List of works - Mirko Trilling

"Activated" STAT proteins: a paradoxical consequence of inhibited JAK-STAT signaling in cytomegalovirus-infected cells

scientific article published on 6 December 2013

A Mass Spectrometry-Based Profiling of Interactomes of Viral DDB1- and Cullin Ubiquitin Ligase-Binding Proteins Reveals NF-κB Inhibitory Activity of the HIV-2-Encoded Vpx

article

A cytomegaloviral protein reveals a dual role for STAT2 in IFN-{gamma} signaling and antiviral responses

scientific article published on 9 May 2005

A dimerized single-chain variable fragment system for the assessment of neutralizing activity of phage display-selected antibody fragments specific for cytomegalovirus

scientific article

A novel assay for detecting virus-specific antibodies triggering activation of Fcγ receptors

scientific article

Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions

scientific article

An A/U-Rich Enhancer Region Is Required for High-Level Protein Secretion through the HlyA Type I Secretion System.

scientific article

Attack, parry and riposte: molecular fencing between the innate immune system and human herpesviruses.

scientific article published on 10 June 2015

Bile Acids Act as Soluble Host Restriction Factors Limiting Cytomegalovirus Replication in Hepatocytes

scientific article

Broad and potent antiviral activity of the NAE inhibitor MLN4924.

scientific article published on February 2016

CD169+ macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection

scientific article

CD4+ T cells develop antiretroviral cytotoxic activity in the absence of regulatory T cells and CD8+ T cells

scientific article published on 27 March 2013

Cellular Cullin RING Ubiquitin Ligases: Druggable Host Dependency Factors of Cytomegaloviruses ⬇️

scientific article published on 02 April 2019

Clinical Utility of Quantitative PCR for Chimerism and Engraftment Monitoring after Allogeneic Stem Cell Transplantation for Hematologic Malignancies

scientific article

Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology

scientific article published on 30 March 2020

Counteraction of Interferon-Induced Antiviral Responses by Cytomegalovirus

article

Data-warehousing of protein-protein interactions indicates that pathogens preferentially target hub and bottleneck proteins

scientific article

Deciphering of the Human Interferon-Regulated Proteome by Mass Spectrometry-Based Quantitative Analysis Reveals Extent and Dynamics of Protein Induction and Repression

scientific article published on 14 September 2017

Deciphering the modulation of gene expression by type I and II interferons combining 4sU-tagging, translational arrest and in silico promoter analysis.

scientific article published on 05 July 2013

Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus

scientific article

Erratum for Westmeier et al., "Impaired Cytotoxic CD8+ T Cell Response in Elderly COVID-19 Patients"

scientific article published on 10 November 2020

Exploitation of herpesviral transactivation allows quantitative reporter gene-based assessment of virus entry and neutralization

scientific article

Gamma interferon-induced interferon regulatory factor 1-dependent antiviral response inhibits vaccinia virus replication in mouse but not human fibroblasts

scientific article published on 11 February 2009

Genome Plasticity of Herpesviruses: Conservative yet Flexible

scholarly article

HLA-E Polymorphism Determines Susceptibility to BK Virus Nephropathy after Living-Donor Kidney Transplant

scientific article published on 07 August 2019

Herpes Simplex Virus Type 2 Is More Difficult to Neutralize by Antibodies Than Herpes Simplex Virus Type 1

scientific article published on 27 August 2020

Highly individual patterns of virus-immune IgG effector responses in humans

scientific article published on 18 May 2016

Human Cytomegalovirus-Induced Degradation of CYTIP Modulates Dendritic Cell Adhesion and Migration

scientific article published on 21 April 2017

Human cytomegalovirus Fcγ binding proteins gp34 and gp68 antagonize Fcγ receptors I, II and III

scientific article

Human cytomegalovirus interferes with signal transducer and activator of transcription (STAT) 2 protein stability and tyrosine phosphorylation

scientific article published on October 2008

Identification of DNA-damage DNA-binding protein 1 as a conditional essential factor for cytomegalovirus replication in interferon-γ-stimulated cells

scientific article

Impaired Cytotoxic CD8+ T Cell Response in Elderly COVID-19 Patients

scientific article published on 18 September 2020

Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation

scientific article

Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection In Vivo

scientific article published on 20 April 2016

Interferon-alpha subtype 11 activates NK cells and enables control of retroviral infection

scientific article

Interplay between CMVs and interferon signaling: implications for pathogenesis and therapeutic intervention

scientific article

M27 expressed by cytomegalovirus counteracts effective type I interferon induction of myeloid cells but not of plasmacytoid dendritic cells

scientific article published on 17 September 2014

MAPKAP kinase 2 regulates IL-10 expression and prevents formation of intrahepatic myeloid cell aggregates during cytomegalovirus infections

scientific article published on 20 August 2015

Mouse cytomegalovirus inhibits beta interferon (IFN- ) gene expression and controls activation pathways of the IFN- enhanceosome

article

Mouse newborn cells allow highly productive mouse cytomegalovirus replication, constituting a novel convenient primary cell culture system

scientific article

Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus.

scientific article

Over 90% of clinical swabs used for SARS-CoV-2 diagnostics contain sufficient nucleic acid concentrations

scientific article published on 02 December 2020

Prophylactic and Therapeutic HBV Vaccination by an HBs-expressing Cytomegalovirus Vector Lacking an Interferon Antagonist in Mice

scientific article published on 07 October 2020

Recipient HLA-G +3142 CC Genotype and Concentrations of Soluble HLA-G Impact on Occurrence of CMV Infection after Living-Donor Kidney Transplantation

scientific article published on 5 November 2017

SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19

scientific article published on 22 March 2021

STAT2-dependent immune responses ensure host survival despite the presence of a potent viral antagonist

scientific article published on 29 June 2018

Structural mechanism of CRL4‐instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor

scientific article published in 2023

Susceptibility of HLA-E*01:03 allele carriers to develop Cytomegalovirus replication after living-donor kidney transplantation

scientific article published on 8 December 2017

TLR ligand induced IL-6 counter-regulates the anti-viral CD8(+) T cell response during an acute retrovirus infection

scientific article published on 21 May 2015

The Canonical Immediate Early 3 Gene Product pIE611 of Mouse Cytomegalovirus Is Dispensable for Viral Replication but Mediates Transcriptional and Posttranscriptional Regulation of Viral Gene Products

scientific article published on 10 June 2015

The Donor Major Histocompatibility Complex Class I Chain-Related Molecule A Allele rs2596538 G Predicts Cytomegalovirus Viremia in Kidney Transplant Recipients.

scientific article

The Transcription and Translation Landscapes during Human Cytomegalovirus Infection Reveal Novel Host-Pathogen Interactions

scientific article published on 24 November 2015

The cytomegaloviral protein pUL138 acts as potentiator of tumor necrosis factor (TNF) receptor 1 surface density to enhance ULb'-encoded modulation of TNF-α signaling

scientific article published on 5 October 2011

The interplay between emerging human coronavirus infections and autophagy

scientific article published on 05 January 2021

c-Src is required for complex formation between the hepatitis C virus-encoded proteins NS5A and NS5B: a prerequisite for replication

scientific article

m6A modification controls the innate immune response to infection by targeting type I interferons

scientific article published on 17 December 2018

List of works by Mirko Trilling

"Activated" STAT proteins: a paradoxical consequence of inhibited JAK-STAT signaling in cytomegalovirus-infected cells

A Mass Spectrometry-Based Profiling of Interactomes of Viral DDB1- and Cullin Ubiquitin Ligase-Binding Proteins Reveals NF-κB Inhibitory Activity of the HIV-2-Encoded Vpx

A cytomegaloviral protein reveals a dual role for STAT2 in IFN-{gamma} signaling and antiviral responses

A dimerized single-chain variable fragment system for the assessment of neutralizing activity of phage display-selected antibody fragments specific for cytomegalovirus

A novel assay for detecting virus-specific antibodies triggering activation of Fcγ receptors

Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions

An A/U-Rich Enhancer Region Is Required for High-Level Protein Secretion through the HlyA Type I Secretion System.

Attack, parry and riposte: molecular fencing between the innate immune system and human herpesviruses.

Bile Acids Act as Soluble Host Restriction Factors Limiting Cytomegalovirus Replication in Hepatocytes

Broad and potent antiviral activity of the NAE inhibitor MLN4924.

CD169+ macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection

CD4+ T cells develop antiretroviral cytotoxic activity in the absence of regulatory T cells and CD8+ T cells

Cellular Cullin RING Ubiquitin Ligases: Druggable Host Dependency Factors of Cytomegaloviruses ⬇️

Clinical Utility of Quantitative PCR for Chimerism and Engraftment Monitoring after Allogeneic Stem Cell Transplantation for Hematologic Malignancies

Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology

Counteraction of Interferon-Induced Antiviral Responses by Cytomegalovirus

Data-warehousing of protein-protein interactions indicates that pathogens preferentially target hub and bottleneck proteins

Deciphering of the Human Interferon-Regulated Proteome by Mass Spectrometry-Based Quantitative Analysis Reveals Extent and Dynamics of Protein Induction and Repression

Deciphering the modulation of gene expression by type I and II interferons combining 4sU-tagging, translational arrest and in silico promoter analysis.

Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus

Erratum for Westmeier et al., "Impaired Cytotoxic CD8+ T Cell Response in Elderly COVID-19 Patients"

Exploitation of herpesviral transactivation allows quantitative reporter gene-based assessment of virus entry and neutralization

Gamma interferon-induced interferon regulatory factor 1-dependent antiviral response inhibits vaccinia virus replication in mouse but not human fibroblasts

Genome Plasticity of Herpesviruses: Conservative yet Flexible

HLA-E Polymorphism Determines Susceptibility to BK Virus Nephropathy after Living-Donor Kidney Transplant

Herpes Simplex Virus Type 2 Is More Difficult to Neutralize by Antibodies Than Herpes Simplex Virus Type 1

Highly individual patterns of virus-immune IgG effector responses in humans

Human Cytomegalovirus-Induced Degradation of CYTIP Modulates Dendritic Cell Adhesion and Migration

Human cytomegalovirus Fcγ binding proteins gp34 and gp68 antagonize Fcγ receptors I, II and III

Human cytomegalovirus interferes with signal transducer and activator of transcription (STAT) 2 protein stability and tyrosine phosphorylation

Identification of DNA-damage DNA-binding protein 1 as a conditional essential factor for cytomegalovirus replication in interferon-γ-stimulated cells

Impaired Cytotoxic CD8+ T Cell Response in Elderly COVID-19 Patients

Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation

Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection In Vivo

Interferon-alpha subtype 11 activates NK cells and enables control of retroviral infection

Interplay between CMVs and interferon signaling: implications for pathogenesis and therapeutic intervention

M27 expressed by cytomegalovirus counteracts effective type I interferon induction of myeloid cells but not of plasmacytoid dendritic cells

MAPKAP kinase 2 regulates IL-10 expression and prevents formation of intrahepatic myeloid cell aggregates during cytomegalovirus infections

Mouse cytomegalovirus inhibits beta interferon (IFN- ) gene expression and controls activation pathways of the IFN- enhanceosome

Mouse newborn cells allow highly productive mouse cytomegalovirus replication, constituting a novel convenient primary cell culture system

Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus.

Over 90% of clinical swabs used for SARS-CoV-2 diagnostics contain sufficient nucleic acid concentrations

Prophylactic and Therapeutic HBV Vaccination by an HBs-expressing Cytomegalovirus Vector Lacking an Interferon Antagonist in Mice

Recipient HLA-G +3142 CC Genotype and Concentrations of Soluble HLA-G Impact on Occurrence of CMV Infection after Living-Donor Kidney Transplantation

SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19

STAT2-dependent immune responses ensure host survival despite the presence of a potent viral antagonist

Structural mechanism of CRL4‐instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor

Susceptibility of HLA-E*01:03 allele carriers to develop Cytomegalovirus replication after living-donor kidney transplantation

TLR ligand induced IL-6 counter-regulates the anti-viral CD8(+) T cell response during an acute retrovirus infection

The Canonical Immediate Early 3 Gene Product pIE611 of Mouse Cytomegalovirus Is Dispensable for Viral Replication but Mediates Transcriptional and Posttranscriptional Regulation of Viral Gene Products

The Donor Major Histocompatibility Complex Class I Chain-Related Molecule A Allele rs2596538 G Predicts Cytomegalovirus Viremia in Kidney Transplant Recipients.

The Transcription and Translation Landscapes during Human Cytomegalovirus Infection Reveal Novel Host-Pathogen Interactions

The cytomegaloviral protein pUL138 acts as potentiator of tumor necrosis factor (TNF) receptor 1 surface density to enhance ULb'-encoded modulation of TNF-α signaling

The interplay between emerging human coronavirus infections and autophagy

c-Src is required for complex formation between the hepatitis C virus-encoded proteins NS5A and NS5B: a prerequisite for replication

m6A modification controls the innate immune response to infection by targeting type I interferons