List of works - Guillaume T Charras

A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells

scientific article (publication date: 2016)

A microstructural finite element simulation of mechanically induced bone formation

scientific article published on 01 December 2001

A phenomenological density-scaling approach to lamellipodial actin dynamics(†).

scientific article

A question of time: tissue adaptation to mechanical forces

scientific article published on 2 March 2016

A short history of blebbing

scientific article

A unified rheological model for cells and cellularised materials

scientific article published on 22 January 2020

Actin cortex architecture regulates cell surface tension.

scientific article published on 22 May 2017

Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers

scientific article published on July 2008

Actin kinetics shapes cortical network structure and mechanics.

scientific article

Actomyosin controls planarity and folding of epithelia in response to compression

scientific article published on 26 August 2019

An open access microfluidic device for the study of the physical limits of cancer cell deformation during migration in confined environments

scientific article

Analysis of ligand-receptor interactions in cells by atomic force microscopy

scientific article published in February 2002

Analysis of turnover dynamics of the submembranous actin cortex

scientific article

Atomic force microscopy can be used to mechanically stimulate osteoblasts and evaluate cellular strain distributions

scientific article published on 01 January 2001

Biological physics: Liquid crystals in living tissue

scientific article

Blebs lead the way: how to migrate without lamellipodia

scientific article

Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts

scientific article

Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging.

scientific article published on 17 October 2013

Cell mechanics: Hydraulic cracking

scientific article published in March 2015

Cellular control of cortical actin nucleation

scientific article

Characterizing the mechanics of cultured cell monolayers

scientific article

Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning.

scientific article published on 25 May 2016

Cortical cell stiffness is independent of substrate mechanics

scientific article published on 25 May 2020

Curling of epithelial monolayers reveals coupling between active bending and tissue tension

scientific article published on 13 April 2020

Death-associated protein kinase (DAPK) and signal transduction: blebbing in programmed cell death.

scientific article published on 30 October 2009

Directional memory arises from long-lived cytoskeletal asymmetries in polarized chemotactic cells

scientific article published on 13 January 2016

Disease-associated missense mutations in the EVH1 domain disrupt intrinsic WASp function causing dysregulated actin dynamics and impaired dendritic cell migration

scientific article

Dissecting protein reaction dynamics in living cells by fluorescence recovery after photobleaching.

scientific article published on 2 April 2015

Emergence of homeostatic epithelial packing and stress dissipation through divisions oriented along the long cell axis.

scientific article

Epithelial repair is a two-stage process driven first by dying cells and then by their neighbours.

scientific article published on 24 January 2014

Excess F-actin mechanically impedes mitosis leading to cytokinesis failure in X-linked neutropenia by exceeding Aurora B kinase error correction capacity

scientific article published on 12 September 2012

Experimental validation of atomic force microscopy-based cell elasticity measurements

scientific article

Fascin Regulates Nuclear Movement and Deformation in Migrating Cells

scientific article published on August 2016

Force transmission during adhesion-independent migration.

scientific article

Fractional viscoelastic models for power-law materials

scientific article published on 01 July 2020

Generating suspended cell monolayers for mechanobiological studies

scientific article published on 21 November 2013

Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

scientific article

Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1.

scientific article

Implications of a poroelastic cytoplasm for the dynamics of animal cell shape

scientific article published on 07 February 2008

Improving the local solution accuracy of large-scale digital image-based finite element analyses

scientific article published on February 2000

In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity

scientific article

Interaction with surrounding normal epithelial cells influences signalling pathways and behaviour of Src-transformed cells

scientific article

L-selectin regulates human neutrophil transendothelial migration

scientific article published on 06 January 2021

L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro

scientific article

Learning biophysical determinants of cell fate with deep neural networks

scientific article published in 2022

Life and times of a cellular bleb

scientific article

Local cellular neighborhood controls proliferation in cell competition.

scientific article

Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells.

scientific article published on 13 November 2017

Mechanisms of leading edge protrusion in interstitial migration.

scientific article

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.

scientific article published on 26 May 2013

Nanoscale stiffness topography reveals structure and mechanics of the transport barrier in intact nuclear pore complexes.

scientific article published on 24 November 2014

New technologies in scanning probe microscopy for studying molecular interactions in cells ⬇️

scientific article published on March 8, 2000

Non-equilibration of hydrostatic pressure in blebbing cells.

scientific article

Optogenetic control of cellular forces and mechanotransduction.

scientific article

PP1-mediated moesin dephosphorylation couples polar relaxation to mitotic exit.

scientific article published on 29 December 2011

Physical influences of the extracellular environment on cell migration

scientific article

Polar stimulation and constrained cell migration in microfluidic channels

scientific article

Quantitative analysis of ezrin turnover dynamics in the actin cortex.

scientific article published on January 2014

Regulation and integrated functions of the actin cytoskeleton

scientific article published on March 2016

SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization

scientific article published on 22 June 2020

Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor

scientific article (publication date: March 2005)

Self-organizing actin patterns shape membrane architecture but not cell mechanics

scientific article

Single cell mechanotransduction and its modulation analyzed by atomic force microscope indentation.

scientific article

Spatiotemporal control of gene expression using microfluidics.

scientific article published in April 2014

Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion

scientific article (publication date: 2012)

Substrate area confinement is a key determinant of cell velocity in collective migration

The cytoplasm of living cells behaves as a poroelastic material

scientific article published on 6 January 2013

The dynamic mechanical properties of cellularised aggregates.

scientific article

The natural product cucurbitacin E inhibits depolymerization of actin filaments

scientific article published on 9 July 2012

The toxoplasma-host cell junction is anchored to the cell cortex to sustain parasite invasive force

scientific article

Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo.

scientific article published on 14 February 2018

WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts.

scientific article

List of works by Guillaume T Charras

A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells

A microstructural finite element simulation of mechanically induced bone formation

A phenomenological density-scaling approach to lamellipodial actin dynamics(†).

A question of time: tissue adaptation to mechanical forces

A short history of blebbing

A unified rheological model for cells and cellularised materials

Actin cortex architecture regulates cell surface tension.

Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers

Actin kinetics shapes cortical network structure and mechanics.

Actomyosin controls planarity and folding of epithelia in response to compression

An open access microfluidic device for the study of the physical limits of cancer cell deformation during migration in confined environments

Analysis of ligand-receptor interactions in cells by atomic force microscopy

Analysis of turnover dynamics of the submembranous actin cortex

Atomic force microscopy can be used to mechanically stimulate osteoblasts and evaluate cellular strain distributions

Biological physics: Liquid crystals in living tissue

Blebs lead the way: how to migrate without lamellipodia

Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts

Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging.

Cell mechanics: Hydraulic cracking

Cellular control of cortical actin nucleation

Characterizing the mechanics of cultured cell monolayers

Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning.

Cortical cell stiffness is independent of substrate mechanics

Curling of epithelial monolayers reveals coupling between active bending and tissue tension

Death-associated protein kinase (DAPK) and signal transduction: blebbing in programmed cell death.

Directional memory arises from long-lived cytoskeletal asymmetries in polarized chemotactic cells

Disease-associated missense mutations in the EVH1 domain disrupt intrinsic WASp function causing dysregulated actin dynamics and impaired dendritic cell migration

Dissecting protein reaction dynamics in living cells by fluorescence recovery after photobleaching.

Emergence of homeostatic epithelial packing and stress dissipation through divisions oriented along the long cell axis.

Epithelial repair is a two-stage process driven first by dying cells and then by their neighbours.

Excess F-actin mechanically impedes mitosis leading to cytokinesis failure in X-linked neutropenia by exceeding Aurora B kinase error correction capacity

Experimental validation of atomic force microscopy-based cell elasticity measurements

Fascin Regulates Nuclear Movement and Deformation in Migrating Cells

Force transmission during adhesion-independent migration.

Fractional viscoelastic models for power-law materials

Generating suspended cell monolayers for mechanobiological studies

Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1.

Implications of a poroelastic cytoplasm for the dynamics of animal cell shape

Improving the local solution accuracy of large-scale digital image-based finite element analyses

In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity

Interaction with surrounding normal epithelial cells influences signalling pathways and behaviour of Src-transformed cells

L-selectin regulates human neutrophil transendothelial migration

L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro

Learning biophysical determinants of cell fate with deep neural networks

Life and times of a cellular bleb

Local cellular neighborhood controls proliferation in cell competition.

Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells.

Mechanisms of leading edge protrusion in interstitial migration.

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.

Nanoscale stiffness topography reveals structure and mechanics of the transport barrier in intact nuclear pore complexes.

New technologies in scanning probe microscopy for studying molecular interactions in cells ⬇️

Non-equilibration of hydrostatic pressure in blebbing cells.

Optogenetic control of cellular forces and mechanotransduction.

PP1-mediated moesin dephosphorylation couples polar relaxation to mitotic exit.

Physical influences of the extracellular environment on cell migration

Polar stimulation and constrained cell migration in microfluidic channels

Quantitative analysis of ezrin turnover dynamics in the actin cortex.

Regulation and integrated functions of the actin cytoskeleton

SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization

Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor

Self-organizing actin patterns shape membrane architecture but not cell mechanics

Single cell mechanotransduction and its modulation analyzed by atomic force microscope indentation.

Spatiotemporal control of gene expression using microfluidics.

Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion

Substrate area confinement is a key determinant of cell velocity in collective migration

The cytoplasm of living cells behaves as a poroelastic material

The dynamic mechanical properties of cellularised aggregates.

The natural product cucurbitacin E inhibits depolymerization of actin filaments

The toxoplasma-host cell junction is anchored to the cell cortex to sustain parasite invasive force

Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo.

WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts.