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List of works by Christoph Fahlke

A beta-lactam antibiotic dampens excitotoxic inflammatory CNS damage in a mouse model of multiple sclerosis

scientific article

A conserved aspartate determines pore properties of anion channels associated with excitatory amino acid transporter 4 (EAAT4).

scientific article published on 2 June 2010

A missense mutation in canine C1C-1 causes recessive myotonia congenita in the dog.

scientific article published on July 1999

A mutation in autosomal dominant myotonia congenita affects pore properties of the muscle chloride channel

scientific article

A novel alteration of muscle chloride channel gating in myotonia levior

scientific article published in December 2002

A point mutation associated with episodic ataxia 6 increases glutamate transporter anion currents

scientific article

A trimeric quaternary structure is conserved in bacterial and human glutamate transporters

scientific article

Allosteric gate modulation confers K+ coupling in glutamate transporters

scientific article published on 10 September 2019

Allosteric modulation of an excitatory amino acid transporter: the subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain.

scientific article published in January 2013

An amino-terminal point mutation increases EAAT2 anion currents without affecting glutamate transport rates

scientific article published on 20 August 2020

An aspartic acid residue important for voltage-dependent gating of human muscle chloride channels

scientific article published on August 1995

Anion channels: regulation of ClC-3 by an orphan second messenger

scientific article

Anion permeation in human ClC-4 channels

scientific article published on April 2003

Anion transport by the cochlear motor protein prestin

scientific journal article

Anion- and proton-dependent gating of ClC-4 anion/proton transporter under uncoupling conditions

scientific article published on March 2011

Aspergillus fumigatus Infection-Induced Neutrophil Recruitment and Location in the Conducting Airway of Immunocompetent, Neutropenic, and Immunosuppressed Mice.

scientific article published on 18 January 2018

Barttin Regulates the Subcellular Localization and Posttranslational Modification of Human Cl/H Antiporter ClC-5

scientific article published on 23 October 2018

Barttin activates ClC-K channel function by modulating gating

scientific article

Barttin modulates trafficking and function of ClC-K channels

scientific article

Behind the scenes of CLC gating: deriving the voltage dependence of membrane proteins by admittance measurements

scientific article published on September 2014

CLC channel function and dysfunction in health and disease

scientific article

CLCN2 chloride channel mutations in familial hyperaldosteronism type II.

scientific article

CLCN2 variants in idiopathic generalized epilepsy

scientific article published on 01 September 2009

CNS Schwann cells display oligodendrocyte precursor-like potassium channel activation and antigenic expression in vitro

scientific article published on 01 February 2014

Carboxy-terminal truncations modify the outer pore vestibule of muscle chloride channels

scientific article published on 24 June 2005

Carboxyl-terminal Truncations of ClC-Kb Abolish Channel Activation by Barttin Via Modified Common Gating and Trafficking

scientific article published on 9 October 2015

Channel-like slippage modes in the human anion/proton exchanger ClC-4.

scientific article published on 13 April 2009

Characterization of the high-conductance Ca(2+)-activated K+ channel in adult human skeletal muscle

scientific article published on March 1995

Chloride channels in cultured human skeletal muscle are regulated by G proteins

scientific article published on 01 September 1992

Chloride channels in renal salt and water transport.

scientific article published on 16 September 2016

Chloride channels take center stage in a muscular drama ⬇️

scientific article published on December 13, 2010

Chloride channels with reduced single-channel conductance in recessive myotonia congenita

scientific article published on 01 February 1993

ClC-1 and ClC-2 form hetero-dimeric channels with novel protopore functions

scientific article published on 19 March 2014

ClC-3 is an intracellular chloride/proton exchanger with large voltage-dependent nonlinear capacitance

scientific article published on 4 April 2013

ClC-3: biophysical properties clarify cellular functions

scientific article published on 29 July 2018

Conserved dimeric subunit stoichiometry of SLC26 multifunctional anion exchangers

scientific journal article

Crystal structure of a light-driven sodium pump

scientific article

Disease-causing dysfunctions of barttin in Bartter syndrome type IV

scientific article published on 5 September 2008

Disease-causing mutations C277R and C277Y modify gating of human ClC-1 chloride channels in myotonia congenita

scientific article published on 28 May 2012

Efficient non-cytotoxic fluorescent staining of halophiles.

scientific article published on 7 February 2018

Electrophysiological Characterization of eGFP-Labeled Intrastriatal Dopamine Grafts

scientific article published on 15 July 2014

Engaging neuroscience to advance translational research in brain barrier biology.

scientific article published in March 2011

Excitatory Amino Acid Transporter EAAT5 Improves Temporal Resolution in the Retina

scientific article published on 01 November 2021

Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities.

scientific article

Functional properties of the retinal glutamate transporters GLT-1c and EAAT5

scientific journal article

Gating Charge Calculations by Computational Electrophysiology Simulations.

scientific article published on April 2017

Gating of human ClC-2 chloride channels and regulation by carboxy-terminal domains

scientific article published on 18 September 2008

Giga-seal formation alters properties of sodium channels of human myoballs

scientific article published on 01 March 1992

Glutamate modifies ion conduction and voltage-dependent gating of excitatory amino acid transporter-associated anion channels

scientific article published on 23 September 2003

Glutamate transporter-associated anion channels adjust intracellular chloride concentrations during glial maturation

scientific article published on 18 November 2016

Human CLC-K Channels Require Palmitoylation of Their Accessory Subunit Barttin to Be Functional

scientific article published on 26 May 2015

Impaired K+ binding to glial glutamate transporter EAAT1 in migraine

scientific article published on 24 October 2017

Impaired surface membrane insertion of homo- and heterodimeric human muscle chloride channels carrying amino-terminal myotonia-causing mutations

scientific journal article

Increased glutamate transporter-associated anion currents cause glial apoptosis in episodic ataxia 6

scientific article published on 04 March 2020

Induced fit substrate binding to an archeal glutamate transporter homologue

scientific article published on 09 July 2013

Intersubunit interactions in EAAT4 glutamate transporters.

scientific article published on July 2006

Involvement of ClC-3 chloride/proton exchangers in controlling glutamatergic synaptic strength in cultured hippocampal neurons.

scientific article published on 23 May 2014

Mechanism of ion permeation in skeletal muscle chloride channels

scientific article

Mechanisms of anion conduction by coupled glutamate transporters

scientific article published on January 2015

Metabolic energy sensing by mammalian CLC anion/proton exchangers

scientific article published on 10 May 2020

Molecular Determinants of Substrate Specificity in Sodium-coupled Glutamate Transporters.

scientific article

Molecular and cellular physiology of sodium-dependent glutamate transporters.

scientific article published on 28 December 2016

Molecular basis for decreased muscle chloride conductance in the myotonic goat

scientific article

Molecular basis of DFNB73: mutations of BSND can cause nonsyndromic deafness or Bartter syndrome.

scientific article published on 30 July 2009

Molecular mechanisms of ion conduction in ClC-type chloride channels: lessons from disease-causing mutations.

scientific article

Molecular physiology of EAAT anion channels.

scientific article published on 19 December 2015

Molecular physiology of anion channels: dual function proteins and new structural motifs--a special issue

scientific article published on 15 January 2016

Mutating a conserved proline residue within the trimerization domain modifies Na+ binding to excitatory amino acid transporters and associated conformational changes.

scientific article

Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies

scientific article (publication date: April 2003)

Na+-dependent gate dynamics and electrostatic attraction ensure substrate coupling in glutamate transporters

scientific article published on 18 November 2020

Neuronal ClC-3 Splice Variants Differ in Subcellular Localizations, but Mediate Identical Transport Functions.

scientific article

Neuronal glutamate transporters vary in substrate transport rate but not in unitary anion channel conductance

scientific article

Neutralizing aspartate 83 modifies substrate translocation of excitatory amino acid transporter 3 (EAAT3) glutamate transporters.

scientific article

Noise analysis to study unitary properties of transporter-associated ion channels ⬇️

scientific article published on 01 November 2011

Novel CLCN1 mutations with unique clinical and electrophysiological consequences

scientific article published in November 2002

Parawixin1: a spider toxin opening new avenues for glutamate transporter pharmacology

scientific article published on 28 August 2007

Physiology and pathophysiology of ClC-K/barttin channels ⬇️

scientific article published on November 26, 2010

Pore stoichiometry of a voltage-gated chloride channel

scientific article published on August 1998

Preferential association with ClC-3 permits sorting of ClC-4 into endosomal compartments

scientific article published on 26 September 2017

Quantitative determination of cellular [Na+] by fluorescence lifetime imaging with CoroNaGreen

scientific article published on 09 October 2019

Reconstitution and NMR Characterization of the Ion-Channel Accessory Subunit Barttin in Detergents and Lipid-Bilayer Nanodiscs

scientific article published on 14 March 2019

Recurrent gain of function mutation in calcium channel CACNA1H causes early-onset hypertension with primary aldosteronism.

scientific article published on 24 April 2015

Regulation of ClC-2 gating by intracellular ATP.

scientific article published on May 2013

Regulation of glial glutamate transporters by C-terminal domains.

scientific article published on 19 November 2010

Regulation of the human skeletal muscle chloride channel hClC-1 by protein kinase C.

scientific article published on February 1999

Retraction: Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies

scientific article published on 01 September 2009

Role of the cytoskeleton in the regulation of Cl- channels in human embryonic skeletal muscle cells

scientific article published on 01 October 1994

Single-channel recordings of chloride currents in cultured human skeletal muscle

scientific article published on 01 June 1992

Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism

scientific article

Substrate-dependent gating of anion channels associated with excitatory amino acid transporter 4

scientific article published on 13 May 2011

The photophysics of LOV-based fluorescent proteins--new tools for cell biology

scientific article

The role of the carboxyl terminus in ClC chloride channel function

scientific article published on 12 January 2004

Tryptophan Scanning Mutagenesis Identifies the Molecular Determinants of Distinct Barttin Functions

scientific article published on 10 June 2015

Two novel CLCN2 mutations accelerating chloride channel deactivation are associated with idiopathic generalized epilepsy.

scientific article

VGLUT1 functions as a glutamate/proton exchanger with chloride channel activity in hippocampal glutamatergic synapses.

scientific article published on 22 December 2017

Whole-cell recordings of chloride currents in cultured human skeletal muscle

scientific article published on 01 June 1992

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