

scientific article published on 01 April 2018

Identification of a calmodulin-dependent glycogen synthase kinase in rabbit skeletal muscle, distinct from phosphorylase kinase

scientific article published on 01 November 1982

Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes.

scientific article published in September 1997

Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance

scientific article published on 8 November 2012

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

scientific article

Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions.

scientific article published on 12 December 2007

Ionizing radiation stimulates a Grb2-mediated association of the stress-activated protein kinase with phosphatidylinositol 3-kinase

scientific article

Isoform specific requirement for GSK3α in sperm for male fertility.

scientific article published on 29 January 2018

JNK1 activity lowers the cellular production of H2O2 and modulates the growth arrest response to scavenging of H2O2 by catalase

scientific article published on April 2003

Kinase-dead PKB gene therapy combined with hyperthermia for human breast cancer

scientific article published on January 2004

Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner

scientific article

Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade

scholarly article

Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy.

scientific article published on 14 March 2016

Mammalian mitogen-activated protein kinase pathways are regulated through formation of specific kinase-activator complexes

scientific article published on November 1996

Micromanaging ideas risks impeding flow of potential benefits

scientific article published in Nature

Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation

scientific article

Modulating autoimmunity: pick your PI3 kinase

scientific article published in September 2005

Molecular stratification within triple-negative breast cancer subtypes

scientific article published on 13 December 2019

Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B

scientific article

Multisite phosphorylation of glycogen synthase

scientific article published on 01 August 1984

Mutational Analysis of Glycogen Synthase Kinase 3β Protein Kinase Together with Kinome-Wide Binding and Stability Studies Suggests Context-Dependent Recognition of Kinases by the Chaperone Heat Shock Protein 90.

scientific article published on 11 January 2016

Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival

scientific article (publication date: 7 February 2003)

Negative regulation of phosphatidylinositol 3-kinase and Akt signalling pathway by PKC.

scientific article published on January 2003

Neurological functions of the masterswitch protein kinase - gsk-3.

scientific article

Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2.

scientific article

Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22.

scientific article published on 08 August 2016

Open Heart Surgery of PI-3 Kinase Signaling

scientific article published on 01 November 2002

Opioid effects on mitogen-activated protein kinase signaling cascades

scientific article published in November 1997

Opposing regulation of B cell receptor-induced activation of mitogen-activated protein kinases by CD45.

scientific article

Overexpressed tau protein in cultured cells is phosphorylated without formation of PHF: implication of phosphoprotein phosphatase involvement

scientific article published on December 1995

PHF-tau from Alzheimer's brain comprises four species on SDS-PAGE which can be mimicked by in vitro phosphorylation of human brain tau by glycogen synthase kinase-3 beta

scientific article published in August 1994

Phorbol ester-induced amino-terminal phosphorylation of human JUN but not JUNB regulates transcriptional activation

scientific article published on August 1992

Phosphatidylinositol 3' kinase signaling in mammary tumorigenesis.

scientific article

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

scientific article

Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation

scientific article

Phosphorylation of c-jun mediated by MAP kinases.

scientific article

Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function

scientific article published in Nature Communications

Polypharmacological Profiles Underlying the Antitumor Property of Root (Danshen) Interfering with NOX-Dependent Neutrophil Extracellular Traps

scientific article published on 19 August 2018

Powering the cell cycle

scientific article published on 01 April 1991

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

scientific article published on February 1999

Protein Kinases: Physiological Roles

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

scientific article published on October 1998

Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

scientific article

Protein kinases: six degrees of separation?

scientific article

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization

scientific article

R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling

scientific article published on 30 March 2007

Ras Signaling Is a Key Determinant for Metastatic Dissemination and Poor Survival of Luminal Breast Cancer Patients.

scientific article published on 23 September 2015

Rationally designed PKA inhibitors for positron emission tomography: Synthesis and cerebral biodistribution of N-(2-(4-bromocinnamylamino)ethyl)-N-[11C]methyl-isoquinoline-5-sulfonamide.

scientific article published on 6 March 2008

Recent advances in the protein kinase B signaling pathway

scientific article

Recent advances in understanding the cellular roles of GSK-3.

scientific article published on 20 February 2017

Regulation of Drosophila tracheal system development by protein kinase B.

scientific article

Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.

scientific article published on 19 April 2013

Regulation of the protein kinase activity of Shaggy(Zeste-white3) by components of the wingless pathway in Drosophila cells and embryos

scientific article published on July 1999

Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

scientific article (publication date: 6 July 2000)

Role of glycogen synthase kinase-3 in cancer: regulation by Wnts and other signaling pathways

scientific article

Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions

scientific article published on January 2007

Role of phosphoinositide 3-kinase {alpha}, protein kinase C, and L-type Ca2+ channels in mediating the complex actions of angiotensin II on mouse cardiac contractility

scientific article published on 9 August 2010

Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3.

scientific article published on 21 June 2006

Selective effects of CAPP1-calmodulin on its target proteins

scientific article published on 01 June 1985

Serum and glucocorticoid-regulated protein kinases: variations on a theme

scientific article

Signals controlling un-differentiated states in embryonic stem and cancer cells: role of the phosphatidylinositol 3' kinase pathway

scientific article published on October 2014

Single unpurified breast tumor-initiating cells from multiple mouse models efficiently elicit tumors in immune-competent hosts

scientific article

Specific deletion of glycogen synthase kinase-3β in the renal proximal tubule protects against acute nephrotoxic injury in mice

scientific article

Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth

scientific article (publication date: 15 April 2003)

Stem cells. PTEN--coupling tumor suppression to stem cells?

scientific article

Stimulation of MAP kinase by v-raf transformation of fibroblasts fails to induce hyperphosphorylation of transfected tau.

scientific article published on May 1995

Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

scientific article

Studies on the primary sequence requirements for PKC-α, -β1 and -γ peptide substrates

scientific article published on 01 December 1990

Targeting GSK-3 family members in the heart: a very sharp double-edged sword

scientific article

Targeting glycogen synthase kinase-3 (GSK-3) in the treatment of Type 2 diabetes

The GSK-3 family as therapeutic target for myocardial diseases ⬇️

scientific article

The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer's disease

scientific article published on 29 November 2001

The links between axin and carcinogenesis

scientific article

The responses of neural stem cells to the level of GSK-3 depend on the tissue of origin

scientific article published on 20 June 2013

The role of protein kinase B (PKB) in modulating heat sensitivity in a human breast cancer cell line

scientific article

The stress-activated protein kinase subfamily of c-Jun kinases

scientific article (publication date: 12 May 1994)

The stress-activated protein kinases. A novel ERK subfamily responsive to cellular stress and inflammatory cytokines

scientific article published on September 1995

Thousand-citation papers are outliers ⬇️

scientific article published on December 20, 2012

Tissue-specific analysis of glycogen synthase kinase-3α (GSK-3α) in glucose metabolism: effect of strain variation

scientific article

Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action

scientific article published on 11 August 2008

Toronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 1: Late Recurrence: Current Understanding, Clinical Considerations

scientific article published on 10 August 2019

Toronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 2: Approaches to Predict and Identify Late Recurrence, Research Directions

scientific article published on 10 August 2019

Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation

scientific article published on 10 January 2012

Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development

scientific article published on 08 December 2008

Unravelling the activation mechanisms of protein kinase B/Akt

scientific article

Utility of metformin in breast cancer treatment, is neoangiogenesis a risk factor?

scientific article published on 26 April 2008

We must be open about our mistakes ⬇️

scientific article published on September 6, 2012

When pathways collide: collaboration and connivance among signalling proteins in development.

scientific article published on 12 May 2010

Who Actually Funds Cancer Research?

scientific article published on 07 October 2019

Xanthatin anti-tumor cytotoxicity is mediated via glycogen synthase kinase-3β and β-catenin

scientific article published on 16 June 2016

mTOR regulates brain morphogenesis by mediating GSK3 signaling

scientific article

β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation.

scientific article

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