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List of works by Jim C Norman

<scp>PTEN</scp> deficiency exposes a requirement for an <scp>ARF GTPase</scp> module for integrin‐dependent invasion in ovarian cancer

scientific article published in 2023

A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression

scientific article published on 05 March 2019

A new radioimmunoassay for the thymic peptide thymulin, and its application for measuring thymulin in blood samples

scientific article published on 01 March 1990

A proteomic approach to identify endosomal cargoes controlling cancer invasiveness.

scientific article published on 6 January 2017

A tal(in) of cell spreading

ARF1 mediates paxillin recruitment to focal adhesions and potentiates Rho-stimulated stress fiber formation in intact and permeabilized Swiss 3T3 fibroblasts

scientific article published on December 1998

ARF6 directs axon transport and traffic of integrins and regulates axon growth in adult DRG neurons.

scientific article published in July 2012

Actin filament organization in activated mast cells is regulated by heterotrimeric and small GTP-binding proteins

scientific article published on August 1994

Aquaporin 2 promotes cell migration and epithelial morphogenesis

scientific article

B-Raf acts via the ROCKII/LIMK/cofilin pathway to maintain actin stress fibers in fibroblasts

scientific journal article

Basic fibroblast growth factor activates the MAPK and NFkappaB pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes

scientific article published on 27 August 2007

Binding of monomeric immunoglobulin G triggers Fc gamma RI-mediated endocytosis

scientific article (publication date: 30 September 1994)

CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer

scientific article

Chloride intracellular channel 3: A secreted pro-invasive oxidoreductase

scientific article published on 21 September 2017

Class I Rab11-family interacting proteins are binding targets for the Rab14 GTPase

scientific article

Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration.

scientific article published on January 2012

Distinct roles of talin and kindlin in regulating integrin α5β1 function and trafficking.

scientific article published on 12 July 2012

ERK1 associates with alpha(v)beta 3 integrin and regulates cell spreading on vitronectin

scientific article published on 19 October 2002

ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2.

scientific article

Endocytic recycling pathways: emerging regulators of cell migration.

scientific article published on 9 August 2006

Endocytic transport of integrins during cell migration and invasion.

scientific article published on 02 May 2008

Endocytosis of FcγRI is regulated by two distinct signalling pathways

scientific article published on 01 November 2000

Endosomal integrin signals for survival

scientific article

Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion

scientific article

FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells

scientific article (publication date: March 2014)

Genomic amplicons target vesicle recycling in breast cancer

scientific article published on 20 July 2009

Glucocorticoid Effects on the Molecular Forms of Adrenocorticotrophic Hormone Secreted by Cultures of Rat Anterior Pituitary Cell Monolayers

article

Integrin trafficking and the control of cell migration

scientific article

Integrin trafficking at a glance

scientific article

Integrin-mediated cell adhesion: the cytoskeletal connection

scientific article

Integrins: masters and slaves of endocytic transport.

scientific article published on December 2009

Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function

scientific article published on 7 June 2011

Interaction of paxillin with poly(A)-binding protein 1 and its role in focal adhesion turnover and cell migration.

scientific article

Late endosomal and lysosomal trafficking during integrin-mediated cell migration and invasion: cell matrix receptors are trafficked through the late endosomal pathway in a way that dictates how cells migrate

scientific article published on 22 April 2013

Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration

scientific article published on 15 January 2015

Lysosomal routing of Fc gamma RI from early endosomes requires recruitment of tyrosine kinases

scientific article

Mechanical stretch has contrasting effects on mediator release from bronchial epithelial cells, with a rho-kinase-dependent component to the mechanotransduction pathway.

scientific article published on 15 February 2006

Mechanisms of integrin activation and trafficking

scientific article published on 14 September 2011

Mutant p53 drives invasion by promoting integrin recycling

scientific article

Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion

scientific article

Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane

scientific article published on 24 February 2021

Mutant p53 regulates Dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype

scientific article published on 12 November 2013

N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods

scientific article

Neuropilin-1-dependent regulation of EGF-receptor signaling.

scientific article

Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.

scientific article

New Roles for Lysosomal Trafficking in Morphogen Gradient Sensing ⬇️

scientific article published on 03 May 2011

Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion

scientific article published on 24 November 2021

P-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments

scientific article

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

scientific article

PDGF-regulated rab4-dependent recycling of alphavbeta3 integrin from early endosomes is necessary for cell adhesion and spreading

scientific article published on September 2001

PKD controls αvβ3 integrin recycling and tumor cell invasive migration through its substrate Rabaptin-5.

scientific article

PKD1/PKCmu promotes alphavbeta3 integrin recycling and delivery to nascent focal adhesions

scientific article

Paxillin associates with poly(A)-binding protein 1 at the dense endoplasmic reticulum and the leading edge of migrating cells

scientific article

Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion

scientific article

Photoactivation approaches reveal a role for Rab11 in FGFR4 recycling and signalling

scientific article published on 31 March 2014

Primaquine, an inhibitor of vesicular transport, blocks the calcium-release-activated current in rat megakaryocytes

scientific article published on August 1995

Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3 and alpha 5 beta 1 integrins

scientific article

Protein kinase D1 regulates VEGF-A-induced alphavbeta3 integrin trafficking and endothelial cell migration

scientific article published on 6 May 2010

RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex

scientific article

Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments.

scientific article

Rab11 and its effector Rab coupling protein contribute to the trafficking of beta 1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells.

scientific article published on September 2010

Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression

scientific article published on March 2016

Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression.

scientific article

Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments

scientific article

Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion

scientific article

Relationships between polyamine, deoxyribonucleic acid and oestrogen receptor binding site concentrations in human breast tumours

scientific article published on 01 April 1988

RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane

scientific article published on December 2004

SPRY2 loss enhances ErbB trafficking and PI3K/AKT signalling to drive human and mouse prostate carcinogenesis

scientific article published on 31 May 2012

Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity.

scientific article published on 15 February 2017

Secretion from permeabilised mast cells is enhanced by addition of gelsolin: contrasting effects of endogenous gelsolin

article

Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors.

scientific article published on 22 March 2009

Structure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6

scientific article

Tensin links energy metabolism to extracellular matrix assembly

scientific article published on 21 March 2017

The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration

scientific article

The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis

scientific article published on 2 March 2016

The diacylglycerol kinase α/atypical PKC/β1 integrin pathway in SDF-1α mammary carcinoma invasiveness

scientific article

The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma

scientific article published on 19 August 2016

The small GTP-binding proteins, Rac and Rho, regulate cytoskeletal organization and exocytosis in mast cells by parallel pathways

scientific article published on September 1996

The small GTPases Rac and Rho as regulators of secretion in mast cells

scientific article published on 01 January 1995

VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment

scientific article published on 25 April 2006

VEGFR1 (Flt1) regulates Rab4 recycling to control fibronectin polymerization and endothelial vessel branching

scientific article published in June 2009

alpha v beta3 and alpha5beta1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration.

scientific article

hnRNP A2 regulates alternative mRNA splicing of TP53INP2 to control invasive cell migration.

scientific article

p53 and its mutants in tumor cell migration and invasion

scientific article published on January 2011

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