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List of works by Shosuke Ito

"Total" acidic metabolites of catecholamines in urine as determined by hydrolysis with hydriodic acid and liquid chromatography: application to patients with neuroblastoma and melanoma.

scientific article

1-(2,4-Dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylpheny)propane inhibits melanin synthesis by dual mechanisms.

scientific article published on 21 April 2011

4-S-Cysteaminylphenol-loaded magnetite cationic liposomes for combination therapy of hyperthermia with chemotherapy against malignant melanoma

scientific article published in March 2007

4-S-cysteaminylphenol and its analogues as substrates for tyrosinase and monoamine oxidase

scientific article published on September 1990

5-S-cysteinyldopa as diagnostic tumor marker for uveal malignant melanoma

scientific article

A New Mutation of Mouse Ruby-eye 2,ru2d/Hps5ru2-dInhibits Eumelanin Synthesis but Stimulates Pheomelanin Synthesis in Melanocytes

scientific article published on 01 October 2012

A case of malignant melanoma: disease progression correlated with serum levels of 5-S-Cysteinyldopa (5-S-CD) and intercellular adhesion molecule-1 (ICAM-1)

A close relationship between androgen levels and eumelanogenesis in the teleost red seabream (Pagrus major): Quantitative analysis of its seasonal variation and effects of oral treatment with methyl-testosterone

scientific article published on 4 February 2010

A convenient screening method to differentiate phenolic skin whitening tyrosinase inhibitors from leukoderma-inducing phenols

scientific article

A facile one-step synthesis of cysteinyldopas using mushroom tyrosinase

scientific article

A novel RFP-RET transgenic mouse model with abundant eumelanin in the cochlea

scientific article published in September 2004

A novel deletion mutation of mouse ruby-eye 2 named ru2(d)/Hps5(ru2-d) inhibits melanocyte differentiation and its impaired differentiation is rescued by L-tyrosine.

scientific article

A role of SH-compounds in maturation of melanosomes in cells cultured from nevus Ota

scientific article published on 01 January 1998

Accelerated disappearance of melanocytes in bcl-2-deficient mice

scientific journal article

Accumulation of N-methyl-4-phenylpyridinium ion (MPP+) in human melanoma cell line, HMV-I and -II

scientific article published on 01 April 1988

Acid hydrolysis reveals a low but constant level of pheomelanin in human black to brown hair

scientific article published on 24 November 2017

Action of cysteaminylphenols on human melanoma cells in vivo and in vitro: 4-S-cysteaminylphenol binds protein disulphide isomerase

scientific article published on June 1991

Adaptation of pelage color and pigment variations in Israeli subterranean blind mole rats, Spalax ehrenbergi [corrected]

scientific article

Adaptive melanin response of the soil fungus Aspergillus niger to UV radiation stress at "Evolution Canyon", Mount Carmel, Israel

scientific article

Advanced chemical methods in melanin determination

scientific article

Aerobic photoreactivity of synthetic eumelanins and pheomelanins: generation of singlet oxygen and superoxide anion

scientific article published on 9 August 2016

Agaritine purified from Agaricus blazei Murrill exerts anti-tumor activity against leukemic cells

scientific article

Age-dependent changes in eumelanin composition in hairs of various ethnic origins

scientific article published on 22 November 2011

Agouti Protein Inhibits the Production of Eumelanin and Phaeomelanin in the Presence and Absence of α-Melanocyte Stimulating Hormone

scientific article published on 01 October 1997

Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway

scientific article published on 26 May 2009

Alteration of Melanoma Melanogenesis by Phenotypic Modifiers

An Improved Modification of Permanganate Oxidation of Eumelanin That Gives a Constant Yield of Pyrrole-2,3,5-Tricarboxylic Acid

scientific article published on 01 June 1994

An insect with selective control of egg coloration

scientific article

An oxygen transporter hemocyanin can act on the late pathway of melanin synthesis

scientific article published in June 2005

Antimelanoma activity of chloroquine, an antimalarial agent with high affinity for melanin

scientific article published on October 1993

Antimelanoma effect of 4-S-cysteaminylcatechol, an activated form of 4-S-cysteaminylphenol.

scientific article

Biochemical Mechanism of Rhododendrol-Induced Leukoderma

scientific article published on 12 February 2018

Biosynthetic pathway to neuromelanin and its aging process

scientific article published on 01 October 2012

Catecholamine oxidative products, but not melanin, are produced by Cryptococcus neoformans during neuropathogenesis in mice.

scientific article

Changes in plasma 5-S-cysteinyldopa concentration in B16 melanoma-bearing mice treated with interferon-beta or dacarbazine

scientific article published on 01 October 1993

Changes in the proliferation and differentiation of neonatal mouse pink-eyed dilution melanocytes in the presence of excess tyrosine

scientific article published in December 2003

Characterization of Structural Properties for Morphologic Differentiation of Melanosomes. III. Free and Protein-bound Dopa and 5-S-Cysteinyldopa in B16 and Harding-Passey Melanomas

scientific article published on 01 March 1983

Characterization of melanin in human iridal and choroidal melanocytes from eyes with various colored irides

scientific article published in February 2008

Characterization of melanogenesis and morphogenesis of melanosomes by physicochemical properties of melanin and melanosomes in malignant melanoma

scientific article published on 01 March 1984

Characterization of melanogenesis in mouse and guinea pig hair by chemical analysis of melanins and of free and bound dopa and 5-S-cysteinyldopa.

scientific article

Chemical Analysis of Melanins and its Application to the Study of the Regulation of Melanogenesis

scientific article published on 01 January 2000

Chemical Characterization of Melanins in Sheep Wool and Human Hair

scientific article published on 01 April 1996

Chemical Degradation of Melanins: Application to Identification of Dopamine‐melanin ⬇️

scientific article published on 01 April 1998

Chemical Evaluation of Eumelanin Maturation by ToF-SIMS and Alkaline Peroxide Oxidation HPLC Analysis

scientific article published on 26 December 2020

Chemical Reactivities of ortho-Quinones Produced in Living Organisms: Fate of Quinonoid Products Formed by Tyrosinase and Phenoloxidase Action on Phenols and Catechols

scientific article published on 24 August 2020

Chemical analysis of constitutive pigmentation of human epidermis reveals constant eumelanin to pheomelanin ratio

scientific article published on 22 September 2015

Chemical analysis of late stages of pheomelanogenesis: conversion of dihydrobenzothiazine to a benzothiazole structure.

scientific article published on 11 June 2009

Chemical analysis of melanin pigments in feather germs of Japanese quail Bh (black at hatch) mutants

scientific article published on August 1999

Chemical characterization of eumelanins with special emphasis on 5,6-dihydroxyindole-2-carboxylic acid content and molecular size

scientific article published in May 1997

Chemical characterization of hair melanins in various coat-color mutants of mice

scientific journal article

Chemical characterization of pheomelanogenesis starting from dihydroxyphenylalanine or tyrosine and cysteine

scientific article published on 01 October 1997

Chemistry of mixed melanogenesis--pivotal roles of dopaquinone

scientific article

Childhood malnutrition is associated with a reduction in the total melanin content of scalp hair

scientific article published on 21 March 2007

Co-polymerization of dopa and cysteinyldopa in melanogenesis in vitro

scientific article published on 01 July 1980

Combined chemical and electron microscopic studies of pheomelanosomes in human red hair

scientific article published in December 1983

Comparative Analysis of Hair Melanins by Chemical and Electron Spin Resonance Methods

scientific article published on 01 February 1991

Comparison of High Performance Liquid Chromatography and Stereological Image Analysis for the Quantitation of Eumelanins and Pheomelanins in Melanoma Cells*

scientific article published on 01 April 1998

Comparison of antimelanoma effects of 4-S-cysteaminylphenol and its homologues

scientific article published on 01 April 1998

Comparison of eumelanin and pheomelanin content between cultured uveal melanoma cells and normal uveal melanocytes

scientific article

Comparison of in vivo anti-melanoma effect of enantiomeric alpha-methyl- and alpha-ethyl-4-S-cysteaminylphenol

scientific article published in April 2004

Comparison of phaeomelanin and its precursor 5-S-cysteinyldopa in the serum of melanoma patients

scientific article published in August 2003

Comparison of structural and chemical properties of black and red human hair melanosomes

scientific article published in January 2005

Comparison of the structural and physical properties of human hair eumelanin following enzymatic or acid/base extraction

scientific article

Comparisons of the structural and chemical properties of melanosomes isolated from retinal pigment epithelium, iris and choroid of newborn and mature bovine eyes

scientific article published in May 2005

Conjugation of dopa and 5-S-cysteinyldopa with cysteine mediated by superoxide radical

scientific article published in September 1982

Correlation between urinary melanin-related metabolites and tumour weight in melanoma-bearing mice.

scientific article published in January 1989

Covalent binding of catechols to proteins through the sulphydryl group

scientific article published on 01 May 1988

Current challenges in understanding melanogenesis: bridging chemistry, biological control, morphology, and function

scientific article

Cutaneous pharmacologic cAMP induction induces melanization of the skin and improves recovery from ultraviolet injury in melanocortin 1 receptor-intact or heterozygous skin

scientific article published on 24 August 2019

Cutaneous photobiology. The melanocyte vs. the sun: who will win the final round?

scientific article

Cutaneous photoprotection and melanoma susceptibility: reaching beyond melanin content to the frontiers of DNA repair

scientific article

Cyclic oscillations in melanin composition within hairs of baboons

scientific article published in June 2001

Cysteine deprivation promotes eumelanogenesis in human melanoma cells.

scientific article published on November 1996

Cysteine transport in melanosomes from murine melanocytes

scientific article published in February 1999

Cysteinyldopamine is not incorporated into neuromelanin

scientific article published on September 1991

Cystinosin is a melanosomal protein that regulates melanin synthesis

scientific article published on 30 May 2012

Degree of polymerization of 5,6-dihydroxyindole-derived eumelanin from chemical degradation study

scientific article published on 12 May 2014

Depigmentation of black guinea pig skin by topical application of cysteaminylphenol, cysteinylphenol, and related compounds

scientific article published on January 1987

Determination of DOPA, dopamine, and 5-S-cysteinyl-DOPA in plasma, urine, and tissue samples by high-performance liquid chromatography with electrochemical detection

scientific article published on 01 November 1984

Determination of eumelanin in human urine

scientific article published in April 2006

Determination of natural thiols by liquid chromatography after derivatization with 3,5-di-tert.-butyl-1,2-benzoquinone

Dihydro-1,4-benzothiazine-6,7-dione, the ultimate toxic metabolite of 4-S-Cysteaminylphenol and 4-S-Cysteaminylcatechol

article

Direct chemical evidence for eumelanin pigment from the Jurassic period

scientific article

Distribution and metabolism of tritium-labelled 5-5-cysteinyldopa in mice

scientific article published on 01 December 1980

Diversity of human hair pigmentation as studied by chemical analysis of eumelanin and pheomelanin ⬇️

scientific article published on December 1, 2011

Diversity of pigmentation in cultured human melanocytes is due to differences in the type as well as quantity of melanin

scientific article published on 01 April 2006

Dominant Red Coat Color in Holstein Cattle Is Associated with a Missense Mutation in the Coatomer Protein Complex, Subunit Alpha (COPA) Gene

scientific article

Dysplastic Melanocytic Nevi Contain High Levels of Pheomelanin: Quantitative Comparison of Pheomelanin/Eumelanin Levels Between Normal Skin, Common Nevi, and Dysplastic Nevi

scientific article published on 01 October 1991

EPR study of melanin-protein interaction: photoinduced free radicals and progressive microwave power saturation

scientific article

Effect of increased intracellular melanin concentration on survival of human melanoma cells exposed to different wavelengths of UV radiation

scientific article published in August 2001

Effects of Aging on Hair Color, Melanosome Morphology, and Melanin Composition in Japanese Females

scientific article published on 31 July 2019

Effects of genic substitution at the agouti, brown, albino, dilute, and pink-eyed dilution loci on the proliferation and differentiation of mouse epidermal melanocytes in serum-free culture

scientific journal article

Effects of genic substitution at the pink-eyed dilution locus on the proliferation and differentiation of mouse epidermal melanocytes in vivo and in vitro

scientific article published in March 2002

Effects of melanocyte-stimulating hormone on tyrosinase expression and melanin synthesis in hair follicular melanocytes of the mouse

scientific article published on 01 May 1993

Effects of melanogenesis-inducing nitric oxide and histamine on the production of eumelanin and pheomelanin in cultured human melanocytes

scientific article

Effects of rhododendrol and its metabolic products on melanocytic cell growth

scientific article published on 26 July 2015

Elemental characterisation of melanin in feathers via synchrotron X-ray imaging and absorption spectroscopy

scientific article

Encapsulation of a reactive core in neuromelanin

scholarly article

Establishment and characterization of human vaginal malignant melanoma xenotransplants.

scientific article published on July 1994

Establishment of a Mouse Model for Post-Inflammatory Hyperpigmentation

scientific article published on 04 July 2020

Estrogen increases hair pigmentation in female recessive yellow mice

scientific article published in June 2010

Eumelanin Biosynthesis Is Regulated by Coordinate Expression of Tyrosinase and Tyrosinase-Related Protein-1 Genes

article

Eumelanin and Phaeomelanin Contents of Human Epidermis and Cultured Melanocytes

scientific article published on 01 August 1995

Eumelanin and phaeomelanin contents of depigmented and repigmented skin in vitiligo patients.

scientific article published in September 2003

Eumelanin and pheomelanin concentrations in human epidermis before and after UVB irradiation

scientific article published in June 2005

Eumelanin levels in rufous feathers explain plasma testosterone levels and survival in swallows

article

Evaluation of 5-S-cysteinyldopa as a marker of melanoma progression: 10 years' experience.

scientific article

Evaluation of melanin-related metabolites as markers of melanoma progression

scientific article published on 01 February 1994

Evaluation of melanin-related metabolites as markers of solar ultraviolet-B radiation

scientific article published on 01 October 2006

Evolution of short tails and breakdown of honest signaling system during a severe winter in the Pacific swallow Hirundo tahitica

article

Excess Tyrosine Stimulates Eumelanin and Pheomelanin Synthesis in Cultured Slaty Melanocytes from Neonatal Mouse Epidermis

scientific article published on 01 March 2007

Excess tyrosine rescues the reduced activity of proliferation and differentiation of cultured recessive yellow melanocytes derived from neonatal mouse epidermis

scientific article published on 01 June 2007

Formation of cysteine conjugates from dihydroxyphenylalanine and its S-cysteinyl derivatives by peroxidase-catalyzed oxidation

scientific article published on 01 January 1981

Gamma-glutamyl transpeptidase and its role in melanogenesis: redox reactions and regulation of tyrosinase

scientific article published in December 2002

Generalized melanosis in metastatic malignant melanoma: the possible role of DOPAquinone metabolites

scientific article

Genotype analysis in a patient with oculocutaneous albinism 1 minimal pigment type

scientific article published on 09 January 2012

Growth inhibition of melanoma cells by N-protected dopa derivatives

scientific article published on 01 October 1987

Growth inhibition of re-challenge B16 melanoma transplant by conjugates of melanogenesis substrate and magnetite nanoparticles as the basis for developing melanoma-targeted chemo-thermo-immunotherapy

scientific article published on 08 October 2009

HPLC analysis of pheomelanin degradation products in human urine

scientific article published in October 2003

Heterozygous HPS1 mutations in a case of Hermansky-Pudlak syndrome with giant melanosomes.

scientific article

High levels of melanin-related metabolites in plasma from pink-eyed dilution mice

scientific article published in June 2007

High-performance liquid chromatography (HPLC) analysis of eu- and pheomelanin in melanogenesis control

scientific article

High-performance liquid chromatography estimation of cross-linking of dihydroxyindole moiety in eumelanin

scientific article

Highly sensitive detection of melanoma at an early stage based on the increased serum secreted protein acidic and rich in cysteine and glypican-3 levels

scientific article published on November 2005

Human hair melanins: what we have learned and have not learned from mouse coat color pigmentation

scientific article published on 01 February 2011

Human iridal stroma melanosomes of varying pheomelanin contents possess a common eumelanic outer surface

scientific article published in August 2009

Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation.

scientific article published in June 2002

Human tyrosinase is able to oxidize both enantiomers of rhododendrol

scientific article published on 3 September 2014

Identification of Shell Colour Pigments in Marine Snails Clanculus pharaonius and C. margaritarius (Trochoidea; Gastropoda)

scientific article

Identification of ester glucuronide and sulfate conjugates of 5-hydroxy-6-methoxyindole-2-carboxylic acid and 6-hydroxy-5-methoxyindole-2-carboxylic acid in melanoma urine

scientific article published on 01 July 1990

Identification of glypican-3 as a novel tumor marker for melanoma

scientific article

Imaging, chemical and spectroscopic studies of the methylation-induced decomposition of melanosomes

scientific article published on 17 March 2010

Improved HPLC Conditions to Determine Eumelanin and Pheomelanin Contents in Biological Samples Using an Ion Pair Reagent

scientific article published on 20 July 2020

Improved HPLC determination of 5-S-cysteinyldopa in serum

scientific article published on 01 March 1994

In vivo antimelanoma effects of 4-S-cysteaminylphenol, a newly synthesized therapeutic agent specific to melanoma

scientific article published on 01 January 1993

Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling

scientific article

Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentation

scientific journal article

Incorporation of sulfhydryl compounds into melanins in vitro

scientific article published on 01 January 1988

Increased cysteinyldopa plasma levels hint to melanocyte as stress sensor in psoriasis ⬇️

scientific article published on 01 March 2011

Independent regulation of hair and skin color by two G protein-coupled pathways

scientific article published on 21 July 2009

Influence of alpha-melanocyte-stimulating hormone and ultraviolet radiation on the transfer of melanosomes to keratinocytes

scientific article

Influences of Sex, Castration, and Androgens on the Eumelanin and Pheomelanin Contents of Different Feathers in Wild Mallards

article

Inhibition of transglutaminase by synthetic tyrosine melanin

scientific article published on June 2002

Insect cuticular melanins are distinctly different from those of mammalian epidermal melanins.

scientific article

Insect melanogenesis. II. Inability of Manduca phenoloxidase to act on 5,6-dihydroxyindole-2-carboxylic acid

scientific article published on April 1999

Interaction of Hermansky-Pudlak Syndrome genes in the regulation of lysosome-related organelles.

scientific article

Interaction of Human Substantia Nigra Neuromelanin with Lipids and Peptides

Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin

scientific article

Ion-exchange and adsorption of Fe(III) by Sepia melanin

scientific article

Isomeric cysteinyldopas provide a (photo)degradable bulk component and a robust structural element in red human hair pheomelanin

scientific article published on 26 February 2009

Lack of red hair phenotype in a North-African obese child homozygous for a novel POMC null mutation: nonsense-mediated decay RNA evaluation and hair pigment chemical analysis

scientific article

Levels of tyrosinase and its mRNA in coat-color mutants of C57BL/10J congenic mice: effects of genic substitution at the agouti, brown, albino, dilute, and pink-eyed dilution loci

scientific article published in June 1989

Liquid chromatography of plasma catecholamines, with electrochemical detection, after treatment with boric acid gel.

scientific article published in July 1984

Measurement of eumelanin precursor metabolites in the urine as a new marker for melanoma metastases

scientific article (publication date: April 1992)

Mechanism of growth inhibition of melanoma cells by 4-S-cysteaminylphenol and its analogues

scientific article published on 01 March 1990

Mechanism of putative neo-antigen formation from N-propionyl-4-S-cysteaminylphenol, a tyrosinase substrate, in melanoma models

scientific article published on 21 June 2012

Mechanism of selective toxicity of 4-S-cysteinylphenol and 4-S-cysteaminylphenol to melanocytes

article

Melanin acts as a potent UVB photosensitizer to cause an atypical mode of cell death in murine skin

scholarly article

Melanin biosynthesis in Cryptococcus neoformans

scientific article published on March 1998

Melanin chemistry and melanin precursors in melanoma.

scientific article published on May 1989

Melanin content and MC1R function independently affect UVR-induced DNA damage in cultured human melanocytes.

scientific article

Melanin-related metabolites as markers of melanoma: a review

scientific article

Melanin-related metabolites in urine of B16 melanoma-bearing mice

scientific article published in January 1988

Melanins and melanogenesis: from pigment cells to human health and technological applications

scientific article

Melanins and melanogenesis: methods, standards, protocols

scientific article published on 21 June 2013

Melanocortin 1 receptor genotype: an important determinant of the damage response of melanocytes to ultraviolet radiation.

scientific article published on 2 June 2010

Melanocytotoxicity and antimelanoma effects of phenolic amine compounds in mice in vivo

Melanoma inhibitory activity (MIA) as a serum marker for early detection of post-surgical relapse in melanoma patients: comparison with 5-S-cysteinyldopa

scientific article published in August 2002

Melanoma-Targeted Chemothermotherapy and In Situ Peptide Immunotherapy through HSP Production by Using Melanogenesis Substrate, NPrCAP, and Magnetite Nanoparticles

scientific article published on 21 February 2013

Melanoma-targeted chemo-thermo-immuno (CTI)-therapy using N-propionyl-4-S-cysteaminylphenol-magnetite nanoparticles elicits CTL response via heat shock protein-peptide complex release

scientific article published on September 2010

Microanalysis of eumelanin and pheomelanin in hair and melanomas by chemical degradation and liquid chromatography.

scientific article

Mineralized rods and cones suggest colour vision in a 300 Myr-old fossil fish

scientific article

Molecular and phenotypic analysis of 25 recessive, homozygous-viable alleles at the mouse agouti locus

scientific article

Molecular and phenotypic analysis of Attractin mutant mice

scientific article

Mutations in dopachrome tautomerase (Dct) affect eumelanin/pheomelanin synthesis, but do not affect intracellular trafficking of the mutant protein

scientific article

N-propionyl-4-S-cysteaminylphenol induces apoptosis in B16F1 cells and mediates tumor-specific T-cell immune responses in a mouse melanoma model

scientific article published on 2 May 2012

N-propionyl-cysteaminylphenol-magnetite conjugate (NPrCAP/M) is a nanoparticle for the targeted growth suppression of melanoma cells

scientific article published on 19 March 2009

Neuromelanins of human brain have soluble and insoluble components with dolichols attached to the melanic structure

scientific article

Neutral pH and copper ions promote eumelanogenesis after the dopachrome stage

scientific article published on 05 August 2013

Nevus Depigmentosus Systematicus With Partial Yellow Scalp Hair Due to Selective Suppression of Eumelanogenesis

scientific article published on 01 September 1993

New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals

scholarly article

Nle4DPhe7α-Melanocyte-Stimulating Hormone Increases the Eumelanin:Phaeomelanin Ratio in Cultured Human Melanocytes

scientific article published on 01 January 1995

Noise-induced hearing loss: the effect of melanin in the stria vascularis

scientific article published in April 2001

Nonenzymatic Spontaneous Oxidative Transformation of 5,6-Dihydroxyindole

scientific article published on 03 October 2020

Norepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the locus coeruleus

scientific article

Normal values of urinary excretion and serum concentration of 5-S-cysteinyldopa and 6-hydroxy-5-methoxyindole-2-carboxylic acid, biochemical markers of melanoma progression

scientific article published on 01 June 1991

Oxidation of tyrosine residues in proteins by tyrosinase. Formation of protein-bonded 3,4-dihydroxyphenylalanine and 5-S-cysteinyl-3,4-dihydroxyphenylalanine

scientific article

Oxidative Oligomerization of DBL Catechol, a potential Cytotoxic Compound for Melanocytes, Reveals the Occurrence of Novel Ionic Diels-Alder Type Additions

scientific article published on 15 September 2020

Oxygen-dependent conjugation of dopa with cysteine catalysed by iron-edta complex

scientific article published on 01 July 1984

Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation

scientific journal article

Pael receptor is involved in dopamine metabolism in the nigrostriatal system

scientific article published on 15 August 2007

Phenolic melanin precursors provide a rational approach to the design of antitumor agents for melanoma

scientific article published on January 1989

Pheomelanin as well as Eumelanin Is Present in Human Epidermis

scientific article published on 01 August 1991

Pheomelanin production in the epidermis from newborn agouti mice is induced by the expression of the agouti gene in the dermis

scientific article published in October 2004

Pheomelanogenesis is promoted at a weakly acidic pH.

scientific article

Photoaging of human retinal pigment epithelium is accompanied by oxidative modifications of its eumelanin

scientific article published on 27 March 2013

Photobleaching of pheomelanin increases its phototoxic potential: Physicochemical studies of synthetic pheomelanin subjected to aerobic photolysis

scientific article published on 11 December 2018

Photoreactivity of Hair Melanin from Different Skin Phototypes-Contribution of Melanin Subunits to the Pigments Photoreactive Properties

scientific article published on 24 April 2021

Pigment types in selected color genotypes of Asiatic sheep

scientific article published in October 1990

Pigment types in sheep, goats, and llamas

scientific article published in January 1988

Pigment-independent cAMP-mediated epidermal thickening protects against cutaneous UV injury by keratinocyte proliferation

scientific article

Pigmentation effects of solar-simulated radiation as compared with UVA and UVB radiation

scientific article published on 20 June 2008

Possible oxidative polymerization mechanism of 5,6-dihydroxyindole from ab initio calculations

scientific article

Predicting phenotype from genotype: normal pigmentation

scientific article

Preparation of eumelanin-related metabolites 5,6-dihydroxyindole, 5,6-dihydroxyindole-2-carboxylic acid, and their O-methyl derivatives

scientific article published on 01 May 1988

Production, circulation, and excretion of melanin-related metabolites in B16 melanoma-bearing mice

article

Prolonged treatment of fair-skinned mice with topical forskolin causes persistent tanning and UV protection

scientific article

Properties of a carboxypeptidase from aloe

scientific article published in April 1979

Protection against UVR involves MC1R-mediated non-pigmentary and pigmentary mechanisms in vivo

scientific article published on 18 March 2010

Protein-bound dopa and 5-S-cysteinyldopa in non-melanogenic tissues.

scientific article published in January 1983

Purification and growth of melanocortin 1 receptor (Mc1r)- defective primary murine melanocytes is dependent on stem cell factor (SFC) from keratinocyte-conditioned media

scientific article published on December 2009

Quantifying variation in human scalp hair fiber shape and pigmentation

scientific article

Quantitative Analysis of Eumelanin and Pheomelanin in Hair and Melanomas

scientific article published on 01 April 1983

Quantitative analysis of eumelanin and pheomelanin in humans, mice, and other animals: a comparative review

scientific article

Quantitative measures of the effect of the melanocortin 1 receptor on human pigmentary status

scientific article published in February 2004

Quantitative trait loci that modify the sootiness of yellow pigmentation in KK-A y /a mice

scientific article published on 01 August 2000

Rate constants for the first two chemical steps of eumelanogenesis

scientific article published in October 2003

Reduction of the nitro group to amine by hydroiodic acid to synthesize o-aminophenol derivatives as putative degradative markers of neuromelanin.

scientific article published on 16 June 2014

Regulation of eumelanin/pheomelanin synthesis and visible pigmentation in melanocytes by ligands of the melanocortin 1 receptor

scientific article published on 27 June 2008

Regulation of human skin pigmentation and responses to ultraviolet radiation

scientific article published on February 2007

Rhododenol-induced leukoderma in a mouse model mimicking Japanese skin

scientific article published on 27 October 2015

Roles of reactive oxygen species in UVA-induced oxidation of 5,6-dihydroxyindole-2-carboxylic acid-melanin as studied by differential spectrophotometric method

scientific article published on 26 February 2016

Seasonal Variation in Serum Concentration of 5-S-Cysteinyldopa and 6-Hydroxy-5-Methoxyindole-2-Carboxylic Acid in Healthy Japanese

scientific article published on 01 June 1995

Seasonal variation in urinary excretion of 5-S-cysteinyldopa in healthy Japanese

scientific article published in January 1987

Segmented heterochromia in black scalp hair associated with iron-deficiency anemia. Canities segmentata sideropaenica

scientific article published on 01 April 1989

Selective cytotoxicity of 4-S-cysteaminylphenol on follicular melanocytes of the black mouse: rational basis for its application to melanoma chemotherapy

Selective cytotoxicity of a phenolic melanin precursor, 4-S-cysteaminylphenol, on in vitro melanoma cells

scientific article published on 01 July 1989

Selective decrease of eumelanin in hypopigmented epidermis of hypomelanosis of Ito.

scientific article published in September 1994

Selective toxicity of 5-S-cysteinyldopa, a melanin precursor, to tumor cells in vitro and in vivo

article

Serum 5-S-Cysteinyldopa (5-S-CD) as a Marker of Melanoma Progression

scientific article published on 01 November 1992

Serum 5-S-cysteinyldopa levels in patients with psoriasis undergoing narrowband ultraviolet B phototherapy

scientific article

Serum levels of 5-s-cysteinyldopa are correlated with skin colors in hemodialysis patients but not in peritoneal dialysis patients

scientific article published on 31 July 2009

Serum levels of pigmentation markers are elevated in patients undergoing hemodialysis

scientific article

Serum levels of sICAM-1 and 5-S-cysteinyldopa as markers of melanoma progression.

scientific article published in February 1997

Short- and long-term effects of UV radiation on the pigmentation of human skin

scientific article

Simultaneous determination of catecholamines and serotonin by liquid chromatography, after treatment with boric acid gel.

scientific article published in March 1988

Simultaneous measurement of serum 5-S-cysteinyldopa, circulating intercellular adhesion molecule-1 and soluble interleukin-2 receptor levels in Japanese patients with malignant melanoma

scientific article published on 01 June 1997

Skin Pigmentation: Is the Control of Melanogenesis a Target within Reach? ⬇️

scientific article published on 14 December 2018

Slc7a11 gene controls production of pheomelanin pigment and proliferation of cultured cells

scientific article

Specific Incorporation of 4-S-Cysteinylphenol into Human Melanoma Cells

scientific article published on 01 May 1988

Spectrophotometric Assay of Eumelanin in Tissue Samples

scientific article published on 01 December 1993

Spectrophotometric Characterization of Eumelanin and Pheomelanin in Hair

scientific article published on 01 October 1996

Spiny mice modulate eumelanin to pheomelanin ratio to achieve cryptic coloration in "evolution canyon," Israel

scientific article

Stem cell factor rescues tyrosinase expression and pigmentation in discreet anatomic locations in albino mice

scientific article published on 04 August 2009

Stimulation of the proliferation and differentiation of mouse pink-eyed dilution epidermal melanocytes by excess tyrosine in serum-free primary culture

scientific article

Structural Characteristics of Human Substantia Nigra Neuromelanin and Synthetic Dopamine Melanins

scientific article published on 01 December 2000

Synthesis and antitumor activity of cysteinyl-3,4-dihydroxyphenylalonines and related compounds

scientific article published on 01 June 1981

Synthesis and selective in vitro anti-melanoma effect of enantiomeric alpha-methyl- and alpha-ethyl-4-S-cysteaminylphenol

scientific article published on December 2003

Synthesis of cysteinylphenol, cysteaminylphenol, and related compounds, and in vivo evaluation of antimelanoma effect

scientific article published on January 1987

T-cell receptor repertoires of tumor-infiltrating lymphocytes after hyperthermia using functionalized magnetite nanoparticles

scientific article published on 15 October 2012

TLR4 and NLRP3 inflammasome activation in monocytes by N-propionyl cysteaminylphenol-maleimide-dextran (NPCMD).

scientific article published on 14 November 2013

TRP-1 expression correlates with eumelanogenesis in human pigment cells in culture

article

TRP-2 expression protects HEK cells from dopamine- and hydroquinone-induced toxicity.

scientific article

The IFPCS presidential lecture: a chemist's view of melanogenesis

scientific article published in June 2003

The Metabolic Fate of ortho-Quinones Derived from Catecholamine Metabolites

scientific article

The MouseBrown(b/Tyrp1b) Allele Does Not Affect Pheomelanin Synthesis in Mice

scientific article published on 01 February 2014

The Oxidative Pathway to Dopamine-Protein Conjugates and Their Pro-Oxidant Activities: Implications for the Neurodegeneration of Parkinson's Disease.

scientific article

The Pro-Oxidant Activity of Pheomelanin Is Significantly Enhanced by UVA Irradiation: Benzothiazole Moieties Are More Reactive than Benzothiazine Moieties

The Pro-Oxidant Activity of Pheomelanin is Significantly Enhanced by UVA Irradiation: Benzothiazole Moieties Are More Reactive than Benzothiazine Moieties

scholarly article by Hitomi Tanaka published in September 2018

The effect of L-dopa on the potentiation of radiation damage to human melanoma cells

scientific article

The eumelanin and pheomelanin contents in dorsal hairs of female recessive yellow mice are greater than in male

scientific article published on 22 November 2006

The expression of tyrosinase, tyrosinase-related proteins 1 and 2 (TRP1 and TRP2), the silver protein, and a melanogenic inhibitor in human melanoma cells of differing melanogenic activities

scientific article published on April 1995

The histological analysis, colorimetric evaluation, and chemical quantification of melanin content in 'suntanned' fish

scientific article published in December 2005

The influence of iron on selected properties of synthetic pheomelanin

scientific article published on 24 May 2020

The killing effect of 4-S-cysteaminylphenol, a newly synthesised melanin precursor, on B16 melanoma cell lines

scientific article published on February 1991

The killing effects of 4-S-cysteinylcatechol and analogues on human melanoma cells

scientific article

The mechanism of toxicity of 5-S-cysteinyldopa to tumour cells

article

The melanocortin-1 receptor is a key regulator of human cutaneous pigmentation

scientific article published in January 2000

The melanogenic system of the liver pigmented macrophages of Rana esculenta L.--tyrosinase activity

scientific article published on 01 October 2007

The mouse pink-eyed dilution allele of the P-gene greatly inhibits eumelanin but not pheomelanin synthesis

article

The mouse ruby-eye 2(d) (ru2(d) /Hps5(ru2-d) ) allele inhibits eumelanin but not pheomelanin synthesis

scientific article published on 3 June 2013

The neuromelanin of human substantia nigra: physiological and pathogenic aspects

scientific article

The neuromelanin of human substantia nigra: structure, synthesis and molecular behaviour

scientific article

The potent pro-oxidant activity of rhododendrol-eumelanin induces cysteine depletion in B16 melanoma cells

scientific article published in January 2017

The potent pro-oxidant activity of rhododendrol-eumelanin is enhanced by ultraviolet A radiation

scientific article published on 12 March 2018

The presence of tyrosinase and related proteins in human epidermis and their relationship to melanin type

scientific article

The role of hydrogen peroxide and singlet oxygen in the photodegradation of melanin

scientific article published on 20 April 2020

The role of tyrosine hydroxylase as a key player in neuromelanin synthesis and the association of neuromelanin with Parkinson's disease

The slaty (slt/Dctslt) allele decreases the content of eumelanin, but not pheomelanin in the mouse hair

scientific article published on 18 November 2015

The slaty mutation affects eumelanin and pheomelanin synthesis in mouse melanocytes

scientific article published on 3 April 2006

The structure of neuromelanin as studied by chemical degradative methods

scientific article published in August 2003

The synthesis of 4-S-cysteinyl-[U-14C]phenol, an experimental antimelanoma agent

scientific article published on 01 January 1989

The underwhite (uw) locus acts autonomously and reduces the production of melanin

scientific article published on October 2000

The usefulness of 4-amino-3-hydroxyphenylalanine as a specific marker of pheomelanin

scientific article published in June 2002

Thein vivo antimelanoma effect of 4-S-cysteaminylphenol and its N-acetyl derivative

scientific article published on 01 November 1990

Tissue factor expression and serum level in patients with melanoma does not correlate with disease progression

scientific article published in June 2001

Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning

scientific article

Tyrosinase Depletion Prevents the Maturation of Melanosomes in the Mouse Hair Follicle

scientific article published on 30 November 2015

Tyrosinase-Catalyzed Oxidation of the Leukoderma-Inducing Agent Raspberry Ketone Produces (E)-4-(3-Oxo-1-butenyl)-1,2-benzoquinone: Implications for Melanocyte Toxicity.

scientific article published on 20 February 2017

Tyrosinase-catalyzed binding of 3,4-dihydroxyphenylalanine with proteins through the sulfhydryl group

scientific article published on 01 May 1986

Tyrosinase-catalyzed metabolism of rhododendrol (RD) in B16 melanoma cells: production of RD-pheomelanin and covalent binding with thiol proteins

scientific article published on 17 March 2015

Tyrosinase-catalyzed oxidation of resveratrol produces a highly reactive ortho-quinone: Implications for melanocyte toxicity

scientific article published on 10 July 2019

Tyrosinase-catalyzed oxidation of rhododendrol produces 2-methylchromane-6,7-dione, the putative ultimate toxic metabolite: implications for melanocyte toxicity

article

Tyrosinase-cytalyzed conjugation of dopa with glutathione

scientific article published on 01 July 1985

Tyrosinase-related proteins suppress tyrosinase-mediated cell death of melanocytes and melanoma cells

scientific article published on August 2004

Tyrosine peptides provide a color palette upon tyrosinase oxidation: nanosize does matter

scientific article published on 30 November 2016

UV-induced DNA damage and melanin content in human skin differing in racial/ethnic origin

scientific article published on 8 April 2003

UVA-induced oxidative degradation of melanins: fission of indole moiety in eumelanin and conversion to benzothiazole moiety in pheomelanin

scientific article

Ultrafast absorption and photothermal studies of decarboxytrichochrome C in solution

scientific article published in July 2003

Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene

scientific article published on 02 September 2008

Urinary 4-hydroxy-3-methoxymandelic (vanillylmandelic) acid, 4-hydroxy-3-methoxyphenylacetic (homovanillic) acid, and 5-hydroxy-3-indoleacetic acid determined by liquid chromatography with electrochemical detection

scientific article published on 01 May 1983

Urinary p-aminobenzoic acid determined in the pancreatic function test by liquid chromatography, with electrochemical detection

scientific article published on February 1982

Usefulness of alkaline hydrogen peroxide oxidation to analyze eumelanin and pheomelanin in various tissue samples: application to chemical analysis of human hair melanins

scientific article published on 17 May 2011

Variants in melanogenesis-related genes associate with skin cancer risk among Japanese populations

scientific article published on 12 March 2014

Visible light accelerates the ultraviolet A‐induced degradation of eumelanin and pheomelanin

scientific article published on 11 December 2018

[5-S-cysteinyldopa as a tumor marker for primary uveal malignant melanoma]

scientific article published on 01 May 1998

[Urinary polyamine analysis and its clinical significance. I. Analysis by HPLC and its clinical application. A. Urinary acetylpolyamine in patients with malignant tumors]

scientific article published on 01 July 1984

[Utilization of melanin precursors for experimental chemotherapy of malignant melanoma]

scientific article published on 01 October 1984

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