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List of works by Osamu Nagano

ADAM-17 associated with CD44 cleavage and metastasis in oral squamous cell carcinoma.

scientific article published in February 2007

Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.

scientific article

CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis.

scientific article

CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence.

scientific article published on 18 June 2013

CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth

scientific article

CD44 variant-dependent regulation of redox balance in EGFR mutation-positive non-small cell lung cancer: A target for treatment.

scientific article

CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis

scientific article published on 18 December 2009

CD44s regulates the TGF-β-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma

scientific article published on 02 May 2012

CD44s signals the acquisition of the mesenchymal phenotype required for anchorage-independent cell survival in hepatocellular carcinoma.

scientific article published on 3 December 2013

Development of a functional thyroid model based on an organoid culture system.

scientific article published on 19 February 2018

Development of an ErbB4 monoclonal antibody that blocks neuregulin-1-induced ErbB4 activation in cancer cells.

scientific article published on 9 January 2016

Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis

scientific article published on 23 June 2016

Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205).

scientific article published on 7 April 2016

EGFR and ErbB2 are functionally coupled to CD44 and regulate shedding, internalization and motogenic effect of CD44.

scientific article published on 13 February 2008

Epigenomic Profiling Discovers Trans-lineage SOX2 Partnerships Driving Tumor Heterogeneity in Lung Squamous Cell Carcinoma

scientific article published on 24 September 2019

Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines.

scientific article published on 31 March 2016

Establishment of a choriocarcinoma model from immortalized normal extravillous trophoblast cells transduced with HRASV12

scientific article

Functional role of CD44v-xCT system in the development of spasmolytic polypeptide-expressing metaplasia.

scientific article

Gene expression profile of a newly established choriocarcinoma cell line, iC3-1, compared to existing choriocarcinoma cell lines and normal placenta.

scientific article published on 28 November 2012

Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors

scientific article published on 04 March 2019

Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma

scientific article published on 13 September 2019

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival.

scientific article published on 19 April 2018

In vivo assessment of cancerous tumors using boron doped diamond microelectrode

scientific article

Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression.

scientific article published on June 2017

Ink4a/Arf-Dependent Loss of Parietal Cells Induced by Oxidative Stress Promotes CD44-Dependent Gastric Tumorigenesis.

scientific article

Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma

scientific article published on 20 November 2007

MEK inhibition suppresses metastatic progression of KRAS-mutated gastric cancer

scientific article published on 07 January 2022

Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation

scientific article published on 6 December 2013

Maintenance of HCT116 colon cancer cell line conforms to a stochastic model but not a cancer stem cell model.

scientific article

Mechanism and biological significance of CD44 cleavage

scientific article

Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells.

scientific article published on 31 January 2012

Molecular mechanisms regulating dissociation of cell-cell junction of epithelial cells by oxidative stress.

scientific article published on 30 April 2009

Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407).

scientific article published on 2 May 2017

Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non-small-cell lung cancer.

scientific article published on July 2017

Potential of sulfasalazine as a therapeutic sensitizer for CD44 splice variant 9-positive urogenital cancer

scientific article published on 4 April 2016

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

scientific article published in March 2003

Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition.

scientific article published in July 2008

Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells

scientific article published on December 2012

Sulfasalazine, a therapeutic agent for ulcerative colitis, inhibits the growth of CD44v9(+) cancer stem cells in ulcerative colitis-related cancer.

scientific article published on 5 January 2016

The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-)

scientific article published on 15 March 2016

The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.

scientific article

The impact of EpCAM expression on response to chemotherapy and clinical outcomes in patients with epithelial ovarian cancer

scientific article

Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells.

scientific article published on 8 August 2011

Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction.

scientific article

Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy

scientific article published on 22 November 2019

cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells.

scientific article published on 27 June 2017

xCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma.

scientific article published on 14 January 2013

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