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List of works by Stephen Tong

A bioplex analysis of cytokines and chemokines in first trimester maternal plasma to screen for predictors of miscarriage

scientific article

A comparison of sample collection methods for quantifying cell-free fetal neurodevelopment transcripts in amniotic fluid

scientific article

A double blind, randomised, placebo-controlled trial to evaluate the efficacy of metformin to treat preterm pre-eclampsia (PI2 Trial): study protocol

scientific article published on 24 April 2019

A wash step at collection of placental biopsies from preeclamptic pregnancies does not adversely affect levels of sFlt-1 or endoglin.

scientific article

ATF3 is a negative regulator of inflammation in human fetal membranes

scientific article

Abnormal plasma DNA profiles in early ovarian cancer using a non-invasive prenatal testing platform: implications for cancer screening.

scientific article

Accurately predicting the risk of serious maternal morbidity in preterm preeclampsia: Can It be done?

scientific article published on 12 February 2018

Activating Transcription Factor 3 Is Reduced in Preeclamptic Placentas and Negatively Regulates sFlt-1 (Soluble fms-Like Tyrosine Kinase 1), Soluble Endoglin, and Proinflammatory Cytokines in Placenta.

scientific article

Activin A, hypoxia and the prediction of obstetric outcomes

scientific article published on 01 April 2006

Acupuncture in pregnancy; primum non nocere

scientific article published on 04 November 2019

Assessing the sensitivity of placental growth factor and soluble fms-like tyrosine kinase 1 at 36 weeks' gestation to predict small-for-gestational-age infants or late-onset preeclampsia: a prospective nested case-control study

scientific article published on 31 August 2018

Association Between Twin Discordance at 6–9 Weeks' of Gestation and Birthweight Complications

scientific article published in August 2010

Association between low day 16 hCG and miscarriage after proven cardiac activity

scientific article published in February 2006

Association between maternal serum cytokine profiles at 7-10 weeks' gestation and birthweight in small for gestational age infants

scientific article published on 03 February 2011

Blood-based biomarkers in the maternal circulation associated with fetal growth restriction

scientific article published on 22 July 2019

Characterization of protocols for primary trophoblast purification, optimized for functional investigation of sFlt-1 and soluble endoglin.

scientific article published on 7 October 2014

Characterization of symptoms immediately preceding eclampsia

scientific article published on November 2011

Chorioamnionitis Occurring in Women With Preterm Rupture of the Fetal Membranes Is Associated With a Dynamic Increase in mRNAs Coding Cytokines in the Maternal Circulation

scientific article published on 23 January 2015

Circulating GATA2 mRNA is decreased among women destined to develop preeclampsia and may be of endothelial origin

scientific article published in Scientific Reports

Circulating MicroRNAs in maternal blood as potential biomarkers for fetal hypoxia in-utero

scientific article

Circulating RNA coding genes regulating apoptosis in maternal blood in severe early onset fetal growth restriction and pre-eclampsia.

scientific article published on 21 February 2013

Circulating adrenomedullin mRNA is decreased in women destined to develop term preeclampsia

scientific article published on 10 February 2019

Combination gefitinib and methotrexate compared with methotrexate alone to treat ectopic pregnancy

scientific article published in October 2013

Combination gefitinib and methotrexate treatment for non-tubal ectopic pregnancies: a case series

scientific article published on 7 May 2014

Combination methotrexate and gefitinib: A potential medical treatment for inoperable nontubal ectopic pregnancy

scientific article published on 09 December 2019

Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction - implications for treating preeclampsia.

scientific article published on 21 February 2018

Cord blood sampling at delivery: do we need to always collect from both vessels?

scientific article published in October 2002

Corin, an enzyme with a putative role in spiral artery remodeling, is up-regulated in late secretory endometrium and first trimester decidua.

scientific article published on 21 February 2013

Corpus luteum across the first trimester: size and laterality as observed by ultrasound

scientific article published on 26 December 2007

Death associated protein kinase 1 (DAPK-1) is increased in preeclampsia

scientific article published on 24 September 2019

Decline in βhCG levels between days 0 and 4 after a single dose of methotrexate for ectopic pregnancy predicts treatment success: a retrospective cohort study

scientific article published on 6 September 2011

Determining zygosity in early pregnancy by ultrasound

scientific article published on 01 January 2004

Diagnostic Accuracy of Maternal Serum Macrophage Inhibitory Cytokine-1 and Pregnancy-Associated Plasma Protein-A at 6–10 Weeks of Gestation to Predict Miscarriage

scientific article published in May 2012

Disulfiram inhibits placental soluble FMS-like tyrosine kinase-1 and soluble endoglin secretion independent of the proteasome

scientific article published on 21 September 2018

Dizygotic twinning as a measure of human fertility

scientific article published on January 1998

Double blind, randomised, placebo-controlled trial to evaluate the efficacy of esomeprazole to treat early onset pre-eclampsia (PIE Trial): a study protocol

scientific article

EGFL7 gene expression is regulated by hypoxia in trophoblast and altered in the plasma of patients with early preeclampsia

scientific article published on 05 September 2018

ELABELA/APELA Levels Are Not Decreased in the Maternal Circulation or Placenta among Women with Preeclampsia

scientific article published in August 2018

Effect of sildenafil citrate on circulating levels of sFlt-1 in preeclampsia

scientific article published on 11 April 2018

Effects of Pravastatin on Human Placenta, Endothelium, and Women With Severe Preeclampsia

scientific article published on 27 July 2015

Effects of gefitinib, an epidermal growth factor receptor inhibitor, on human placental cell growth

scientific article published on October 2013

Effects of maternal obstructive sleep apnoea on fetal growth: a prospective cohort study.

scientific article published on 24 July 2013

Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta

scientific article

Epidermal Growth Factor Rescues Endothelial Dysfunction in Primary Human Tissues In Vitro

scientific article published on 5 December 2016

Esomeprazole to treat women with preterm preeclampsia: a randomized placebo controlled trial

scientific article published on 26 July 2018

Evaluation of ADAM-12 as a diagnostic biomarker of ectopic pregnancy in women with a pregnancy of unknown location.

scientific article

Expectant management of severe preterm preeclampsia: a comparison of maternal and fetal indications for delivery.

scientific article

Fetal activin A: associations with labour, umbilical artery pH and neonatal outcome

scientific article published in April 2004

First trimester levels of inhibins and activin A in normal and failing pregnancies

scientific article published in April 2004

Galectin-7 acts as an adhesion molecule during implantation and increased expression is associated with miscarriage.

scientific article published on 24 January 2014

Gefitinib and Methotrexate to Treat Ectopic Pregnancies with a Pre-Treatment Serum hCG 1000-10,000 IU/L: Phase II Open Label, Single Arm Multi-Centre Trial

scientific article published on 22 June 2018

Has increased clinical experience with methotrexate reduced the direct costs of medical management of ectopic pregnancy compared to surgery?

scientific article

Heme Oxygenase-1 Is Not Decreased in Preeclamptic Placenta and Does Not Negatively Regulate Placental Soluble fms-Like Tyrosine Kinase-1 or Soluble Endoglin Secretion.

scientific article

High-dose compared with low-dose oxytocin for induction of labour of nulliparous women at term.

scientific article published on 10 September 2017

Highly specific and sensitive rise in Days 14–17 pro-αC inhibin with clinical pregnancy after frozen embryo transfer with ovulatory cycles

scientific article published on 3 June 2007

Human HtrA4 Expression Is Restricted to the Placenta, Is Significantly Up-Regulated in Early-Onset Preeclampsia, and High Levels of HtrA4 Cause Endothelial Dysfunction

scientific article published on 6 May 2015

Hysteroscopy under general anaesthesia, a near painless procedure

scientific article

Identifying late-onset fetal growth restriction by measuring circulating placental RNA in the maternal blood at 28 weeks' gestation.

scientific article

Impairment of Angiogenic Sphingosine Kinase-1/Sphingosine-1-Phosphate Receptors Pathway in Preeclampsia.

scientific article

Increased day 15-17 serum pro-alphaC inhibin levels specific to successful pregnancy

scientific article published in September 2004

Inhibins and activins: clinical advances in reproductive medicine

scientific article published in February 2003

Is fetal growth restriction associated with a more severe maternal phenotype in the setting of early onset pre-eclampsia? A retrospective study

scientific article

Jumonji Domain Containing Protein 6 Is Decreased in Human Preeclamptic Placentas and Regulates sFLT-1 Splice Variant Production.

scientific article published on 27 January 2016

Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction.

scientific article published on 4 January 2017

Loss of Akt increases soluble endoglin release from endothelial cells but not placenta.

scientific article

Low levels of pregnancy-associated plasma protein-A in asymptomatic women destined for miscarriage.

scientific article

MHR welcomes high-quality basic reproductive research around pregnancy.

scientific article published in November 2013

MMP-14 Is Expressed in Preeclamptic Placentas and Mediates Release of Soluble Endoglin ⬇️

scientific article published on January 31, 2012

MMP-15 is upregulated in preeclampsia, but does not cleave endoglin to produce soluble endoglin

scientific article

MT-MMPs in pre-eclamptic placenta: relationship to soluble endoglin production

scientific article published on 20 December 2012

Maternal and foetal activin A levels: associations with normal and abnormal labour

scientific article published on September 2002

Maternal and foetal activin A levels: associations with normal and abnormal labour

scientific article published in August 2002

Maternal mortality at the National Referral Hospital in Honiara, Solomon Islands over a five-year period

scientific article published on 11 September 2019

Maternal plasma concentrations of the placental specific sFLT-1 variant, sFLT-1 e15a, in fetal growth restriction and preeclampsia.

scientific article

Maternal serum activin A and the prediction of intrauterine growth restriction

scientific article published in April 2006

Maternal serum and amniotic fluid levels of macrophage inhibitory cytokine 1 in Down syndrome and chromosomally normal pregnancies

scientific article

Maternal serum interleukin-33 and soluble ST2 across early pregnancy, and their association with miscarriage ⬇️

scientific article published on July 28, 2012

Measurement of mRNA Transcripts of Very High Placental Expression in Maternal Blood as Biomarkers of Preeclampsia

scientific article published in November 2011

Measuring circulating placental RNAs to non-invasively assess the placental transcriptome and to predict pregnancy complications.

scientific article

Measuring hypoxia-induced RNA in maternal blood: a new way to identify critically hypoxic fetuses in utero?

scientific article published on 30 April 2014

Measuring thyroid peroxidase antibodies on the day nulliparous women present for management of miscarriage: a descriptive cohort study.

scientific article published on 14 May 2013

Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia.

scientific article published on 11 April 2018

Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction.

scientific article published on 22 December 2015

Miscarriage Risk for Asymptomatic Women After a Normal First-Trimester Prenatal Visit

scientific article published in March 2008

Molecular diagnostics and therapeutics for ectopic pregnancy.

scientific article published on 17 September 2014

Nuclear factor of activated T-cells (NFAT) regulates soluble fms-like tyrosine kinase-1 secretion (sFlt-1) from human placenta.

scientific article published on 21 October 2016

Of leaves and butterflies: how methotrexate came to be the savior of women

scientific article published on November 2011

PAPPA2 is increased in severe early onset pre-eclampsia and upregulated with hypoxia

scientific article published on January 2014

PLAC4 is upregulated in severe early onset preeclampsia and upregulated with syncytialisation but not hypoxia

scientific article published on 9 January 2013

PSG7 and 9 (Pregnancy-Specific β-1 Glycoproteins 7 and 9): Novel Biomarkers for Preeclampsia

scientific article published on 24 March 2022

Paternal obesity in a rodent model affects placental gene expression in a sex-specific manner.

scientific article

Peptides do not prevent cleavage of endoglin to produce soluble endoglin.

scientific article published on 22 October 2014

Phase II single arm open label multicentre clinical trial to evaluate the efficacy and side effects of a combination of gefitinib and methotrexate to treat tubal ectopic pregnancies (GEM II): study protocol

scientific article published on 19 July 2013

Placental HtrA3 is regulated by oxygen tension and serum levels are altered during early pregnancy in women destined to develop preeclampsia

scientific article published on 3 November 2010

Placental Insufficiency in Fetuses That Slow in Growth but Are Born Appropriate for Gestational Age: A Prospective Longitudinal Study

scientific article published on 5 January 2016

Placental SEMA3B expression is not altered in severe early onset preeclampsia

scientific article published on 16 October 2014

Placental expression of a novel primate-specific splice variant of sFlt-1 is upregulated in pregnancies complicated by severe early onset pre-eclampsia.

scientific article

Placental specific mRNA in the maternal circulation are globally dysregulated in pregnancies complicated by fetal growth restriction

scientific article

Placental-Specific sFLT-1 e15a Protein Is Increased in Preeclampsia, Antagonizes Vascular Endothelial Growth Factor Signaling, and Has Antiangiogenic Activity.

scientific article published on 28 September 2015

Placental-specific sFLT-1: role in pre-eclamptic pathophysiology and its translational possibilities for clinical prediction and diagnosis

scientific article

Plasma MIC-1 and PAPP-a levels are decreased among women presenting to an early pregnancy assessment unit, have fetal viability confirmed but later miscarry

scientific article

Predicting perinatal outcome through changes in umbilical artery Doppler studies after antenatal corticosteroids in the growth-restricted fetus

scientific article published in March 2009

Prediction of adverse maternal outcomes in preeclampsia at term

scientific article published on 20 September 2019

Predictive Value of the Signs and Symptoms Preceding Eclampsia: A Systematic Review

scientific article published on 01 October 2019

Preventing preeclampsia with aspirin: does dose or timing matter?

scientific article published on 01 February 2017

Prognostic value of human chorionic gonadotropin levels 4 days after a single dose of methotrexate for ectopic pregnancy

scientific article published on 10 February 2012

Proton Pump Inhibitors Decrease Soluble fms-Like Tyrosine Kinase-1 and Soluble Endoglin Secretion, Decrease Hypertension, and Rescue Endothelial Dysfunction

scientific article published on 23 January 2017

Proton Pump Inhibitors and Preeclampsia Risk Among 157 720 Women

scientific article published on 01 May 2019

Quantifying circulating hypoxia-induced RNA transcripts in maternal blood to determine in utero fetal hypoxic status

scientific article published on 9 December 2013

Quantifying mRNA coding growth genes in the maternal circulation to detect fetal growth restriction

scientific article published on 10 April 2013

Rational design of immunostimulatory siRNAs.

scientific article

Reduced growth velocity across the third trimester is associated with placental insufficiency in fetuses born at a normal birthweight: a prospective cohort study.

scientific article published on 31 August 2017

Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction - implications as a preeclampsia treatment.

scientific article

Screening circulating proteins to identify biomarkers of fetal macrosomia

scientific article published on 18 September 2019

Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as a predictor of miscarriage

scientific article published in The Lancet

Serum concentrations of soluble Flt-1 are decreased among women with a viable fetus and no symptoms of miscarriage destined for pregnancy loss

scientific article

Severe early-onset preeclampsia is not associated with a change in placental catechol O-methyltransferase (COMT) expression.

scientific article

Sofalcone upregulates the nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1 pathway, reduces soluble fms-like tyrosine kinase-1, and quenches endothelial dysfunction: potential therapeutic for preeclampsia.

scientific article

Soluble endoglin production is upregulated by oxysterols but not quenched by pravastatin in primary placental and endothelial cells

scientific article

Sonography: dizygotic twin survival in early pregnancy

scientific article published in March 2002

Stability of absolute copy number of housekeeping genes in preeclamptic and normal placentas, as measured by digital PCR.

scientific article published on 16 October 2014

Steroid sulfatase is increased in the placentas and whole blood of women with early-onset preeclampsia

scientific article published on 15 October 2016

Sulfasalazine decreases soluble fms-like tyrosine kinase-1 secretion potentially via inhibition of upstream placental epidermal growth factor receptor signalling

scientific article published on 10 September 2019

Sulfasalazine reduces placental secretion of antiangiogenic factors, up-regulates the secretion of placental growth factor and rescues endothelial dysfunction

scientific article published on 26 February 2019

Systematic review of areca (betel nut) use and adverse pregnancy outcomes

scientific article published on 03 October 2019

Targeted nanoparticle delivery of doxorubicin into placental tissues to treat ectopic pregnancies.

scientific article published on 3 January 2013

The cerebral-placental-uterine ratio as a novel predictor of late fetal growth restriction: a prospective cohort study

scientific article published on 01 September 2019

The circulating microRNA-200 family in whole blood are potential biomarkers for high-grade serous epithelial ovarian cancer

scientific article

The evolution of methotrexate as a treatment for ectopic pregnancy and gestational trophoblastic neoplasia: a review.

scientific article published on 19 February 2012

The role of leukemia inhibitory factor in tubal ectopic pregnancy.

scientific article published on 13 September 2013

The untapped potential of placenta-enriched molecules for diagnostic and therapeutic development

scientific article published on 04 February 2019

The use of miRNA microarrays for the analysis of cancer samples with global miRNA decrease

scientific article published on 24 May 2013

Thyroid function and autoantibody status among women who spontaneously deliver under 35 weeks of gestation.

scientific article published on 28 May 2009

Transcription factors E2F1 and E2F3 are expressed in placenta but do not regulate MMP14.

scientific article

Treatment of early-onset preeclampsia with continuous positive airway pressure

scientific article

Two Corpora Lutea Seen at 6–13 Weeks' Gestation Infers Dizygosity Among Spontaneous Same-Sexed Dichorionic Twins

scientific article published on 01 April 2009

Ultrasound Reference Chart Based on IVF Dates to Estimate Gestational Age at 6–9 weeks’ Gestation ⬇️

scientific article published on July 22, 2012

Use of dizygotic to monozygotic twinning ratio as a measure of fertility

scientific article

Using a decline in serum hCG between days 0-4 to predict ectopic pregnancy treatment success after single-dose methotrexate: a retrospective cohort study.

scientific article

Variable effect of maternal oral glucose load on circulating cell-free placental mRNAs.

scientific article published on 12 April 2016

Vinorelbine Potently Induces Placental Cell Death, Does Not Harm Fertility and is a Potential Treatment for Ectopic Pregnancy.

scientific article published on 2 February 2018

YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia

scientific article published on 6 July 2015

sFlt-1 and soluble endoglin concentrations in serum vs plasma in preterm preeclampsia: Are they interchangeable for biomarker studies?

scientific article

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