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List of works by Francesca Fallarino

3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine

scientific article published on 21 July 2021

A GpC-Rich Oligonucleotide Acts on Plasmacytoid Dendritic Cells To Promote Immune Suppression

scientific article published on 27 July 2012

A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells

scientific article published on 13 February 2017

A crucial role for tryptophan catabolism at the host/Candida albicans interface.

scientific article

A defect in tryptophan catabolism impairs tolerance in nonobese diabetic mice

scientific article

Accumulation of an endogenous tryptophan-derived metabolite in colorectal and breast cancers

scientific article published on 16 April 2015

AhR-Mediated, Non-Genomic Modulation of IDO1 Function

scientific article

AhR: far more than an environmental sensor

scientific article published in January 2014

Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells

scientific article

Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration

scientific article published in Nature Communications

Antigen-specific regression of established tumors induced by active immunization with irradiated IL-12- but not B7-1-transfected tumor cells ⬇️

scientific article published on September 1, 1997

Aryl Hydrocarbon Receptor-Dependent Pathways in Immune Regulation.

scientific article

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

scientific article

Azithromycin protects mice against ischemic stroke injury by promoting macrophage transition towards M2 phenotype

scientific article published on 27 October 2015

B7-1 Engagement of Cytotoxic T Lymphocyte Antigen 4 Inhibits T Cell Activation in the Absence of CD28 ⬇️

scientific article published on July 6, 1998

BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

scientific journal article

Balancing inflammation and tolerance in vivo through dendritic cells by the commensal Candida albicans

scientific article published on 6 May 2009

Bioactive long-term release from biodegradable microspheres preserves implanted ALG-PLO-ALG microcapsules from in vivo response to purified alginate

scientific article published on 31 December 2009

CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86.

scientific article published on 3 October 2004

CD40 ligation prevents onset of tolerogenic properties in human dendritic cells treated with CTLA-4-Ig.

scientific article published in June 2005

CD8+ cell activation to a major mastocytoma rejection antigen, P815AB: requirement for tum− or helper peptides in priming for skin test reactivity to a P815AB‐related peptide ⬇️

scientific article published on 01 October 1995

CTLA-4-Ig regulates tryptophan catabolism in vivo.

scientific article published on 30 September 2002

Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice.

scientific article published on 21 February 2014

Comparative proteomic analysis of two distinct stem-cell populations from human amniotic fluid

scientific article published on 26 March 2015

CpG Type A Induction of an Early Protective Environment in Experimental Multiple Sclerosis.

scientific article published on 05 March 2017

Cytokines in systemic juvenile idiopathic arthritis and haemophagocytic lymphohistiocytosis: tipping the balance between interleukin-18 and interferon-γ

scientific article published on 12 March 2015

Cytotoxic T lymphocyte antigen 4-immunoglobulin G is a potent adjuvant for experimental allergen immunotherapy

scientific article published on 01 April 2013

Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease.

scientific article

Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes.

scientific article published on 22 March 2018

Delineating the Role of Toll-Like Receptors in the Neuro-inflammation Model EAE.

scientific article published in January 2016

Distinct and complementary roles for Aspergillus fumigatus-specific Tr1 and Foxp3+ regulatory T cells in humans and mice

scientific article

Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1.

scientific article published on 30 September 2016

Effects of a nutraceutical combination on lipids, inflammation and endothelial integrity in patients with subclinical inflammation: a randomized clinical trial

scientific article published on 23 March 2016

Effects of intraperitoneal injection of microencapsulated Sertoli cells on chronic and presymptomatic dystrophic mice

scientific article

Enhanced tryptophan catabolism in the absence of the molecular adapter DAP12.

scientific article

Forced IDO1 expression in dendritic cells restores immunoregulatory signalling in autoimmune diabetes

scientific article

Functional yet balanced reactivity to Candida albicans requires TRIF, MyD88, and IDO-dependent inhibition of Rorc.

scientific article published in November 2007

Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor

scientific article published on 20 March 2020

Generation of T cell regulatory activity by plasmacytoid dendritic cells and tryptophan catabolism.

scientific article published on 18 September 2007

Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction.

scientific article published in May 2010

High doses of CpG oligodeoxynucleotides stimulate a tolerogenic TLR9-TRIF pathway.

scientific article published in January 2013

IDO mediates TLR9-driven protection from experimental autoimmune diabetes.

scientific article published on 19 October 2009

IDO1 Deficiency Does Not Affect Disease in Mouse Models of Systemic Juvenile Idiopathic Arthritis and Secondary Hemophagocytic Lymphohistiocytosis.

scientific article

IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII.

scientific article published on 31 August 2015

IL-17 and therapeutic kynurenines in pathogenic inflammation to fungi

scientific article published on April 2008

IL-22 defines a novel immune pathway of antifungal resistance.

scientific article published on 5 May 2010

Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism

scientific article published in February 2006

Immunosuppression via tryptophan catabolism: the role of kynurenine pathway enzymes

scientific article published on 01 July 2007

Improved efficacy of dendritic cell vaccines and successful immunization with tumor antigen peptide-pulsed peripheral blood mononuclear cells by coadministration of recombinant murine interleukin-12

scientific article published on 01 January 1999

In vitro cadmium effects on ECM gene expression in human bronchial epithelial cells.

scientific article published on 23 December 2014

Increased GILZ expression in transgenic mice up-regulates Th-2 lymphokines

scientific article published on 4 October 2005

Indoleamine 2,3-dioxygenase (IDO) in inflammation and allergy to Aspergillus

scientific article published on 04 June 2008

Indoleamine 2,3-dioxygenase 1 (IDO1) is up-regulated in thyroid carcinoma and drives the development of an immunosuppressant tumor microenvironment.

scientific article published on 11 February 2014

Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host

scientific article published on 25 October 2008

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

scientific journal article

Indoleamine 2,3‐dioxygenase: From catalyst to signaling function ⬇️

scientific article published on August 1, 2012

Interaction of 7-Alkoxycoumarins with the Aryl Hydrocarbon Receptor.

scientific article published on 19 May 2017

Intranasally delivered siRNA targeting PI3K/Akt/mTOR inflammatory pathways protects from aspergillosis.

scientific article published on 18 November 2009

Intraperitoneal injection of microencapsulated Sertoli cells restores muscle morphology and performance in dystrophic mice

scientific article published on 23 October 2015

Jack of all trades: thymosin α1 and its pleiotropy

scientific article published on October 2012

LPS-conditioned dendritic cells confer endotoxin tolerance contingent on tryptophan catabolism

scientific article published on 28 September 2014

Ligand and cytokine dependence of the immunosuppressive pathway of tryptophan catabolism in plasmacytoid dendritic cells.

scientific article published on 19 September 2005

Ligand binding and functional selectivity of L-tryptophan metabolites at the mouse aryl hydrocarbon receptor (mAhR).

scientific article published on 21 November 2014

Long-term stability, functional competence, and safety of microencapsulated specific pathogen-free neonatal porcine Sertoli cells: a potential product for cell transplant therapy

scientific article published on 2 July 2015

Melanoma presenting as circulating tumor cells associated with failed angiogenesis

scientific article

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation.

scientific article published on 25 July 2010

Modulation of tryptophan catabolism by regulatory T cells.

scientific article published on 26 October 2003

NEDD4 controls the expression of GUCD1, a protein upregulated in proliferating liver cells

scientific article

On-treatment C-reactive protein and HDL cholesterol levels in patients at intermediate cardiovascular risk: impact on carotid intima-media thickness

scientific article published on 19 July 2013

PCSK9 at the crossroad of cholesterol metabolism and immune function during infections

scientific article published on 7 January 2017

Prolongation of skin allograft survival in rats by the transplantation of microencapsulated xenogeneic neonatal porcine Sertoli cells.

scientific article published on 3 May 2012

Proteasomal Degradation of Indoleamine 2,3-Dioxygenase in CD8+ Dendritic Cells is Mediated by Suppressor of Cytokine Signaling 3 (SOCS3) ⬇️

scientific article published on June 10, 2010

Receptors and pathways in innate antifungal immunity: the implication for tolerance and immunity to fungi.

scientific article published on January 2007

Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy

scientific article published on 08 April 2007

Signal Transducer and Activator of Transcription 1 Plays a Pivotal Role in RET/PTC3 Oncogene-induced Expression of Indoleamine 2,3-Dioxygenase 1.

scientific article published on 19 December 2016

Stem cells from human amniotic fluid exert immunoregulatory function via secreted indoleamine 2,3-dioxygenase1.

scientific article published on 17 March 2015

T cell apoptosis by tryptophan catabolism

scientific article published in October 2002

TLR3 essentially promotes protective class I-restricted memory CD8⁺ T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients

scientific article published on 6 December 2011

TLRs govern neutrophil activity in aspergillosis

scientific article published in December 2004

Targeting Aryl hydrocarbon receptor for next-generation immunotherapies: Selective modulators (SAhRMs) versus rapidly metabolized ligands (RMAhRLs)

scientific article published on 02 November 2019

Targeting metabotropic glutamate receptors in neuroimmune communication ⬇️

scientific article published on May 26, 2012

Th17/Treg imbalance in murine cystic fibrosis is linked to indoleamine 2,3-dioxygenase deficiency but corrected by kynurenines.

scientific article

The 2004 FASEB Summer Research Conference on Transplant Immunology: closer to the goal of transplant-specific tolerance

scientific article published in January 2005

The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen-Activated Protein Kinase Inhibitors.

scientific article published on 14 January 2015

The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells

scientific article published on 01 June 2006

Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone.

scientific article

Thymosin 1 activates dendritic cell tryptophan catabolism and establishes a regulatory environment for balance of inflammation and tolerance

scientific article published on 01 June 2006

Thymosin alpha1: the regulator of regulators?

scientific article published on April 2010

Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis

scientific article

Tolerance, DCs and tryptophan: much ado about IDO

scientific article (publication date: May 2003)

Toll-like receptor 9-mediated induction of the immunosuppressive pathway of tryptophan catabolism.

scientific article

Toll-like receptors as novel therapeutic targets for herpes simplex virus infection

scientific article published on 02 July 2019

Topical application of soluble CD83 induces IDO-mediated immune modulation, increases Foxp3+ T cells, and prolongs allogeneic corneal graft survival

scientific article published on 12 July 2013

Toward the identification of a tolerogenic signature in IDO-competent dendritic cells.

scientific article published on 8 December 2005

Tryptophan Feeding of the IDO1-AhR Axis in Host-Microbial Symbiosis

scientific article published on 15 December 2014

Tryptophan catabolism generates autoimmune-preventive regulatory T cells

scientific article published on 10 October 2006

Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22.

scientific article published in August 2013

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

scientific article published on 01 May 2019

Xenograft of microencapsulated Sertoli cells restores glucose homeostasis in db/db mice with spontaneous diabetes mellitus

scientific article published on 27 September 2016

Xenograft of microencapsulated sertoli cells reverses T1DM in NOD mice by inducing neogenesis of beta-cells

scientific article published on December 2010

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