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List of works by Nils Metzler-Nolte

1,n′-Disubstituted ferrocenoyl amino acids and dipeptides: Conformational analysis by CD spectroscopy, X-ray crystallography, and DFT calculations

A Blocking Group Scan Using a Spherical Organometallic Complex Identifies an Unprecedented Binding Mode with Potent Activity In Vitro and In Vivo for the Opioid Peptide Dermorphin

scientific article

A Combined Spectroscopic and Protein Crystallography Study Reveals Protein Interactions of RhI(NHC) Complexes at the Molecular Level

scientific article published on 12 November 2020

A CuAAC Click Approach for the Introduction of Bidentate Metal Complexes to a Sulfanilamide-Derived Antibiotic Fragment

scientific article published on 27 June 2019

A Remarkably Simple Class of Imidazolium-Based Lipids and Their Biological Properties

scientific article published on 2 September 2015

A cobaltocenium-peptide bioconjugate shows enhanced cellular uptake and directed nuclear delivery.

scientific article

A deadly organometallic luminescent probe: anticancer activity of a ReI bisquinoline complex.

scientific article published on 24 January 2014

A novel organometallic ReI complex with favourable properties for bioimaging and applicability in solid-phase peptide synthesis

scientific article published on 11 January 2011

A ruthenocene-PNA bioconjugate--synthesis, characterization, cytotoxicity, and AAS-detected cellular uptake.

scientific article

A single-electrode, dual-potential ferrocene-PNA biosensor for the detection of DNA.

scientific article published on August 2010

A structural view of synthetic cofactor integration into [FeFe]-hydrogenases.

scientific article published on 26 October 2015

Amino acid and peptide bioconjugates of copper(II) and zinc(II) complexes with a modified N,N-bis(2-picolyl)amine ligand

scientific article published in July 2005

An organometallic structure-activity relationship study reveals the essential role of a Re(CO)3 moiety in the activity against gram-positive pathogens including MRSA.

scientific article

Analysis of the mechanism of action of potent antibacterial hetero-tri-organometallic compounds: a structurally new class of antibiotics

scientific article published on 26 April 2013

Asymmetric rhenium tricarbonyl complexes show superior luminescence properties in live cell imaging.

scientific article published on 23 December 2016

Azidomethyl-ruthenocene: facile synthesis of a useful metallocene derivative and its application in the 'click' labelling of biomolecules

scientific article published on 21 September 2011

Benzannulated Re(i)-NHC complexes: synthesis, photophysical properties and antimicrobial activity.

scientific article published on 25 October 2017

Bioconjugates of Co(III) complexes with Schiff base ligands and cell penetrating peptides: Solid phase synthesis, characterization and antiproliferative activity

scientific article published on 20 February 2020

Bioconjugation of Cyclometalated Gold(III) Lipoic Acid Fragments to Linear and Cyclic Breast Cancer Targeting Peptides

scientific article published on 09 October 2019

Bioorganometallic chemistry of ferrocene

scientific article

Biophysical Characterization of Pro-apoptotic BimBH3 Peptides Reveals an Unexpected Capacity for Self-Association

scientific article published on 14 September 2020

C-Terminal acetylene derivatized peptides via silyl-based alkyne immobilization

scientific article published on 4 June 2013

Cellular Uptake Quantification of Metalated Peptide and Peptide Nucleic Acid Bioconjugates by Atomic Absorption Spectroscopy

scientific article published on 01 January 2008

Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

article

Chemistry of SURMOFs: layer-selective installation of functional groups and post-synthetic covalent modification probed by fluorescence microscopy.

scientific article

Chiral Ferrocene Amines Derived from Amino Acids and Peptides: Synthesis, Solution and X-ray Crystal Structures and Electrochemical Investigations

scientific article published on 01 November 2000

Comparison of proteomic responses as global approach to antibiotic mechanism of action elucidation

scientific article published on 12 October 2020

Conjugation of a novel histidine derivative to biomolecules and labelling with [99mTc(OH2)3(CO)3]+.

scientific article published on 13 August 2004

Corynebacterium glutamicum exhibits a membrane-related response to a small ferrocene-conjugated antimicrobial peptide

article

Cytotoxicity studies of water soluble coordination compounds with a [Mo2O2S2](2+) core.

scientific article published on 12 February 2016

Effects of enzymatic activation on the distribution of fluorescently tagged MMP-2 cleavable peptides in cancer cells and spheroids

scientific article published on 7 June 2012

Electronic structure of a stable silylene: photoelectron spectra and theoretical calculations of Si(NRCHCHNR), Si(NRCH2CH2NR) and SiH2(NRCHCHNR)

scientific article published in 1994

Elucidation of Plasma-induced Chemical Modifications on Glutathione and Glutathione Disulphide

scientific article published on 23 October 2017

Enhanced cellular uptake and cytotoxicity studies of organometallic bioconjugates of the NLS peptide in Hep G2 cells

scientific article

Escherichia coli exhibits a membrane-related response to a small arginine- and tryptophan-rich antimicrobial peptide.

scientific article published in August 2012

Exploring Structure-Activity Relationships in Synthetic Antimicrobial Peptides (synAMPs) by a Ferrocene Scan

Ferrocenoyl peptides with sulfur-containing side chains: synthesis, solid state and solution structures

Fluxional processes in diamagnetic and paramagnetic allyl dicarbonyl and 2-methylallyl dicarbonyl molybdenum histidinato complexes as revealed by spectroscopic data and density functional calculations

scientific article

Force-Field Development and Molecular Dynamics Simulations of Ferrocene–Peptide Conjugates as a Scaffold for Hydrogenase Mimics

article

Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus

scientific article published on 06 November 2019

Helically chiral ferrocene peptides containing 1'-aminoferrocene-1-carboxylic acid subunits as turn inducers

scientific article published on 01 June 2006

Highly Potent Antibacterial Organometallic Peptide Conjugates

scientific article

Highly active antibacterial ferrocenoylated or ruthenocenoylated Arg-Trp peptides can be discovered by an l-to-d substitution scan

Identification of Chaoborus kairomone chemicals that induce defences in Daphnia

scientific article published on 14 November 2018

Identification of the structural determinants for anticancer activity of a ruthenium arene peptide conjugate

scientific article published on 27 May 2013

Impact of single basepair mismatches on electron-transfer processes at Fc-PNA⋅DNA modified gold surfaces

scientific article

In vivo demonstration of an active tumor pretargeting approach with peptide nucleic acid bioconjugates as complementary system.

scientific article published on 17 June 2015

Influence of lipidation on the mode of action of a small RW-rich antimicrobial peptide.

scientific article published on 18 November 2015

Influence of metallocene substitution on the antibacterial activity of multivalent peptide conjugates

scientific article

Influence of the Multivalency of Ultrashort Arg-Trp-Based Antimicrobial Peptides (AMP) on Their Antibacterial Activity

scientific article published on 6 July 2015

Influence of the substituent on the phosphine ligand in novel rhenium(i) aldehydes. Synthesis, computational studies and first insights into the antiproliferative activity

scientific article published on 01 October 2018

Insertion of an internal dipeptide into PNA oligomers: thermal melting studies and further functionalization

scientific article published on 20 March 2006

Interactions between BIM Protein and Beta-Amyloid May Reveal a Crucial Missing Link between Alzheimer's Disease and Neuronal Cell Death

scientific article published on 12 June 2019

Intracellular Catalysis with Selected Metal Complexes and Metallic Nanoparticles: Advances toward the Development of Catalytic Metallodrugs

scientific article published on 08 January 2019

Introduction: Metals in Medicine

scientific article published on 01 January 2019

Iridium(I) Compounds as Prospective Anticancer Agents: Solution Chemistry, Antiproliferative Profiles and Protein Interactions for a Series of Iridium(I) N-Heterocyclic Carbene Complexes.

scientific article

Iron metal-organic frameworks MIL-88B and NH2-MIL-88B for the loading and delivery of the gasotransmitter carbon monoxide

scientific article published on 27 March 2013

Label-free imaging of metal-carbonyl complexes in live cells by Raman microspectroscopy

scientific article published on 01 April 2010

Label-free screening of drug-protein interactions by time-resolved Fourier transform infrared spectroscopic assays exemplified by Ras interactions

scientific article published on September 2010

Labeling of Biomolecules for Medicinal Applications-Bioorganometallic Chemistry at Its Best The author thanks A. P. Schubiger and D. Grotjahn for reprints, and K. Severin for insightful discussions. The data in Figure 1 are used with the help and ki

scientific article

Labeling of the neuropeptide enkephalin with functionalized tris(pyrazolyl)borate complexes: solid-phase synthesis and characterization of p-[Enk-OH]COC6H4TpPtMe3 and p-[Enk-OH]COC6H4TpMeRe(CO)3.

scientific article published on 29 September 2007

Labelling of [Leu5]-enkephalin with organometallic Mo complexes by solid-phase synthesis

scientific article

Letter from the editor

scientific article published on 01 February 2020

Letter from the editor

scientific article published on 13 May 2020

Low fouling peptides with an all (D) amino acid sequence provide enhanced stability against proteolytic degradation while maintaining low antifouling properties

scientific article published on 22 August 2020

Luminescent Bimetallic Ir(III)/Au(I) Peptide Bioconjugates as Potential Theranostic Agents

scientific article published on 16 June 2020

Luminescent Bimetallic IrIII /AuI Peptide Bioconjugates as Potential Theranostic Agents

scientific article published on 31 August 2020

Mechanism-based inhibition of human persulfide dioxygenase by γ-glutamyl-homocysteinyl-glycine

scientific article published on 06 July 2018

Mechanistic studies of Fc-PNA(⋅DNA) surface dynamics based on the kinetics of electron-transfer processes

scientific article published on 06 July 2011

Membrane-binding mechanism of a bacterial phospholipid N-methyltransferase

scientific article published on 19 December 2014

Metal-containing peptide nucleic acid conjugates

scientific article published on 03 May 2011

Microwave-assisted synthesis of the Tp sandwich compound TpRu(p-Br-C6H4Tp) and application of its benzoic acid derivative TpRu(p-(CO2H)-C6H4Tp) in the covalent labelling of biomolecules

scientific article published on 22 November 2010

Modification with organometallic compounds improves crossing of the blood-brain barrier of [Leu5]-enkephalin derivatives in an in vitro model system

scientific article

Modulating the activity of short arginine-tryptophan containing antibacterial peptides with N-terminal metallocenoyl groups

scientific article published on 15 October 2012

New Talent: Europe, 2018

scientific article published on 30 July 2018

New Ways of Killing the Beast: Prospects for Inorganicâ Organic Hybrid Nanomaterials as Antibacterial Agents

article

New organometallic imines of rhenium(i) as potential ligands of GSK-3β: synthesis, characterization and biological studies

scientific article published on 4 January 2018

New principles in medicinal organometallic chemistry

scientific article published on 01 February 2006

Nitridocyanometalates of CrV, MnV, and MnVI †

Nitridomanganese(V) and -(VI) Complexes Containing Macrocyclic Amine Ligands

scientific article published in 1998

On the interaction of N-heterocyclic carbene Ir+I complexes with His and Cys containing peptides

scientific article published on 01 September 2019

Organometallic anticancer compounds

scientific article

Organometallic β-turn mimetics. A structural and spectroscopic study of inter-strand hydrogen bonding in ferrocene and cobaltocenium conjugates of amino acids and dipeptides

Organometallic-Peptide Bioconjugates: Synthetic Strategies and Medicinal Applications

scientific article published on 14 September 2016

Peptide Bioconjugates of Electron-Poor Metallocenes: Synthesis, Characterization, and Anti-Proliferative Activity

scientific article published on 26 May 2015

Peptide-based SAMs that resist the adsorption of proteins

scientific article published on 18 October 2008

Photothermally Active Cryogel Devices for Effective Release of Antimicrobial Peptides: On-Demand Treatment of Infections

scientific article published on 08 December 2020

Planar chiral (η6-arene)Cr(CO)3 containing carboxylic acid derivatives: synthesis and use in the preparation of organometallic analogues of the antibiotic platensimycin

scientific article published on 10 November 2011

Platinum(II) Complexes with O,S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding

scientific article

Postformation Modification of SAMs: using click chemistry to functionalize organic surfaces

scientific article published in October 2009

Potent Inhibition of Thioredoxin Reductase by the Rh Derivatives of Anticancer M(arene/Cp*)(NHC)Cl2 Complexes

scientific article published on 19 February 2020

Preparation and Biological Evaluation of Di-Hetero-Organometallic-Containing PNA Bioconjugates

article published in 2011

Preparation, 99mTc-labeling and biodistribution studies of a PNA oligomer containing a new ligand derivative of 2,2'-dipicolylamine

scientific article published on 31 July 2010

Probing CO Generation through Metal-Assisted Alcohol Dehydrogenation in Metal-2-(arylazo)phenol Complexes Using Isotopic Labeling (Metal = Ru, Ir): Synthesis, Characterization, and Cytotoxicity Studies

scientific article published on 30 September 2020

Proteomic response of Bacillus subtilis to lantibiotics reflects differences in interaction with the cytoplasmic membrane.

scientific article

Proteomic signature of fatty acid biosynthesis inhibition available for in vivo mechanism-of-action studies.

scientific article published on 7 March 2011

Resistance-breaking profiling and gene expression analysis on an organometallic ReI-phenanthridine complex reveal parallel activation of two apoptotic pathways

scientific article published on 20 December 2017

Reversible site-specific tagging of enzymatically synthesized RNAs using aldehyde-hydrazine chemistry and protease-cleavable linkers.

scientific article published on 26 January 2007

Ru(ii)-Peptide bioconjugates with the cppH linker (cppH = 2-(2'-pyridyl)pyrimidine-4-carboxylic acid): synthesis, structural characterization, and different stereochemical features between organic and aqueous solvents

Ruthenium Complexes Containing “Noninnocent”o-Benzoquinone Diimine/o-Phenylenediamide(2−) Ligands. Synthesis and Crystal Structure of the Nitrido-Bridged Complex [{LRu(o-C6H4(NH)2)}2(μ-N)](PF6)2·3CH3CN·C6H5CH3

scientific article published on 01 January 1998

Sandwich and Half-Sandwich Derivatives of Platensimycin: Synthesis and Biological Evaluation

article published in 2012

Selective Dynamic Assembly of Disulfide Macrocyclic Helical Foldamers with Remote Communication of Handedness.

scientific article

Sequential insertion of three different organometallics into a versatile building block containing a PNA backbone

scientific article published on 19 May 2010

Short antibacterial peptides with significantly reduced hemolytic activity can be identified by a systematic L-to-D exchange scan of their amino acid residues

scientific article

Silyl-based alkyne-modifying linker for the preparation of C-terminal acetylene-derivatized protected peptides

scientific article published on 8 November 2012

Small cationic antimicrobial peptides delocalize peripheral membrane proteins

scientific article published on 24 March 2014

Small organometallic compounds as antibacterial agents

scientific article published on 12 March 2012

Solid-phase synthesis of oxaliplatin-TAT peptide bioconjugates.

scientific article published on 27 January 2012

Solid-phase synthesis, characterization, and antibacterial activities of metallocene-peptide bioconjugates

scientific article

Spectroscopic and Electrochemical Studies of Ferrocenyl Triazole Amino Acid and Peptide Bioconjugates Synthesized by Click Chemistry

Structural and biological implications of the binding of Leu-enkephalin and its metal derivatives to opioid receptors

scientific article

Structural complexity in metal-organic frameworks: simultaneous modification of open metal sites and hierarchical porosity by systematic doping with defective linkers

scientific article published on 25 June 2014

Structural studies on radiopharmaceutical DOTA-minigastrin analogue (CP04) complexes and their interaction with CCK2 receptor

scientific article published on 16 April 2018

Structure-activity relationship of trifluoromethyl-containing metallocenes: electrochemistry, lipophilicity, cytotoxicity, and ROS production

scientific article published on 18 May 2014

Study on Chemical Modifications of Glutathione by Cold Atmospheric Pressure Plasma (Cap) Operated in Air in the Presence of Fe(II) and Fe(III) Complexes

scientific article published on 02 December 2019

Synthesis and Biological Evaluation of Ferrocene-Containing Bioorganometallics Inspired by the Antibiotic Platensimycin Lead Structure

scholarly article by Malay Patra et al published 11 October 2010 in Organometallics

Synthesis and Mode of Action Studies on Iridium(I)-NHC Anticancer Drug Candidates

scholarly article by Yvonne Gothe et al published 24 May 2018 in European Journal of Inorganic Chemistry

Synthesis and Structure of a Stable Silylene

article

Synthesis and antibacterial activity of trivalent ultrashort Arg-Trp-based antimicrobial peptides (AMPs)

Synthesis and biological evaluation of chromium bioorganometallics based on the antibiotic platensimycin lead structure

scientific article published on November 2009

Synthesis and characterisation of hetero-bimetallic organometallic phenylalanine and PNA monomer derivatives

scientific article published on 9 February 2009

Synthesis and characterization of dicobalthexacarbonyl-alkyne derivatives of amino acids, peptides, and peptide nucleic acid (PNA) monomers

scientific article

Synthesis and cytotoxicity of a bimetallic ruthenocene dicobalt-hexacarbonyl alkyne peptide bioconjugate

scientific article published on 23 December 2010

Synthesis and cytotoxicity of a cobaltcarbonyl-alkyne enkephalin bioconjugate

scientific article

Synthesis and in vitro cytotoxicity of cis,cis,trans-diamminedichloridodisuccinatoplatinum(IV)-peptide bioconjugates

scientific article published on 7 February 2012

Synthesis and structural characterization of metallated bioconjugates: C-terminal labeling of amino acids with aminoferrocene

Synthesis and structure-activity relationship study of organometallic bioconjugates of the cyclic octapeptide octreotate

scientific article published on 11 November 2013

Synthesis of Alkynyl Amino Acids and Peptides and Their Palladium-Catalyzed Coupling to Ferrocene

Synthesis of Optically Active Ferrocene-Containing Platensimycin Derivatives with a C6-C7 Substitution Pattern

Synthesis of a C-linked glycosylated thymine-based PNA monomer and its incorporation into a PNA oligomer

scientific article published on 17 August 2006

Synthesis of a silylene–borane adduct and its slow conversion to a silylborane

scientific article published in 1996

Synthesis of bisarylethyne–peptide conjugates

Synthesis of monofunctional platinum(iv) carboxylate precursors for use in Pt(iv)-peptide bioconjugates

scientific article published on 18 October 2018

Synthesis of organometallic PNA oligomers by click chemistry

scientific article published on 10 June 2008

Synthesis of organometallic amines and their coupling to the C-terminus of amino acids and peptides

article published in 1999

Synthesis, characterisation and bioimaging of a fluorescent rhenium-containing PNA bioconjugate

scientific article published on 20 December 2011

Synthesis, structural and spectroscopic study of aromatic thioester compounds

Synthesis, structural characterisation and anti-proliferative activity of NHC gold amino acid and peptide conjugates

scientific article

Synthesis, structure and comparison of the DNA cleavage ability of metal complexes M(II)L with the N-(2-ethoxyethanol)-bis(2-picolyl)amine ligand L (M = Co, Ni, Cu and Zn).

scientific article published on 15 March 2004

Systematizing structural motifs and nomenclature in 1,n'-disubstituted ferrocene peptides.

scientific article

The Mo(η-allyl)(CO)2Moiety as a Robust Marker Group in Bioorganometallic Chemistry. Unusual Crystal Structure of the Phenylalanine Derivative Mo(C5H4-CO-Phe-OMe)(η-allyl)(CO)2

The X-ray Single Crystal Structures of an Acid-functionalized Bis(2-picolyl)amine (bpa) Ligand with Palladium(II) and Zinc(II) Display Different Intermoleclar Interactions around the Common (H2O)2(anion)2 Motif

The chemoselective reactions of tyrosine-containing G-protein-coupled receptor peptides with [Cp*Rh(H2O)3](OTf)2, including 2D NMR structures and the biological consequences

scientific article

The first oligopeptide derivative of 1'-aminoferrocene-1-carboxylic acid shows helical chirality with antiparallel strands

scientific article published on 11 August 2004

The potential of organometallic complexes in medicinal chemistry

scientific article published on 25 February 2012

The scaffold protein MUPP1 regulates odorant-mediated signaling in olfactory sensory neurons

scientific article published on 20 March 2014

Themed Issue on "Metallodrugs: Activation, Targeting, and Delivery".

scientific article

Thermal melting studies of alkyne- and ferrocene-containing PNA bioconjugates

scientific article published on 13 October 2009

Towards Profiles of Resistance Development and Toxicity for the Small Cationic Hexapeptide RWRWRW-NH2.

scientific article published on 26 August 2016

Towards peptide-substituted titanocene anticancer drugs

Towards the Preparation of Novel Re/99mTc Tricarbonyl-Containing Peptide Nucleic Acid Bioconjugates

Tuning the activity of a short arg-trp antimicrobial Peptide by lipidation of a C- or N-terminal lysine side-chain

scientific article

Use of the Sonogashira coupling reaction for the "two-step" labeling of phenylalanine peptide side chains with organometallic compounds

scientific article published in January 2006

Variable temperature electrochemistry as a powerful method for conformational investigations on the fluxional organometallic complex Mo(His-Nɛ-C2H4CO2Me)(η-allyl)(CO)2 (His = Nδ, N,O-l-histidinate)

article by Dave R. van Staveren et al published 2001 in Chemical Communications

Vesicular disruption of lysosomal targeting organometallic polyarginine bioconjugates

scientific article published in February 2015

Zwitterionic Peptides Reduce Accumulation of Marine and Freshwater Biofilm Formers

[N,N'-Bis(salicylidene)-1,2-phenylenediamine]metal complexes with cell death promoting properties

scientific article

“Four-Potential” Ferrocene Labeling of PNA Oligomers via Click Chemistry

scientific article published on 08 July 2009

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