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List of works by Stefanie D Krämer

5-(2-18F-fluoroethoxy)-L-tryptophan as a substrate of system L transport for tumor imaging by PET.

scientific article

A first-in-man PET study of [18F]PSS232, a fluorinated ABP688 derivative for imaging metabotropic glutamate receptor subtype 5.

scientific article published on 27 November 2017

A liposomal fluorescence assay to study permeation kinetics of drug-like weak bases across the lipid bilayer.

scientific article published on 6 November 2013

Accurate molecular imaging of small animals taking into account animal models, handling, anaesthesia, quality control and imaging system performance

scientific article

Alpha-tocopherol influences the lipid membrane affinity of desipramine in a pH-dependent manner

scientific article published in February 2004

Anti-VEGF antibody treatment accelerates polycystic kidney disease

scientific article published on 15 June 2011

Brain glucose transport and phosphorylation under acute insulin-induced hypoglycemia in mice: an 18F-FDG PET study

scientific article published on 24 October 2013

CD80 Is Upregulated in a Mouse Model with Shear Stress-Induced Atherosclerosis and Allows for Evaluating CD80-Targeting PET Tracers

scientific article published on 18 July 2016

Cannabinoid receptor type 2 (CB2) as one of the candidate genes in human carotid plaque imaging: Evaluation of the novel radiotracer [11C]RS-016 targeting CB2 in atherosclerosis.

scientific article published on 8 January 2017

Cell cultures as tools in biopharmacy.

scientific article

Cell-free microfluidic determination of P-glycoprotein interactions with substrates and inhibitors

scientific article published on 14 June 2014

Characterization of different osteosarcoma phenotypes by PET imaging in preclinical animal models

scientific article published on 25 June 2013

Cholesterol-mediated activation of P-glycoprotein: distinct effects on basal and drug-induced ATPase activities

scientific article published on May 2009

Chronic Nicotine Exposure Alters Metabotropic Glutamate Receptor 5: Longitudinal PET Study and Behavioural Assessment in Rats

scientific article published on 22 May 2019

Comparative analysis of CK2 expression and function in tumor cell lines displaying sensitivity vs. resistance to chemical induced apoptosis

scientific article

Comparing the lipid membrane affinity and permeation of drug-like acids: the intriguing effects of cholesterol and charged lipids.

scientific article published on 27 March 2007

Comparison of Permeation through Phosphatidylcholine Bilayers ofN-Dipicolinyl-α- and -β-Oligopeptides

scientific article published on 01 November 2006

Considerations on the potentiometric log P determination

scientific article published on 01 August 1998

Design, synthesis, and initial evaluation of a high affinity positron emission tomography probe for imaging matrix metalloproteinases 2 and 9.

scientific article published on 7 June 2013

Development and evaluation of novel PET tracers for imaging cannabinoid receptor type 2 in brain

scientific article published on January 2014

Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of σ₂ receptors

scientific article published on 20 September 2013

Development of [(18)F]-PSS223 as a PET tracer for imaging of metabotropic glutamate receptor subtype 5 (mGluR5).

scientific article published in January 2012

Discovery of a fluorinated 4-oxo-quinoline derivative as a potential positron emission tomography radiotracer for imaging cannabinoid receptor type 2.

scientific article published on 6 July 2016

Discovery of a high affinity and selective pyridine analog as a potential positron emission tomography imaging agent for cannabinoid type 2 receptor.

scientific article

Dynamics and Cleavability at the alpha-cleavage site of APP(684-726) in different lipid environments ⬇️

scientific article

Effect of the modulation of the membrane lipid composition on the localization and function of P-glycoprotein in MDR1-MDCK cells.

scientific article

Enhanced sensitivity to drugs of abuse and palatable foods following maternal overnutrition

scientific article published on 04 October 2016

Evaluation of [11C]Me-NB1 as a potential PET radioligand for measuring GluN2B-containing NMDA receptors, drug occupancy and receptor crosstalk

scientific article published on 30 November 2017

Evaluation of fluorescence anisotropy to assess drug-lipid membrane partitioning

scientific article published on 17 August 2012

Evaluation of the radiolabeled boronic acid-based FAP inhibitor MIP-1232 for atherosclerotic plaque imaging.

scientific article published on 27 January 2015

Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

scientific article published on 04 April 2012

Ex vivo differential phase contrast and magnetic resonance imaging for characterization of human carotid atherosclerotic plaques

scientific article

Expression profiles of metabolic enzymes and drug transporters in the liver and along the intestine of beagle dogs

scientific article

FDG kinetic modeling in small rodent brain PET: optimization of data acquisition and analysis

scientific article published on 6 August 2013

Free fatty acids cause pH-dependent changes in drug-lipid membrane interactions around physiological pH.

scientific article published in June 1997

GABAA receptor subtypes in the mouse brain: Regional mapping and diazepam receptor occupancy by in vivo [18F]flumazenil PET.

scientific article published on 10 February 2017

Gene expression levels of matrix metalloproteinases in human atherosclerotic plaques and evaluation of radiolabeled inhibitors as imaging agents for plaque vulnerability

scientific article published on 21 April 2014

Identification and Preclinical Evaluation of a Radiofluorinated Benzazepine Derivative for Imaging the GluN2B Subunit of the Ionotropic NMDA Receptor

scientific article published on 20 July 2018

Imaging atherosclerotic plaque inflammation via folate receptor targeting using a novel 18F-folate radiotracer

scientific article

Imaging tumour ATB0,+ transport activity by PET with the cationic amino acid O-2((2-[18F]fluoroethyl)methyl-amino)ethyltyrosine.

scientific article published on 5 December 2013

In Vivo Imaging of Local Inflammation: Monitoring LPS-Induced CD80/CD86 Upregulation by PET

scientific article published on 28 September 2020

In vitro and in vivo evaluation of [18F]-FDEGPECO as a PET tracer for imaging the metabotropic glutamate receptor subtype 5 (mGluR5).

scientific article published on 21 March 2011

Injected Human Muscle Precursor Cells Overexpressing PGC-1α Enhance Functional Muscle Regeneration after Trauma.

scientific article published on 21 January 2018

Interaction kinetics of salmeterol with egg phosphatidylcholine liposomes by surface plasmon resonance

scientific article

Isolated rafts from adriamycin-resistant P388 cells contain functional ATPases and provide an easy test system for P-glycoprotein-related activities

scientific article published in March 2005

Kinetics of iron absorption from ferrous fumarate with and without galacto-oligosaccharides determined from stable isotope appearance curves in women

scientific article published on 01 March 2022

Kinetics of lipid bilayer permeation of a series of ionisable drugs and their correlation with human transporter-independent intestinal permeability

scientific article

Lipid membrane interactions of indacaterol and salmeterol: do they influence their pharmacological properties?

scientific article published on 9 October 2009

Lipid-bilayer permeation of drug-like compounds.

scientific article

Lipids in blood-brain barrier models in vitro I: Thin-layer chromatography and high-performance liquid chromatography for the analysis of lipid classes and long-chain polyunsaturated fatty acids

scientific article published on November 2002

Lipids in blood-brain barrier models in vitro II: Influence of glial cells on lipid classes and lipid fatty acids

scientific article published on November 2002

MDCK cell cultures as an epithelial in vitro model: cytoskeleton and tight junctions as indicators for the definition of age-related stages by confocal microscopy.

scientific article

MRS glucose mapping and PET joining forces: re-evaluation of the lumped constant in the rat brain under isoflurane anaesthesia

scientific article

No entry for TAT(44-57) into liposomes and intact MDCK cells: novel approach to study membrane permeation of cell-penetrating peptides.

scientific article

Noninvasive PET Imaging and Tracking of Engineered Human Muscle Precursor Cells for Skeletal Muscle Tissue Engineering

scientific article published on 19 May 2016

P-Glycoprotein in cell cultures: a combined approach to study expression, localisation, and functionality in the confocal microscope.

scientific article

P-glycoprotein in proteoliposomes with low residual detergent: the effects of cholesterol

scientific article

Particle size and activation threshold: a new dimension of danger signaling

scientific article published on 19 March 2010

Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition

scientific article published on 06 May 2014

Permeation of a beta-heptapeptide derivative across phospholipid bilayers

scientific article published on 26 July 2007

Permeation of aromatic carboxylic acids across lipid bilayers: the pH-partition hypothesis revisited

scientific article

Permeation studies in vitro and in vivo of potential radiopharmaceuticals with affinity to neuro receptors

scientific article published on June 2000

Pharmacokinetics and safety of panobacumab: specific adjunctive immunotherapy in critical patients with nosocomial Pseudomonas aeruginosa O11 pneumonia.

scientific article published on 10 March 2011

Physicochemical properties in pharmacokinetic lead optimization

scientific article

Physiologically Based Pharmacokinetic Modelling with Dynamic PET Data to Study the In Vivo Effects of Transporter Inhibition on Hepatobiliary Clearance in Mice.

scientific article

Preclinical Evaluation of Benzazepine-Based PET Radioligands (R)- and (S)-11C-Me-NB1 Reveals Distinct Enantiomeric Binding Patterns and a Tightrope Walk Between GluN2B- and σ1-Receptor-Targeted PET Imaging

scientific article published on 25 January 2019

Preclinical evaluation and test-retest studies of [(18)F]PSS232, a novel radioligand for targeting metabotropic glutamate receptor 5 (mGlu5).

scientific article published on 20 August 2014

Preclinical imaging of the co-stimulatory molecules CD80 and CD86 with indium-111-labeled belatacept in atherosclerosis.

scientific article

Quantification of brain glucose metabolism by 18F-FDG PET with real-time arterial and image-derived input function in mice

scientific article

Quantitative aspects of drug permeation across in vitro and in vivo barriers

scientific article published on 19 October 2015

Quantitative positron emission tomography of mGluR5 in rat brain with [(18) F]PSS232 at minimal invasiveness and reduced model complexity

scientific article published on 28 January 2015

Radiofluorinated histamine H₃ receptor antagonist as a potential probe for in vivo PET imaging: radiosynthesis and pharmacological evaluation

scientific article

Radiolabeling and in vitro /in vivo evaluation of N-(1-adamantyl)-8-methoxy-4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxamide as a PET probe for imaging cannabinoid type 2 receptor.

scientific article published on 19 July 2013

Radiosynthesis and preclinical evaluation of 3'-Aza-2'-[(18)F]fluorofolic acid: a novel PET radiotracer for folate receptor targeting

scientific article

Studies toward the development of new silicon-containing building blocks for the direct (18)F-labeling of peptides

scientific article

SwissPK<sup>cdw</sup> - A clinical data warehouse for the optimization of pediatric dosing regimens

scientific article published on 02 November 2021

Syntheses and pharmacological characterization of novel thiazole derivatives as potential mGluR5 PET ligands

scientific article published on 25 June 2010

Synthesis and Pharmacological Evaluation of [11C]Granisetron and [18F]Fluoropalonosetron as PET Probes for 5-HT3 Receptor Imaging

scientific article published on 29 August 2016

Synthesis and Preliminary Evaluation of a 2-Oxoquinoline Carboxylic Acid Derivative for PET Imaging the Cannabinoid Type 2 Receptor

scientific article published on 06 March 2014

Synthesis and Structure-Affinity Relationship of Small Molecules for Imaging Human CD80 by Positron Emission Tomography

scientific article published on 29 August 2019

Synthesis and biological evaluation of (18)F-labeled Fluoroethoxy tryptophan analogues as potential PET tumor imaging agents.

scientific article

Synthesis and biological evaluation of ¹⁸F-labeled fluoropropyl tryptophan analogs as potential PET probes for tumor imaging.

scientific article published on 30 October 2013

Synthesis and evaluation of a C-6 alkylated pyrimidine derivative for the in vivo imaging of HSV1-TK gene expression

article

Synthesis and evaluation of novel α-fluorinated (E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-enone-O-methyl oxime (ABP688) derivatives as metabotropic glutamate receptor subtype 5 PET radiotracers

scientific article published on 9 August 2012

Synthesis and pharmacological evaluation of ¹¹C-labeled piperazine derivative as a PET probe for sigma-2 receptor imaging.

scientific article

Synthesis and preclinical evaluation of a new C-6 alkylated pyrimidine derivative as a PET imaging agent for HSV1-tk gene expression.

scientific article published on 5 January 2013

Synthesis and preliminary biological evaluation of O-2((2-[(18)F]fluoroethyl)methylamino)ethyltyrosine ([(18)F]FEMAET) as a potential cationic amino acid PET tracer for tumor imaging.

scientific article published on 7 May 2014

Synthesis, Radiolabeling, and Biological Evaluation of 5-Hydroxy-2-[(18)F]fluoroalkyl-tryptophan Analogues as Potential PET Radiotracers for Tumor Imaging.

scientific article published on 18 May 2016

Synthesis, radiolabeling and evaluation of novel 4-oxo-quinoline derivatives as PET tracers for imaging cannabinoid type 2 receptor

scientific article published on 13 January 2015

Synthesis, radiolabelling and in vitro and in vivo evaluation of a novel fluorinated ABP688 derivative for the PET imaging of metabotropic glutamate receptor subtype 5.

scientific article published on 10 December 2011

The biochemistry of drug metabolism--an introduction: Part 2. Redox reactions and their enzymes

scientific article

The biochemistry of drug metabolism--an introduction: part 1. Principles and overview.

scientific article

The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes

scientific article

The biochemistry of drug metabolism--an introduction: part 5. Metabolism and bioactivity

scientific article

The biochemistry of drug metabolism--an introduction: part 6. Inter-individual factors affecting drug metabolism

scientific article

The biochemistry of drug metabolism--an introduction: part 7. Intra-individual factors affecting drug metabolism.

scientific article published on October 2009

The pH-dependence in the partitioning behaviour of (RS)-[3H]propranolol between MDCK cell lipid vesicles and buffer

scientific article published on December 1996

Towards non-invasive imaging of vulnerable atherosclerotic plaques by targeting co-stimulatory molecules.

scientific article published on 13 April 2014

Towards the predictability of drug-lipid membrane interactions: the pH-dependent affinity of propanolol to phosphatidylinositol containing liposomes

scientific article published in May 1998

When barriers ignore the "rule-of-five".

scientific article published on 11 February 2016

[11C]mHED PET follows a two-tissue compartment model in mouse myocardium with norepinephrine transporter (NET)-dependent uptake, while [18F]LMI1195 uptake is NET-independent

scientific article published on 29 September 2020

[18F]Fluoro-Deoxy-Glucose Folate: A Novel PET Radiotracer with Improved in Vivo Properties for Folate Receptor Targeting

scientific article published on 13 March 2012

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