List of works - Dominique Guianvarc'h

A direct label-free MALDI-TOF mass spectrometry based assay for the characterization of inhibitors of protein lysine methyltransferases.

scientific article

An active site mutant of Escherichia coli cyclopropane fatty acid synthase forms new non-natural fatty acids providing insights on the mechanism of the enzymatic reaction

scientific article published on 15 August 2013

Biotin synthase, a new member of the family of enzymes which uses S-adenosylmethionine as a source of deoxyadenosyl radical.

scientific article published in July 1997

C5-DNA methyltransferase inhibitors: from screening to effects on zebrafish embryo development.

scientific article

Challenges in developing novel DNA methyltransferases inhibitors for cancer therapy

scientific article

Combined analysis of DNA methylation and cell cycle in cancer cells

scientific article published on 23 January 2015

Design of artificial nucleobases for the recognition of the AT inversion by triple-helix forming oligonucleotides: a structure-stability relationship study and neighbour bases effect.

scientific article

Exploring the cellular activity of camptothecin-triple-helix-forming oligonucleotide conjugates

scientific article

First access to a mycolic acid-based bioorthogonal reporter for the study of the mycomembrane and mycoloyltransferases in Corynebacteria

scientific article published on 01 October 2019

Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors

scientific article published on 01 June 2018

Identification of inhibitors of the E. coli cyclopropane fatty acid synthase from the screening of a chemical library: In vitro and in vivo studies

scientific article

Identification of new inhibitors of E. coli cyclopropane fatty acid synthase using a colorimetric assay

scientific article

Identification of novel inhibitors of DNA methylation by screening of a chemical library.

scientific article

Improved synthesis of daunomycin conjugates with triplex-forming oligonucleotides. The polypurine tract of HIV-1 as a target

scientific article

Improving the selectivity of the phosphoric acid β-elimination on a biotinylated phosphopeptide.

scientific article

Label-free measurement of histone lysine methyltransferases activity by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

scientific article

Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine

scientific article

Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides

scientific article

Peptidoglycan potentiates the membrane disrupting effect of the carboxyamidated form of DMS-DA6, a Gram-positive selective antimicrobial peptide isolated from Pachymedusa dacnicolor skin

scientific article published in PLoS ONE

Photoactivatable oligonucleotide probes to trap single-stranded DNA binding proteins: Updating the potential of 4-thiothymidine from a comparative study

scientific article published on 29 August 2018

Probing the in-air growth of large area of 3D functional structures into a 2D supramolecular nanoporous network

scholarly article by Romain Brisse et al published 6 September 2018 in Chemical Communications

Rapid synthesis of new DNMT inhibitors derivatives of procainamide

scientific article

Rational Design of Bisubstrate-Type Analogues as Inhibitors of DNA Methyltransferases in Cancer Cells.

scientific article

Sequence-specific base pair mimics are efficient topoisomerase IB inhibitors.

scientific article

Stereocontrolled synthesis of heterocyclic C-nucleosides. Protecting group effect and molecular modeling studies

scientific article published in May 2002

Synthesis and Studies of Modified Oligonucleotides- Directed Triple Helix Formation at the Purine-Pyrimidine Interrupted Site

scientific article published on 01 May 2003

Synthesis and biological activity of sulfonamide derivatives of epipodophyllotoxin

scientific article published on April 2004

Synthesis and biological study of a new series of 4'-demethylepipodophyllotoxin derivatives.

scientific article

Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1.

scientific article published on 9 January 2014

Synthesis, incorporation into triplex-forming oligonucleotide, and binding properties of a novel 2'-deoxy-C-nucleoside featuring a 6-(thiazolyl-5)benzimidazole nucleobase.

scientific article

Triple helix-forming oligonucleotides conjugated to new inhibitors of topoisomerase II: synthesis and binding properties

scientific article

β-Amino acids containing peptides and click-cyclized peptide as β-turn mimics: a comparative study with 'conventional' lactam- and disulfide-bridged hexapeptides

scientific article published on 6 June 2011

List of works by Dominique Guianvarc'h

A direct label-free MALDI-TOF mass spectrometry based assay for the characterization of inhibitors of protein lysine methyltransferases.

An active site mutant of Escherichia coli cyclopropane fatty acid synthase forms new non-natural fatty acids providing insights on the mechanism of the enzymatic reaction

Biotin synthase, a new member of the family of enzymes which uses S-adenosylmethionine as a source of deoxyadenosyl radical.

C5-DNA methyltransferase inhibitors: from screening to effects on zebrafish embryo development.

Challenges in developing novel DNA methyltransferases inhibitors for cancer therapy

Combined analysis of DNA methylation and cell cycle in cancer cells

Design of artificial nucleobases for the recognition of the AT inversion by triple-helix forming oligonucleotides: a structure-stability relationship study and neighbour bases effect.

Exploring the cellular activity of camptothecin-triple-helix-forming oligonucleotide conjugates

First access to a mycolic acid-based bioorthogonal reporter for the study of the mycomembrane and mycoloyltransferases in Corynebacteria

Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors

Identification of inhibitors of the E. coli cyclopropane fatty acid synthase from the screening of a chemical library: In vitro and in vivo studies

Identification of new inhibitors of E. coli cyclopropane fatty acid synthase using a colorimetric assay

Identification of novel inhibitors of DNA methylation by screening of a chemical library.

Improved synthesis of daunomycin conjugates with triplex-forming oligonucleotides. The polypurine tract of HIV-1 as a target

Improving the selectivity of the phosphoric acid β-elimination on a biotinylated phosphopeptide.

Label-free measurement of histone lysine methyltransferases activity by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine

Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides

Peptidoglycan potentiates the membrane disrupting effect of the carboxyamidated form of DMS-DA6, a Gram-positive selective antimicrobial peptide isolated from Pachymedusa dacnicolor skin

Photoactivatable oligonucleotide probes to trap single-stranded DNA binding proteins: Updating the potential of 4-thiothymidine from a comparative study

Probing the in-air growth of large area of 3D functional structures into a 2D supramolecular nanoporous network

Rapid synthesis of new DNMT inhibitors derivatives of procainamide

Rational Design of Bisubstrate-Type Analogues as Inhibitors of DNA Methyltransferases in Cancer Cells.

Sequence-specific base pair mimics are efficient topoisomerase IB inhibitors.

Stereocontrolled synthesis of heterocyclic C-nucleosides. Protecting group effect and molecular modeling studies

Synthesis and Studies of Modified Oligonucleotides- Directed Triple Helix Formation at the Purine-Pyrimidine Interrupted Site

Synthesis and biological activity of sulfonamide derivatives of epipodophyllotoxin

Synthesis and biological study of a new series of 4'-demethylepipodophyllotoxin derivatives.

Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1.

Synthesis, incorporation into triplex-forming oligonucleotide, and binding properties of a novel 2'-deoxy-C-nucleoside featuring a 6-(thiazolyl-5)benzimidazole nucleobase.

Triple helix-forming oligonucleotides conjugated to new inhibitors of topoisomerase II: synthesis and binding properties

β-Amino acids containing peptides and click-cyclized peptide as β-turn mimics: a comparative study with 'conventional' lactam- and disulfide-bridged hexapeptides