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List of works by Rui Moreira

11(th) National Meeting of Organic Chemistry and 4(th) Meeting of Therapeutic Chemistry

scientific article published on 17 March 2016

1H NMR spectroscopic identification of protonable sites in cryptolepines with C-11 substituents containing two amino functionalities

scientific article published on 26 February 2012

3-Oxo-β-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling

scientific article published on 20 March 2020

4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.

scientific article published in January 2010

A carbamate-based approach to primaquine prodrugs: antimalarial activity, chemical stability and enzymatic activation

scientific article published on 3 December 2011

Acyloxymethyl as a drug protecting group. Part 3. Tertiary O-amidomethyl esters of penicillin G: chemical hydrolysis and anti-bacterial activity.

scientific article

Acyloxymethyl as a drug protecting group. Part 6

scientific article published on 01 April 2000

Acyloxymethyl as a drug protecting group. Part 7: Tertiary sulfonamidomethyl ester prodrugs of benzylpenicillin: chemical hydrolysis and anti-bacterial activity

scientific article published on July 2000

Acyloxymethyl as a drug protecting group: Part 4. The hydrolysis of tertiary amidomethyl ester prodrugs of carboxylic acid agents

scientific article published on 01 November 1997

Addressing Latent Tuberculosis: New Advances in Mimicking the Disease, Discovering Key Targets, and Designing Hit Compounds

scientific article published on 23 November 2020

Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: suppressing the rearrangement pathway in aqueous media

scientific article published on 01 January 2007

An Overview of Drug Resistance in Protozoal Diseases

scientific article published on 15 November 2019

An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites

scientific article published on 12 July 2013

Analytical profiles of "legal highs" containing cathinones available in the area of Lisbon, Portugal

scientific article

Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones

scientific article published on 3 December 2007

Anti-tumoral activity of imidazoquines, a new class of antimalarials derived from primaquine

scientific article

Antiplasmodial Drugs in the Gas Phase: A CID and DFT Study of Quinolon-4(1H)-Imine Derivatives

scientific article published on 08 July 2014

Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives

scientific article published on 15 August 2012

Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition

scientific article published on 03 May 2009

Aspartic vinyl sulfones: Inhibitors of a caspase-3-dependent pathway

scientific article published on 05 March 2011

Aza vinyl sulfones: synthesis and evaluation as antiplasmodial agents

scientific article published on 14 October 2011

Azaaurones as Potent Antimycobacterial Agents Active against MDR- and XDR-TB

scientific article published on 25 July 2019

Azetidine-2,4-diones (4-oxo-beta-lactams) as scaffolds for designing elastase inhibitors

scientific article

Biological Evaluation and Mechanistic Studies of Quinolin-(1<i>H</i>)-Imines as a New Chemotype against Leishmaniasis

scientific article published on 17 June 2021

Bis-alkylamine Indolo[3,2-b]quinolines as hemozoin ligands: implications for antimalarial cytostatic and cytocidal activities

scientific article published on 15 April 2014

Bis-alkylamine quindolone derivatives as new antimalarial leads

scientific article published on 12 August 2010

Bis{(E)-3-[(diethyl-methyl-ammonio)meth-yl]-N-[3-(N,N-dimethyl-sulfamo-yl)-1-methyl-pyridin-4-yl-idene]-4-methoxy-anilinium} tetra-iodide penta-hydrate

scientific article published on 10 January 2009

C-11 diamino cryptolepine derivatives NSC748392, NSC748393, and NSC748394: anticancer profile and G-quadruplex stabilization

scientific article published on 29 September 2010

Characterizing the dynamics and ligand-specific interactions in the human leukocyte elastase through molecular dynamics simulations.

scientific article

Chemical Variations on the p53 Reactivation Theme

scientific article

Cleavage of tertiary amidomethyl ester prodrugs of carboxylic acids by rat liver homogenates.

scientific article

Clickable 4-Oxo-β-lactam-Based Selective Probing for Human Neutrophil Elastase Related Proteomes.

scientific article

Comparative analysis of in vitro rat liver metabolism of the antimalarial primaquine and a derived imidazoquine

scientific article published in March 2012

Comparative in vitro and in vivo antimalarial activity of the indole alkaloids ellipticine, olivacine, cryptolepine and a synthetic cryptolepine analog.

scientific article published on 23 October 2012

Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: synthesis, antiplasmodial activity, and cytotoxicity

scientific article published on 9 January 2008

Crystallization and Preliminary Diffraction Studies of Porcine Pancreatic Elastase in Complex with a Novel Inhibitor

scientific article published on 01 January 2007

Cyclization-activated prodrugs.

scientific article

Cyclization-activated prodrugs. Synthesis, reactivity and toxicity of dipeptide esters of paracetamol

scientific article published in March 2005

Cytotoxic bile acids, but not cytoprotective species, inhibit the ordering effect of cholesterol in model membranes at physiologically active concentrations.

scientific article published on 5 June 2013

Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties

scientific article

Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy

scientific article

Design of Modular G-quadruplex Ligands.

scientific article published on 7 March 2018

Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials

scientific article published on 15 January 2011

Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors

scientific article published in April 2001

Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials

scientific article published on 9 May 2009

Design, synthesis, and enzymatic evaluation of N1-acyloxyalkyl- and N1-oxazolidin-2,4-dion-5-yl-substituted beta-lactams as novel inhibitors of human leukocyte elastase

scientific article published in July 2005

Diazaborines as New Inhibitors of Human Neutrophil Elastase

scientific article published on 06 July 2018

Dipeptide derivatives of AZT: synthesis, chemical stability, activation in human plasma, hPEPT1 affinity, and antiviral activity

scientific article

Dipeptide derivatives of primaquine as transmission-blocking antimalarials: effect of aliphatic side-chain acylation on the gametocytocidal activity and on the formation of carboxyprimaquine in rat liver homogenates

scientific article published in June 1999

Dipeptide vinyl sultams: synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum

scientific article published on 12 May 2006

Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation.

scientific article published on 31 October 2016

Discovery of new heterocycles with activity against human neutrophile elastase based on a boron promoted one-pot assembly reaction

scientific article published on 01 July 2013

Dopamine- and tyramine-based derivatives of triazenes: activation by tyrosinase and implications for prodrug design.

scientific article published on 27 March 2009

Drug discovery in tuberculosis. New drug targets and antimycobacterial agents.

scientific article published on 9 March 2018

Drug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drug

scientific article

Effect of synthesized inhibitors on babesipain-1, a new cysteine protease from the bovine piroplasm Babesia bigemina

scientific article

Electrospray ionization mass spectrometry as a valuable tool in the characterization of novel primaquine peptidomimetic derivatives

scientific article published in January 2009

Electrospray ionization-ion trap mass spectrometry study of PQAAPro and PQProAA mimetic derivatives of the antimalarial primaquine

scientific article published in July 2008

Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites

scientific article published on 3 November 2015

Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity

scientific article published on 27 October 2010

Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability.

scientific article

Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype

scientific article published on 31 July 2015

Exploring the Molecular Basis of Qo bc1 Complex Inhibitors Activity to Find Novel Antimalarials Hits.

scientific article published on 20 June 2013

Five-membered iminocyclitol α-glucosidase inhibitors: synthetic, biological screening and in silico studies.

scientific article

Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds

scientific article published on 20 September 2013

Four-Component Assembly of Chiral N–B Heterocycles with a Natural Product-Like Framework

scientific article published on 08 February 2012

From hybrid compounds to targeted drug delivery in antimalarial therapy

scientific article published on 11 April 2015

Half-Sandwich Cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype

scientific article published on 24 August 2020

Harnessing Protein-Ligand Interaction Fingerprints to Predict New Scaffolds of RIPK1 Inhibitors

scientific article published in 2022

Identification of new antimalarial leads by use of virtual screening against cytochrome bc₁.

scientific article published on 10 September 2011

Imidazolidin-4-one derivatives of primaquine as novel transmission-blocking antimalarials

scientific article published in February 2005

Imidazolidin-4-one peptidomimetic derivatives of primaquine: synthesis and antimalarial activity

scientific article published on 23 May 2008

Imidazoquines as antimalarial and antipneumocystis agents

scientific article published on December 2009

Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies

scientific article published on 5 January 2011

Indolo[3,2-c]quinoline G-quadruplex stabilizers: a structural analysis of binding to the human telomeric G-quadruplex

scientific article published on 26 March 2015

Indoloquinolines as scaffolds for drug discovery.

scientific article published on January 2010

KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines.

scientific article published on 8 April 2015

Kinetics and mechanism of hydrolysis of N-acyloxymethyl derivatives of azetidin-2-one

scientific article

Malaria combination therapies: advantages and shortcomings.

scientific article published on March 2008

Metabolism of primaquine by liver homogenate fractions. Evidence for monoamine oxidase and cytochrome P450 involvement in the oxidative deamination of primaquine to carboxyprimaquine

scientific article published on 01 July 1999

Michael acceptors as cysteine protease inhibitors.

scientific article published on October 2007

N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases

scientific article published on 28 April 2012

N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: design, synthesis and antiplasmodial activity

scientific article published on 13 February 2015

Naphtho[2,3-d]isoxazole-4,9-dione-3-carboxylates: potent, non-cytotoxic, antiapoptotic agents.

scientific article published on 24 March 2009

New Hope in the Fight Against Malaria? ⬇️

scientific article published on January 1, 2011

Novel 3+1 mixed-ligand Technetium-99m complexes carrying dipeptides as monodentate ligands

scientific article published on 01 January 2004

Novel anti-plasmodial hits identified by virtual screening of the ZINC database

scientific article

Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities

scientific article

Novel potent metallocenes against liver stage malaria

scientific article published on 12 December 2011

Novel squaramides with in vitro liver stage antiplasmodial activity

scientific article published on 03 March 2016

Optimization of O3-acyl kojic acid derivatives as potent and selective human neutrophil elastase inhibitors

scientific article published on 20 November 2013

PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity

Peptidomimetic and organometallic derivatives of primaquine active against Leishmania infantum

scientific article published on 27 August 2012

Phenotypic Effects of Wild-Type and Mutant SOD1 Expression in N9 Murine Microglia at Steady State, Inflammatory and Immunomodulatory Conditions

scientific article published on 09 April 2019

Phthalimidomethyl as a drug pro-moiety. Probing its reactivity

scientific article published on 01 April 1998

Primaquine dipeptide derivatives bearing an imidazolidin-4-one moiety at the N-terminus as potential antimalarial prodrugs

scientific article published on 29 January 2009

Primaquine revisited six decades after its discovery

scientific article

Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites

scientific article

Probing the aurone scaffold against Plasmodium falciparum: design, synthesis and antimalarial activity.

scientific article

Quinolin-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria

scientific article published on 23 May 2013

Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and antifungal activity of naphtho[2,3-d]isoxazole-4,9-diones.

scientific article published on 4 November 2009

Recovery of Depleted miR-146a in ALS Cortical Astrocytes Reverts Cell Aberrancies and Prevents Paracrine Pathogenicity on Microglia and Motor Neurons

scientific article published on 23 April 2021

Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties

scientific article published on 21 September 2017

Squaric acid/4-aminoquinoline conjugates: novel potent antiplasmodial agents

scientific article published on 13 September 2013

Squaric acid: a valuable scaffold for developing antimalarials?

article published in 2012

Stabilization of porcine pancreatic elastase crystals by glutaraldehyde cross-linking

scientific article published on 23 September 2015

Starch nanocapsules containing a novel neutrophil elastase inhibitor with improved pharmaceutical performance.

scientific article published on 31 January 2018

Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: toward increased potency and metabolic stability

scientific article published on 30 September 2013

Structure based virtual screening for discovery of novel human neutrophil elastase inhibitors

Structure-activity relationships for dipeptide prodrugs of acyclovir: implications for prodrug design

scientific article published on 11 September 2008

Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents

scientific article published on 7 November 2013

Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study.

scientific article published on 24 May 2010

Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains.

scientific article published on 19 August 2013

Synthesis, stability and in vitro dermal evaluation of aminocarbonyloxymethyl esters as prodrugs of carboxylic acid agents.

scientific article published in March 2002

Synthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-β-lactam inhibitor of human leukocyte elastase

scientific article published on 14 June 2010

Synthetic condensed 1,4-naphthoquinone derivative shifts neural stem cell differentiation by regulating redox state

scientific article

Targeting COPD: advances on low‐molecular‐weight inhibitors of human neutrophil elastase ⬇️

scientific article published on June 16, 2011

Targeting Gliomas: Can a New Alkylating Hybrid Compound Make a Difference?

scientific article published on 26 September 2016

Targeting gliomas with triazene-based hybrids: Structure-activity relationship, mechanistic study and stability

scientific article published on 22 March 2019

Targeting the Liver Stage of Malaria Parasites: A Yet Unmet Goal ⬇️

scientific article published on December 21, 2011

Targeting the erythrocytic and liver stages of malaria parasites with s-triazine-based hybrids.

scientific article published on 17 March 2015

Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials

scientific article published on 22 May 2014

The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors

scientific article published on 06 May 2007

The Bsmoc group as a novel scaffold for the design of irreversible inhibitors of cysteine proteases

scientific article published on 28 February 2006

The efficiency of C-4 substituents in activating the beta-lactam scaffold towards serine proteases and hydroxide ion

scientific article

Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

scientific article published on 08 July 2013

Unanticipated acyloxymethylation of sumatriptan indole nitrogen atom and its implications in prodrug design

scientific article published in June 2008

Unanticipated stereoselectivity in the reaction of primaquine alpha-aminoamides with substituted benzaldehydes: a computational and experimental study

scientific article

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