List of works by Yifan Han

A Novel Danshensu Derivative Prevents Cardiac Dysfunction and Improves the Chemotherapeutic Efficacy of Doxorubicin in Breast Cancer Cells

scientific article published on 8 June 2015

A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor

scientific article published on 12 February 2018

A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine.

scientific article published on 17 May 2015

A flavonol glycoside, isolated from roots of Panax notoginseng, reduces amyloid-beta-induced neurotoxicity in cultured neurons: signaling transduction and drug development for Alzheimer's disease.

scientific article published in January 2010

A novel experimental model of acute hypertriglyceridemia induced by schisandrin B

article

A novel tetramethylpyrazine bis-nitrone (TN-2) protects against 6-hydroxyldopamine-induced neurotoxicity via modulation of the NF-κB and the PKCα/PI3-K/Akt pathways.

scientific article

Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis

scientific article published on 22 May 2006

Acetylcholinesterase is associated with apoptosis in cells and contributes to insulin-dependent diabetes mellitus pathogenesis

scientific article published on 10 January 2012

Activation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects.

scientific article

Activity deprivation-dependent induction of the proapoptotic BH3-only protein Bim is independent of JNK/c-Jun activation during apoptosis in cerebellar granule neurons

scientific journal article

Advance of sporadic Alzheimer's disease animal models

scientific article published on 22 July 2019

Alkylene tether-length dependent gamma-aminobutyric acid type A receptor competitive antagonism by tacrine dimers

scientific article published on 20 October 2006

Alzheimer and beta-amyloid-treated fibroblasts demonstrate a decrease in a memory-associated GTP-binding protein, Cp20

scientific article

An analysis of chemical ingredients network of Chinese herbal formulae for the treatment of coronary heart disease

scientific article

Association between osteoarthritis and increased risk of dementia: A systemic review and meta-analysis

scientific article published on 01 March 2019

Attenuation of secondary damage and Aβ deposits in the ipsilateral thalamus of dMCAO rats through reduction of cathepsin B by bis(propyl)-cognitin, a multifunctional dimer

scientific article published on 11 November 2019

Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathways.

scientific article

Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade.

scientific article

Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through α7 nAChR.

scientific article published on 25 May 2011

Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels

scientific article published on 12 June 2006

Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptors.

scientific article published on 6 March 2008

Bis(7)-tacrine, a novel acetylcholinesterase inhibitor, reverses AF64A-induced deficits in navigational memory in rats.

scientific article published in March 2000

Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine

scientific article published on 01 September 2000

Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemia

scientific article published on 8 May 2008

Bis(propyl)-cognitin Prevents β-amyloid-induced Memory Deficits as Well as Synaptic Formation and Plasticity Impairments via the Activation of PI3-K Pathway

scientific article published on 10 July 2015

Bis(propyl)-cognitin potentiates rehabilitation of treadmill exercise after a transient focal cerebral ischemia, possibly via inhibiting NMDA receptor and regulating VEGF expression

scientific article published on 26 April 2019

Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3β pathways

scientific article published on 26 January 2013

Botanical drug puerarin coordinates with nerve growth factor in the regulation of neuronal survival and neuritogenesis via activating ERK1/2 and PI3K/Akt signaling pathways in the neurite extension process.

scientific article published on 14 October 2014

Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity.

scientific article published on 23 January 2015

Cloning and characterization of the yjeA gene, encoding a novel deoxyribonuclease, from Bacillus subtilis

scientific article published on 18 September 2007

Cloning and expression of MP13 gene from rat hippocampus, a new factor related to guanosine triphosphate regulation.

scientific article

Comparison of the inhibitory efficacy of four belladonna drugs on gastrointestinal movement and cognitive function in food-deprived mice

scientific article published in November 2004

Corrigendum to 'Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor' [Neurosci. Lett. 288 (2000) 95–98]

scientific article published on 01 August 2000

Development and validation of an HPLC-DAD method for bis(12)-hupyridone and its application to a pharmacokinetic study.

scientific article published on 24 November 2008

Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer's dimer, in rat blood

article

Diazepam inhibits the induction and maintenance of LTP of C-fiber evoked field potentials in spinal dorsal horn of rats.

scientific article published in December 2005

Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's β-Amyloid Neurotoxicity Via the Inhibition of Aβ Fibrils Formation and Disaggregation of Preformed Fibrils

scientific article published on 28 October 2015

Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease

scientific article published on 17 September 2016

Dual actions of (-)-stepholidine on the dopamine receptor-mediated adenylate cyclase activity in rat corpus striatum

scientific article published on January 1997

Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities

scientific article published on 01 November 1999

Effect of tacrine-3-caffeic acid, a novel multifunctional anti-Alzheimer's dimer, against oxidative-stress-induced cell death in HT22 hippocampal neurons: involvement of Nrf2/HO-1 pathway.

scientific article

Effective kinetics of schisandrin B on serum/hepatic triglyceride and total cholesterol levels in mice with and without the influence of fenofibrate

scientific article published on 28 April 2011

Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine

scientific article published in January 2006

Enzyme biosensor for studying therapeutics of Alzheimer's disease.

scientific article

Evaluation of acute bis(7)-tacrine treatment on behavioral functions in 17-day-old and 30-day-old mice, with attention to drug toxicity.

scientific article published on 15 March 2007

Evaluation of acute tacrine treatment on passive-avoidance response, open-field behavior, and toxicity in 17- and 30-day-old mice

scientific article

Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis

scientific article published in February 1999

Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease

article

Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin.

scientific article published on 24 May 2008

Extracellular signal-regulated kinases are not involved in activity-dependent survival or apoptosis in cerebellar granule neurons

scientific article published on 14 September 2006

Gallic acid-l-leucine (GAL) conjugate enhances macrophage phagocytosis via inducing leukotriene B4 12-hydroxydehydrogenase (LTB4DH) expression.

scientific article published on 2 May 2016

Gartanin Protects Neurons against Glutamate-Induced Cell Death in HT22 Cells: Independence of Nrf-2 but Involvement of HO-1 and AMPK.

scientific article published on 9 May 2016

Heterodimeric Tacrine-Based Acetylcholinesterase Inhibitors: Investigating Ligand−Peripheral Site Interactions

scientific article published on 01 October 1999

High doses of bifendate elevate serum and hepatic triglyceride levels in rabbits and mice: animal models of acute hypertriglyceridemia1

scientific article published on 01 June 2006

Human cytomegalovirus induces caspase-dependent apoptosis of megakaryocytic CHRF-288-11 cells by activating the JNK pathway

scientific article

Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats.

scientific article published in June 2000

Identification of a novel Wee1 isoform

scientific article published on 9 March 2005

Indirubin Derivative 7-Bromoindirubin-3-Oxime (7Bio) Attenuates Aβ Oligomer-Induced Cognitive Impairments in Mice

scientific article published on 28 November 2017

Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β.

scientific article published on 7 September 2015

Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3β and the ERK Pathway.

scientific article published on 13 July 2016

Induction of unspliced c-fos messenger RNA in rodent brain by kainic acid and lipopolysaccharide

scientific article published on 2001

Inhibiting β-amyloid-associated Alzheimer's pathogenesis in vitro and in vivo by a multifunctional dimeric bis(12)-hupyridone derived from its natural analogue

scientific article

Inhibition by bis(7)-tacrine of 5-HT-activated current in rat TG neurons.

scientific article

Inhibition by bis(7)-tacrine of native delayed rectifier and KV1.2 encoded potassium channels

scientific article published on 15 December 2006

Inhibition of AGEs/RAGE/Rho/ROCK pathway suppresses non-specific neuroinflammation by regulating BV2 microglial M1/M2 polarization through the NF-κB pathway

scientific article published on 8 February 2017

Inhibition of NMDA-gated ion channels by bis(7)-tacrine: whole-cell and single-channel studies

scientific article published on 2 March 2008

Inhibition of glycogen synthase kinase-3beta protects dopaminergic neurons from MPTP toxicity

scientific article

Intestinal transport of bis(12)-hupyridone in Caco-2 cells and its improved permeability by the surfactant Brij-35

scientific article published on 27 January 2011

Intranasal delivery of a novel acetylcholinesterase inhibitor HLS-3 for treatment of Alzheimer's disease

scientific article published on 30 June 2018

Isorhynchophylline ameliorates cognitive impairment via modulating amyloid pathology, tau hyperphosphorylation and neuroinflammation: Studies in a transgenic mouse model of Alzheimer's disease

scientific article published on 30 August 2019

L-F001, a novel multifunctional ROCK inhibitor, suppresses neuroinflammation in vitro and in vivo: Involvement of NF-κB inhibition and Nrf2 pathway activation

scientific article published on 16 March 2017

Mecamylamine prevents neuronal apoptosis induced by glutamate and low potassium via differential anticholinergic-independent mechanisms.

scientific article published on 23 December 2007

Mechanism of bis(7)-tacrine inhibition of GABA-activated current in cultured rat hippocampal neurons.

scientific article published on 22 April 2009

Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways

scientific article published in December 2004

Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons.

scientific article

Molecular Targets of Bis (7)-Cognitin and Its Relevance in Neurological Disorders: A Systematic Review

scientific article published on 09 May 2019

Multifunction of Chrysin in Parkinson's Model: Anti-Neuronal Apoptosis, Neuroprotection via Activation of MEF2D, and Inhibition of Monoamine Oxidase-B.

scientific article published on 31 May 2016

Natural Xanthones from Garcinia mangostana with Multifunctional Activities for the Therapy of Alzheimer's Disease.

scientific article published on 02 April 2016

Neuroprotection Against MPP+-Induced Cytotoxicity Through the Activation of PI3-K/Akt/GSK3β/MEF2D Signaling Pathway by Rhynchophylline, the Major Tetracyclic Oxindole Alkaloid Isolated From Uncaria rhynchophylla

scientific article published on 19 July 2018

Neuroprotection against excitotoxic and ischemic insults by bis(12)-hupyridone, a novel anti-acetylcholinesterase dimer, possibly via acting on multiple targets

scientific article published on 16 September 2011

Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models

scientific article published on 18 July 2016

Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine

scientific article published in April 2006

New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics.

scientific article

New Perspectives on Innovative Drug Discovery: An Overview ⬇️

scientific article published on January 1, 2010

New perspectives on chinese herbal medicine (zhong-yao) research and development

scientific article

Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets

scientific article published on January 2009

Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors

scientific article

Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents

scientific article published on 20 July 2007

PI3-K/Akt and ERK pathways activated by VEGF play opposite roles in MPP+-induced neuronal apoptosis.

scientific article

Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin

scientific article

Pharmacological Characterizations of anti-Dementia Memantine Nitrate via Neuroprotection and Vasodilation in Vitro and in Vivo

scientific article published on 22 January 2020

Pharmacological induction of leukotriene B4-12-hydroxydehydrogenase suppresses the oncogenic transformation of human hepatoma HepG2 cells.

scientific article published on 16 June 2011

Phorbol ester- and glutamate-sensitive phosphorylation of hippocampal membrane proteins from adult and neonatal rats

scientific article published in May 1993

Plant Natural Product Formononetin Protects Rat Cardiomyocyte H9c2 Cells against Oxygen Glucose Deprivation and Reoxygenation via Inhibiting ROS Formation and Promoting GSK-3β Phosphorylation

scientific article published on 6 January 2016

Potent Protection Against MPP(+)-Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine

scientific article

Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors

scientific article published on 01 August 1999

Potential roles of PI3K/Akt and Nrf2-Keap1 pathways in regulating hormesis of Z-ligustilide in PC12 cells against oxygen and glucose deprivation.

scientific article

Preclinical characterization of intestinal absorption and metabolism of promising anti-Alzheimer's dimer bis(7)-tacrine

scientific article published on 02 February 2008

Preventing H2O2-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone

scientific article published on 09 February 2011

Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity

scientific article published on 26 November 2007

Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently

scientific article published on 16 September 2009

Protection against 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells

scientific article published on 22 February 2011

Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin

scientific article published on 21 July 2015

Protective effects of huperzine A on β-amyloid25–35 induced oxidative injury in rat pheochromocytoma cells

article

Protein phosphatases 1 and 2A dephosphorylate B-50 in presynaptic plasma membranes from rat brain

scientific article published in July 1992

Research and development of anti-Alzheimer's disease drugs: an update from the perspective of technology flows

scientific article published on 8 February 2018

Robust Neuritogenesis-Promoting Activity by Bis(heptyl)-Cognitin Through the Activation of alpha7-Nicotinic Acetylcholine Receptor/ERK Pathway.

scientific article

SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease

scientific article published in February 2004

Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice.

scientific article published in March 2002

Senkyunolides reduce hydrogen peroxide-induced oxidative damage in human liver HepG2 cells via induction of heme oxygenase-1.

scientific article

Silk fibroin-based woven endovascular prosthesis with heparin surface modification.

scientific article published on 12 April 2018

Silk-based biomaterials in biomedical textiles and fiber-based implants

scientific article published on 13 March 2015

Stimulus-specific adaptation at the synapse level in vitro.

scientific article

Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer's Dimer

scientific article published on 16 July 2015

Substantial neuroprotection against K+ deprivation-induced apoptosis in primary cerebellar granule neurons by novel dimer bis(propyl)-cognitin via the activation of VEGFR-2 signaling pathway

scientific article

Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B.

scientific article published on 11 August 2017

Sunitinib produces neuroprotective effect via inhibiting nitric oxide overproduction.

scientific article

Sunitinib, a Clinically Used Anticancer Drug, Is a Potent AChE Inhibitor and Attenuates Cognitive Impairments in Mice

scientific article

Synergistic inhibition on acetylcholinesterase by the combination of berberine and palmatine originally isolated from Chinese medicinal herbs

scientific article published on 4 May 2014

Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase.

scientific article

Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD.

scientific article

Synthesis, biological activity, and biopharmaceutical characterization of tacrine dimers as acetylcholinesterase inhibitors

scientific article published on 31 October 2014

Tacrine and bis(7)-tacrine attenuate cycloheximide-induced amnesia in mice, with attention to acute toxicity

scientific article

Tacrine treatment at high dose suppresses the recognition memory in juvenile and adult mice with attention to hepatotoxicity

scientific article published on 22 February 2011

Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice

scientific article published on 07 November 2018

Tacrine(10)-hupyridone, a dual-binding acetylcholinesterase inhibitor, potently attenuates scopolamine-induced impairments of cognition in mice.

scientific article published on 21 March 2018

Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway.

scientific article published on 10 September 2011

Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo

scientific article

Tanshinone II A, a multiple target neuroprotectant, promotes caveolae-dependent neuronal differentiation

scientific article published on 9 September 2015

The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS

scientific journal article

The dual-functional memantine nitrate MN-08 alleviates cerebral vasospasm and brain injury in experimental subarachnoid haemorrhage models

scientific article published on 31 July 2019

The expression of Cdk5, p35, p39, and Cdk5 kinase activity in developing, adult, and aged rat brains.

scientific article published in July 2000

The novel tetramethylpyrazine bis-nitrone (TN-2) protects against MPTP/MPP+-induced neurotoxicity via inhibition of mitochondrial-dependent apoptosis

scientific article published on March 2014

The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine

scientific article published on 4 September 2007

Unexpected neuronal protection of SU5416 against 1-Methyl-4-phenylpyridinium ion-induced toxicity via inhibiting neuronal nitric oxide synthase

scientific article

Z-ligustilide potentiates the cytotoxicity of dopamine in rat dopaminergic PC12 cells

scientific article

p38 and ERK, but not JNK, are involved in copper-induced apoptosis in cultured cerebellar granule neurons.

scientific article

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