List of works - Giuseppe Manfroni

1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity

scientific article published on 05 March 2020

1,4-Benzothiazine ATP-sensitive potassium channel openers: modifications at the C-2 and C-6 positions

scientific article published on 28 May 2013

2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction

scientific article published on 17 August 2018

A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Subunits

scientific article published on 20 April 2015

A Comprehensive Structural Overview of p38α MAPK in Complex with Type I Inhibitors

scientific article published on 09 April 2015

A Comprehensive Structural Overview of p38α Mitogen-Activated Protein Kinase in Complex with ATP-Site and Non-ATP-Site Binders

scientific article published on 6 December 2017

A cellular screening platform, stably expressing DENV2 NS5, defines a novel anti-DENV mechanism of action of Apigenin based on STAT2 activation

scientific article published in June 2023

Accounting for target flexibility and water molecules by docking to ensembles of target structures: the HCV NS5B palm site I inhibitors case study.

scientific article

Allosteric inhibition of the hepatitis C virus NS5B polymerase: in silico strategies for drug discovery and development

scientific article published on June 2011

C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors

scientific article published on 01 December 2020

Computer-aided design, synthesis and validation of 2-phenylquinazolinone fragments as CDK9 inhibitors with anti-HIV-1 Tat-mediated transcription activity.

scientific article published on 21 October 2013

Discovery of Novel Inhibitors of the NorA Multidrug Transporter ofStaphylococcus aureus

Discovery of the 2-phenyl-4,5,6,7-Tetrahydro-1H-indole as a novel anti-hepatitis C virus targeting scaffold

scientific article

Enantioresolution, stereochemical characterization and biological activity of a chiral large-conductance calcium-activated potassium channel opener

Ethyl 1,8-naphthyridone-3-carboxylates downregulate human papillomavirus-16 E6 and E7 oncogene expression.

scientific article

Evolution from a Natural Flavones Nucleus to Obtain 2-(4-Propoxyphenyl)quinoline Derivatives As Potent Inhibitors of theS. aureusNorA Efflux Pump

scientific article published on 03 August 2011

Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands.

scientific article published on 22 July 2014

From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors

article

Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase

scientific article published on 11 November 2017

Inhibition of subgenomic hepatitis C virus RNA replication by acridone derivatives: identification of an NS3 helicase inhibitor

scientific article published on May 2009

Lipid nanoparticles for brain targeting III. Long-term stability and in vivo toxicity ⬇️

scientific article published on July 4, 2013

Modifications on C6 and C7 Positions of 3-Phenylquinolone Efflux Pump Inhibitors Led to Potent and Safe Antimycobacterial Treatment Adjuvants

scientific article published on 04 April 2019

Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium

scientific article

New pyrazolobenzothiazine derivatives as hepatitis C virus NS5B polymerase palm site I inhibitors

scientific article

Novel 1,4-benzothiazine derivatives as large conductance Ca2+-activated potassium channel openers

scientific article

Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors

scientific article

Pyrazolo[4,3-c][1,2]benzothiazines 5,5-dioxide: a promising new class of Staphylococcus aureus NorA efflux pump inhibitors.

scientific article

Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase

scientific article

Re-evolution of the 2-phenylquinolines: ligand-based design, synthesis, and biological evaluation of a potent new class of Staphylococcus aureus NorA efflux pump inhibitors to combat antimicrobial resistance

scientific article published on 13 June 2013

Searching for Novel Inhibitors of the S. aureus NorA Efflux Pump: Synthesis and Biological Evaluation of the 3-Phenyl-1,4-benzothiazine Analogues

scientific article published on 9 June 2017

Structural investigation of cycloheptathiophene-3-carboxamide derivatives targeting influenza virus polymerase assembly

scientific article published on 13 December 2013

Structural investigation of the naphthyridone scaffold: identification of a 1,6-naphthyridone derivative with potent and selective anti-HIV activity

scientific article published on 12 May 2011

Structure modifications of 6-aminoquinolones with potent anti-HIV activity

scientific article

Structure-activity relationship study on anti-HIV 6-desfluoroquinolones

scientific article published on 19 August 2008

Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication

scientific article

Studies of anti-HIV transcription inhibitor quinolones: identification of potent N1-vinyl derivatives

scientific article published on November 2010

Studies on 2-phenylquinoline Staphylococcus aureus NorA efflux pump inhibitors: New insights on the C-6 position

Studies on anti-HIV quinolones: New insights on the C-6 position

article

Synthesis and anti-BVDV activity of acridones as new potential antiviral agents

scientific article published in April 2006

Synthesis and biological evaluation of 2-phenylquinolones targeted at Tat/TAR recognition.

scientific article

Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor

scientific article

The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen-Activated Protein Kinase Inhibitors.

scientific article published on 14 January 2015

The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors

scientific article

List of works by Giuseppe Manfroni

1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity

1,4-Benzothiazine ATP-sensitive potassium channel openers: modifications at the C-2 and C-6 positions

2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction

A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Subunits

A Comprehensive Structural Overview of p38α MAPK in Complex with Type I Inhibitors

A Comprehensive Structural Overview of p38α Mitogen-Activated Protein Kinase in Complex with ATP-Site and Non-ATP-Site Binders

A cellular screening platform, stably expressing DENV2 NS5, defines a novel anti-DENV mechanism of action of Apigenin based on STAT2 activation

Accounting for target flexibility and water molecules by docking to ensembles of target structures: the HCV NS5B palm site I inhibitors case study.

Allosteric inhibition of the hepatitis C virus NS5B polymerase: in silico strategies for drug discovery and development

C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors

Computer-aided design, synthesis and validation of 2-phenylquinazolinone fragments as CDK9 inhibitors with anti-HIV-1 Tat-mediated transcription activity.

Discovery of Novel Inhibitors of the NorA Multidrug Transporter ofStaphylococcus aureus

Discovery of the 2-phenyl-4,5,6,7-Tetrahydro-1H-indole as a novel anti-hepatitis C virus targeting scaffold

Enantioresolution, stereochemical characterization and biological activity of a chiral large-conductance calcium-activated potassium channel opener

Ethyl 1,8-naphthyridone-3-carboxylates downregulate human papillomavirus-16 E6 and E7 oncogene expression.

Evolution from a Natural Flavones Nucleus to Obtain 2-(4-Propoxyphenyl)quinoline Derivatives As Potent Inhibitors of theS. aureusNorA Efflux Pump

Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands.

From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors

Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase

Inhibition of subgenomic hepatitis C virus RNA replication by acridone derivatives: identification of an NS3 helicase inhibitor

Lipid nanoparticles for brain targeting III. Long-term stability and in vivo toxicity ⬇️

Modifications on C6 and C7 Positions of 3-Phenylquinolone Efflux Pump Inhibitors Led to Potent and Safe Antimycobacterial Treatment Adjuvants

Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium

New pyrazolobenzothiazine derivatives as hepatitis C virus NS5B polymerase palm site I inhibitors

Novel 1,4-benzothiazine derivatives as large conductance Ca2+-activated potassium channel openers

Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors

Pyrazolo[4,3-c][1,2]benzothiazines 5,5-dioxide: a promising new class of Staphylococcus aureus NorA efflux pump inhibitors.

Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase

Re-evolution of the 2-phenylquinolines: ligand-based design, synthesis, and biological evaluation of a potent new class of Staphylococcus aureus NorA efflux pump inhibitors to combat antimicrobial resistance

Searching for Novel Inhibitors of the S. aureus NorA Efflux Pump: Synthesis and Biological Evaluation of the 3-Phenyl-1,4-benzothiazine Analogues

Structural investigation of cycloheptathiophene-3-carboxamide derivatives targeting influenza virus polymerase assembly

Structural investigation of the naphthyridone scaffold: identification of a 1,6-naphthyridone derivative with potent and selective anti-HIV activity

Structure modifications of 6-aminoquinolones with potent anti-HIV activity

Structure-activity relationship study on anti-HIV 6-desfluoroquinolones

Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication

Studies of anti-HIV transcription inhibitor quinolones: identification of potent N1-vinyl derivatives

Studies on 2-phenylquinoline Staphylococcus aureus NorA efflux pump inhibitors: New insights on the C-6 position

Studies on anti-HIV quinolones: New insights on the C-6 position

Synthesis and anti-BVDV activity of acridones as new potential antiviral agents

Synthesis and biological evaluation of 2-phenylquinolones targeted at Tat/TAR recognition.

Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor

The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen-Activated Protein Kinase Inhibitors.

The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors