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List of works by Michelandrea De Cesare

1,4-Substituted Triazoles as Nonsteroidal Anti-Androgens for Prostate Cancer Treatment

scientific article published on 8 March 2017

3-Arylidene-N-hydroxyoxindoles: A New Class of Compounds Endowed with Antitumor Activity

scientific article published on 17 June 2016

8,11-dihydroxy-6-[(aminoalkyl)amino]-7H-benzo[e]perimidin-7-ones with activity in multidrug-resistant cell lines: synthesis and antitumor evaluation

scientific article published on September 1999

A new avenue toward androgen receptor pan-antagonists: C2 sterically hindered substitution of hydroxy-propanamides

scientific article published on 28 August 2014

Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma.

scientific article published on 27 November 2013

Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism

scientific article published on 18 January 2017

Antitumor activity of the combination of synthetic retinoid ST1926 and cisplatin in ovarian carcinoma models

scientific article published on 13 August 2007

Ascites Regression and Survival Increase in Mice Bearing Advanced-stage Human Ovarian Carcinomas and Repeatedly Treated Intraperitoneally With CpG-ODN

scientific article published on 01 January 2010

Biodistribution of haematoporphyrin analogues in a lung carcinoma model

article

Biological properties of IDN5174, a new synthetic camptothecin with the open lactone ring

scientific article published on November 2006

Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity

scientific article published on 3 February 2016

Cellular bases of the antitumor activity of a 7-substituted camptothecin in hormone-refractory human prostate carcinoma models

scientific article published in April 2003

Cellular basis of antiproliferative and antitumor activity of the novel camptothecin derivative, gimatecan, in bladder carcinoma models

scientific article

Characterization of an established human, malignant, glioblastoma cell line (GBM) and its response to conventional drugs.

scientific article published on January 1994

Configurational requirements of the sugar moiety for the pharmacological activity of anthracycline disaccharides

scientific article published on 01 May 1999

CpG-oligodeoxynucleotides exert remarkable antitumor activity against diffuse malignant peritoneal mesothelioma orthotopic xenografts.

scientific article published on 25 January 2016

Design, modeling, synthesis and biological activity evaluation of camptothecin-linked platinum anticancer agents

scientific article published on March 2013

Design, synthesis and biological evaluation of novel dimeric and tetrameric cRGD-paclitaxel conjugates for integrin-assisted drug delivery

scientific article published on July 2015

Design, synthesis, and biological evaluation of novel cRGD-paclitaxel conjugates for integrin-assisted drug delivery.

scientific article

Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors

scientific article

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

scientific article

Down-regulation of human telomerase reverse transcriptase through specific activation of RNAi pathway quickly results in cancer cell growth impairment

scientific article published on 01 February 2007

E-ring-modified 7-oxyiminomethyl camptothecins: Synthesis and preliminary in vitro and in vivo biological evaluation

scientific article

Effects of MnDPDP and ICRF-187 on Doxorubicin-Induced Cardiotoxicity and Anticancer Activity

scientific article

Efficacy and toxicity profile of oral topotecan in a panel of human tumour xenografts

scientific article published on August 2000

Efficacy of a Selective Binder of αVβ3 Integrin Linked to the Tyrosine Kinase Inhibitor Sunitinib in Ovarian Carcinoma Preclinical Models

scientific article published on 13 April 2019

Efficacy of the novel camptothecin gimatecan against orthotopic and metastatic human tumor xenograft models

scientific article published in November 2004

Enhanced antitumour efficacy of gimatecan in combination with Bcl-2 antisense oligonucleotide in human melanoma xenografts.

scientific article

Eradication of Ovarian Tumor Xenografts by Locoregional Administration of Targeted Immunotherapy

scientific article published on 01 September 2008

FoxO-1 contributes to the efficacy of the combination of the XPO1 inhibitor selinexor and cisplatin in ovarian carcinoma preclinical models.

scientific article published on 16 November 2017

High efficacy of CpG-ODN, Cetuximab and Cisplatin combination for very advanced ovarian xenograft tumors ⬇️

scientific article published on January 29, 2013

Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment.

scientific article published on 17 December 2013

Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors

scientific article published on 8 April 2014

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

scientific article

Intracellular accumulation and DNA damage persistence as determinants of human squamous cell carcinoma hypersensitivity to the novel camptothecin ST1968.

scientific article published on 27 April 2008

Isoxazolo(aza)naphthoquinones: a new class of cytotoxic Hsp90 inhibitors

scientific article published on 28 March 2012

Modulation of cell growth and cisplatin sensitivity by membrane gamma-glutamyltransferase in melanoma cells.

scientific article published on 22 August 2006

Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors

scientific article published on July 2010

Novel 1H-pyrrolo[2,3-b]pyridine derivative nortopsentin analogues: synthesis and antitumor activity in peritoneal mesothelioma experimental models.

scientific article published on 23 August 2013

Novel 7-oxyiminomethyl derivatives of camptothecin with potent in vitro and in vivo antitumor activity

scientific article

Novel 7-substituted camptothecins with potent antitumor activity

scientific article

Novel cytotoxic 7-iminomethyl and 7-aminomethyl derivatives of camptothecin.

scientific article

Preclinical efficacy of ST1976, a novel camptothecin analog of the 7-oxyiminomethyl series

scientific article published on 9 November 2006

Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.

scientific article

Ribozyme-mediated down-regulation of survivin expression sensitizes human melanoma cells to topotecan in vitro and in vivo

scientific article published on 4 February 2004

Ribozyme-mediated inhibition of survivin expression increases spontaneous and drug-induced apoptosis and decreases the tumorigenic potential of human prostate cancer cells

scientific article published on January 2004

Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition.

scientific article published on 29 September 2011

Sensitization of ovarian carcinoma cells to the atypical retinoid ST1926 by the histone deacetylase inhibitor, RC307: enhanced DNA damage response

scientific article published in March 2010

Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity

scientific article

Spontaneous lung metastases in a human lung tumor xenograft: a new experimental model

scientific article

Sulfonates-PMMA nanoparticles conjugates: a versatile system for multimodal application

scientific article

Synergistic antitumor activity of cetuximab and namitecan in human squamous cell carcinoma models relies on cooperative inhibition of EGFR expression and depends on high EGFR gene copy number

scientific article published on 10 December 2013

Synergistic antitumor effects of novel HDAC inhibitors and paclitaxel in vitro and in vivo

scientific article (publication date: 2011)

Synergistic interaction between the novel histone deacetylase inhibitor ST2782 and the proteasome inhibitor bortezomib in platinum-sensitive and resistant ovarian carcinoma cells

scientific article

Synthesis and Superpotent Anticancer Activity of Tubulysins Carrying Non-hydrolysable N-Substituents on Tubuvaline

scientific article

Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors

scientific article published on 25 January 2011

Synthesis and cytotoxic activity of polyamine analogues of camptothecin

scientific article published on August 2006

TLR9 agonists oppositely modulate DNA repair genes in tumor versus immune cells and enhance chemotherapy effects.

scientific article

Targeting peptidyl-prolyl isomerase pin1 to inhibit tumor cell aggressiveness.

scientific article

The curative efficacy of namitecan (ST1968) in preclinical models of pediatric sarcoma is associated with antiangiogenic effects.

scientific article

Tissue distribution, antitumour activity and in vivo apoptosis induction by MEN10755 in nude mice

scientific article published on 01 February 2001

YM155 sensitizes triple-negative breast cancer to membrane-bound TRAIL through p38 MAPK- and CHOP-mediated DR5 upregulation.

scientific article published on 5 June 2014

miR-205 impairs the autophagic flux and enhances cisplatin cytotoxicity in castration-resistant prostate cancer cells

scientific article published on 24 December 2013

miR-205 regulates basement membrane deposition in human prostate: implications for cancer development

scientific article published on 4 May 2012

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