List of works - Ko Fujimori

A Limonoid Kihadanin B from Immature Citrus unshiu Peels Suppresses Adipogenesis through Repression of the Akt-FOXO1-PPARγ Axis in Adipocytes

scientific article published on 15 December 2016

A Limonoid, 7-Deacetoxy-7-Oxogedunin (CG-1) from Andiroba (Carapa guianensis, Meliaceae) Lowers the Accumulation of Intracellular Lipids in Adipocytes via Suppression of IRS-1/Akt-Mediated Glucose Uptake and a Decrease in GLUT4 Expression

scientific article published on 28 April 2019

A novel pathway to enhance adipocyte differentiation of 3T3-L1 cells by up-regulation of lipocalin-type prostaglandin D synthase mediated by liver X receptor-activated sterol regulatory element-binding protein-1c

scientific article published on 17 April 2007

Activation of adipogenesis by lipocalin-type prostaglandin D synthase-generated Δ¹²-PGJ₂ acting through PPARγ-dependent and independent pathways

scientific article published on June 2012

Activation of early phase of adipogenesis through Krüppel-like factor KLF9-mediated, enhanced expression of CCAAT/enhancer-binding protein β in 3T3-L1 cells

scientific article published on 9 November 2013

Adipokine ganglioside GM2 activator protein stimulates insulin secretion

scientific article

An Arabidopsis cDNA encoding a bifunctional glutamine amidotransferase/cyclase suppresses the histidine auxotrophy of a Saccharomyces cerevisiae his7 mutant

scientific article published on May 1998

Antiadipogenic effect of dietary apigenin through activation of AMPK in 3T3-L1 cells

scientific article published on 30 November 2011

Avicularin, a Plant Flavonoid, Suppresses Lipid Accumulation through Repression of C/EBPα-Activated GLUT4-Mediated Glucose Uptake in 3T3-L1 Cells ⬇️

scientific article published on May 16, 2013

Coupling between cyclooxygenase, terminal prostanoid synthase, and phospholipase A2.

scientific article

De novo synthesis, uptake and proteolytic processing of lipocalin-type prostaglandin D synthase, beta-trace, in the kidneys

scientific article

Differential expression and function of alternative splicing variants of human liver X receptor α.

scientific article

Differential resuscitative effect of pyruvate and its analogues on VBNC (viable but non-culturable) Salmonella.

scientific article

Drug transporters on arachnoid barrier cells contribute to the blood-cerebrospinal fluid barrier.

scientific article published on 8 January 2013

Enhancement of prostaglandin D(2) production through cyclooxygenase-2 and lipocalin-type prostaglandin D synthase by upstream stimulatory factor 1 in human brain-derived TE671 cells under serum starvation

scientific article published on 11 September 2008

Fisetin Suppresses Lipid Accumulation in Mouse Adipocytic 3T3-L1 Cells by Repressing GLUT4-Mediated Glucose Uptake through Inhibition of mTOR-C/EBPα Signaling

scientific article published on 18 May 2015

Forkhead transcription factor Foxa1 is a novel target gene of C/EBPβ and suppresses the early phase of adipogenesis

scientific article published on 15 December 2010

Increased production of lipocalin-type prostaglandin D synthase in leptomeningeal cells through contact with astrocytes

scientific article published on August 2007

Influence of the culture medium on the production of nitric oxide and expression of inducible nitric oxide synthase by activated macrophages in vitro

scientific article published on 13 January 2016

Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3.

scientific article published on 13 August 2003

Isolation and characterization of mutations affecting expression of the Δ9‐ fatty acid desaturase gene, OLE1, in Saccharomyces cerevisiae ⬇️

scientific article published on August 18, 1997

L-PGDS-produced PGD in premature, but not in mature, adipocytes increases obesity and insulin resistance

scientific article published in Scientific Reports

Limonoid 7-Deacetoxy-7-oxogedunin from Andiroba, Carapa guianensis, Meliaceae, Decreased Body Weight Gain, Improved Insulin Sensitivity, and Activated Brown Adipose Tissue in High-Fat-Diet-Fed Mice

scientific article published on 03 September 2019

Lipocalin-type prostaglandin D synthase protects against oxidative stress-induced neuronal cell death ⬇️

scientific article published on April 1, 2012

Matrix metalloproteinases and lysosomal cysteine proteases in osteoclasts contribute to bone resorption through distinct modes of action

scientific article published on 01 April 1999

Molecular cloning and characterization of the gene encoding N'-[(5'-phosphoribosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide (BBM II) isomerase from Arabidopsis thaliana.

scientific article

NMR solution structure of lipocalin-type prostaglandin D synthase: evidence for partial overlapping of catalytic pocket and retinoic acid-binding pocket within the central cavity

scientific journal article

Niacin promotes adipogenesis by reducing production of anti-adipogenic PGF2α through suppression of C/EBPβ-activated COX-2 expression

scientific article published on 12 January 2011

Nonacidic Chemotype Possessing N-Acylated Piperidine Moiety as Potent Farnesoid X Receptor (FXR) Antagonists

scientific article published on 4 January 2018

Novel suppression mechanism operating in early phase of adipogenesis by positive feedback loop for enhancement of cyclooxygenase-2 expression through prostaglandin F2α receptor mediated activation of MEK/ERK-CREB cascade

scientific journal article

Prevention of paraquat-induced apoptosis in human neuronal SH-SY5Y cells by lipocalin-type prostaglandin D synthase

scientific article

Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo.

scientific article published on 3 February 2010

Prostaglandin D2 enhances lipid accumulation through suppression of lipolysis via DP2 (CRTH2) receptors in adipocytes

scientific article published on 13 June 2017

Prostaglandin F(2alpha) suppresses early phase of adipogenesis, but is not associated with osteoblastogenesis in mouse mesenchymal stem cells

scientific article published on 30 June 2010

Prostaglandins as PPARγModulators in Adipogenesis ⬇️

scientific article published on December 25, 2012

Protective Effects of Fisetin Against 6-OHDA-Induced Apoptosis by Activation of PI3K-Akt Signaling in Human Neuroblastoma SH-SY5Y Cells

scientific article

Protective effects of quercetin against hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells

scientific article published on 21 September 2011

Protein kinase C activates human lipocalin-type prostaglandin D synthase gene expression through de-repression of notch-HES signaling and enhancement of AP-2 beta function in brain-derived TE671 cells.

scientific article published on 2 March 2005

Rapid degradation of cyclooxygenase-1 and hematopoietic prostaglandin D synthase through ubiquitin-proteasome system in response to intracellular calcium level

scientific article

Regulatory role of cardiolipin in the activity of an ATP-dependent protease, Lon, from Escherichia coli.

scientific article

Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase

article

Suppression of Fatty Acid and Triglyceride Synthesis by the Flavonoid Orientin through Decrease of C/EBPδ Expression and Inhibition of PI3K/Akt-FOXO1 Signaling in Adipocytes

scientific article

Suppression of Very Early Stage Of Adipogenesis by Baicalein, a Plant-Derived Flavonoid through Reduced Akt-C/EBPα-GLUT4 Signaling-Mediated Glucose Uptake in 3T3-L1 Adipocytes

scientific article

Suppression of adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F2alpha synthase

scientific article published on 21 January 2010

Suppression of adipogenesis by valproic acid through repression of USF1-activated fatty acid synthesis in adipocytes

scientific article published on May 2014

Synergistic suppression of early phase of adipogenesis by microsomal PGE synthase-1 (PTGES1)-produced PGE2 and aldo-keto reductase 1B3-produced PGF2α.

scientific article

Synthesis of Novel Farnesoid X Receptor Agonists and Validation of Their Efficacy in Activating Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells into Osteoblasts

scientific article published on 16 November 2019

Synthetic substrates specific to activated plasmin can monitor the enzymatic functional status in situ in breast cancer cells.

scientific article

Termination mechanism of CREB-dependent activation of COX-2 expression in early phase of adipogenesis

scientific article published on 27 December 2013

The P-OLE1 gene of Pichia angusta encodes a delta 9-fatty acid desaturase and complements the ole1 mutation of Saccharomyces cerevisiae

scientific article

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.

scientific article

Transcriptional activation of the human hematopoietic prostaglandin D synthase gene in megakaryoblastic cells. Roles of the oct-1 element in the 5'-flanking region and the AP-2 element in the untranslated exon 1.

scientific article

Transcriptional regulation in adipogenesis through PPARγ-dependent and -independent mechanisms by prostaglandins

scientific article published on January 2014

Triiodothyronine enhances accumulation of intracellular lipids in adipocytes through thyroid hormone receptor α via direct and indirect mechanisms

scientific article

Very long-chain-fatty acids enhance adipogenesis through coregulation of Elovl3 and PPARγ in 3T3-L1 cells

scientific article published on 20 March 2012

Zebrafish and chicken lipocalin-type prostaglandin D synthase homologues: Conservation of mammalian gene structure and binding ability for lipophilic molecules, and difference in expression profile and enzyme activity.

scientific article published on 17 April 2006

List of works by Ko Fujimori

A Limonoid Kihadanin B from Immature Citrus unshiu Peels Suppresses Adipogenesis through Repression of the Akt-FOXO1-PPARγ Axis in Adipocytes

A Limonoid, 7-Deacetoxy-7-Oxogedunin (CG-1) from Andiroba (Carapa guianensis, Meliaceae) Lowers the Accumulation of Intracellular Lipids in Adipocytes via Suppression of IRS-1/Akt-Mediated Glucose Uptake and a Decrease in GLUT4 Expression

A novel pathway to enhance adipocyte differentiation of 3T3-L1 cells by up-regulation of lipocalin-type prostaglandin D synthase mediated by liver X receptor-activated sterol regulatory element-binding protein-1c

Activation of adipogenesis by lipocalin-type prostaglandin D synthase-generated Δ¹²-PGJ₂ acting through PPARγ-dependent and independent pathways

Activation of early phase of adipogenesis through Krüppel-like factor KLF9-mediated, enhanced expression of CCAAT/enhancer-binding protein β in 3T3-L1 cells

Adipokine ganglioside GM2 activator protein stimulates insulin secretion

An Arabidopsis cDNA encoding a bifunctional glutamine amidotransferase/cyclase suppresses the histidine auxotrophy of a Saccharomyces cerevisiae his7 mutant

Antiadipogenic effect of dietary apigenin through activation of AMPK in 3T3-L1 cells

Avicularin, a Plant Flavonoid, Suppresses Lipid Accumulation through Repression of C/EBPα-Activated GLUT4-Mediated Glucose Uptake in 3T3-L1 Cells ⬇️

Coupling between cyclooxygenase, terminal prostanoid synthase, and phospholipase A2.

De novo synthesis, uptake and proteolytic processing of lipocalin-type prostaglandin D synthase, beta-trace, in the kidneys

Differential expression and function of alternative splicing variants of human liver X receptor α.

Differential resuscitative effect of pyruvate and its analogues on VBNC (viable but non-culturable) Salmonella.

Drug transporters on arachnoid barrier cells contribute to the blood-cerebrospinal fluid barrier.

Enhancement of prostaglandin D(2) production through cyclooxygenase-2 and lipocalin-type prostaglandin D synthase by upstream stimulatory factor 1 in human brain-derived TE671 cells under serum starvation

Fisetin Suppresses Lipid Accumulation in Mouse Adipocytic 3T3-L1 Cells by Repressing GLUT4-Mediated Glucose Uptake through Inhibition of mTOR-C/EBPα Signaling

Forkhead transcription factor Foxa1 is a novel target gene of C/EBPβ and suppresses the early phase of adipogenesis

Increased production of lipocalin-type prostaglandin D synthase in leptomeningeal cells through contact with astrocytes

Influence of the culture medium on the production of nitric oxide and expression of inducible nitric oxide synthase by activated macrophages in vitro

Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3.

Isolation and characterization of mutations affecting expression of the Δ9‐ fatty acid desaturase gene, OLE1, in Saccharomyces cerevisiae ⬇️

L-PGDS-produced PGD in premature, but not in mature, adipocytes increases obesity and insulin resistance

Limonoid 7-Deacetoxy-7-oxogedunin from Andiroba, Carapa guianensis, Meliaceae, Decreased Body Weight Gain, Improved Insulin Sensitivity, and Activated Brown Adipose Tissue in High-Fat-Diet-Fed Mice

Lipocalin-type prostaglandin D synthase protects against oxidative stress-induced neuronal cell death ⬇️

Matrix metalloproteinases and lysosomal cysteine proteases in osteoclasts contribute to bone resorption through distinct modes of action

Molecular cloning and characterization of the gene encoding N'-[(5'-phosphoribosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide (BBM II) isomerase from Arabidopsis thaliana.

NMR solution structure of lipocalin-type prostaglandin D synthase: evidence for partial overlapping of catalytic pocket and retinoic acid-binding pocket within the central cavity

Niacin promotes adipogenesis by reducing production of anti-adipogenic PGF2α through suppression of C/EBPβ-activated COX-2 expression

Nonacidic Chemotype Possessing N-Acylated Piperidine Moiety as Potent Farnesoid X Receptor (FXR) Antagonists

Novel suppression mechanism operating in early phase of adipogenesis by positive feedback loop for enhancement of cyclooxygenase-2 expression through prostaglandin F2α receptor mediated activation of MEK/ERK-CREB cascade

Prevention of paraquat-induced apoptosis in human neuronal SH-SY5Y cells by lipocalin-type prostaglandin D synthase

Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo.

Prostaglandin D2 enhances lipid accumulation through suppression of lipolysis via DP2 (CRTH2) receptors in adipocytes

Prostaglandin F(2alpha) suppresses early phase of adipogenesis, but is not associated with osteoblastogenesis in mouse mesenchymal stem cells

Prostaglandins as PPARγModulators in Adipogenesis ⬇️

Protective Effects of Fisetin Against 6-OHDA-Induced Apoptosis by Activation of PI3K-Akt Signaling in Human Neuroblastoma SH-SY5Y Cells

Protective effects of quercetin against hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells

Protein kinase C activates human lipocalin-type prostaglandin D synthase gene expression through de-repression of notch-HES signaling and enhancement of AP-2 beta function in brain-derived TE671 cells.

Rapid degradation of cyclooxygenase-1 and hematopoietic prostaglandin D synthase through ubiquitin-proteasome system in response to intracellular calcium level

Regulatory role of cardiolipin in the activity of an ATP-dependent protease, Lon, from Escherichia coli.

Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase

Suppression of Fatty Acid and Triglyceride Synthesis by the Flavonoid Orientin through Decrease of C/EBPδ Expression and Inhibition of PI3K/Akt-FOXO1 Signaling in Adipocytes

Suppression of Very Early Stage Of Adipogenesis by Baicalein, a Plant-Derived Flavonoid through Reduced Akt-C/EBPα-GLUT4 Signaling-Mediated Glucose Uptake in 3T3-L1 Adipocytes

Suppression of adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F2alpha synthase

Suppression of adipogenesis by valproic acid through repression of USF1-activated fatty acid synthesis in adipocytes

Synergistic suppression of early phase of adipogenesis by microsomal PGE synthase-1 (PTGES1)-produced PGE2 and aldo-keto reductase 1B3-produced PGF2α.

Synthesis of Novel Farnesoid X Receptor Agonists and Validation of Their Efficacy in Activating Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells into Osteoblasts

Synthetic substrates specific to activated plasmin can monitor the enzymatic functional status in situ in breast cancer cells.

Termination mechanism of CREB-dependent activation of COX-2 expression in early phase of adipogenesis

The P-OLE1 gene of Pichia angusta encodes a delta 9-fatty acid desaturase and complements the ole1 mutation of Saccharomyces cerevisiae

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.

Transcriptional activation of the human hematopoietic prostaglandin D synthase gene in megakaryoblastic cells. Roles of the oct-1 element in the 5'-flanking region and the AP-2 element in the untranslated exon 1.

Transcriptional regulation in adipogenesis through PPARγ-dependent and -independent mechanisms by prostaglandins

Triiodothyronine enhances accumulation of intracellular lipids in adipocytes through thyroid hormone receptor α via direct and indirect mechanisms

Very long-chain-fatty acids enhance adipogenesis through coregulation of Elovl3 and PPARγ in 3T3-L1 cells

Zebrafish and chicken lipocalin-type prostaglandin D synthase homologues: Conservation of mammalian gene structure and binding ability for lipophilic molecules, and difference in expression profile and enzyme activity.