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List of works by Stephen Griffin

"Too little, too late?" Will inhibitors of the hepatitis C virus p7 ion channel ever be used in the clinic?

scientific article published on January 2014

A Conserved Proline between Domains II and III of Hepatitis C Virus NS5A Influences both RNA Replication and Virus Assembly

scientific article

A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria

scientific article published on February 2004

A link between translation of the hepatitis C virus polyprotein and polymerase function; possible consequences for hyperphosphorylation of NS5A.

scientific article published on January 2006

A novel method for the measurement of hepatitis C virus infectious titres using the IncuCyte ZOOM and its application to antiviral screening ⬇️

scientific article published on 20 March 2015

Alkyl-imino sugars inhibit the pro-oncogenic ion channel function of human papillomavirus (HPV) E5 ⬇️

scholarly article by Laura F Wetherill published in October 2018

Chimeric GB virus B genomes containing hepatitis C virus p7 are infectious in vivo

scientific article published on 15 September 2008

Determinants of Hepatitis C Virus p7 Ion Channel Function and Drug Sensitivity Identified In Vitro

scientific article (publication date: August 2009)

Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability

scientific article published on 20 May 2010

Domain III of NS5A contributes to both RNA replication and assembly of hepatitis C virus particles

scientific article published on 4 March 2009

Evidence for the formation of a heptameric ion channel complex by the hepatitis C virus p7 protein in vitro

scientific article published on 10 October 2006

Expression of hepatitis C virus (HCV) structural proteins in trans facilitates encapsidation and transmission of HCV subgenomic RNA.

scientific article

Genetic and functional heterogeneity of the hepatitis C virus p7 ion channel during natural chronic infection

scientific article published on 14 December 2011

Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel

scientific article published on December 2008

Genotype-specific differences in structural features of hepatitis C virus (HCV) p7 membrane protein

scientific article

Hepatitis C virus-induced autophagy is independent of the unfolded protein response

scientific article

High-risk human papillomavirus E5 oncoprotein displays channel-forming activity sensitive to small-molecule inhibitors ⬇️

scientific article

Identification of a novel phosphorylation site in hepatitis C virus NS5A ⬇️

scientific article

Inhibition of hepatitis C virus p7 membrane channels in a liposome-based assay system

scientific article

Internalization of oncolytic reovirus by human dendritic cell carriers protects the virus from neutralization

scientific article published on 9 March 2011

Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production ⬇️

scientific article

Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade. ⬇️

scientific article published in January 2018

Ion Channel Function and Cross-Species Determinants in Viral Assembly of Nonprimate Hepacivirus p7 ⬇️

scientific article published on 9 March 2016

MicroRNA-18a targeting of the STK4/MST1 tumour suppressor is necessary for transformation in HPV positive cervical cancer

scientific article published on 18 June 2020

Modulation of calcium signaling pathway by hepatitis C virus core protein stimulates NLRP3 inflammasome activation

scientific article published on 27 February 2019

Mosquito  saliva enhances virus infection through sialokinin-dependent vascular leakage

scientific article published on 08 June 2022

Mutations in hepatitis C virus p7 reduce both the egress and infectivity of assembled particles via impaired proton channel function

scientific article published on August 2013

NS2 is dispensable for efficient assembly of hepatitis C virus-like particles in a bipartite trans-encapsidation system ⬇️

scientific article

Nucleotide requirements at positions +1 to +4 for the initiation of hepatitis C virus positive-strand RNA synthesis

scientific article published on 26 January 2011

Oncolytic reovirus as a combined antiviral and anti-tumour agent for the treatment of liver cancer ⬇️

scientific article

P12A PHASE I TRIAL OF INTRAVENOUS ONCOLYTIC REOLYSIN® IN PATIENTS WITH BRAIN TUMOURS.

scientific article published in October 2014

Plugging the holes in hepatitis C virus antiviral therapy

scientific article

Progress in clinical oncolytic virus-based therapy for hepatocellular carcinoma ⬇️

scientific article

Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

scientific article published on 10 November 2020

Release of Infectious Hepatitis C Virus from Huh7 Cells Occurs via a trans-Golgi Network-to-Endosome Pathway Independent of Very-Low-Density Lipoprotein Secretion ⬇️

scientific article published on 25 May 2016

Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel

scientific article published on July 2011

Signal peptide cleavage and internal targeting signals direct the hepatitis C virus p7 protein to distinct intracellular membranes

scientific article

Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza

scientific article published on 11 August 2020

Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza

Small molecule ligand docking to genotype specific bundle structures of hepatitis C virus (HCV) p7 protein

scientific article published on 20 May 2016

Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release

scientific article

Suppression of a pro-apoptotic K+ channel as a mechanism for hepatitis C virus persistence

scientific article (publication date: 15 September 2009)

Tagging of NS5A expressed from a functional hepatitis C virus replicon

scientific article published on March 2006

Targeting hepatitis C virus p7 channel activity reveals prospect for bimodal antiviral prophylaxis

The hepatitis C virus non-structural protein NS5A alters the trafficking profile of the epidermal growth factor receptor

scientific article

The major human immunodeficiency virus type 2 (HIV-2) packaging signal is present on all HIV-2 RNA species: cotranslational RNA encapsidation and limitation of Gag protein confer specificity

scientific article published on December 2001

The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine

scientific article (publication date: 30 January 2003)

The stability of secreted, acid-labile H77/JFH-1 hepatitis C virus (HCV) particles is altered by patient isolate genotype 1a p7 sequences ⬇️

scientific article published on 24 October 2013

The subcellular localization of the hepatitis C virus non-structural protein NS2 is regulated by an ion channel-independent function of the p7 protein ⬇️

scientific article

Viroporins: structure, function and potential as antiviral targets ⬇️

scientific article published on 28 May 2015

Vps4 and the ESCRT-III complex are required for the release of infectious hepatitis C virus particles

scientific article published on 14 October 2009

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