List of works by Hiroshi Ichinose

(6R)-5,6,7,8-tetrahydro-L-monapterin from Escherichia coli, a novel natural unconjugated tetrahydropterin

scientific article

A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice--as a mouse model for Parkinson's disease

scientific article

A case of late-onset Segawa syndrome (autosomal dominant dopa-responsive dystonia) with a novel mutation of the GTP-cyclohydrase I (GCH1) gene

scientific article

A functional polymorphism of the GTP cyclohydrolase 1 gene predicts attention performance.

scientific article published on 20 February 2014

A missense mutation in a patient with guanosine triphosphate cyclohydrolase I deficiency missed in the newborn screening program

scientific article published on 01 March 1995

A nationwide survey of Aicardi-Goutières syndrome patients identifies a strong association between dominant TREX1 mutations and chilblain lesions: Japanese cohort study.

scientific article

A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function

article

A new mutation (Thr106Ile) of the GTP cyclohydrolase 1 gene associated with DYT5 dystonia (Segawa disease).

scientific article published in August 2005

A new mutation in the GCH1 gene presents as early-onset Parkinsonism

scientific article published on 03 June 2008

A new splicing variant for human tyrosine hydroxylase in the adrenal medulla

scientific article

A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus

scientific article

AADC deficiency: occurring in humans, modeled in rodents.

scientific article

Accumulation of phosphorylated tyrosine hydroxylase into insoluble protein aggregates by inhibition of an ubiquitin-proteasome system in PC12D cells.

scientific article published on 12 September 2009

Activation of tyrosine hydroxylase (TH) gene transcription induced by brain-derived neurotrophic factor (BDNF) and its selective inhibition through Ca(2+) signals evoked via the N-methyl-D-aspartate (NMDA) receptor

scientific article published on 18 October 2010

Administration of tetrahydrobiopterin restored the decline of dopamine in the striatum induced by an acute action of MPTP

scientific article published on 07 February 2019

Advanced research on dopamine signaling to develop drugs for the treatment of mental disorders: regulation of dopaminergic neural transmission by tyrosine hydroxylase protein at nerve terminals.

scientific article published on 12 August 2010

Alterations in catecholamine system enzymes

scientific article published on 01 December 1995

Alterations in multiple tyrosine hydroxylase mRNAs in the substantia nigra, locus coeruleus and adrenal gland of MPTP-treated parkinsonian monkeys

scientific article published on 01 March 1995

Alterations in the reduced pteridine contents in the cerebrospinal fluids of LRRK2 mutation carriers and patients with Parkinson's disease

scientific article published in September 2017

Arg(184)His mutant GTP cyclohydrolase I, causing recessive hyperphenylalaninemia, is responsible for dopa-responsive dystonia with parkinsonism: a case report

scientific article

Aromatic L-amino acid decarboxylase activities in human lung tissues: comparison between normal lung and lung carcinomas

scientific article published on 01 August 1985

Association of monoamine-synthesizing genes with the depression tendency and personality in chronic fatigue syndrome patients

scientific article published on 13 December 2012

Behavioral recovery in 6-hydroxydopamine-lesioned rats by cotransduction of striatum with tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes using two separate adeno-associated virus vectors

scientific article published on November 1998

Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes

scientific article published in February 2002

Biopterin levels in the cerebrospinal fluid of patients with PARK8 (I2020T)

scientific article published on 03 February 2011

Biopterin metabolism in patients with malignant syndrome

scientific article published in April 2003

Birth regulates the initiation of sensory map formation through serotonin signaling

scientific article published on 01 October 2013

Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease

scientific article published in July 1999

Catecholamines and serotonin are differently regulated by tetrahydrobiopterin. A study from 6-pyruvoyltetrahydropterin synthase knockout mice

scientific article published on 21 August 2001

Centrally mediated activation of tyrosine hydroxylation in rat adrenals by thyrotropin-releasing hormone

scientific article published in April 1988

Characterization of wild-type and mutants of recombinant human GTP cyclohydrolase I: relationship to etiology of dopa-responsive dystonia

scientific article published on 01 December 1999

Comparison of characteristics of bovine aromatic L-amino acid decarboxylase with human enzyme

scientific article published in February 1992

Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection

scientific article published on 25 October 2011

Correction: Dopa-Responsive Dystonia: Functional Analysis of Single Nucleotide Substitutions within the 5’ Untranslated Region

DRD2 allele frequencies and linkage disequilibria, including the -141CIns/Del promoter polymorphism, in European-American, African-American, and Japanese subjects

scientific article published in July 1998

Decrease in GTP cyclohydrolase I gene expression caused by inactivation of one allele in hereditary progressive dystonia with marked diurnal fluctuation

scientific article published on 01 July 1999

Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.

scientific article published on 8 January 2007

Deficiency of ascorbic acid decreases the contents of tetrahydrobiopterin in the liver and the brain of ODS rats

scientific article published on 30 November 2019

Differential involvement of striosome and matrix dopamine systems in a transgenic model of dopa-responsive dystonia.

scientific article

Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse

scientific article published on 19 September 2014

Dopa-responsive dystonia: functional analysis of single nucleotide substitutions within the 5' untranslated GCH1 region

scientific article

Dopamine or biopterin deficiency potentiates phosphorylation at (40)Ser and ubiquitination of tyrosine hydroxylase to be degraded by the ubiquitin proteasome system

scientific article published on 27 July 2015

Effect of metals and phenylalanine on the activity of human tryptophan hydroxylase-2: comparison with that on tyrosine hydroxylase activity

scientific article published on 11 April 2006

Effects of TRK-820, a selective kappa opioid receptor agonist, on rat schizophrenia models

scientific article published on 5 February 2009

Effects of chronic treatment with L-arginine on atherosclerosis in apoE knockout and apoE/inducible NO synthase double-knockout mice

scientific article published in January 2003

Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta

scientific article published on 21 April 2008

Enzymes related to catecholamine biosynthesis in Tetrahymena pyriformis. Presence of GTP cyclohydrolase I

scientific article published on 01 August 1998

Functional polymorphism (C-824T) of the tyrosine hydroxylase gene affects IQ in schizophrenia.

scientific article published on 26 February 2014

GTP cyclohydrolase 1 gene haplotypes as predictors of SSRI response in Japanese patients with major depressive disorder

scientific article published on 6 July 2012

GTP cyclohydrolase I activity in mononuclear blood cells in juvenile parkinsonism

scientific article published on May 1995

GTP cyclohydrolase I gene in hereditary progressive dystonia with marked diurnal fluctuation

scientific article published on 01 August 1995

GTP cyclohydrolase I gene, tetrahydrobiopterin, and tyrosine hydroxylase gene: their relations to dystonia and parkinsonism

scientific article published on February 1996

GTP cyclohydrolase I utilizes metal-free GTP as its substrate

scientific article

GTP cyclohydrolase regulation: implications for brain development and function

scientific journal article

Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity.

scientific article

Generation of human artificial chromosomes expressing naturally controlled guanosine triphosphate cyclohydrolase I gene

scientific article published on October 2002

Genetic and pharmacological correction of aberrant dopamine synthesis using patient iPSCs with BH4 metabolism disorders

scientific article published on 18 October 2016

Genetically rescued tetrahydrobiopterin-depleted mice survive with hyperphenylalaninemia and region-specific monoaminergic abnormalities

scientific article published on 31 August 2005

Genomic organization and chromosomal localization of the human sepiapterin reductase gene

scientific journal article

Glial cell line-derived neurotrophic factor in the substantia nigra from control and parkinsonian brains

scientific article published on March 2001

H(2)O(2) increases de novo synthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin via GTP cyclohydrolase I and its feedback regulatory protein in vitiligo

scientific article

Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene

scientific article

Identification of ATF-2 as a transcriptional regulator for the tyrosine hydroxylase gene

scientific journal article

Identification of an enhancer region for immune activation in the human GTP cyclohydrolase I gene

scientific article published on 9 November 2013

Immunocytochemical localization of GTP cyclohydrolase I in the brain, adrenal gland, and liver of mice

scientific article published on 01 January 1995

Increase in level of tumor necrosis factor (TNF)-alpha in 6-hydroxydopamine-lesioned striatum in rats without influence of systemic L-DOPA on the TNF-alpha induction

scientific article

Increase in level of tumor necrosis factor-alpha in 6-hydroxydopamine-lesioned striatum in rats is suppressed by immunosuppressant FK506

scientific article published on 01 August 2000

Increased expression of tyrosine hydroxylase and anomalous neurites in catecholaminergic neurons of ATF-2 null mice

scientific article published in February 2008

Increased heterogeneity of tyrosine hydroxylase in humans

scientific article

Inhibition of aromatic L-aminoacid decarboxylase in clonal pheochromocytoma PC12h cells by N-methyl-4-phenylpyridinium ion (MPP+).

scientific article published in April 1988

Isolation of a full-length cDNA clone encoding human tyrosine hydroxylase type 3

scientific article

Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma

scientific article published on 01 January 1995

Isolation of a novel cDNA clone for human tyrosine hydroxylase: alternative RNA splicing produces four kinds of mRNA from a single gene

scientific article

L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor.

scientific article published on 21 September 2017

Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2

scientific article

Localization of sepiapterin reductase in the human brain

scientific article published in November 2002

Loss of dopaminergic neurons by the induction of inducible nitric oxide synthase and cyclooxygenase-2 via CD 40: relevance to Parkinson's disease

scientific article published in September 2005

Metabolism of tetrahydrobiopterin: its relevance in monoaminergic neurons and neurological disorders

scientific article

Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice

scientific article published in February 2016

Molecular biology of catecholamine-related enzymes in relation to Parkinson's disease.

scientific article

Molecular genetics of hereditary dystonia--mutations in the GTP cyclohydrolase I gene

scientific article published on January 1997

Molecular mechanism for pterin-mediated inactivation of tyrosine hydroxylase: formation of insoluble aggregates of tyrosine hydroxylase

scientific article published on 01 April 2006

Mouse sepiapterin reductase: an enzyme involved in the final step of tetrahydrobiopterin biosynthesis. Primary structure deduced from the cDNA sequence

scientific article published on February 1995

Multiple mRNA forms of human GTP cyclohydrolase I

scientific article published on August 31, 1992

Multiple mRNAs of monkey tyrosine hydroxylase

scientific article published in December 1990

Nerve growth factor-induced expression of the GTP cyclohydrolase I gene via Ras/MEK pathway in PC12D cells

scientific article

Nicotine-induced regulation of tyrosine hydroxylase activity in adrenal gland of transgenic mouse carrying human tyrosine hydroxylase gene

scientific article

Novel mutations in the guanosine triphosphate cyclohydrolase 1 gene associated with DYT5 dystonia

scientific article

Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis.

scientific article published on 20 January 2013

Nurr1 expression is regulated by voltage-dependent calcium channels and calcineurin in cultured hippocampal neurons

scientific article published on 26 November 2013

Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons

scientific article published in December 2009

Overexpression of midbrain-specific transcription factor Nurr1 modifies susceptibility of mouse neural stem cells to neurotoxins

scientific article published on November 2002

Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain

scientific article

Patrolling monocytes control tumor metastasis to the lung.

scientific article

Phosphoinositide 3-kinase in nitric oxide synthesis in macrophage: critical dimerization of inducible nitric-oxide synthase.

scientific article published on 24 April 2006

Prevention of dopaminergic neuron death by adeno-associated virus vector-mediated GDNF gene transfer in rat mesencephalic cells in vitro

scientific article published on May 1998

Quantification of mRNA of tyrosine hydroxylase and aromatic L-amino acid decarboxylase in the substantia nigra in Parkinson's disease and schizophrenia

scientific article published in January 1994

Ras/MEK pathway is required for NGF-induced expression of tyrosine hydroxylase gene

scientific article published in March 2004

Real-time bioluminescence imaging of a protein secretory pathway in living mammalian cells using Gaussia luciferase

scientific article published on 27 August 2007

Recovery of neurogenic amines in phenylketonuria mice after liver-targeted gene therapy

scientific article published in January 2012

Redox sensor proteins for highly sensitive direct imaging of intracellular redox state

scientific article published on 13 January 2015

Reduction of aromatic L-amino acid decarboxylase activity in clonal pheochromocytoma PC12h cells by culture in the presence of N-methyl-4-phenylpyridinium ion (MPP+)

scientific article published on 01 December 1988

Reduction of enzyme activity of tyrosine hydroxylase and aromatic L-aminoacid decarboxylase in clonal pheochromocytoma PC12h cells by carcinogenic heterocyclic amines

scientific article published on December 1988

Regulation of the dopaminergic system in a murine model of aromatic L-amino acid decarboxylase deficiency.

scientific article published on 26 December 2012

Reversible S-glutathionylation of human 6-pyruvoyl tetrahydropterin synthase protects its enzymatic activity

scientific article published on 04 December 2018

Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha

scientific article

Sepiapterin reductase gene-disrupted mice suffer from hypertension with fluctuation and bradycardia.

scientific article published on March 2017

Simple purification of aromatic L-amino acid decarboxylase from human pheochromocytoma using high-performance liquid chromatography

article by Hiroshi Ichinose et al published 1 November 1985 in Analytical Biochemistry

Sonic hedgehog and FGF8 collaborate to induce dopaminergic phenotypes in the Nurr1-overexpressing neural stem cell

scientific article published on June 2003

Stimulus-coupled interaction of tyrosine hydroxylase with 14-3-3 proteins.

scientific article published on November 1999

Suppression by an h current of spontaneous Na+ action potentials in human cone and rod photoreceptors

scientific article published in January 2005

Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells

scientific article

Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function

scientific article

The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation

scientific article published on 14 April 2017

The complete amino acid sequence of the mature form of rat sepiapterin reductase

scientific article published on 01 December 1990

The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in Drosophila

scientific article

The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells ⬇️

scientific article

The orphan nuclear receptor NR4A1 promotes FcεRI-stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axis

scientific article published on 04 January 2019

The role of tetrahydrobiopterin and catecholamines in the developmental regulation of tyrosine hydroxylase level in the brain

scientific article

Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease

scientific article published on July 2000

Uptake of heterocyclic amines, Trp-P-1 and Trp-P-2, into clonal rat pheochromocytoma PC12h cells by dopamine uptake system.

scientific article published in May 1989

Viral-mediated temporally controlled dopamine production in a rat model of Parkinson disease

scientific article published on 22 September 2005

cAMP inhibits cytokine-induced biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells

scientific article

cGMP inhibits GTP cyclohydrolase I activity and biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells

scientific article

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