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List of works by Jan Koster

A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma

scientific article published on 04 April 2019

A NOTCH3 transcriptional module induces cell motility in neuroblastoma

scientific article published on 6 May 2013

A Novel Organoid Model of Damage and Repair Identifies HNF4α as a Critical Regulator of Intestinal Epithelial Regeneration

scientific article published on 05 March 2020

A library of Neo Open Reading Frame peptides (NOPs) as a sustainable resource of common neoantigens in up to 50% of cancer patients

scientific article published on 29 April 2019

A novel gene expression signature for bone metastasis in breast carcinomas

scientific article published on 10 March 2016

A secondary role for hypoxia and HIF1 in the regulation of (IFNγ-induced) PD-L1 expression in melanoma

scholarly article

Accelerating drug development for neuroblastoma - New Drug Development Strategy: an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Euro

scientific article published on 12 June 2017

Altered Gut Structure and Anti-Bacterial Defense in Adult Mice Treated with Antibiotics during Early Life

Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome

scientific article published on 24 February 2021

Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly

scientific article

Antiplectin autoantibodies in subepidermal blistering diseases

scientific article published on 10 April 2009

Association between gene expression profile of the primary tumor and chemotherapy response of metastatic breast cancer.

scientific article published on 13 November 2017

Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism.

scientific article

Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

scientific article

Author Correction: The landscape of genomic alterations across childhood cancers

scientific article published in Nature

Author Correction: c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies

scientific article published on 01 January 2020

Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8 + T cells

CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status

scientific article

Clonal selection drives genetic divergence of metastatic medulloblastoma

scientific article published on 15 February 2012

Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion

scientific article published on 21 March 2016

Combined therapy of AXL and HDAC inhibition reverses mesenchymal transition in diffuse intrinsic pontine glioma

scientific article published on 12 March 2020

Comprehensive RNA dataset of tissue and plasma from patients with esophageal cancer or precursor lesions

publication published on 14 March 2022

Copy number defects of G1-cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis

scientific article published on 27 October 2011

Correction: MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma

correction of a scholarly article

Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma

scientific article published on 6 March 2018

Culture methods of diffuse intrinsic pontine glioma cells determine response to targeted therapies

scientific article

Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma

scientific article published in April 2008

Cyclin D1 is a direct transcriptional target of GATA3 in neuroblastoma tumor cells

DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma

scientific article published on 21 February 2013

DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma

scientific article published in 2022

DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells

scientific article published on 30 December 2015

Data from MELK Inhibition in Diffuse Intrinsic Pontine Glioma

Data from MELK Inhibition in Diffuse Intrinsic Pontine Glioma

Data from RAS–MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

scientific article

Deoxyhypusine synthase (DHPS) inhibitor GC7 induces p21/Rb-mediated inhibition of tumor cell growth and DHPS expression correlates with poor prognosis in neuroblastoma patients

scientific article published on 15 October 2014

Dickkopf-1 is down-regulated by MYCN and inhibits neuroblastoma cell proliferation

scientific article published on 23 July 2007

Dickkopf-3 expression is a marker for neuroblastic tumor maturation and is down-regulated by MYCN.

scientific article published on April 2008

Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium

scientific article

Direct regulation of the minichromosome maintenance complex by MYCN in neuroblastoma

scientific article published on 10 September 2007

Discovery and visualization of miRNA-mRNA functional modules within integrated data using bicluster analysis

scientific article

Dissecting the genomic complexity underlying medulloblastoma

scientific article

Dissection of the oncogenic MYCN transcriptional network reveals a large set of clinically relevant cell cycle genes as drivers of neuroblastoma tumorigenesis

scientific article

Domain-wide regulation of gene expression in the human genome

scientific article

Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target

scientific article published on 21 June 2015

Efficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profiles

scientific article

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

scientific article

Enhancer of zeste homologue 2 plays an important role in neuroblastoma cell survival independent of its histone methyltransferase activity

scientific article published on 16 February 2017

Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity

scientific article published on 17 March 2020

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

scientific article

Epithelium-derived Indian Hedgehog restricts stromal expression of ErbB family members that drive colonic tumor cell proliferation

Exon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcome

scientific article

Expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in neuroblastoma: correlation with clinical features, cellular localization, and cerulenin-mediated apoptosis regulation

scientific article published on November 2007

Extensive polycistronism and antisense transcription in the mammalian Hox clusters

scientific article

FOXO3a is a major target of inactivation by PI3K/AKT signaling in aggressive neuroblastoma

scientific article published on February 2013

FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells

scientific article

Figure S1 from MELK Inhibition in Diffuse Intrinsic Pontine Glioma

Figure S1 from MELK Inhibition in Diffuse Intrinsic Pontine Glioma

Figure S2 from MELK Inhibition in Diffuse Intrinsic Pontine Glioma

Figure S2 from MELK Inhibition in Diffuse Intrinsic Pontine Glioma

Figure S3 from MELK Inhibition in Diffuse Intrinsic Pontine Glioma

Figure S3 from MELK Inhibition in Diffuse Intrinsic Pontine Glioma

Figure S4 from MELK Inhibition in Diffuse Intrinsic Pontine Glioma

Figure S4 from MELK Inhibition in Diffuse Intrinsic Pontine Glioma

Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification

scientific article

GPx2 suppression of H2O2 stress links the formation of differentiated tumor mass to metastatic capacity in colorectal cancer

scientific article published on 26 September 2014

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

scientific article

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

scientific article

Genome-wide DNA methylation analysis of neuroblastic tumors reveals clinically relevant epigenetic events and large-scale epigenomic alterations localized to telomeric regions

article

Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells

scientific article published on 11 February 2008

Genomic imbalances in rhabdomyosarcoma cell lines affect expression of genes frequently altered in primary tumors: an approach to identify candidate genes involved in tumor development

scientific article

Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome

scientific article published on 21 September 2016

Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome

Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth.

scientific article

High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition

scientific article published on April 2016

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma

scientific article published in October 2012

How germline genes promote malignancy in cancer cells

Hypermutation of the inactive X chromosome is a frequent event in cancer

scientific article published on 17 October 2013

Identification of BIRC6 as a novel intervention target for neuroblastoma therapy

scientific article

In search of druggable targets for GBM amino acid metabolism

scientific article

Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells

scholarly article

Indian Hedgehog Suppresses a Stromal Cell-Driven Intestinal Immune Response

scientific article published on 5 September 2017

Individual patient risk stratification of high-risk neuroblastomas using a two-gene score suited for clinical use.

scientific article published on 20 February 2015

Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features

scientific article

Joint binding of OTX2 and MYC in promotor regions is associated with high gene expression in medulloblastoma

scientific article

Kinome expression profiling of human neuroblastoma tumors identifies potential drug targets for ultra high-risk patients

scientific article

Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe

scientific article

LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR)

scientific article published on 16 November 2012

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.

scientific article published on 7 October 2012

Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy

scientific article (publication date: March 2009)

MEK inhibition causes Bim stabilization and sensitivity to Bcl2 family member inhibitors in RAS-MAPK mutated neuroblastoma

MELK Inhibition in Diffuse Intrinsic Pontine Glioma

scientific article published on 30 July 2018

MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3.

scientific article published on 7 October 2009

MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma.

scientific article published on 17 April 2018

MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma

scientific article published on 27 August 2016

MYCN transcriptionally represses CD9 to trigger an invasion-metastasis cascade in neuroblastoma

scientific article

Macrophages induce "budding" in aggressive human colon cancer subtypes by protease-mediated disruption of tight junctions.

scientific article

Maintenance of Clonogenic KIT(+) Human Colon Tumor Cells Requires Secretion of Stem Cell Factor by Differentiated Tumor Cells

scientific article published on 8 May 2015

Massive expression of germ cell-specific genes is a hallmark of cancer and a potential target for novel treatment development

scholarly article by Jan Willem Bruggeman published in October 2018

Maternal diabetes causes developmental delay and death in early-somite mouse embryos

scientific article published on 15 September 2017

Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients

scientific article published in November 2011

Mismatch repair deficiency: a temozolomide resistance factor in medulloblastoma cell lines that is uncommon in primary medulloblastoma tumours

scientific article

Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAs

scientific article

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

scientific article

Molecular consequences of deletion of the cytoplasmic domain of bullous pemphigoid 180 in a patient with predominant features of epidermolysis bullosa simplex

scientific article published on January 2004

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

scientific article

Mutations in the Ras-Raf Axis underlie the prognostic value of CD133 in colorectal cancer

scientific article

Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors

scientific article published in February 2015

NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome

scientific article

Neuroblastoma is composed of two super-enhancer-associated differentiation states.

scientific article published on 26 June 2017

Neuroblastoma stage 4S: Tumor regression rate and risk factors of progressive disease

scientific article published on 17 November 2019

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

scientific article

Newly-derived neuroblastoma cell lines propagated in serum-free media recapitulate the genotype and phenotype of primary neuroblastoma tumours

scientific article published on 6 December 2013

Novel interaction of ornithine decarboxylase with sepiapterin reductase regulates neuroblastoma cell proliferation

scientific article

OTX2 directly activates cell cycle genes and inhibits differentiation in medulloblastoma cells

scientific article published on 8 November 2011

OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels

scientific article published on 18 November 2012

Oncogenic activation of FOXR1 by 11q23 intrachromosomal deletion-fusions in neuroblastoma

scientific article

PDGFRB promotes liver metastasis formation of mesenchymal-like colorectal tumor cells

scientific article

PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma

scientific article

PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma

scientific article published on 21 February 2013

Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways

article

Prevalence and clinical implications of chromothripsis in cancer genomes

scientific article published on January 2014

Prevalence and patterns of morphological abnormalities in patients with childhood cancer

scientific article

Production of the bullous pemphigoid antigen 230 (BP230) by Saccharomyces cerevisiae and Pichia pastoris

article

Prospective derivation of a living organoid biobank of colorectal cancer patients.

scientific article published on May 2015

Protein arginine methyltransferase 1 is a novel regulator of MYCN in neuroblastoma.

scientific article published on 23 August 2016

RAS–MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma

scientific article published on 16 August 2018

RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics

scientific article

Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV.

scientific article

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

scientific article

Regulation of cell cycle genes and induction of senescence by overexpression of OTX2 in medulloblastoma cell lines

scientific article published on 13 September 2010

Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations

scientific article published on 29 June 2015

Robust selection of cancer survival signatures from high-throughput genomic data using two-fold subsampling

scientific article

Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes.

scientific article published on 10 December 2003

SIRT1/PGC1α-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer

scientific article published on 16 March 2015

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

scientific article

Silencing of the microtubule-associated proteins doublecortin-like and doublecortin-like kinase-long induces apoptosis in neuroblastoma cells.

scientific article published on 21 April 2010

Specific and Sensitive Detection of Neuroblastoma mRNA Markers by Multiplex RT-qPCR

Specificity of binding of the plectin actin-binding domain to beta4 integrin

scientific article published on 11 July 2003

Subcellular distribution and expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in malignant glioma: Influence on cell survival and migration

scientific article published on 19 March 2010

Supplemental legend from MELK Inhibition in Diffuse Intrinsic Pontine Glioma

Supplemental legend from MELK Inhibition in Diffuse Intrinsic Pontine Glioma

Supplementary Figures from RAS–MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma

Supplementary Figures from RAS–MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma

Supplementary Tables from RAS–MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma

Supplementary Tables from RAS–MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma

Synergistic drug combination GC7/DFMO suppresses hypusine/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma

scientific article published on 2 January 2018

TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors

scientific article published on 2 November 2015

Table S1 from MELK Inhibition in Diffuse Intrinsic Pontine Glioma

Table S1 from MELK Inhibition in Diffuse Intrinsic Pontine Glioma

Table S2 from MELK Inhibition in Diffuse Intrinsic Pontine Glioma

Table S2 from MELK Inhibition in Diffuse Intrinsic Pontine Glioma

Target Actionability Review: a systematic evaluation of replication stress as a therapeutic target for paediatric solid malignancies

Targeted BCL2 inhibition effectively inhibits neuroblastoma tumour growth

scientific article

Targeted BIRC5 silencing using YM155 causes cell death in neuroblastoma cells with low ABCB1 expression

scientific article

Targeting CDKs with Roscovitine Increases Sensitivity to DNA Damaging Drugs of Human Osteosarcoma Cells

scientific article

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers

scientific article published on 12 June 2012

The MSX1 homeobox transcription factor is a downstream target of PHOX2B and activates the Delta-Notch pathway in neuroblastoma

scientific article published on 16 January 2008

The Neo-Open Reading Frame Peptides That Comprise the Tumor Framome Are a Rich Source of Neoantigens for Cancer Immunotherapy

scientific article published in 2024

The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits

scientific article (publication date: March 2002)

The TRPM7 interactome defines a cytoskeletal complex linked to neuroblastoma progression

scientific article published on 24 June 2016

The construction of genome-based transcriptional units

scientific article published in April 2009

The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression

scientific article

The landscape of genomic alterations across childhood cancers

scientific article published on 28 February 2018

The low-affinity neurotrophin receptor, p75, is upregulated in ganglioneuroblastoma/ganglioneuroma and reduces tumorigenicity of neuroblastoma cells in vivo

scientific article

The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification

scientific article

The role of histone demethylase KDM4B in Myc signaling in neuroblastoma

scientific article

The three-dimensional structure of human interphase chromosomes is related to the transcriptome map.

scientific article published on 9 April 2007

The whole-genome landscape of medulloblastoma subtypes

scientific article published in July 2017

Transcriptomic Differences Underlying the Activin-A Induced Large Osteoclast Formation in Both Healthy Control and Fibrodysplasia Ossificans Progressiva Osteoclasts

scientific article published in 2023

Tumorigenic and anti-proliferative properties of the TALE-transcription factors MEIS2D and MEIS2A in neuroblastoma

scientific article

Tumors Widely Express Hundreds of Embryonic Germline Genes

scientific article published on 17 December 2020

Tumors widely express hundreds of embryonic germline genes

Two different mutations in the cytoplasmic domain of the integrin beta 4 subunit in nonlethal forms of epidermolysis bullosa prevent interaction of beta 4 with plectin.

scientific article published in December 2001

Two opposing gene expression patterns within ATRX aberrant neuroblastoma

Whole-Genome Sequencing Identifies Patient-Specific DNA Minimal Residual Disease Markers in Neuroblastoma

scholarly article by Esther M. van Wezel et al published January 2015 in The Journal of Molecular Diagnostics

Workshop Report on the European Bone Sarcoma Networking Meeting: Integration of Clinical Trials with Tumor Biology

scientific article published in September 2011

ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome

scientific article

c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies

scientific article published on 01 July 2019

snoRNPs Regulate Telomerase Activity in Neuroblastoma and Are Associated with Poor Prognosis.

scientific article published on August 2013

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