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List of works by Michio Shimabukuro

A novel insulinotropic mechanism of whole grain-derived γ-oryzanol via the suppression of local dopamine D2 receptor signalling in mouse islet

scientific article

A synthetic prostacyclin agonist with thromboxane synthase inhibitory activity, ONO-1301, protects myocardium from ischemia/reperfusion injury

scientific article published on 09 November 2011

Activation of AMPK-Sirt1 pathway by telmisartan in white adipose tissue: A possible link to anti-metabolic effects

scientific article published on 20 July 2012

Age-Dependent Efficacy of Ezetimibe for Low-Density Lipoprotein Cholesterol Reduction in Japanese Patients with or without Type 2 Diabetes Mellitus

scientific article published on 01 June 2020

Association of borderline ankle-brachial index with mortality and the incidence of peripheral artery disease in diabetic patients

scientific article published on 27 March 2014

Association of lower limb muscle mass and energy expenditure with visceral fat mass in healthy men.

scientific article published on 26 February 2014

Associations between Dietary Patterns and Cardiometabolic Risks in Japan: A Cross-Sectional Study from the Fukushima Health Management Survey, 2011-2015

scientific article published on 02 January 2020

Author Correction: Randomized Evaluation of Anagliptin vs Sitagliptin On low-density lipoproteiN cholesterol in diabetes (REASON) Trial: A 52-week, open-label, randomized clinical trial

scientific article published on 21 February 2020

Azilsartan, an angiotensin II type 1 receptor blocker, restores endothelial function by reducing vascular inflammation and by increasing the phosphorylation ratio Ser(1177)/Thr(497) of endothelial nitric oxide synthase in diabetic mice

scientific article published on 31 January 2014

Beneficial effect of a synthetic prostacyclin agonist, ONO-1301, in rat autoimmune myocarditis model.

scientific article published on 5 December 2012

Brachial-ankle pulse wave velocity predicts all-cause mortality and cardiovascular events in patients with diabetes: the Kyushu Prevention Study of Atherosclerosis

scientific article published on 4 June 2014

Brown rice and its component, γ-oryzanol, attenuate the preference for high-fat diet by decreasing hypothalamic endoplasmic reticulum stress in mice.

scientific article

Cilazapril prevents cardiac hypertrophy and postischemic myocardial dysfunction in hyperthyroid rats

scientific article published in November 2001

Combination of n-3 polyunsaturated fatty acids reduces atherogenesis in apolipoprotein E-deficient mice by inhibiting macrophage activation

scientific article published on 5 October 2016

Comparison of the prognostic values of three calculation methods for echocardiographic relative wall thickness in acute decompensated heart failure

scientific article published on 03 December 2019

Defects of vascular nitric oxide bioavailability in subjects with impaired glucose tolerance: a potential link to insulin resistance

scientific article published on 15 October 2012

Depot- and gender-specific expression of NLRP3 inflammasome and toll-like receptors in adipose tissue of cancer patients

scientific article published on 18 April 2016

Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and atherogenesis in normoglycemic apolipoprotein-E deficient mice

scientific article published on 13 August 2015

Dissimilar Effects of Anagliptin and Sitagliptin on Lipoprotein Subclass in Standard or Strong Statin-Treated Patients with Type-2 Diabetes Mellitus: A Subanalysis of the REASON (Randomized Evaluation of Anagliptin versus Sitagliptin on Low-Density

scientific article published on 30 December 2019

Effect of Empagliflozin on Endothelial Function in Patients With Type 2 Diabetes and Cardiovascular Disease: Results from the Multicenter, Randomized, Placebo-Controlled, Double-Blind EMBLEM Trial

scientific article published on 18 September 2019

Effect of combination tablets containing amlodipine 10 mg and irbesartan 100 mg on blood pressure and cardiovascular risk factors in patients with hypertension

scientific article

Effect of ghrelin on autonomic activity in healthy volunteers.

scientific article published on 29 September 2014

Effect of sodium channel blocker, pilsicainide hydrochloride, on net inward current of atrial myocytes in thyroid hormone toxicosis rats

scientific article published in July 2005

Effective prediction of response to cardiac resynchronization therapy using a novel program of gated myocardial perfusion single photon emission computed tomography

scientific article published on 25 August 2011

Effects of Docosahexaenoic Acid on the Endothelial Function in Patients with Coronary Artery Disease

scientific article published on 24 October 2014

Effects of the brown rice diet on visceral obesity and endothelial function: the BRAVO study

scientific article published on 12 August 2013

Eicosapentaenoic Acid supplementation changes Fatty Acid composition and corrects endothelial dysfunction in hyperlipidemic patients

scientific article published on 26 December 2012

Electrophysiologic characteristics of atrial myocytes in levo-thyroxine-treated rats

scientific article

Elevated Concentration of Interferon-Inducible Protein of 10 kD (IP-10) Is Associated With Coronary Atherosclerosis

scientific article published on 23 April 2015

Epicardial adipose tissue volume and adipocytokine imbalance are strongly linked to human coronary atherosclerosis

scientific article published on 7 March 2013

Exendin-4, a glucagon-like peptide-1 receptor agonist, attenuates neointimal hyperplasia after vascular injury

scientific article published on 7 December 2012

Expression of NLRP3 in subcutaneous adipose tissue is associated with coronary atherosclerosis

scientific article published on 29 July 2015

Factors Associated with Risk of Diabetic Complications in Novel Cluster-Based Diabetes Subgroups: A Japanese Retrospective Cohort Study

scientific article published on 02 July 2020

Fast eating is a strong risk factor for new-onset diabetes among the Japanese general population.

scientific article published on 3 June 2019

Gender disparities in the association between epicardial adipose tissue volume and coronary atherosclerosis: a 3-dimensional cardiac computed tomography imaging study in Japanese subjects

scientific article

Gender-linked impact of epicardial adipose tissue volume in patients who underwent coronary artery bypass graft surgery or non-coronary valve surgery

scientific article

Ghrelin protects the heart against ischemia-induced arrhythmias by preserving connexin-43 protein

scientific article published on 15 March 2013

Glycemic Control with Ipragliflozin, a Novel Selective SGLT2 Inhibitor, Ameliorated Endothelial Dysfunction in Streptozotocin-Induced Diabetic Mouse

scientific article published on 26 October 2016

HMGB1 plays a critical role in vascular inflammation and lesion formation via toll-like receptor 9.

scientific article published on 2 October 2013

Histopathological heterogeneity of in-stent restenosis in four coronary endarterectomy specimens.

scientific article

Identification of three new mutations of the HNF-1 alpha gene in Japanese MODY families

scientific article

Impact of individual metabolic risk components or its clustering on endothelial and smooth muscle cell function in men.

scientific article published on 17 May 2016

Impaired Glucose Tolerance, but Not Impaired Fasting Glucose, Underlies Left Ventricular Diastolic Dysfunction ⬇️

scientific article published on February 7, 2011

Increased oxidative stress in obesity and its impact on metabolic syndrome

scientific article (publication date: 15 December 2004)

Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker diabetic fatty rats

scientific article published on August 1997

Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity

scientific article

Longitudinal Trends in Blood Pressure Associated with The Changes in Living Environment Caused by the Great East Japan Earthquake: The Fukushima Health Management Survey

scientific article published in 2023

Low fasting plasma glucose level as a predictor of new-onset diabetes mellitus on a large cohort from a Japanese general population

scientific article published in Scientific Reports

MicroRNA-378 regulates adiponectin expression in adipose tissue: a new plausible mechanism

scientific article

Miglitol, α-glycosidase inhibitor, reduces visceral fat accumulation and cardiovascular risk factors in subjects with the metabolic syndrome: a randomized comparable study

scientific article published on 20 June 2012

New risk prediction model of coronary heart disease in participants with and without diabetes: Assessments of the Framingham risk and Suita scores in 3-year longitudinal database in a Japanese population

scientific article published on 26 February 2019

Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance

scientific article published on 25 March 2016

Pentraxin 3 is a local inflammatory marker in atrial fibrillation

scientific article published on 27 August 2013

Perivascular adipose tissue-secreted angiopoietin-like protein 2 (Angptl2) accelerates neointimal hyperplasia after endovascular injury

scientific article published on 16 January 2013

Plasma microRNA-100 is associated with coronary plaque vulnerability.

scientific article published on 17 December 2014

Predictive Factors for Efficacy of Dipeptidyl Peptidase-4 Inhibitors in Patients with Type 2 Diabetes Mellitus.

scientific article

Protective effects of selective mineralocorticoid receptor antagonist against aortic aneurysm progression in a novel murine model

scientific article published on 23 May 2013

Randomized Evaluation of Anagliptin vs Sitagliptin On low-density lipoproteiN cholesterol in diabetes (REASON) Trial: A 52-week, open-label, randomized clinical trial.

scientific article published on 12 June 2019

Rationale and design of a multicenter placebo-controlled double-blind randomized trial to evaluate the effect of empagliflozin on endothelial function: the EMBLEM trial

scientific article

Rationale and design of a multicenter randomized controlled study to evaluate the preventive effect of ipragliflozin on carotid atherosclerosis: the PROTECT study.

scientific article published on 13 September 2016

Reduced ratio of eicosapentaenoic acid and docosahexaenoic acid to arachidonic acid is associated with early onset of acute coronary syndrome

scientific article

Relationship between local production of microRNA-328 and atrial substrate remodeling in atrial fibrillation

article

Resistance to adenovirally induced hyperleptinemia in rats. Comparison of ventromedial hypothalamic lesions and mutated leptin receptors ⬇️

scientific article published on August 15, 1998

Rivaroxaban, a novel oral anticoagulant, attenuates atherosclerotic plaque progression and destabilization in ApoE-deficient mice.

scientific article

Rivaroxaban, a specific FXa inhibitor, improved endothelium-dependent relaxation of aortic segments in diabetic mice

scientific article published on 01 August 2019

Role of macrophage-derived hypoxia-inducible factor (HIF)-1α as a mediator of vascular remodelling

scientific article published on 10 June 2013

Role of nitric oxide in obesity-induced beta cell disease ⬇️

scientific article published on July 15, 1997

Serum concentration of eicosapentaenoic acid is associated with cognitive function in patients with coronary artery disease

scientific article

Subclinical Carotid Atherosclerosis Burden in the Japanese: Comparison between Okinawa and Nagano Residents

scientific article

Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice

scientific article

Teneligliptin, a dipeptidyl peptidase-4 inhibitor, attenuated pro-inflammatory phenotype of perivascular adipose tissue and inhibited atherogenesis in normoglycemic apolipoprotein-E-deficient mice

scientific article published on 24 March 2017

The pathophysiological role of oxidized cholesterols in epicardial fat accumulation and cardiac dysfunction: a study in swine fed a high caloric diet with an inhibitor of intestinal cholesterol absorption, ezetimibe

scientific article published on 31 May 2016

The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation.

scientific article published on 6 March 2012

Walking Speed is the Sole Determinant Criterion of Sarcopenia of Mild Cognitive Impairment in Japanese Elderly Patients with Type 2 Diabetes Mellitus

scientific article published on 06 July 2020

Women with type 2 diabetes and coronary artery disease have a higher risk of heart failure than men, with a significant gender interaction between heart failure risk and risk factor management: a retrospective registry study

scientific article published in 2022

γ-Oryzanol protects pancreatic β-cells against endoplasmic reticulum stress in male mice.

scientific article

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