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List of works by Mark Harris

A Conserved Proline between Domains II and III of Hepatitis C Virus NS5A Influences both RNA Replication and Virus Assembly

scientific article

A comparative analysis of the fluorescence properties of the wild-type and active site mutants of the hepatitis C virus autoprotease NS2-3

scientific article

A comparative cell biological analysis reveals only limited functional homology between the NS5A proteins of hepatitis C virus and GB virus B.

scientific article

A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria

scientific article published on February 2004

A diarylamine derived from anthranilic acid inhibits ZIKV replication.

scientific article published on 27 November 2019

A link between translation of the hepatitis C virus polyprotein and polymerase function; possible consequences for hyperphosphorylation of NS5A.

scientific article published on January 2006

A pivotal role of serine 225 phosphorylation in the function of hepatitis C virus NS5A revealed with the application of a phosphopeptide antiserum and super-resolution microscopy

A role for domain I of the hepatitis C virus NS5A protein in virus assembly. ⬇️

scientific article published on 19 January 2018

All three domains of the hepatitis C virus nonstructural NS5A protein contribute to RNA binding

scientific article

Analysis of the interactions between Nef and cellular proteins

scientific article published on January 1997

Carbon monoxide protects against oxidant-induced apoptosis via inhibition of Kv2.1.

scientific article published on 19 January 2011

Characterisation of the role of zinc in the hepatitis C virus NS2/3 auto-cleavage and NS3 protease activities

scientific article published on 28 December 2006

Chimeric GB virus B genomes containing hepatitis C virus p7 are infectious in vivo

scientific article published on 15 September 2008

Co-translational myristoylation alters the quaternary structure of HIV-1 Nef in solution

scientific article published in September 2005

Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner

scientific article published on 18 May 2011

DNA sequences required for the initiation of adenovirus type 4 DNA replication in vitro

article by Mark Harris et al published 5 May 1988 in Journal of Molecular Biology

Determinants of Hepatitis C Virus p7 Ion Channel Function and Drug Sensitivity Identified In Vitro

scientific article (publication date: August 2009)

Different patterns of BK and JC polyomavirus reactivation following renal transplantation

scientific article published on August 2010

Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability

scientific article published on 20 May 2010

Domain III of NS5A contributes to both RNA replication and assembly of hepatitis C virus particles

scientific article published on 4 March 2009

Early BK polyomavirus (BKV) reactivation in donor kidney is a risk factor for development of BKV-associated nephropathy

scientific article published on 24 October 2012

Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase

scientific article

Epoxide based inhibitors of the hepatitis C virus non-structural 2 autoprotease ⬇️

scientific article

Evaluation of a range of mammalian and mosquito cell lines for use in Chikungunya virus research ⬇️

scientific article published on 7 November 2017

Evaluation of canonical siRNA and Dicer substrate RNA for inhibition of hepatitis C virus genome replication--a comparative study ⬇️

scientific article published on 23 February 2015

Evidence for the formation of a heptameric ion channel complex by the hepatitis C virus p7 protein in vitro

scientific article published on 10 October 2006

Expression of feline recombinant interferon-gamma in baculovirus and demonstration of biological activity

scientific article published on July 1998

Expression of the NS3 protease of cytopathogenic bovine viral diarrhea virus results in the induction of apoptosis but does not block activation of the beta interferon promoter

scientific article published on 30 September 2009

Flavonoids from Pterogyne nitens Inhibit Hepatitis C Virus Entry ⬇️

scientific article published on 23 November 2017

Foot-and-mouth disease virus genome replication is unaffected by inhibition of type III phosphatidylinositol-4-kinases ⬇️

scientific article published on 20 June 2016

Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling

scientific article

Genetic and functional heterogeneity of the hepatitis C virus p7 ion channel during natural chronic infection

scientific article published on 14 December 2011

Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel

scientific article published on December 2008

HIV: a new role for Nef in the spread of HIV.

scientific article

Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis ⬇️

scientific article

Hepatitis C virus NS5A protein binds the SH3 domain of the Fyn tyrosine kinase with high affinity: mutagenic analysis of residues within the SH3 domain that contribute to the interaction ⬇️

scientific article

Hepatitis C virus NS5A protein interacts with beta-catenin and stimulates its transcriptional activity in a phosphoinositide-3 kinase-dependent fashion

scientific article published on 21 October 2009

Hepatitis C virus NS5A-mediated activation of phosphoinositide 3-kinase results in stabilization of cellular beta-catenin and stimulation of beta-catenin-responsive transcription

scientific article

Hepatitis C virus NS5A: enigmatic but still promiscuous 10 years on! ⬇️

scientific article

Hepatitis C virus NS5A: tales of a promiscuous protein

scientific article

Hepatitis C virus RNA replication is regulated by Ras-Erk signalling

scientific article published on 4 November 2009

Hepatitis C virus attenuates mitochondrial lipid β-oxidation by downregulating mitochondrial trifunctional-protein expression ⬇️

scientific article published on 11 February 2015

Hepatitis C virus-induced autophagy is independent of the unfolded protein response

scientific article

High efficiency gene transfer into cultured primary rat and human hepatic stellate cells using baculovirus vectors

scientific article published on February 2002

High-risk human papillomavirus E5 oncoprotein displays channel-forming activity sensitive to small-molecule inhibitors ⬇️

scientific article

Higher-order structures of the foot-and-mouth disease virus RNA-dependent RNA polymerase required for dynamic inter-molecular interactions involved in viral genome replication

Identification of a lead like inhibitor of the hepatitis C virus non-structural NS2 autoprotease ⬇️

scientific article published on 27 October 2015

Identification of a novel phosphorylation site in hepatitis C virus NS5A ⬇️

scientific article

Inhibition of hepatitis C virus p7 membrane channels in a liposome-based assay system

scientific article

Insights into the complexity and functionality of hepatitis C virus NS5A phosphorylation ⬇️

scientific article

Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production ⬇️

scientific article

Introduction of replication-competent hepatitis C virus transcripts using a tetracycline-regulable baculovirus delivery system

scientific article published on February 2004

Multiple roles of the non-structural protein 3 (nsP3) alphavirus unique domain (AUD) during Chikungunya virus genome replication and transcription

Multiple roles of the non-structural protein 3 (nsP3) alphavirus unique domain (AUD) during Chikungunya virus genome replication and transcription. ⬇️

scientific article published on 22 January 2019

Mutation of a C-terminal motif affects Kaposi's sarcoma-associated herpesvirus ORF57 RNA binding, nuclear trafficking, and multimerization

scientific article

Myristoylation-dependent binding of HIV-1 Nef to CD4.

scientific article published on August 1994

Natural compounds isolated from Brazilian plants are potent inhibitors of hepatitis C virus replication in vitro. ⬇️

scientific article

Nucleotide requirements at positions +1 to +4 for the initiation of hepatitis C virus positive-strand RNA synthesis

scientific article published on 26 January 2011

Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection ⬇️

scientific article

Persistent Chikungunya Virus Replication in Human Cells is Associated with Presence of Stable Cytoplasmic Granules Containing Non-structural Protein 3

Persistent Replication of a Chikungunya Virus Replicon in Human Cells Is Associated with Presence of Stable Cytoplasmic Granules Containing Nonstructural Protein 3 ⬇️

scientific article published on 31 July 2018

Perturbation of epidermal growth factor receptor complex formation and Ras signalling in cells harbouring the hepatitis C virus subgenomic replicon

scientific article

Phosphorylation of Serine 225 in Hepatitis C Virus NS5A Regulates Protein-Protein Interactions ⬇️

scientific article

Protection of hepatocytes from cytotoxic T cell mediated killing by interferon-alpha ⬇️

scientific article

Protein Kinase C-mediated Phosphorylation of HIV-I Nef in Human Cell Lines

scientific article published in Journal of Biological Chemistry

Recombinant human L-ficolin directly neutralizes hepatitis C virus entry.

scientific article published on 15 May 2014

Requirement for chloride channel function during the hepatitis C virus life cycle ⬇️

scientific article published on 21 January 2015

Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel

scientific article published on July 2011

Role of myristoylation and N-terminal basic residues in membrane association of the human immunodeficiency virus type 1 Nef protein

scientific article published in March 2006

SNAP-tagged Chikungunya Virus Replicons Improve Visualisation of Non-Structural Protein 3 by Fluorescence Microscopy ⬇️

scientific article

Serine phosphorylation of the hepatitis C virus NS5A protein controls the establishment of replication complexes ⬇️

scientific article

Signal peptide cleavage and internal targeting signals direct the hepatitis C virus p7 protein to distinct intracellular membranes

scientific article

Structure-function analysis of the equine hepacivirus 5' untranslated region highlights the conservation of translational mechanisms across the hepaciviruses

scientific article published on 01 November 2019

Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release

scientific article

Suppression of a pro-apoptotic K+ channel as a mechanism for hepatitis C virus persistence

scientific article (publication date: 15 September 2009)

Tagging of NS5A expressed from a functional hepatitis C virus replicon

scientific article published on March 2006

The C terminus of NS5A domain II is a key determinant of hepatitis C virus genome replication, but is not required for virion assembly and release ⬇️

scientific article published on 16 January 2013

The Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade

scientific article published on 5 January 2004

The broad-spectrum antiviral drug arbidol inhibits foot-and-mouth disease virus genome replication

scientific article published on 04 June 2019

The di-leucine motif in the cytoplasmic tail of CD4 is not required for binding to human immunodeficiency virus type 1 Nef, but is critical for CD4 down-modulation

scientific article

The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity

scientific article

The hepatitis C virus non-structural NS5A protein inhibits activating protein-1 function by perturbing ras-ERK pathway signaling

scientific article published on 5 March 2003

The hepatitis C virus non-structural protein NS5A alters the trafficking profile of the epidermal growth factor receptor

scientific article

The human immunodeficiency virus type 1 Nef protein binds the Src-related tyrosine kinase Lck SH2 domain through a novel phosphotyrosine independent mechanism.

scientific article

The non-primate hepacivirus 5' untranslated region possesses internal ribosomal entry site activity ⬇️

scientific article published on 11 September 2013

The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine

scientific article (publication date: 30 January 2003)

The stability of secreted, acid-labile H77/JFH-1 hepatitis C virus (HCV) particles is altered by patient isolate genotype 1a p7 sequences ⬇️

scientific article published on 24 October 2013

The subcellular localization of the hepatitis C virus non-structural protein NS2 is regulated by an ion channel-independent function of the p7 protein ⬇️

scientific article

Viruses and the fuel sensor: the emerging link between AMPK and virus replication

scientific article published on 28 April 2011

Visualisation and analysis of hepatitis C virus non-structural proteins using super-resolution microscopy ⬇️

scientific article published in Scientific Reports

Vps4 and the ESCRT-III complex are required for the release of infectious hepatitis C virus particles

scientific article published on 14 October 2009

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