List of works - Abdallah Hamze

1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation

scientific article published on 21 December 2018

A general synthesis of arylindoles and (1-arylvinyl)carbazoles via a one-pot reaction from N-tosylhydrazones and 2-nitro-haloarenes and their potential application to colon cancer

scientific article published on 18 October 2016

An efficient coupling of N-tosylhydrazones with 2-halopyridines: synthesis of 2-α-styrylpyridines endowed with antitumor activity

scientific article published on June 2013

An update on the use of sulfinate derivatives as versatile coupling partners in organic chemistry

scientific article published on 02 October 2020

B-ring-modified isocombretastatin A-4 analogues endowed with interesting anticancer activities

scientific article published on 11 October 2011

Catalytic three-component one-pot reaction of hydrazones, dihaloarenes, and amines

scientific article published on 18 December 2012

Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: synthesis, cytotoxicity and antitubulin activity

scientific article

Copper-catalyzed reductive coupling of tosylhydrazones with amines: a convenient route to α-branched amines

scientific article published on 28 July 2011

Csp2-Csp2 and Csp2-N Bond Formation in a One-Pot Reaction between N-Tosylhydrazones and Bromonitrobenzenes: An Unexpected Cyclization to Substituted Indole Derivatives

scientific article published on 5 December 2017

Csp2-N bond formation via ligand-free Pd-catalyzed oxidative coupling reaction of N-tosylhydrazones and indole derivatives.

scientific article

Cyclic Peptides with a Diversely Substituted Guanidine Bridge: Solid-Phase Synthesis and Structural Analysis

article

Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4

scientific article published on 26 July 2018

Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted isocombretastatin A-4 analogs

scientific article published on 4 January 2013

Discovery and hit to lead optimization of novel combretastatin A-4 analogues: dependence of C-linker length and hybridization

scientific article published on December 2013

Discovery of isoerianin analogues as promising anticancer agents

scientific article published on 14 January 2011

Exploration of potential prodrug approach of the bis-thiazolium salts T3 and T4 for orally delivered antimalarials.

scientific article published on 10 May 2010

How do we improve histone deacetylase inhibitor drug discovery?

scientific article published on 02 March 2020

Iron-catalyzed reductive cyclization of nitroarenes: Synthesis of aza-heterocycles and DFT calculations

scientific article published in 2022

Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent

scientific article

Mono- and bis-thiazolium salts have potent antimalarial activity

scientific article published in May 2005

N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents

scientific article published on 16 February 2019

One-Pot Reaction between N-Tosylhydrazones and 2-Nitrobenzyl Bromide: Route to NH-Free C2-Arylindoles

scientific article published on 17 December 2018

Palladium-Catalyzed One-Pot Reaction of Hydrazones, Dihaloarenes, and Organoboron Reagents: Synthesis and Cytotoxic Activity of 1,1-Diarylethylene Derivatives.

scientific article published on 12 June 2015

Palladium-catalyzed Markovnikov terminal arylalkynes hydrostannation: application to the synthesis of 1,1-diarylethylenes

scientific article

Pd-catalyzed reaction of sterically hindered hydrazones with aryl halides: synthesis of tetra-substituted olefins related to iso-combretastatin A4

scientific article published on 01 September 2010

Platinum oxide catalyzed hydrosilylation of unsymmetrical internal aryl alkynes under ortho-substituent regiocontrol

scientific article published on 01 December 2005

Platinum oxide catalyzed silylation of aryl halides with triethylsilane: an efficient synthetic route to functionalized aryltriethylsilanes

scientific article published on 01 March 2006

Pyrrolo-imidazo[1,2-a]pyridine Scaffolds through a Sequential Coupling of N-Tosylhydrazones with Imidazopyridines and Reductive Cadogan Annulation, Synthetic Scope, and Application

scientific article published on 09 October 2019

Rapid synthesis of 4-arylchromenes from ortho-substituted alkynols: A versatile access to restricted isocombretastatin A-4 analogues as antitumor agents.

scientific article published on 15 December 2014

Regiocontrol of the palladium-catalyzed tin hydride addition to Z-enynols: remarkable Z-directing effects

scientific article published on 14 April 2007

Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: an easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4.

scientific article published on 12 May 2010

Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to spindle poisons by exogenous activation of JNK and p38 MAP kinases

scientific article published on May 2014

Selective Metal-Free Deoxygenation of Unsymmetrical 1,2-Dicarbonyl Compounds by Chlorotrimethylsilane and Sodium Iodide

scientific article published on 23 June 2016

Sequential One-Pot Synthesis of 3-Arylbenzofurans from N-Tosylhydrazones and Bromophenol Derivatives

scientific article published on 22 October 2020

Solid phase synthesis of mono- or disubstituted arginine containing peptides from an isothiocitrulline precursor

Solid-phase synthesis of arginine-containing peptides and fluorogenic substrates using a side-chain anchoring approach

scientific article published in November 2004

Solid-phase synthesis of dipeptidic and pseudo-dipeptidic potential NOS inhibitors through a side-chain anchoring approach

Stereoretentive palladium-catalyzed arylation, alkenylation, and alkynylation of 1-thiosugars and thiols using aminobiphenyl palladacycle precatalyst at room temperature

scientific article published on 15 April 2015

Sulfinate derivatives: dual and versatile partners in organic synthesis.

scientific article

Synthesis and antitumor activity of benzils related to combretastatin A-4.

scientific article published on 25 April 2008

Synthesis of (R) and (S) enantiomers of Fmoc-protected 1,2,4-oxadiazole-containing β3-amino acids from Fmoc-(R)-β-HAsp(OtBu)-OH

Synthesis of 1,1-diarylethylenes via efficient iron/copper co-catalyzed coupling of 1-arylvinyl halides with Grignard reagents

scientific article published on 22 May 2012

Synthesis of ortho/ortho'-substituted 1,1-diarylethylenes through cross-coupling reactions of sterically encumbered hydrazones and aryl halides.

scientific article

Synthesis of various 3-substituted 1,2,4-oxadiazole-containing chiral beta 3- and alpha-amino acids from Fmoc-protected aspartic acid

scientific article published in September 2003

Synthesis, biological evaluation and molecular modeling studies of imidazo[1,2-a]pyridines derivatives as protein kinase inhibitors

scientific article published on 21 July 2016

Synthesis, biological evaluation of 1,1-diarylethylenes as a novel class of antimitotic agents

scientific article published on November 2009

Synthesis, biological evaluation, and structure-activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors

scientific article

Tandem one-pot palladium-catalyzed coupling of hydrazones, haloindoles, and amines: synthesis of amino-N-vinylindoles and their effect on human colon carcinoma cells.

scientific article

Toward a Greener Barluenga-Valdés Cross-Coupling: Microwave-Promoted C-C Bond Formation with a Pd/PEG/H2O Recyclable Catalytic System

scientific article published on 16 October 2019

List of works by Abdallah Hamze

1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation

A general synthesis of arylindoles and (1-arylvinyl)carbazoles via a one-pot reaction from N-tosylhydrazones and 2-nitro-haloarenes and their potential application to colon cancer

An efficient coupling of N-tosylhydrazones with 2-halopyridines: synthesis of 2-α-styrylpyridines endowed with antitumor activity

An update on the use of sulfinate derivatives as versatile coupling partners in organic chemistry

B-ring-modified isocombretastatin A-4 analogues endowed with interesting anticancer activities

Catalytic three-component one-pot reaction of hydrazones, dihaloarenes, and amines

Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: synthesis, cytotoxicity and antitubulin activity

Copper-catalyzed reductive coupling of tosylhydrazones with amines: a convenient route to α-branched amines

Csp2-Csp2 and Csp2-N Bond Formation in a One-Pot Reaction between N-Tosylhydrazones and Bromonitrobenzenes: An Unexpected Cyclization to Substituted Indole Derivatives

Csp2-N bond formation via ligand-free Pd-catalyzed oxidative coupling reaction of N-tosylhydrazones and indole derivatives.

Cyclic Peptides with a Diversely Substituted Guanidine Bridge: Solid-Phase Synthesis and Structural Analysis

Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4

Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted isocombretastatin A-4 analogs

Discovery and hit to lead optimization of novel combretastatin A-4 analogues: dependence of C-linker length and hybridization

Discovery of isoerianin analogues as promising anticancer agents

Exploration of potential prodrug approach of the bis-thiazolium salts T3 and T4 for orally delivered antimalarials.

How do we improve histone deacetylase inhibitor drug discovery?

Iron-catalyzed reductive cyclization of nitroarenes: Synthesis of aza-heterocycles and DFT calculations

Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent

Mono- and bis-thiazolium salts have potent antimalarial activity

N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents

One-Pot Reaction between N-Tosylhydrazones and 2-Nitrobenzyl Bromide: Route to NH-Free C2-Arylindoles

Palladium-Catalyzed One-Pot Reaction of Hydrazones, Dihaloarenes, and Organoboron Reagents: Synthesis and Cytotoxic Activity of 1,1-Diarylethylene Derivatives.

Palladium-catalyzed Markovnikov terminal arylalkynes hydrostannation: application to the synthesis of 1,1-diarylethylenes

Pd-catalyzed reaction of sterically hindered hydrazones with aryl halides: synthesis of tetra-substituted olefins related to iso-combretastatin A4

Platinum oxide catalyzed hydrosilylation of unsymmetrical internal aryl alkynes under ortho-substituent regiocontrol

Platinum oxide catalyzed silylation of aryl halides with triethylsilane: an efficient synthetic route to functionalized aryltriethylsilanes

Pyrrolo-imidazo[1,2-a]pyridine Scaffolds through a Sequential Coupling of N-Tosylhydrazones with Imidazopyridines and Reductive Cadogan Annulation, Synthetic Scope, and Application

Rapid synthesis of 4-arylchromenes from ortho-substituted alkynols: A versatile access to restricted isocombretastatin A-4 analogues as antitumor agents.

Regiocontrol of the palladium-catalyzed tin hydride addition to Z-enynols: remarkable Z-directing effects

Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: an easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4.

Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to spindle poisons by exogenous activation of JNK and p38 MAP kinases

Selective Metal-Free Deoxygenation of Unsymmetrical 1,2-Dicarbonyl Compounds by Chlorotrimethylsilane and Sodium Iodide

Sequential One-Pot Synthesis of 3-Arylbenzofurans from N-Tosylhydrazones and Bromophenol Derivatives

Solid phase synthesis of mono- or disubstituted arginine containing peptides from an isothiocitrulline precursor

Solid-phase synthesis of arginine-containing peptides and fluorogenic substrates using a side-chain anchoring approach

Solid-phase synthesis of dipeptidic and pseudo-dipeptidic potential NOS inhibitors through a side-chain anchoring approach

Stereoretentive palladium-catalyzed arylation, alkenylation, and alkynylation of 1-thiosugars and thiols using aminobiphenyl palladacycle precatalyst at room temperature

Sulfinate derivatives: dual and versatile partners in organic synthesis.

Synthesis and antitumor activity of benzils related to combretastatin A-4.

Synthesis of (R) and (S) enantiomers of Fmoc-protected 1,2,4-oxadiazole-containing β3-amino acids from Fmoc-(R)-β-HAsp(OtBu)-OH

Synthesis of 1,1-diarylethylenes via efficient iron/copper co-catalyzed coupling of 1-arylvinyl halides with Grignard reagents

Synthesis of ortho/ortho'-substituted 1,1-diarylethylenes through cross-coupling reactions of sterically encumbered hydrazones and aryl halides.

Synthesis of various 3-substituted 1,2,4-oxadiazole-containing chiral beta 3- and alpha-amino acids from Fmoc-protected aspartic acid

Synthesis, biological evaluation and molecular modeling studies of imidazo[1,2-a]pyridines derivatives as protein kinase inhibitors

Synthesis, biological evaluation of 1,1-diarylethylenes as a novel class of antimitotic agents

Synthesis, biological evaluation, and structure-activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors

Tandem one-pot palladium-catalyzed coupling of hydrazones, haloindoles, and amines: synthesis of amino-N-vinylindoles and their effect on human colon carcinoma cells.

Toward a Greener Barluenga-Valdés Cross-Coupling: Microwave-Promoted C-C Bond Formation with a Pd/PEG/H2O Recyclable Catalytic System