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List of works by Nobuyuki Takahashi

10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPARγ and stimulates adipogenesis.

scientific article published on 5 March 2015

A combination of soy isoflavones and cello-oligosaccharides changes equol/O-desmethylangolensin production ratio and attenuates bone fragility in ovariectomized mice

scientific article

Abietic acid activates peroxisome proliferator-activated receptor-gamma (PPARgamma) in RAW264.7 macrophages and 3T3-L1 adipocytes to regulate gene expression involved in inflammation and lipid metabolism.

scientific article published on August 2003

Activation of TRPV2 negatively regulates the differentiation of mouse brown adipocytes.

scientific article published on 18 June 2016

Activation of maxi-anion channel by protein tyrosine dephosphorylation

scientific article

Activation of peroxisome proliferator-activated receptor-α (PPARα) in proximal intestine improves postprandial lipidemia in obese diabetic KK-Ay mice

scientific article published on 01 September 2013

Activation of peroxisome proliferator-activated receptor-α (PPARα) suppresses postprandial lipidemia through fatty acid oxidation in enterocytes

scientific article published on 25 May 2011

Activation of peroxisome proliferator-activated receptor-α enhances fatty acid oxidation in human adipocytes.

scientific article published on 2 April 2011

An Efficient Purification Method for Quantitative Determinations of Protodioscin, Dioscin and Diosgenin in Plasma of Fenugreek-Fed Mice

scientific article published on 01 January 2015

Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes

scientific article (publication date: 26 March 2004)

Auraptene regulates gene expression involved in lipid metabolism through PPARα activation in diabetic obese mice

scientific article published on 28 October 2011

Auraptene suppresses inflammatory responses in activated RAW264 macrophages by inhibiting p38 mitogen-activated protein kinase activation.

scientific article published on 14 March 2013

Auraptene, a citrus fruit compound, regulates gene expression as a PPARalpha agonist in HepG2 hepatocytes.

scientific article published on January 2008

Bixin activates PPARα and improves obesity-induced abnormalities of carbohydrate and lipid metabolism in mice

scientific article published on 21 November 2012

Bixin regulates mRNA expression involved in adipogenesis and enhances insulin sensitivity in 3T3-L1 adipocytes through PPARgamma activation.

scientific article published on 3 November 2009

Brazilian propolis-derived components inhibit TNF-α-mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes

scientific article

Campest-5-en-3-one, an oxidized derivative of campesterol, activates PPARalpha, promotes energy consumption and reduces visceral fat deposition in rats

scientific article published on 23 March 2006

Capsaicin inhibits the production of tumor necrosis factor alpha by LPS-stimulated murine macrophages, RAW 264.7: a PPARgamma ligand-like action as a novel mechanism.

scientific article published on August 2004

Chloride channel inhibition prevents ROS-dependent apoptosis induced by ischemia-reperfusion in mouse cardiomyocytes.

scientific article

ClC-3-independent sensitivity of apoptosis to Cl- channel blockers in mouse cardiomyocytes

scientific article published in January 2005

DHA attenuates postprandial hyperlipidemia via activating PPARα in intestinal epithelial cells.

scientific article published on 16 October 2013

Dehydroabietic acid activates peroxisome proliferator-activated receptor-γ and stimulates insulin-dependent glucose uptake into 3T3-L1 adipocytes.

scientific article published on July 2011

Dehydroabietic acid, a diterpene, improves diabetes and hyperlipidemia in obese diabetic KK-Ay mice.

scientific article published in September 2009

Development of a novel PPARγ ligand screening system using pinpoint fluorescence-probed protein

scientific article published on 07 February 2011

Dietary factors evoke thermogenesis in adipose tissues

scientific article published on 18 January 2014

Dill seed extract improves abnormalities in lipid metabolism through peroxisome proliferator-activated receptor-α (PPAR-α) activation in diabetic obese mice.

scientific article

Diosgenin attenuates inflammatory changes in the interaction between adipocytes and macrophages

scientific article published on June 2010

Diosgenin, the main aglycon of fenugreek, inhibits LXRα activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese diabetic mice.

scientific article published on 24 November 2010

Double dioxygenation by mouse 8S-lipoxygenase: specific formation of a potent peroxisome proliferator-activated receptor alpha agonist

scientific article published on 15 August 2005

Dysfunction of regulatory volume increase is a key component of apoptosis

scientific article published on 09 November 2006

Evaluation of canine T-cell dependent antibody response to the primary and secondary immunization with keyhole limpet hemocyanin.

scientific article published in January 2013

Expression of novel isoforms of the CIC-1 chloride channel in astrocytic glial cells in vitro

scientific article published on July 2004

Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2

scientific article

Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways.

scientific article published on 23 August 2011

Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist.

scientific article published on August 2011

Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system.

scientific article

Food Components Modulate Obesity and Energy Metabolism via the Transcriptional Regulation of Lipid-Sensing Nuclear Receptors.

scientific article

Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies.

scientific article published on 25 May 2010

Genome science of lipid metabolism and obesity.

scientific article published on 07 April 2009

Geranylgeranyl pyrophosphate performs as an endogenous regulator of adipocyte function via suppressing the LXR pathway

scientific article published on 25 August 2016

Gut Microbial Fatty Acid Metabolites Reduce Triacylglycerol Levels in Hepatocytes.

scientific article published on 23 September 2015

Inflammation induced by RAW macrophages suppresses UCP1 mRNA induction via ERK activation in 10T1/2 adipocytes.

scientific article published on 9 January 2013

Inhibitory effect of monoacylglycerol on fatty acid uptake into rat intestinal epithelial cells

scientific article

Involvement of mast cells in adipose tissue fibrosis

scientific article published on 10 December 2013

Ischemia-induced enhancement of CFTR expression on the plasma membrane in neonatal rat ventricular myocytes

scientific journal article

Lack of TRPV2 impairs thermogenesis in mouse brown adipose tissue

scientific article published on 11 February 2016

Loss of claudins 2 and 15 from mice causes defects in paracellular Na+ flow and nutrient transport in gut and leads to death from malnutrition

scientific article published on 23 October 2012

Luteolin, a food-derived flavonoid, suppresses adipocyte-dependent activation of macrophages by inhibiting JNK activation.

scientific article published on 23 October 2009

Macrophage infiltration into obese adipose tissues suppresses the induction of UCP1 level in mice.

scientific article

Natural compounds regulate energy metabolism by the modulating the activity of lipid-sensing nuclear receptors.

scientific article

Overexpression and ribozyme-mediated targeting of transcriptional coactivators CREB-binding protein and p300 revealed their indispensable roles in adipocyte differentiation through the regulation of peroxisome proliferator-activated receptor gamma

scientific article published on 7 March 2002

Oxytocin receptor-deficient mice developed late-onset obesity

scientific article published in June 2008

Phenolic compounds from leaves of Casimiroa edulis showed adipogenesis activity.

scientific article published on 23 April 2014

Physiological and pharmacological function of PPARs

scientific article published in May 2001

Phytol directly activates peroxisome proliferator-activated receptor alpha (PPARalpha) and regulates gene expression involved in lipid metabolism in PPARalpha-expressing HepG2 hepatocytes.

scientific article

Plasma metabolites of dietary flavonoids after combination meal consumption with onion and tofu in humans.

scientific article published on 4 September 2013

Posttranscriptional regulation of alpha-catenin expression is required for Wnt signaling in L cells.

scientific article

Potent PPARα activator derived from tomato juice, 13-oxo-9,11-octadecadienoic acid, decreases plasma and hepatic triglyceride in obese diabetic mice

scientific article (publication date: 2012)

Proinflammatory cytokine interleukin-1β suppresses cold-induced thermogenesis in adipocytes.

scientific article published on 7 November 2015

Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo.

scientific article published on 3 February 2010

Recognition system for dietary fatty acids in the rat small intestine

scientific article published on 01 August 1995

Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line.

scientific article

Signalling events employed in the hypertonic activation of cation channels in HeLa cells

scientific article published on 01 January 2007

Soymorphin-5, a soy-derived μ-opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPARα systems in diabetic KKAy mice.

scientific article

Sulforaphane inhibits osteoclast differentiation by suppressing the cell-cell fusion molecules DC-STAMP and OC-STAMP.

scientific article published on 12 December 2016

Sulforaphene attenuates multinucleation of pre-osteoclasts by suppressing expression of cell-cell fusion-associated genes DC-STAMP, OC-STAMP, and Atp6v0d2.

scientific article published on 30 January 2017

Taurine improves obesity-induced inflammatory responses and modulates the unbalanced phenotype of adipose tissue macrophages.

scientific article published on 12 August 2013

Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice.

scientific article published in September 2011

Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes

scientific article published on 09 November 2011

Various Terpenoids Derived from Herbal and Dietary Plants Function as PPAR Modulators and Regulate Carbohydrate and Lipid Metabolism.

scientific article published on 3 June 2010

Volume-sensitive chloride channels involved in apoptotic volume decrease and cell death.

scientific article

Volume-sensitive outwardly rectifying chloride channel in white adipocytes from normal and diabetic mice.

scientific article published on 27 January 2010

Yamogenin in fenugreek inhibits lipid accumulation through the suppression of gene expression in fatty acid synthesis in hepatocytes

γ-Mangostin from Garcinia mangostana pericarps as a dual agonist that activates Both PPARα and PPARδ.

scientific article published on 7 December 2013

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