List of works - Richard S. Bruno

5-nitro-gamma-tocopherol increases in human plasma exposed to cigarette smoke in vitro and in vivo.

scientific article published in December 2003

A green tea-containing starch confection increases plasma catechins without protecting against postprandial impairments in vascular function in normoglycemic adults.

scientific article published on 5 August 2016

A simple assay for frequency of chromosome breaks and loss (micronuclei) by flow cytometry of human reticulocytes

scientific article published on 15 December 2004

Acute effects of ingestion of a novel whey-derived extract on vascular endothelial function in overweight, middle-aged men and women

scientific article published on 13 June 2012

Acute glutathione depletion induces hepatic methylglyoxal accumulation by impairing its detoxification to D-lactate.

scientific article published in April 2013

Acute, quercetin-induced reductions in blood pressure in hypertensive individuals are not secondary to lower plasma angiotensin-converting enzyme activity or endothelin-1: nitric oxide

scientific article published on 16 August 2012

Alpha-tocopherol modulates genes involved in hepatic xenobiotic pathways in mice

scientific article published on 11 September 2008

Altered gene expression in cloned piglets.

scientific article published on January 2009

Altered gene expression profiles in the brain, kidney, and lung of deceased neonatal cloned pigs

scientific article

Altered gene expression profiles in the brain, kidney, and lung of one-month-old cloned pigs

scientific article

Anti-inflammatory effects of freeze-dried black raspberry powder in ulcerative colitis ⬇️

scientific article published on November 23, 2010

Ascorbylated 4-hydroxy-2-nonenal as a potential biomarker of oxidative stress response

scientific article published on 14 July 2005

Astaxanthin-Rich Extract from the Green Alga Haematococcus pluvialis Lowers Plasma Lipid Concentrations and Enhances Antioxidant Defense in Apolipoprotein E Knockout Mice ⬇️

scientific article published on July 6, 2011

Benefits of prolonged gradient separation for high-performance liquid chromatography-tandem mass spectrometry quantitation of plasma total 15-series F-isoprostanes

scientific article published on 13 January 2006

Catechin-Rich Green Tea Extract and the Loss-of-TLR4 Signaling Differentially Alter the Hepatic Metabolome in Mice with Nonalcoholic Steatohepatitis

scientific article published on 28 November 2020

Chlorogenic acid differentially alters hepatic and small intestinal thiol redox status without protecting against azoxymethane-induced colon carcinogenesis in mice

scientific article published in January 2010

Cigarette smoking increases human vitamin E requirements as estimated by plasma deuterium-labeled CEHC.

scientific article

Consumption of green tea extract results in osteopenia in growing male mice

scientific article published on 26 August 2009

Dairy milk proteins attenuate hyperglycemia-induced impairments in vascular endothelial function in adults with prediabetes by limiting increases in glycemia and oxidative stress that reduce nitric oxide bioavailability

scientific article published on 25 September 2018

Development and validation of an algorithm to establish a total antioxidant capacity database of the US diet

scientific article

Dietary fat increases quercetin bioavailability in overweight adults

scientific article published on 15 January 2013

Dietary fructose feeding increases adipose methylglyoxal accumulation in rats in association with low expression and activity of glyoxalase-2

scientific article published on 21 August 2013

Dietary zinc restriction and repletion affects DNA integrity in healthy men.

scientific article published on 10 June 2009

Dietary zinc restriction in rats alters antioxidant status and increases plasma F2 isoprostanes

scientific article published on 04 December 2006

Dietary α- and γ-tocopherol supplementation attenuates lipopolysaccharide-induced oxidative stress and inflammatory-related responses in an obese mouse model of nonalcoholic steatohepatitis

scientific article published in December 2010

Effects of step-wise increases in dietary carbohydrate on circulating saturated Fatty acids and palmitoleic Acid in adults with metabolic syndrome

scientific article published in 2014

Endogenous and exogenous mediators of quercetin bioavailability.

scientific article

Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation.

scientific article published on 15 November 2005

Greater γ-tocopherol status during acute smoking abstinence with nicotine replacement therapy improved vascular endothelial function by decreasing 8-iso-15(S)-prostaglandin F2α.

scientific article published on 30 October 2014

Green Tea Extract Treatment in Obese Mice with Nonalcoholic Steatohepatitis Restores the Hepatic Metabolome in Association with Limiting Endotoxemia-TLR4-NFκB-Mediated Inflammation

scientific article published on 09 October 2019

Green Tea Lowers Hepatic COX-2 and Prostaglandin E2 in Rats with Dietary Fat-Induced Nonalcoholic Steatohepatitis

scientific article published on 2 December 2014

Green tea extract inhibits early oncogenic responses in mice with nonalcoholic steatohepatitis

scientific article published on 01 October 2019

Green tea extract prevents obesity in male mice by alleviating gut dysbiosis in association with improved intestinal barrier function that limits endotoxin translocation and adipose inflammation

scientific article published on 08 February 2019

Green tea extract protects against hepatic NFκB activation along the gut-liver axis in diet-induced obese mice with nonalcoholic steatohepatitis by reducing endotoxin and TLR4/MyD88 signaling.

scientific article published on 3 November 2017

Green tea extract protects against nonalcoholic steatohepatitis in ob/ob mice by decreasing oxidative and nitrative stress responses induced by proinflammatory enzymes.

scientific article published on 02 May 2011

Green tea extract provides extensive Nrf2-independent protection against lipid accumulation and NFκB pro- inflammatory responses during nonalcoholic steatohepatitis in mice fed a high-fat diet.

scientific article published on 17 December 2015

Green tea extract suppresses NFκB activation and inflammatory responses in diet-induced obese rats with nonalcoholic steatohepatitis.

scientific article

Green tea extract treatment reduces NFκB activation in mice with diet-induced nonalcoholic steatohepatitis by lowering TNFR1 and TLR4 expression and ligand availability

scientific article published on 21 December 2016

Increased static and decreased capacity oxidation-reduction potentials in plasma are predictive of metabolic syndrome

scientific article (publication date: 14 February 2017)

Induction of regulatory T cells by green tea polyphenol EGCG ⬇️

scientific article published on May 20, 2011

Low-fat milk ingestion prevents postprandial hyperglycemia-mediated impairments in vascular endothelial function in obese individuals with metabolic syndrome.

scientific article published on 21 August 2013

Metabolic syndrome increases dietary α-tocopherol requirements as assessed using urinary and plasma vitamin E catabolites: a double-blind, crossover clinical trial.

scientific article published on 11 January 2017

Postprandial Metabolism of Macronutrients and Cardiometabolic Risk: Recent Developments, Emerging Concepts, and Future Directions.

scientific article

Postprandial hyperglycemia impairs vascular endothelial function in healthy men by inducing lipid peroxidation and increasing asymmetric dimethylarginine:arginine.

scientific article

Protective role of dairy and its constituents on vascular function independent of blood pressure-lowering activities

scientific article published on January 2015

Quercetin bioavailability is associated with inadequate plasma vitamin C status and greater plasma endotoxin in adults

scientific article published on 11 June 2014

Quercetin-containing self-nanoemulsifying drug delivery system for improving oral bioavailability

scientific article

Response to Harri Hemilä, “Conclusions about intervention effects should not be based on surrogate end points”

scientific article published on 01 February 2007

Single Low-Density Lipoprotein Apheresis Does Not Improve Vascular Endothelial Function in Chronically Treated Hypercholesterolemic Patients

scientific article published on 22 February 2016

Soy proteins and isoflavones affect bone mineral density in older women: a randomized controlled trial

scientific article published on 27 May 2009

Soy proteins and isoflavones reduce interleukin-6 but not serum lipids in older women: a randomized controlled trial

scientific article published on 18 September 2013

Supplementation of a γ-tocopherol-rich mixture of tocopherols in healthy men protects against vascular endothelial dysfunction induced by postprandial hyperglycemia

scientific article published on 25 July 2012

Therapeutic potential of green tea in nonalcoholic fatty liver disease.

scientific article published on January 2012

Triglyceride recrystallized phytosterols in fat-free milk improve lipoprotein profiles more than unmodified free phytosterols in hypercholesterolemic men and women

scientific article published on 01 January 2013

Validation of high-performance liquid chromatography-boron-doped diamond detection for assessing hepatic glutathione redox status

scientific article published on 10 August 2010

Vitamin A and D Absorption in Adults with Metabolic Syndrome versus Healthy Controls - A Pilot Study Utilizing Targeted and Untargeted LC-MS Lipidomics

scientific article published on 09 November 2020

Vitamin C status is related to proinflammatory responses and impaired vascular endothelial function in healthy, college-aged lean and obese men

scientific article published on 01 May 2011

Vitamin C supplementation lowers urinary levels of 4-hydroperoxy-2-nonenal metabolites in humans

scientific article

Vitamin E

article

Vitamin E biokinetics, oxidative stress and cigarette smoking

scientific article published on 30 June 2006

Whey protein supplementation during resistance training augments lean body mass

scientific article

Women and smokers have elevated urinary F(2)-isoprostane metabolites: a novel extraction and LC-MS methodology

scientific article published on 27 August 2008

Zinc status alters growth and oxidative stress responses in rat hepatoma cells

scientific article published on 10 December 2013

α-Tocopherol bioavailability is lower in adults with metabolic syndrome regardless of dairy fat co-ingestion: a randomized, double-blind, crossover trial

scientific article

α-Tocopherol supplementation reduces 5-nitro-γ-tocopherol accumulation by decreasing γ-tocopherol in young adult smokers

scientific article published on 12 May 2015

γ-Carboxyethyl hydroxychroman, a metabolite of γ-tocopherol, preserves nitric oxide bioavailability in endothelial cells challenged with high glucose

scientific article published on 27 July 2016

γ-Tocopherol abolishes postprandial increases in plasma methylglyoxal following an oral dose of glucose in healthy, college-aged men.

scientific article published on 2 May 2011

γ-Tocopherol-rich supplementation additively improves vascular endothelial function during smoking cessation

scientific article published on 27 September 2013

List of works by Richard S. Bruno

5-nitro-gamma-tocopherol increases in human plasma exposed to cigarette smoke in vitro and in vivo.

A green tea-containing starch confection increases plasma catechins without protecting against postprandial impairments in vascular function in normoglycemic adults.

A simple assay for frequency of chromosome breaks and loss (micronuclei) by flow cytometry of human reticulocytes

Acute effects of ingestion of a novel whey-derived extract on vascular endothelial function in overweight, middle-aged men and women

Acute glutathione depletion induces hepatic methylglyoxal accumulation by impairing its detoxification to D-lactate.

Acute, quercetin-induced reductions in blood pressure in hypertensive individuals are not secondary to lower plasma angiotensin-converting enzyme activity or endothelin-1: nitric oxide

Alpha-tocopherol modulates genes involved in hepatic xenobiotic pathways in mice

Altered gene expression in cloned piglets.

Altered gene expression profiles in the brain, kidney, and lung of deceased neonatal cloned pigs

Altered gene expression profiles in the brain, kidney, and lung of one-month-old cloned pigs

Anti-inflammatory effects of freeze-dried black raspberry powder in ulcerative colitis ⬇️

Ascorbylated 4-hydroxy-2-nonenal as a potential biomarker of oxidative stress response

Astaxanthin-Rich Extract from the Green Alga Haematococcus pluvialis Lowers Plasma Lipid Concentrations and Enhances Antioxidant Defense in Apolipoprotein E Knockout Mice ⬇️

Benefits of prolonged gradient separation for high-performance liquid chromatography-tandem mass spectrometry quantitation of plasma total 15-series F-isoprostanes

Catechin-Rich Green Tea Extract and the Loss-of-TLR4 Signaling Differentially Alter the Hepatic Metabolome in Mice with Nonalcoholic Steatohepatitis

Chlorogenic acid differentially alters hepatic and small intestinal thiol redox status without protecting against azoxymethane-induced colon carcinogenesis in mice

Cigarette smoking increases human vitamin E requirements as estimated by plasma deuterium-labeled CEHC.

Consumption of green tea extract results in osteopenia in growing male mice

Dairy milk proteins attenuate hyperglycemia-induced impairments in vascular endothelial function in adults with prediabetes by limiting increases in glycemia and oxidative stress that reduce nitric oxide bioavailability

Development and validation of an algorithm to establish a total antioxidant capacity database of the US diet

Dietary fat increases quercetin bioavailability in overweight adults

Dietary fructose feeding increases adipose methylglyoxal accumulation in rats in association with low expression and activity of glyoxalase-2

Dietary zinc restriction and repletion affects DNA integrity in healthy men.

Dietary zinc restriction in rats alters antioxidant status and increases plasma F2 isoprostanes

Dietary α- and γ-tocopherol supplementation attenuates lipopolysaccharide-induced oxidative stress and inflammatory-related responses in an obese mouse model of nonalcoholic steatohepatitis

Effects of step-wise increases in dietary carbohydrate on circulating saturated Fatty acids and palmitoleic Acid in adults with metabolic syndrome

Endogenous and exogenous mediators of quercetin bioavailability.

Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation.

Greater γ-tocopherol status during acute smoking abstinence with nicotine replacement therapy improved vascular endothelial function by decreasing 8-iso-15(S)-prostaglandin F2α.

Green Tea Extract Treatment in Obese Mice with Nonalcoholic Steatohepatitis Restores the Hepatic Metabolome in Association with Limiting Endotoxemia-TLR4-NFκB-Mediated Inflammation

Green Tea Lowers Hepatic COX-2 and Prostaglandin E2 in Rats with Dietary Fat-Induced Nonalcoholic Steatohepatitis

Green tea extract inhibits early oncogenic responses in mice with nonalcoholic steatohepatitis

Green tea extract prevents obesity in male mice by alleviating gut dysbiosis in association with improved intestinal barrier function that limits endotoxin translocation and adipose inflammation

Green tea extract protects against hepatic NFκB activation along the gut-liver axis in diet-induced obese mice with nonalcoholic steatohepatitis by reducing endotoxin and TLR4/MyD88 signaling.

Green tea extract protects against nonalcoholic steatohepatitis in ob/ob mice by decreasing oxidative and nitrative stress responses induced by proinflammatory enzymes.

Green tea extract provides extensive Nrf2-independent protection against lipid accumulation and NFκB pro- inflammatory responses during nonalcoholic steatohepatitis in mice fed a high-fat diet.

Green tea extract suppresses NFκB activation and inflammatory responses in diet-induced obese rats with nonalcoholic steatohepatitis.

Green tea extract treatment reduces NFκB activation in mice with diet-induced nonalcoholic steatohepatitis by lowering TNFR1 and TLR4 expression and ligand availability

Increased static and decreased capacity oxidation-reduction potentials in plasma are predictive of metabolic syndrome

Induction of regulatory T cells by green tea polyphenol EGCG ⬇️

Low-fat milk ingestion prevents postprandial hyperglycemia-mediated impairments in vascular endothelial function in obese individuals with metabolic syndrome.

Metabolic syndrome increases dietary α-tocopherol requirements as assessed using urinary and plasma vitamin E catabolites: a double-blind, crossover clinical trial.

Postprandial Metabolism of Macronutrients and Cardiometabolic Risk: Recent Developments, Emerging Concepts, and Future Directions.

Postprandial hyperglycemia impairs vascular endothelial function in healthy men by inducing lipid peroxidation and increasing asymmetric dimethylarginine:arginine.

Protective role of dairy and its constituents on vascular function independent of blood pressure-lowering activities

Quercetin bioavailability is associated with inadequate plasma vitamin C status and greater plasma endotoxin in adults

Quercetin-containing self-nanoemulsifying drug delivery system for improving oral bioavailability

Response to Harri Hemilä, “Conclusions about intervention effects should not be based on surrogate end points”

Single Low-Density Lipoprotein Apheresis Does Not Improve Vascular Endothelial Function in Chronically Treated Hypercholesterolemic Patients

Soy proteins and isoflavones affect bone mineral density in older women: a randomized controlled trial

Soy proteins and isoflavones reduce interleukin-6 but not serum lipids in older women: a randomized controlled trial

Supplementation of a γ-tocopherol-rich mixture of tocopherols in healthy men protects against vascular endothelial dysfunction induced by postprandial hyperglycemia

Therapeutic potential of green tea in nonalcoholic fatty liver disease.

Triglyceride recrystallized phytosterols in fat-free milk improve lipoprotein profiles more than unmodified free phytosterols in hypercholesterolemic men and women

Validation of high-performance liquid chromatography-boron-doped diamond detection for assessing hepatic glutathione redox status

Vitamin A and D Absorption in Adults with Metabolic Syndrome versus Healthy Controls - A Pilot Study Utilizing Targeted and Untargeted LC-MS Lipidomics

Vitamin C status is related to proinflammatory responses and impaired vascular endothelial function in healthy, college-aged lean and obese men

Vitamin C supplementation lowers urinary levels of 4-hydroperoxy-2-nonenal metabolites in humans

Vitamin E

Vitamin E biokinetics, oxidative stress and cigarette smoking

Whey protein supplementation during resistance training augments lean body mass

Women and smokers have elevated urinary F(2)-isoprostane metabolites: a novel extraction and LC-MS methodology

Zinc status alters growth and oxidative stress responses in rat hepatoma cells

α-Tocopherol bioavailability is lower in adults with metabolic syndrome regardless of dairy fat co-ingestion: a randomized, double-blind, crossover trial

α-Tocopherol supplementation reduces 5-nitro-γ-tocopherol accumulation by decreasing γ-tocopherol in young adult smokers

γ-Carboxyethyl hydroxychroman, a metabolite of γ-tocopherol, preserves nitric oxide bioavailability in endothelial cells challenged with high glucose

γ-Tocopherol abolishes postprandial increases in plasma methylglyoxal following an oral dose of glucose in healthy, college-aged men.

γ-Tocopherol-rich supplementation additively improves vascular endothelial function during smoking cessation