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List of works by Peter J. Crack

A global transcriptomic view of the multifaceted role of glutathione peroxidase-1 in cerebral ischemic-reperfusion injury

scientific article published on 28 December 2010

A nonfibrin macromolecular cofactor for tPA-mediated plasmin generation following cellular injury

scientific article

Ablation of Type-1 IFN Signaling in Hematopoietic Cells Confers Protection Following Traumatic Brain Injury

scientific article published on January 2016

Abrogation of type-I interferon signalling alters the microglial response to Aβ1-42

scientific article published on 21 February 2020

Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion

scientific article

Age-dependent release of high-mobility group box protein-1 and cellular neuroinflammation after traumatic brain injury in mice

scientific article published on 30 December 2018

Akt phosphorylation and NFκB activation are counterregulated under conditions of oxidative stress

scientific article published on 01 November 2004

Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes

scientific article published on 27 February 2014

Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells

article

COPD and stroke: are systemic inflammation and oxidative stress the missing links?

scientific article

Ceruloplasmin and β-amyloid precursor protein confer neuroprotection in traumatic brain injury and lower neuronal iron.

scientific article published on 7 February 2014

Characterisation of neurons with nitric oxide synthase immunoreactivity that project to prevertebral ganglia

scientific article published in April 1995

Compartment- and context-specific changes in tissue-type plasminogen activator (tPA) activity following brain injury and pharmacological stimulation

scientific article published on 25 April 2011

Deletion of the type-1 interferon receptor in APPSWE/PS1ΔE9 mice preserves cognitive function and alters glial phenotype

scientific article published on 11 July 2016

Diminished Akt phosphorylation in neurons lacking glutathione peroxidase-1 (Gpx1) leads to increased susceptibility to oxidative stress-induced cell death

scientific journal article

Divergent roles of glutathione peroxidase-1 (Gpx1) in regulation of leukocyte-endothelial cell interactions in the inflamed cerebral microvasculature

scientific article published on 01 January 2011

Effects of GDNF-loaded injectable gelatin-based hydrogels on endogenous neural progenitor cell migration.

scientific article published on 4 March 2014

Evidence for the recruitment of autophagic vesicles in human brain after stroke

scientific article

Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death

scientific journal article

Glutathione peroxidase 1 and a high cellular glutathione concentration are essential for effective organic hydroperoxide detoxification in astrocytes.

scientific article published in December 2006

Glutathione peroxidase 1 and glutathione are required to protect mouse astrocytes from iron-mediated hydrogen peroxide toxicity

scientific article published in August 2006

Glutathione peroxidase-1 contributes to the protection of glutamine synthetase in astrocytes during oxidative stress

scientific article published on 6 February 2006

Glutathione peroxidase-1 primes pro-inflammatory cytokine production after LPS challenge in vivo

scientific article

Glutathione peroxidase-1 protects against cigarette smoke-induced lung inflammation in mice.

scientific article published on 28 May 2010

Glutathione peroxidase-1 reduces influenza A virus-induced lung inflammation.

scientific article

High-throughput screening for small molecule inhibitors of the type-I interferon signaling pathway.

scientific article published on 10 July 2018

Impact of oxidative stress on neuronal survival.

scientific article published in July 2004

Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury

scientific journal article

Inflammation in epileptogenesis after traumatic brain injury.

scientific article published on 13 January 2017

Insulin-regulated aminopeptidase deficiency provides protection against ischemic stroke in mice.

scientific article

Lack of glutathione peroxidase-1 exacerbates Abeta-mediated neurotoxicity in cortical neurons

scientific article

Levosimendan preserves the contractile responsiveness of hypoxic human myocardium via mitochondrial K(ATP) channel and potential pERK 1/2 activation.

scientific article

Metal chaperones: a novel therapeutic strategy for brain injury?

scientific article published on 03 December 2018

Mice lacking glutathione peroxidase-1 activity show increased TUNEL staining and an accelerated inflammatory response in brain following a cold-induced injury.

scientific article published in September 2002

Modulation of neuro-inflammation and vascular response by oxidative stress following cerebral ischemia-reperfusion injury.

scientific article published on January 2008

MyD88 is a critical regulator of hematopoietic cell-mediated neuroprotection seen after stroke.

scientific article

Nanofibrous scaffolds releasing a small molecule BDNF-mimetic for the re-direction of endogenous neuroblast migration in the brain.

scientific article published on 7 January 2014

Neural injury following stroke: are Toll-like receptors the link between the immune system and the CNS?

scientific article

Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis.

scientific article

Oxidation of Iron under Physiologically Relevant Conditions in Biological Fluids from Healthy and Alzheimer's Disease Subjects ⬇️

scientific article published on 28 December 2016

Perturbation of the transcriptome: implications of the innate immune system in Alzheimer's disease

scientific article

Potential contribution of NF-kappaB in neuronal cell death in the glutathione peroxidase-1 knockout mouse in response to ischemia-reperfusion injury

scientific article

Purification, characterisation and distribution of ovine neuronal nitric oxide synthase

scientific article published in August 1998

Reactive oxygen species and the modulation of stroke.

scientific article

Reactive oxygen species enhance insulin sensitivity

scientific article

Reduction of cerebral infarct volume by apocynin requires pretreatment and is absent in Nox2-deficient mice.

scientific article published on 23 January 2009

STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury

scientific article published on 21 November 2018

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

scientific article published on 15 January 2006

Synthesis of a hypoxia-targeted conjugate of the cardioprotective agent 3′,4′-dihydroxyflavonol and evaluation of its ability to reduce ischaemia/reperfusion injury

scientific article published on 17 March 2011

Targeted disruption of SPI3/Serpinb6 does not result in developmental or growth defects, leukocyte dysfunction, or susceptibility to stroke

scientific article

Targeting high-mobility group box protein 1 (HMGB1) in pediatric traumatic brain injury: Chronic neuroinflammatory, behavioral, and epileptogenic consequences

scientific article published on 21 June 2019

The association of metalloendopeptidase EC 3.4.24.15 at the extracellular surface of the AtT-20 cell plasma membrane

scientific article (publication date: 24 July 1999)

The contribution of astrocytes and microglia to traumatic brain injury

scientific article

The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease.

scientific article

The involvement of microglia in Alzheimer's disease: a new dog in the fight

scientific article published on 18 December 2018

The involvement of nitric oxide in the secretion of beta-endorphin from the pituitary intermediate lobe of the rat.

scientific article published in June 1997

The use of bioactive matrices in regenerative therapies for traumatic brain injury

scientific article published on 18 November 2019

The σ 1 receptor agonist 4-PPBP elicits ERK1/2 phosphorylation in primary neurons: a possible mechanism of neuroprotective action

scientific article published on 9 June 2010

Thimerosal blocks stimulated but not basal release of endothelium-derived relaxing factor (EDRF) in dog isolated coronary artery ⬇️

scientific article published on October 1, 1992

Toll-like receptors in the brain and their potential roles in neuropathology.

scientific article published on 31 July 2007

Type-1 interferon signaling mediates neuro-inflammatory events in models of Alzheimer's disease

scientific article published on 29 October 2013

Type-1 interferons contribute to oxygen glucose deprivation induced neuro-inflammation in BE(2)M17 human neuroblastoma cells

scientific article published on 06 March 2014

Type-1 interferons contribute to the neuroinflammatory response and disease progression of the MPTP mouse model of Parkinson's disease.

scientific article published on 12 July 2016

Type-I interferon pathway in neuroinflammation and neurodegeneration: focus on Alzheimer's disease

scientific article

Type-I interferon signalling through IFNAR1 plays a deleterious role in the outcome after stroke.

scientific article

Type-I interferons mediate the neuroinflammatory response and neurotoxicity induced by rotenone

scientific article published on 28 December 2016

Weight-bearing locomotion in the developing opossum, Monodelphis domestica following spinal transection: remodeling of neuronal circuits caudal to lesion

scientific article

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