List of works - Annamaria Biroccio

156 DNA damage induced by camptothecins is stabilized by G-quadruplex ligands

A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds

scientific article

A bimodal fluorescent and photocytotoxic naphthalene diimide for theranostic applications

scientific article published on 7 July 2016

A novel pathway links telomeres to NK-cell activity: Implications for immunotherapy

scientific article published on January 2014

AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance

scientific article published on 25 June 2015

Alpha-tocopherol protects against cisplatin-induced toxicity without interfering with antitumor efficacy.

scientific article

Anacardic acid and thyroid hormone enhance cardiomyocytes production from undifferentiated mouse ES cells along functionally distinct pathways

scientific article

Antiproliferative effect of Aurora kinase targeting in mesothelioma

scientific article published on 3 April 2010

Antisense clusterin oligodeoxynucleotides increase the response ofHER-2 gene amplified breast cancer cells to Trastuzumab

article

Aromatase inhibitor exemestane has antiproliferative effects on human mesothelioma cells

scientific article published on March 2011

Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells

scientific article

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

scientific article published on 20 July 2017

Bcl-2 has differing effects on the sensitivity of breast cancer cells depending on the antineoplastic drug used.

scientific article published on December 2002

Bcl-2 overexpression decreases BCNU sensitivity of a human glioblastoma line through enhancement of catalase activity.

scientific article

Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis

scholarly article

Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration

scientific article

Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2

scientific article published on 18 April 2019

Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter

scientific article

Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance

scientific article published on 24 May 2019

DNA Damage Persistence as Determinant of Tumor Sensitivity to the Combination of Topo I Inhibitors and Telomere-Targeting Agents

scientific article published on 25 February 2011

Design and synthesis of a new dimeric xanthone derivative: enhancement of G-quadruplex selectivity and telomere damage

scientific article

Diagnosis and treatment of ALT tumors: is Trabectedin a new therapeutic option?

scientific article published on 22 December 2017

Dyads of G-Quadruplex Ligands Triggering DNA Damage Response and Tumour Cell Growth Inhibition at Subnanomolar Concentration

scientific article published on 01 August 2019

EMICORON: A multi-targeting G4 ligand with a promising preclinical profile

scientific article

Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft

scientific article

Encapsulation of c-myc antisense oligodeoxynucleotides in lipid particles improves antitumoral efficacy in vivo in a human melanoma line

scientific article published on 01 June 2001

Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: requirement for Akt activation

scientific article published in March 2002

Erratum: identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

scientific article published on 5 February 2015

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis

scientific article published on 11 December 2013

Evidence for G-quadruplex in the promoter of VEGFR-2 and its targeting to inhibit tumor angiogenesis.

scientific article

Exploring the chemical space of G-quadruplex binders: discovery of a novel chemotype targeting the human telomeric sequence

scientific article published on 27 November 2013

G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors.

scientific article

Gamma-glutamylcysteine synthetase mediates the c-Myc-dependent response to antineoplastic agents in melanoma cells

scientific article

Glutathione influences c-Myc-induced apoptosis in M14 human melanoma cells

scientific article published on 10 September 2002

Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

scientific article

Identification of novel interactors of human telomeric G-quadruplex DNA

In vivo administration of liposomal vincristine sensitizes drug-resistant human solid tumors

scientific article published on July 2004

Increase of BCNU sensitivity by wt-p53 gene therapy in glioblastoma lines depends on the administration schedule

scientific article

Inhibition of PARP activity by PJ-34 leads to growth impairment and cell death associated with aberrant mitotic pattern and nucleolar actin accumulation in M14 melanoma cell line.

scientific article

Inhibition of c-Myc oncoprotein limits the growth of human melanoma cells by inducing cellular crisis

scientific article

Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor

scientific article published on January 2003

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance

scientific article published on 27 October 2015

Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment.

scientific article

Looking for efficient G-quadruplex ligands: evidence for selective stabilizing properties and telomere damage by drug-like molecules

scientific article

Methods of studying telomere damage induced by quadruplex-ligand complexes ⬇️

scientific article published on 04 March 2012

N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage

scientific article

Neuroprotective effect of vitamin E supplementation in patients treated with cisplatin chemotherapy.

scientific article

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts

scientific article published on 19 September 2013

PARP1 allows proper telomere replication through TRF1 poly (ADP-ribosyl)ation and helicase recruitment

scientific article published in 2023

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy

scientific article published on 30 August 2010

Patient-derived xenografts: a relevant preclinical model for drug development

scientific article

Perylene and coronene derivatives binding to G-rich promoter oncogene sequences efficiently reduce their expression in cancer cells

scientific article published on 13 April 2016

SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage.

scientific article

Shading the TRF2 Recruiting Function: A New Horizon in Drug Development

article

Shooting for Selective Druglike G-Quadruplex Binders: Evidence for Telomeric DNA Damage and Tumor Cell Death

article

Smad-interacting protein-1 and microRNA 200 family define a nitric oxide-dependent molecular circuitry involved in embryonic stem cell mesendoderm differentiation

scientific article published on 13 January 2011

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

scientific article published on 13 July 2009

TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage

scientific article

TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells

scientific article

TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells

scientific article

Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes.

scientific article

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

scientific article published on 29 December 2015

Targeting G-Quadruplex DNA Structures by EMICORON Has a Strong Antitumor Efficacy against Advanced Models of Human Colon Cancer

scientific article published on 24 August 2015

Telomerase activity, apoptosis and cell cycle progression in ataxia telangiectasia lymphocytes expressing TCL1.

scientific article published on September 2003

Telomerase as a new target for the treatment of hormone-refractory prostate cancer

scientific article published in September 2004

Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect

scientific article

Telomere dysfunction increases cisplatin and ecteinascidin-743 sensitivity of melanoma cells

scientific article published in March 2003

Therapeutic integration of c-myc and bcl-2 antisense molecules with docetaxel in a preclinical model of hormone-refractory prostate cancer

scientific article

ZD1839 (IRESSA), an EGFR-selective tyrosine kinase inhibitor, enhances taxane activity in bcl-2 overexpressing, multidrug-resistant MCF-7 ADR human breast cancer cells

scientific article published in March 2002

c-Myc phosphorylation is required for cellular response to oxidative stress

scientific article published in February 2006

β-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced β-catenin signaling.

scientific article

List of works by Annamaria Biroccio

156 DNA damage induced by camptothecins is stabilized by G-quadruplex ligands

A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds

A bimodal fluorescent and photocytotoxic naphthalene diimide for theranostic applications

A novel pathway links telomeres to NK-cell activity: Implications for immunotherapy

AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance

Alpha-tocopherol protects against cisplatin-induced toxicity without interfering with antitumor efficacy.

Anacardic acid and thyroid hormone enhance cardiomyocytes production from undifferentiated mouse ES cells along functionally distinct pathways

Antiproliferative effect of Aurora kinase targeting in mesothelioma

Antisense clusterin oligodeoxynucleotides increase the response ofHER-2 gene amplified breast cancer cells to Trastuzumab

Aromatase inhibitor exemestane has antiproliferative effects on human mesothelioma cells

Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

Bcl-2 has differing effects on the sensitivity of breast cancer cells depending on the antineoplastic drug used.

Bcl-2 overexpression decreases BCNU sensitivity of a human glioblastoma line through enhancement of catalase activity.

Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis

Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration

Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2

Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter

Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance

DNA Damage Persistence as Determinant of Tumor Sensitivity to the Combination of Topo I Inhibitors and Telomere-Targeting Agents

Design and synthesis of a new dimeric xanthone derivative: enhancement of G-quadruplex selectivity and telomere damage

Diagnosis and treatment of ALT tumors: is Trabectedin a new therapeutic option?

Dyads of G-Quadruplex Ligands Triggering DNA Damage Response and Tumour Cell Growth Inhibition at Subnanomolar Concentration

EMICORON: A multi-targeting G4 ligand with a promising preclinical profile

Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft

Encapsulation of c-myc antisense oligodeoxynucleotides in lipid particles improves antitumoral efficacy in vivo in a human melanoma line

Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: requirement for Akt activation

Erratum: identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis

Evidence for G-quadruplex in the promoter of VEGFR-2 and its targeting to inhibit tumor angiogenesis.

Exploring the chemical space of G-quadruplex binders: discovery of a novel chemotype targeting the human telomeric sequence

G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors.

Gamma-glutamylcysteine synthetase mediates the c-Myc-dependent response to antineoplastic agents in melanoma cells

Glutathione influences c-Myc-induced apoptosis in M14 human melanoma cells

Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

Identification of novel interactors of human telomeric G-quadruplex DNA

In vivo administration of liposomal vincristine sensitizes drug-resistant human solid tumors

Increase of BCNU sensitivity by wt-p53 gene therapy in glioblastoma lines depends on the administration schedule

Inhibition of PARP activity by PJ-34 leads to growth impairment and cell death associated with aberrant mitotic pattern and nucleolar actin accumulation in M14 melanoma cell line.

Inhibition of c-Myc oncoprotein limits the growth of human melanoma cells by inducing cellular crisis

Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance

Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment.

Looking for efficient G-quadruplex ligands: evidence for selective stabilizing properties and telomere damage by drug-like molecules

Methods of studying telomere damage induced by quadruplex-ligand complexes ⬇️

N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage

Neuroprotective effect of vitamin E supplementation in patients treated with cisplatin chemotherapy.

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts

PARP1 allows proper telomere replication through TRF1 poly (ADP-ribosyl)ation and helicase recruitment

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy

Patient-derived xenografts: a relevant preclinical model for drug development

Perylene and coronene derivatives binding to G-rich promoter oncogene sequences efficiently reduce their expression in cancer cells

SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage.

Shading the TRF2 Recruiting Function: A New Horizon in Drug Development

Shooting for Selective Druglike G-Quadruplex Binders: Evidence for Telomeric DNA Damage and Tumor Cell Death

Smad-interacting protein-1 and microRNA 200 family define a nitric oxide-dependent molecular circuitry involved in embryonic stem cell mesendoderm differentiation

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage

TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells

TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells

Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes.

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

Targeting G-Quadruplex DNA Structures by EMICORON Has a Strong Antitumor Efficacy against Advanced Models of Human Colon Cancer

Telomerase activity, apoptosis and cell cycle progression in ataxia telangiectasia lymphocytes expressing TCL1.

Telomerase as a new target for the treatment of hormone-refractory prostate cancer

Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect

Telomere dysfunction increases cisplatin and ecteinascidin-743 sensitivity of melanoma cells

Therapeutic integration of c-myc and bcl-2 antisense molecules with docetaxel in a preclinical model of hormone-refractory prostate cancer

ZD1839 (IRESSA), an EGFR-selective tyrosine kinase inhibitor, enhances taxane activity in bcl-2 overexpressing, multidrug-resistant MCF-7 ADR human breast cancer cells

c-Myc phosphorylation is required for cellular response to oxidative stress

β-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced β-catenin signaling.