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List of works by Lin-Hua Jiang

A Role of BK Channel in Regulation of Ca2+ Channel in Ventricular Myocytes by Substrate Stiffness ⬇️

scientific article published in April 2017

A critical role of TRPM2 channel in Aβ42 -induced microglial activation and generation of tumor necrosis factor-α. ⬇️

scientific article

A critical role of the KCa 3.1 channel in mechanical stretch-induced proliferation of rat bone marrow-derived mesenchymal stem cells

scientific article published on 17 February 2020

A critical role of the transient receptor potential melastatin 2 channel in a positive feedback mechanism for reactive oxygen species-induced delayed cell death ⬇️

A crucial role for hydrogen sulfide in oxygen sensing via modulating large conductance calcium-activated potassium channels

scientific article published in May 2010

A differential role of macrophage TRPM2 channels in Ca²⁺ signaling and cell death in early responses to H₂O₂.

scientific article published on 17 April 2013

A dual role of transient receptor potential melastatin 2 channel in cytotoxicity induced by silica nanoparticles ⬇️

scientific article

A residue in the TRPM2 channel outer pore is crucial in determining species-dependent sensitivity to extracellular acidic pH

article

ATP-activated P2X7 receptor in the pathophysiology of mood disorders and as an emerging target for the development of novel antidepressant therapeutics. ⬇️

scientific article published on 14 February 2018

ATP-induced P2X Receptor-Dependent Large Pore Formation: How Much Do We Know? ⬇️

scientific article published on 29 January 2016

Adenosine Triphosphate Release and P2 Receptor Signaling in Piezo1 Channel-Dependent Mechanoregulation

scientific article published on 06 November 2019

Alteration in Intracellular Zn2+ Homeostasis as a Result of TRPM2 Channel Activation Contributes to ROS-Induced Hippocampal Neuronal Death. ⬇️

scientific article published on 12 December 2017

Amino acid residues involved in gating identified in the first membrane-spanning domain of the rat P2X(2) receptor

scientific article published on 6 February 2001

An organelle K+ channel is required for osmoregulation in Chlamydomonas reinhardtii. ⬇️

scientific article published on 16 June 2016

Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors

article published in 2013

Automated Planar Patch-Clamp Recording of P2X Receptors

scientific article published on 01 January 2020

Carcinoma-specific expression of P2Y11 receptor and its contribution in ATP-induced purinergic signalling and cell migration in human hepatocellular carcinoma cells ⬇️

scientific article

Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373.

scientific article published on 9 October 2006

Chemical activation of the Piezo1 channel drives mesenchymal stem cell migration via inducing ATP release and activation of P2 receptor purinergic signaling

scientific article published on 21 January 2020

Conformational changes during human P2X7 receptor activation examined by structural modelling and cysteine-based cross-linking studies ⬇️

scientific article published on 26 December 2016

Conserved cysteine residues in the pore region are obligatory for human TRPM2 channel function

scientific article published on 5 July 2006

Contribution of Val/Ile87 residue in the extracellular domain in agonist-induced current responses of the human and rat P2X7 receptors

scientific article published on 08 October 2020

Cysteine-based cross-linking approach to study inter-domain interactions in ion channels

scientific article published in January 2013

Direct Gating of the TRPM2 Channel by cADPR via Specific Interactions with the ADPR Binding Pocket

scientific article published on 01 June 2019

Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human ⬇️

scientific article published on 6 June 2015

Escape from adamantane: Scaffold optimization of novel P2X7 antagonists featuring complex polycycles. ⬇️

scientific article published on 16 January 2017

Ethanol Induces Microglial Cell Death via the NOX/ROS/PARP/TRPM2 Signalling Pathway

scientific article published on 09 December 2020

HIV drug nucleoside reverse transcriptase inhibitors as promising anti-inflammation therapeutics by targeting P2X7-dependent large pore formation: one stone for two birds? ⬇️

scientific article published on 25 February 2015

Heterologous Expression and Patch-Clamp Recording of P2X Receptors in HEK293 Cells

scientific article published on 01 January 2020

High glucose-induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission. ⬇️

scientific article published in August 2017

Identification of Amino Acid Residues Contributing to the ATP-binding Site of a Purinergic P2X Receptor

scientific article published in Journal of Biological Chemistry

Identification of a trafficking motif involved in the stabilization and polarization of P2X receptors

scientific article

Identification of an intracellular microdomain of the P2X7 receptor that is crucial in basolateral membrane targeting in epithelial cells

scientific article published on 10 November 2010

Identification of pore residues engaged in determining divalent cationic permeation in transient receptor potential melastatin subtype channel 2.

scientific article

Identification of the ADPR binding pocket in the NUDT9 homology domain of TRPM2. ⬇️

scientific article published on 20 January 2017

Identification of the amino acid residues in the extracellular domain of rat P2X(7) receptor involved in functional inhibition by acidic pH.

scientific article

Immunological Responses to Total Hip Arthroplasty ⬇️

scientific article published on August 2017

Inactivation of TRPM2 channels by extracellular divalent copper ⬇️

scientific article

Increasing the TRPM2 Channel Expression in Human Neuroblastoma SH-SY5Y Cells Augments the Susceptibility to ROS-Induced Cell Death ⬇️

Inhibition of ATP-induced macrophage death by emodin via antagonizing P2X7 receptor

scientific article

Inhibition of P2X(7) receptors by divalent cations: old action and new insight

scientific article published on 15 April 2008

Inhibitory interaction between P2X4 and GABA(C) rho1 receptors

scientific article published on 31 July 2008

Insights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide Polymorphisms

scientific article

Interaction between cysteines introduced into each transmembrane domain of the rat P2X2 receptor

scientific article published on January 2003

Interactions, functions, and independence of plasma membrane STIM1 and TRPC1 in vascular smooth muscle cells

scientific article published on 18 September 2008

Intracellular coiled-coil domain engaged in subunit interaction and assembly of melastatin-related transient receptor potential channel 2.

scientific article published on 23 October 2006

Kinetics of antagonist actions at rat P2X2/3 heteromeric receptors

scientific article published on March 2002

Melastatin-related transient receptor potential 2 channel in Aβ42-induced neuroinflammation: implications to Alzheimer's disease mechanism and development of therapeutics. ⬇️

scientific article published in March 2018

Multiple molecular mechanisms form a positive feedback loop driving amyloid β42 peptide-induced neurotoxicity via activation of the TRPM2 channel in hippocampal neurons ⬇️

scientific article published on 7 February 2018

N-methyl-D-glucamine and propidium dyes utilize different permeation pathways at rat P2X(7) receptors

scientific article published on 10 August 2005

New structure enlivens interest in P2X receptors.

scientific article published on 11 March 2010

Non-NMDAR neuronal Ca(2+)-permeable channels in delayed neuronal death and as potential therapeutic targets for ischemic brain damage

scientific article

Non-synonymous single nucleotide polymorphisms in the P2X receptor genes: association with diseases, impact on receptor functions and potential use as diagnosis biomarkers ⬇️

scientific article

P2X receptor-mediated ATP purinergic signaling in health and disease

article

P2X7 Receptor Promotes Mouse Mammary Cancer Cell Invasiveness and Tumour Progression, and Is a Target for Anticancer Treatment

scientific article published on 19 August 2020

Pharmacological and biophysical properties of the human P2X5 receptor

scientific article published on June 2003

Pharmacological properties of ATP-sensitive purinergic receptors expressed in human G292 osteoblastic cells

scientific article

Pharmacological properties of the rhesus macaque monkey P2X7 receptor

scientific article

Proteomic and functional evidence for a P2X7 receptor signalling complex

scientific article

Purinergic and Store-Operated Ca(2+) Signaling Mechanisms in Mesenchymal Stem Cells and Their Roles in ATP-Induced Stimulation of Cell Migration. ⬇️

scientific article published in April 2016

Regulation of cloned cardiac L-type calcium channels by cGMP-dependent protein kinase

scientific article published in March 2000

Requirement for the N-terminal coiled-coil domain for expression and function, but not subunit interaction of, the ADPR-activated TRPM2 channel

scientific article

Residues 155 and 348 contribute to the determination of P2X7 receptor function via distinct mechanisms revealed by single-nucleotide polymorphisms

scientific article

Robotic multiwell planar patch-clamp for native and primary mammalian cells

scientific article published in January 2009

Role of ectodomain lysines in the subunits of the heteromeric P2X2/3 receptor

scientific article published on 13 July 2006

Role of the domain encompassing Arg304-Ile328 in rat P2X2 receptor conformation revealed by alterations in complex glycosylation at Asn298

scientific journal article

Signalling mechanisms mediating Zn2+-induced TRPM2 channel activation and cell death in microglial cells ⬇️

scientific article published on 21 March 2017

Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions

scientific article

Site-directed mutagenesis to study the structure-function relationships of ion channels

scientific article

State-dependent inhibition of TRPM2 channel by acidic pH.

scientific article published on 26 July 2010

Stiff substrates enhance cultured neuronal network activity. ⬇️

scientific article

Structure, function and techniques of investigation of the P2X7 receptor (P2X7R) in mammalian cells

scientific article published on 03 September 2019

Structure-based identification and characterisation of structurally novel human P2X7 receptor antagonists ⬇️

scientific article

TRPC channel activation by extracellular thioredoxin

scientific article

TRPM2 Channel in Microglia as a New Player in Neuroinflammation Associated With a Spectrum of Central Nervous System Pathologies

scientific article published on 12 March 2019

TRPM2 Channel-Mediated ROS-Sensitive Ca(2+) Signaling Mechanisms in Immune Cells ⬇️

scientific article (publication date: 2015)

TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1 pyramidal neuronal death after transient global ischemia ⬇️

scientific article

TRPM2 channel properties, functions and therapeutic potentials

scientific article published on September 2010

TRPM2 channel: A novel target for alleviating ischaemia-reperfusion, chronic cerebral hypo-perfusion and neonatal hypoxic-ischaemic brain damage

scientific article published on 30 September 2019

TRPM2-mediated intracellular Zn2+ release triggers pancreatic β-cell death

scientific article

The TRPM2 channel nexus from oxidative damage to Alzheimer’s pathologies: An emerging novel intervention target for age-related dementia ⬇️

scholarly article by Lin-Hua Jiang published in November 2018

Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives ⬇️

scientific article

Zinc inactivates melastatin transient receptor potential 2 channels via the outer pore

scientific article published on 20 May 2011

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