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List of works by Neil M O'Brien-Simpson

A Rapid and Quantitative Flow Cytometry Method for the Analysis of Membrane Disruptive Antimicrobial Activity

scientific article

A novel Porphyromonas gingivalis FeoB plays a role in manganese accumulation

scientific article published on 18 May 2005

A therapeutic Porphyromonas gingivalis gingipain vaccine induces neutralising IgG1 antibodies that protect against experimental periodontitis

scientific article published in December 2016

Acute phase protein and cytokine levels in serum and saliva: a comparison of detectable levels and correlations in a depressed and healthy adolescent sample

scientific article published on 31 August 2013

Adolescent sympathetic activity and salivary C-reactive protein: The effects of parental behavior.

scientific article published on 22 June 2017

Adolescent temperament dimensions as stable prospective risk and protective factors for salivary C-reactive protein.

scientific article

Adolescent-Onset Depression: Are Obesity and Inflammation Developmental Mechanisms or Outcomes?

scientific article published on 10 February 2015

An efficient method for enumerating oral spirochetes using flow cytometry

scientific article published on 22 November 2009

An immune response directed to proteinase and adhesin functional epitopes protects against Porphyromonas gingivalis-induced periodontal bone loss

scientific article

Antigens of bacteria associated with periodontitis.

scientific article published on January 2004

Antimicrobial nanoparticle coatings for medical implants: Design challenges and prospects

scientific article published on 19 November 2020

Architectural Effects of Star-Shaped "Structurally Nanoengineered Antimicrobial Peptide Polymers" (SNAPPs) on Their Biological Activity

scientific article published on 02 September 2018

Associations between observed parenting behavior and adolescent inflammation two and a half years later in a community sample

scientific article

Biocompatibility and Osteogenic/Calcification Potential of Casein Phosphopeptide-amorphous Calcium Phosphate Fluoride.

scientific article published on 21 December 2017

Bionano Interaction Study on Antimicrobial Star-Shaped Peptide Polymer Nanoparticles.

scientific article

C-Terminal Modification and Multimerization Increase the Efficacy of a Proline-Rich Antimicrobial Peptide

scientific article published on 16 November 2016

Candida virulence and ethanol-derived acetaldehyde production in oral cancer and non-cancer subjects

scientific article published on 6 August 2016

Celogentin mimetics as inhibitors of tubulin polymerization

scientific article published on 17 December 2019

Characterization of T cell responses to the RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis in BALB/c mice

scientific article published on September 2008

Characterization of a second cell-associated Arg-specific cysteine proteinase of Porphyromonas gingivalis and identification of an adhesin-binding motif involved in association of the prtR and prtK proteinases and adhesins into large complexes

scientific article published in June 1998

Characterization of proteinase-adhesin complexes of Porphyromonas gingivalis

scientific article published on 01 August 2006

Chemically modified and conjugated antimicrobial peptides against superbugs

scientific article published in January 2021

Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice

scientific article published in PLoS ONE

Clinical isolates and laboratory reference Candida species and strains have varying abilities to form biofilms

scientific article published on 6 September 2013

Codelivery of NOD2 and TLR9 Ligands via Nanoengineered Protein Antigen Particles for Improving and Tuning Immune Responses

article

Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers.

scientific article published on 12 September 2016

Comparative study of novel in situ decorated porous chitosan-selenium scaffolds and porous chitosan-silver scaffolds towards antimicrobial wound dressing application

scientific article

Determination of Active Phagocytosis of Unopsonized Porphyromonas gingivalis by Macrophages and Neutrophils Using the pH-Sensitive Fluorescent Dye pHrodo.

scientific article published on 28 March 2016

Differential Responses of Pattern Recognition Receptors to Outer Membrane Vesicles of Three Periodontal Pathogens

scientific article

Differential roles of the protein corona in the cellular uptake of nanoporous polymer particles by monocyte and macrophage cell lines

scientific article published on 20 November 2013

Divalent metal cations increase the activity of the antimicrobial Peptide kappacin

scientific article published on June 2005

Engineering highly effective antimicrobial selenium nanoparticles through control of particle size

scientific article published on 01 August 2019

Fabrication of planarised conductively patterned diamond for bio-applications

scientific article published on 10 July 2014

Free radical induced polymerization of synthetic peptides into polymeric immunogens

scientific article published on 01 October 1997

GM-CSF and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model.

scientific article published on 10 March 2015

Histatin 5 Is a Substrate and Not an Inhibitor of the Arg- and Lys-Specific Proteinases ofPorphyromonas gingivalis ⬇️

scientific article published on September 18, 1998

Immunization with the RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis protects against periodontal bone loss in the rat periodontitis model

scientific article published on May 2002

Interplay between Porphyromonas gingivalis and EGF signalling in the regulation of CXCL14

scientific article published on 23 March 2018

Kappacin, a novel antibacterial peptide from bovine milk.

scientific article

Keratinocyte-specific ablation of protease-activated receptor 2 prevents gingival inflammation and bone loss in a mouse model of periodontal disease

scientific article published on 31 July 2018

Kgp and RgpB, but not RgpA, are important for Porphyromonas gingivalis virulence in the murine periodontitis model.

scientific article published on 12 January 2007

Localization of Outer Membrane Proteins in Treponema denticola by Quantitative Proteome Analyses of Outer Membrane Vesicles and Cellular Fractions

scientific article published on 26 February 2019

Low cytotoxic trace element selenium nanoparticles and their differential antimicrobial properties against S. aureus and E. coli

scientific article

Macrophage depletion abates Porphyromonas gingivalis-induced alveolar bone resorption in mice

scientific article published on 28 July 2014

Maculatin 1.1 disrupts Staphylococcus aureus lipid membranes via a pore mechanism.

scientific article published on 20 May 2013

Major proteins and antigens of Treponema denticola

scientific article

Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by Porphyromonas gingivalis and Its Outer Membrane Vesicles.

scientific article

Monospecies and polymicrobial biofilms differentially regulate the phenotype of genotype-specific oral cancer cells

scientific article published on 01 March 2019

Multimerization of a Proline-Rich Antimicrobial Peptide, Chex-Arg20, Alters Its Mechanism of Interaction with the Escherichia coli Membrane

scientific article published on September 2015

Oral Candida colonization in oral cancer patients and its relationship with traditional risk factors of oral cancer: a matched case-control study

scientific article

Oral health risk factors for bisphosphonate-associated jaw osteonecrosis.

scientific article published on 11 April 2013

Outer Membrane Vesicle-Host Cell Interactions

scientific article published on 01 January 2019

Outer Membrane Vesicles Prime and Activate Macrophage Inflammasomes and Cytokine Secretion In Vitro and In Vivo.

scientific article

Outer membrane proteome and antigens of Tannerella forsythia

scientific article published in September 2009

Oxantel disrupts polymicrobial biofilm development of periodontal pathogens.

scientific article published on 28 October 2013

Peptide Multimerization as Leads for Therapeutic Development

scientific article published on 30 December 2021

Peripheral neutrophil phenotypes during management of periodontitis

scientific article published on 17 August 2020

Physicochemical and immunological assessment of engineered pure protein particles with different redox states

scientific article

Porphyromonas gingivalis cysteine proteinase inhibition by kappa-casein peptides.

scientific article published on 20 December 2010

Porphyromonas gingivalis lipopolysaccharide weakly activates M1 and M2 polarized mouse macrophages but induces inflammatory cytokines.

scientific article

Porphyromonas gingivalis outer membrane vesicles exclusively contain outer membrane and periplasmic proteins and carry a cargo enriched with virulence factors

scientific article published on 3 April 2014

Porphyromonas gingivalis-derived RgpA-Kgp Complex Activates the Macrophage Urokinase Plasminogen Activator System: IMPLICATIONS FOR PERIODONTITIS

scientific article published on 15 May 2015

Porphyromonas gulae Activates Unprimed and Gamma Interferon-Primed Macrophages via the Pattern Recognition Receptors Toll-Like Receptor 2 (TLR2), TLR4, and NOD2.

scientific article published on 19 June 2017

Porphyromonas gulae Has Virulence and Immunological Characteristics Similar to Those of the Human Periodontal Pathogen Porphyromonas gingivalis.

scientific article published on 27 June 2016

Proline-rich antimicrobial peptides: potential therapeutics against antibiotic-resistant bacteria

scientific article

Protease-activated receptor 2 has pivotal roles in cellular mechanisms involved in experimental periodontitis

scientific article

Purification and characterization of a putative fimbrial protein/receptor of Porphyromonas gingivalis

scientific article published in April 1998

Rapid Chair-Side Test for Detection of Porphyromonas gingivalis

scientific article published in February 2017

Response of Porphyromonas gingivalis to heme limitation in continuous culture.

scientific article

Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids

scientific article published on 23 June 2020

Selenium nanoparticles as anti-infective implant coatings for trauma orthopedics against methicillin-resistant Staphylococcus aureus and epidermidis: in vitro and in vivo assessment

scientific article published on 01 July 2019

Serum immunoglobulin G (IgG) and IgG subclass responses to the RgpA-Kgp proteinase-adhesin complex of Porphyromonas gingivalis in adult periodontitis

scientific article

Synergistic virulence of Porphyromonas gingivalis and Treponema denticola in a murine periodontitis model

scientific article published on 02 May 2011

Tannerella forsythia Outer Membrane Vesicles Are Enriched with Substrates of the Type IX Secretion System and TonB-Dependent Receptors

scientific article published on 05 November 2015

The A-chain of insulin is a hot-spot for CD4+ T cell epitopes in human type 1 diabetes.

scientific article published on 9 March 2009

The Effect of Selective D- or Nα-Methyl Arginine Substitution on the Activity of the Proline-Rich Antimicrobial Peptide, Chex1-Arg20.

scientific article published on 19 January 2017

The RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis Inactivate the Th2 cytokines interleukin-4 and interleukin-5

scientific article published on 21 January 2009

The SENSE Study (Sleep and Education: learning New Skills Early): a community cognitive-behavioural therapy and mindfulness-based sleep intervention to prevent depression and improve cardiac health in adolescence

scientific article

The development and validation of a rapid genetic method for species identification and genotyping of medically important fungal pathogens using high-resolution melting curve analysis

scientific article published on 12 April 2014

The outer membrane protein LptO is essential for the O-deacylation of LPS and the co-ordinated secretion and attachment of A-LPS and CTD proteins in Porphyromonas gingivalis.

scientific article

The role of the RgpA-Kgp proteinase-adhesin complexes in the adherence of Porphyromonas gingivalis to fibroblasts

scientific article published on October 2008

Unprimed, M1 and M2 Macrophages Differentially Interact with Porphyromonas gingivalis.

scientific article

Vaccination with recombinant adhesins from the RgpA-Kgp proteinase-adhesin complex protects against Porphyromonas gingivalis infection.

scientific article published on 23 June 2006

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