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List of works by Valentina Zuco

3-Arylidene-N-hydroxyoxindoles: A New Class of Compounds Endowed with Antitumor Activity

scientific article published on 17 June 2016

A novel atypical retinoid endowed with proapoptotic and antitumor activity

scientific article published in March 2003

A role for c-myc in DNA damage-induced apoptosis in a human TP53-mutant small-cell lung cancer cell line

scientific article

ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968.

scientific article

Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism

scientific article published on 18 January 2017

Antitumor activity of the combination of synthetic retinoid ST1926 and cisplatin in ovarian carcinoma models

scientific article published on 13 August 2007

Apoptosis and growth arrest induced by platinum compounds in U2-OS cells reflect a specific DNA damage recognition associated with a different p53-mediated response.

scientific article

Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity

scientific article published on 3 February 2016

Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation

scientific article

Cell cycle checkpoint efficiency and cellular response to paclitaxel in prostate cancer cells

scientific article

Cellular bases of the antitumor activity of a 7-substituted camptothecin in hormone-refractory human prostate carcinoma models

scientific article published in April 2003

Cellular bases of the antitumor activity of the novel taxane IDN 5109 (BAY59-8862) on hormone-refractory prostate cancer

scientific article published in August 2002

Corrigendum to “Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors” [Bioorg. Med. Chem. 18 (2010) 6031–6043]

scholarly article published in Bioorganic & Medicinal Chemistry

Cyclic pifithrin-alpha sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis

scientific article published on June 2008

Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors

scientific article

Development of resistance to the atypical retinoid, ST1926, in the lung carcinoma cell line H460 is associated with reduced formation of DNA strand breaks and a defective DNA damage response

scientific article published on July 2005

Drug Combinations with Proteasome Inhibitors in Antitumor Therapy ⬇️

scientific article published on January 1, 2013

Efficacy of ST1968 (namitecan) on a topotecan-resistant squamous cell carcinoma

scientific article published on February 2010

Evaluation of Mediators Associated with the Inflammatory Response in Prostate Cancer Patients Undergoing Radiotherapy.

scientific article published on 25 February 2018

Exosome-like Nanovectors for Drug Delivery in Cancer

scientific article published on 01 January 2019

Histone deacetylase and microtubules as targets for the synthesis of releasable conjugate compounds

scientific article published on 30 September 2009

Induction of apoptosis and stress response in ovarian carcinoma cell lines treated with ST1926, an atypical retinoid

scientific article published on March 2004

Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors

scientific article published on 8 April 2014

Intracellular accumulation and DNA damage persistence as determinants of human squamous cell carcinoma hypersensitivity to the novel camptothecin ST1968.

scientific article published on 27 April 2008

Investigation on the ZBG-functionality of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase inhibitors

scientific article published on 5 September 2015

Isoxazolo(aza)naphthoquinones: a new class of cytotoxic Hsp90 inhibitors

scientific article published on 28 March 2012

Metabolic approach to the enhancement of antitumor effect of chemotherapy: a key role of acetyl-L-carnitine

scientific article published on 18 June 2010

Modulation of cell sensitivity to antitumor agents by targeting survival pathways.

scientific article published on 3 August 2010

Modulation of survival signaling pathways and persistence of the genotoxic stress as a basis for the synergistic interaction between the atypical retinoid ST1926 and the epidermal growth factor receptor inhibitor ZD1839.

scientific article

Namitecan: a hydrophilic camptothecin with a promising preclinical profile

scientific article published on January 2012

Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors

scientific article published on July 2010

New macrocyclic analogs of the natural histone deacetylase inhibitor FK228; design, synthesis and preliminary biological evaluation

scientific article

Overcoming ABC transporter-mediated multidrug resistance: The dual role of tyrosine kinase inhibitors as multitargeting agents.

scientific article published on 3 August 2017

PLK1 is a critical determinant of tumor cell sensitivity to CPT11 and its inhibition enhances the drug antitumor efficacy in squamous cell carcinoma models sensitive and resistant to camptothecins.

scientific article published in April 2015

Patient-derived solitary fibrous tumour xenografts predict high sensitivity to doxorubicin/dacarbazine combination confirmed in the clinic and highlight the potential effectiveness of trabectedin or eribulin against this tumour.

scientific article published on 8 March 2017

Preclinical Activity of New [1,2]Oxazolo[5,4-e]isoindole Derivatives in Diffuse Malignant Peritoneal Mesothelioma.

scientific article published on 18 July 2016

Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.

scientific article

Proteomic analysis of cellular response to novel proapoptotic agents related to atypical retinoids in human IGROV-1 ovarian carcinoma cells

scientific article published on 18 January 2011

Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins

scientific article published on 19 September 2013

Role of c-myc protein in hormone refractory prostate carcinoma: cellular response to paclitaxel

scientific article

Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells

scientific article (publication date: 10 January 2002)

Sensitization of ovarian carcinoma cells to the atypical retinoid ST1926 by the histone deacetylase inhibitor, RC307: enhanced DNA damage response

scientific article published in March 2010

Sensitization of tumor cells by targeting histone deacetylases

scientific article

Subcellular localization of the camptothecin analogues, topotecan and gimatecan

scientific article published in March 2004

Synergistic antitumor activity of cetuximab and namitecan in human squamous cell carcinoma models relies on cooperative inhibition of EGFR expression and depends on high EGFR gene copy number

scientific article published on 10 December 2013

Synergistic antitumor effects of novel HDAC inhibitors and paclitaxel in vitro and in vivo

scientific article (publication date: 2011)

Synthesis and Evaluation of the Tumor Cell Growth Inhibitory Potential of New Putative HSP90 Inhibitors.

scientific article published on 13 February 2018

Synthesis and Superpotent Anticancer Activity of Tubulysins Carrying Non-hydrolysable N-Substituents on Tubuvaline

scientific article

Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors

scientific article published on 25 January 2011

Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with antiproliferative and proapoptotic activity

scientific article published on July 2005

Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids

scientific article

Synthesis, modelling, and antimitotic properties of tricyclic systems characterised by a 2-(5-Phenyl-1H-pyrrol-3-yl)-1,3,4-oxadiazole moiety

scientific article published on June 2009

Targeting DNA topoisomerase I with non-camptothecin poisons.

scientific article published on January 2012

Targeting of RET oncogene by naphthalene diimide-mediated gene promoter G-quadruplex stabilization exerts anti-tumor activity in oncogene-addicted human medullary thyroid cancer.

scientific article published on 16 June 2016

Targeting the Akt kinase to modulate survival, invasiveness and drug resistance of cancer cells

scientific article published on January 2013

Targeting the invasive phenotype of cisplatin-resistant non-small cell lung cancer cells by a novel histone deacetylase inhibitor.

scientific article

Telomere as a Therapeutic Target in Dedifferentiated Liposarcoma

scientific article published on 25 May 2022

The curative efficacy of namitecan (ST1968) in preclinical models of pediatric sarcoma is associated with antiangiogenic effects.

scientific article

The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition

scientific article published on 29 December 2009

UV-induced DNA incision and proliferating cell nuclear antigen recruitment to repair sites occur independently of p53-replication protein A interaction in p53 wild type and mutant ovarian carcinoma cells

scientific article (publication date: December 2001)

[1,2]Oxazolo[5,4-e]isoindoles as promising tubulin polymerization inhibitors.

scientific article published on 05 September 2016

miR-205 enhances radiation sensitivity of prostate cancer cells by impairing DNA damage repair through PKCε and ZEB1 inhibition

scientific article published on 04 February 2019

miR-875-5p counteracts epithelial-to-mesenchymal transition and enhances radiation response in prostate cancer through repression of the EGFR-ZEB1 axis

scientific article published on 5 March 2017

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