List of works - Didier Devys

A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing

scientific article

A heterogeneous set of FMR1 proteins is widely distributed in mouse tissues and is modulated in cell culture

article

ARX polyalanine expansions are highly implicated in familial cases of mental retardation with infantile epilepsy and/or hand dystonia

scientific article published on 01 January 2011

Alternative splicing of exon 14 determines nuclear or cytoplasmic localisation of fmr1 protein isoforms

scientific article

An expanding story

scientific article published on 01 November 1993

Analysis of full fragile X mutations in fetal tissues and monozygotic twins indicate that abnormal methylation and somatic heterogeneity are established early in development

article

Architecture of TAF11/TAF13/TBP complex suggests novel regulation properties of general transcription factor TFIID.

scientific article published on 7 November 2017

Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes

scientific article

Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form

scientific journal article

Clinical, molecular, and genotype-phenotype correlation studies from 25 cases of oral-facial-digital syndrome type 1: a French and Belgian collaborative study

scientific article

DNA binding by Sgf11 protein affects histone H2B deubiquitination by Spt-Ada-Gcn5-acetyltransferase (SAGA).

scientific article published on 07 February 2014

Deciphering the causes of sporadic late-onset cerebellar ataxias: a prospective study with implications for diagnostic work

scientific article published on 6 May 2017

Differential distribution of the normal and mutated forms of huntingtin in the human brain

scientific article published in November 1997

Disease progression despite early loss of polyglutamine protein expression in SCA7 mouse model.

scientific article published in February 2004

Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance.

scientific article published in August 2009

Global role for coactivator complexes in RNA polymerase II transcription

article

Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.

scientific article

H2B mono-ubiquitylation facilitates fork stalling and recovery during replication stress by coordinating Rad53 activation and chromatin assembly

scientific article

Hereditary systemic angiopathy (HSA) with cerebral calcifications, retinopathy, progressive nephropathy, and hepatopathy

scientific article

Histone H2B ubiquitination: signaling not scrapping.

scientific article published on June 2014

Homozygous TAF8 mutation in a patient with intellectual disability results in undetectable TAF8 protein, but preserved RNA Polymerase II transcription.

scientific article published on 10 April 2018

Hsp70 and Hsp40 chaperones do not modulate retinal phenotype in SCA7 mice.

scientific article

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

scientific article published in October 1998

In vivo chromatin organization of mouse rod photoreceptors correlates with histone modifications

scientific article

Juvenile Huntington disease in an 18-month-old boy revealed by global developmental delay and reduced cerebellar volume

scientific article published on 15 March 2011

LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation.

scientific article published in January 2013

Lessons from genome-wide studies: an integrated definition of the coactivator function of histone acetyl transferases

scientific article

Mediator is essential for small nuclear and nucleolar RNA transcription in yeast

scientific article published on 28 November 2018

Morphological features in juvenile Huntington disease associated with cerebellar atrophy - magnetic resonance imaging morphometric analysis

scientific article published on 20 June 2018

Pathogenesis of Spinocerebellar Ataxia Type 7: New Insights from Mouse Models and Ataxin-7 Function

Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias

scientific article published on November 1995

Polyglutamine expansion causes neurodegeneration by altering the neuronal differentiation program

scientific article published on 24 January 2006

Polyglutamine expansion induces a protein-damaging stress connecting heat shock protein 70 to the JNK pathway

scientific article published on 21 February 2003

Prenatally detected fragile X females: Long-term follow-up studies show high risk of mental impairment

scientific article published on 01 April 1992

Progressive retinal degeneration and dysfunction in R6 Huntington's disease mice

scientific article published on December 2002

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

scientific article published on August 2002

Rapid antibody test for fragile X syndrome.

scientific article

Rôle d’une désorganisation de la chromatine dans la neurodégénérescence due à une expansion de polyglutamine dans l’ataxine-7

scientific article published on 01 August 2006

SAGA Is a General Cofactor for RNA Polymerase II Transcription

scientific article published on 01 June 2018

SAGA Is a General Cofactor for RNA Polymerase II Transcription.

scientific article published on 11 September 2017

SCA7 Mouse Models

SH3 domain-dependent association of huntingtin with epidermal growth factor receptor signaling complexes

scientific article

Saccharomyces cerevisiae Metabolic Labeling with 4-thiouracil and the Quantification of Newly Synthesized mRNA As a Proxy for RNA Polymerase II Activity

scientific article published on 22 October 2018

The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription.

scientific article

The human TREX-2 complex is stably associated with the nuclear pore basket.

scientific article

The linker histone H1C contributes to the SCA7 nuclear phenotype

scientific article published on 01 September 2011

The structural plasticity of SCA7 domains defines their differential nucleosome-binding properties

scientific article

The tightly controlled deubiquitination activity of the human SAGA complex differentially modifies distinct gene regulatory elements

scientific article

Transcription of Nearly All Yeast RNA Polymerase II-Transcribed Genes Is Dependent on Transcription Factor TFIID.

scientific article published on 13 September 2017

Transcriptional alterations and chromatin remodeling in polyglutamine diseases.

scientific article published on 5 September 2006

Xq28 duplication including MECP2 in six unreported affected females: what can we learn for diagnosis and genetic counselling?

scientific article

Zinc-finger UBPs: regulators of deubiquitylation

scientific article

List of works by Didier Devys

A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing

A heterogeneous set of FMR1 proteins is widely distributed in mouse tissues and is modulated in cell culture

ARX polyalanine expansions are highly implicated in familial cases of mental retardation with infantile epilepsy and/or hand dystonia

Alternative splicing of exon 14 determines nuclear or cytoplasmic localisation of fmr1 protein isoforms

An expanding story

Analysis of full fragile X mutations in fetal tissues and monozygotic twins indicate that abnormal methylation and somatic heterogeneity are established early in development

Architecture of TAF11/TAF13/TBP complex suggests novel regulation properties of general transcription factor TFIID.

Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes

Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form

Clinical, molecular, and genotype-phenotype correlation studies from 25 cases of oral-facial-digital syndrome type 1: a French and Belgian collaborative study

DNA binding by Sgf11 protein affects histone H2B deubiquitination by Spt-Ada-Gcn5-acetyltransferase (SAGA).

Deciphering the causes of sporadic late-onset cerebellar ataxias: a prospective study with implications for diagnostic work

Differential distribution of the normal and mutated forms of huntingtin in the human brain

Disease progression despite early loss of polyglutamine protein expression in SCA7 mouse model.

Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance.

Global role for coactivator complexes in RNA polymerase II transcription

Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.

H2B mono-ubiquitylation facilitates fork stalling and recovery during replication stress by coordinating Rad53 activation and chromatin assembly

Hereditary systemic angiopathy (HSA) with cerebral calcifications, retinopathy, progressive nephropathy, and hepatopathy

Histone H2B ubiquitination: signaling not scrapping.

Homozygous TAF8 mutation in a patient with intellectual disability results in undetectable TAF8 protein, but preserved RNA Polymerase II transcription.

Hsp70 and Hsp40 chaperones do not modulate retinal phenotype in SCA7 mice.

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

In vivo chromatin organization of mouse rod photoreceptors correlates with histone modifications

Juvenile Huntington disease in an 18-month-old boy revealed by global developmental delay and reduced cerebellar volume

LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation.

Lessons from genome-wide studies: an integrated definition of the coactivator function of histone acetyl transferases

Mediator is essential for small nuclear and nucleolar RNA transcription in yeast

Morphological features in juvenile Huntington disease associated with cerebellar atrophy - magnetic resonance imaging morphometric analysis

Pathogenesis of Spinocerebellar Ataxia Type 7: New Insights from Mouse Models and Ataxin-7 Function

Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias

Polyglutamine expansion causes neurodegeneration by altering the neuronal differentiation program

Polyglutamine expansion induces a protein-damaging stress connecting heat shock protein 70 to the JNK pathway

Prenatally detected fragile X females: Long-term follow-up studies show high risk of mental impairment

Progressive retinal degeneration and dysfunction in R6 Huntington's disease mice

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

Rapid antibody test for fragile X syndrome.

Rôle d’une désorganisation de la chromatine dans la neurodégénérescence due à une expansion de polyglutamine dans l’ataxine-7

SAGA Is a General Cofactor for RNA Polymerase II Transcription

SAGA Is a General Cofactor for RNA Polymerase II Transcription.

SCA7 Mouse Models

SH3 domain-dependent association of huntingtin with epidermal growth factor receptor signaling complexes

Saccharomyces cerevisiae Metabolic Labeling with 4-thiouracil and the Quantification of Newly Synthesized mRNA As a Proxy for RNA Polymerase II Activity

The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription.

The human TREX-2 complex is stably associated with the nuclear pore basket.

The linker histone H1C contributes to the SCA7 nuclear phenotype

The structural plasticity of SCA7 domains defines their differential nucleosome-binding properties

The tightly controlled deubiquitination activity of the human SAGA complex differentially modifies distinct gene regulatory elements

Transcription of Nearly All Yeast RNA Polymerase II-Transcribed Genes Is Dependent on Transcription Factor TFIID.

Transcriptional alterations and chromatin remodeling in polyglutamine diseases.

Xq28 duplication including MECP2 in six unreported affected females: what can we learn for diagnosis and genetic counselling?

Zinc-finger UBPs: regulators of deubiquitylation