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List of works by Peter R. Flatt

(D-Ser2)Oxm[mPEG-PAL]: a novel chemically modified analogue of oxyntomodulin with antihyperglycaemic, insulinotropic and anorexigenic actions

scientific article published on 22 August 2010

(Pro(3))GIP[mPEG]: novel, long-acting, mPEGylated antagonist of gastric inhibitory polypeptide for obesity-diabetes (diabesity) therapy.

scientific article

(Val(8))GLP-1-Glu-PAL: a GLP-1 agonist that improves hippocampal neurogenesis, glucose homeostasis, and β-cell function in high-fat-fed mice

scientific article

(pGlu-Gln)-CCK-8[mPEG]: a novel, long-acting, mini-PEGylated cholecystokinin (CCK) agonist that improves metabolic status in dietary-induced diabetes

scientific article published on 10 April 2013

13C NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and gamma-glutamyl cycle activity in a clonal pancreatic beta-cell line.

scientific article published on 4 September 2003

A DPP-IV-resistant triple-acting agonist of GIP, GLP-1 and glucagon receptors with potent glucose-lowering and insulinotropic actions in high-fat-fed mice

scientific article published on 17 March 2013

A Novel CCK-8/GLP-1 Hybrid Peptide Exhibiting Prominent Insulinotropic, Glucose-Lowering, and Satiety Actions With Significant Therapeutic Potential in High-Fat-Fed Mice

scientific article published on 16 April 2015

A comparative study of amino acid consumption by rat islet cells and the clonal beta-cell line BRIN-BD11 - the functional significance of L-alanine

scientific article published on December 2003

A comparison of the cellular and biological properties of DPP-IV-resistant N-glucitol analogues of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide.

scientific article

A glycine-leucine-rich peptide structurally related to the plasticins from skin secretions of the frog Leptodactylus laticeps (Leptodactylidae).

scientific article published on 22 January 2009

A new stable GIP-Oxyntomodulin hybrid peptide improved bone strength both at the organ and tissue levels in genetically-inherited type 2 diabetes mellitus

scientific article published on 08 April 2016

A novel DPP IV-resistant C-terminally extended glucagon analogue exhibits weight-lowering and diabetes-protective effects in high-fat-fed mice mediated through glucagon and GLP-1 receptor activation.

scientific article published on 25 June 2014

A novel GIP-oxyntomodulin hybrid peptide acting through GIP, glucagon and GLP-1 receptors exhibits weight reducing and anti-diabetic properties

scientific article published on 18 March 2013

A novel acylated form of (d-Ala(2))GIP with improved antidiabetic potential, lacking effect on body fat stores

scientific article

A novel chemically modified analogue of xenin-25 exhibits improved glucose-lowering and insulin-releasing properties.

scientific article published on 20 January 2016

A novel glucagon-like peptide-1 (GLP-1)/glucagon hybrid peptide with triple-acting agonist activity at glucose-dependent insulinotropic polypeptide, GLP-1, and glucagon receptors and therapeutic potential in high fat-fed mice

scientific article published on 28 October 2013

A novel, long-acting agonist of glucose-dependent insulinotropic polypeptide suitable for once-daily administration in type 2 diabetes.

scientific article

A peptide of the phylloseptin family from the skin of the frog Hylomantis lemur (Phyllomedusinae) with potent in vitro and in vivo insulin-releasing activity

scientific article published on 21 September 2008

A potent, non-toxic insulin-releasing peptide isolated from an extract of the skin of the Asian frog, Hylarana guntheri (Anura:Ranidae).

scientific article

A stable analogue of glucose-dependent insulinotropic polypeptide, GIP(LysPAL16), enhances functional differentiation of mouse embryonic stem cells into cells expressing islet-specific genes and hormones

scientific article published on July 2006

Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice

scientific article published on 01 May 1981

Actions of PGLa-AM1 and its [A14K] and [A20K] analogues and their therapeutic potential as anti-diabetic agents.

scientific article

Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet

scientific article published on 30 March 2010

Actions of glucagon-like peptide-1 on KATP channel-dependent and -independent effects of glucose, sulphonylureas and nateglinide

scientific article published on September 2006

Actions of incretin metabolites on locomotor activity, cognitive function and in vivo hippocampal synaptic plasticity in high fat fed mice.

scientific article published on 24 March 2012

Activation of GPR119 by fatty acid agonists augments insulin release from clonal β-cells and isolated pancreatic islets and improves glucose tolerance in mice.

scientific article published on April 2014

Active immunization against (Pro(3))GIP improves metabolic status in high-fat-fed mice

scientific article published on September 2010

Acute and long-term effects of metformin on the function and insulin secretory responsiveness of clonal β-cells

scientific article published on December 2010

Acute and long-term effects of nateglinide on insulin secretory pathways

scientific article published on May 2004

Acute and long-term effects of peroxisome proliferator-activated receptor-γ activation on the function and insulin secretory responsiveness of clonal beta-cells

scientific article published on 16 December 2010

Administration of an acylated GLP-1 and GIP preparation provides added beneficial glucose-lowering and insulinotropic actions over single incretins in mice with Type 2 diabetes and obesity.

scientific article

Alteration of the bone tissue material properties in type 1 diabetes mellitus: A Fourier transform infrared microspectroscopy study

scientific article published on 23 March 2015

Alterations of glucose-dependent insulinotropic polypeptide (GIP) during cold acclimation

scientific article published on 10 December 2010

Alterations of glucose-dependent insulinotropic polypeptide and expression of genes involved in mammary gland and adipose tissue lipid metabolism during pregnancy and lactation

scientific article

Alterations of insulin secretion following long-term manipulation of ATP-sensitive potassium channels by diazoxide and nateglinide.

scientific article published in January 2005

Amino terminal glycation of gastric inhibitory polypeptide enhances its insulinotropic action on clonal pancreatic B-cells.

scientific article published on October 1998

An enzymatically stable GIP/xenin hybrid peptide restores GIP sensitivity, enhances beta cell function and improves glucose homeostasis in high-fat-fed mice

scientific article published on 21 December 2016

Antagonism of gastric inhibitory polypeptide (GIP) by palmitoylation of GIP analogues with N- and C-terminal modifications improves obesity and metabolic control in high fat fed mice.

scientific article published on 6 November 2014

Antagonistic effects of two novel GIP analogs, (Hyp3)GIP and (Hyp3)GIPLys16PAL, on the biological actions of GIP and longer-term effects in diabetic ob/ob mice.

scientific article published on 13 February 2007

Anti-diabetic actions of esculentin-2CHa(1-30) and its stable analogues in a diet-induced model of obesity-diabetes.

scientific article

Antidiabetic effects of sub-chronic activation of the GIP receptor alone and in combination with background exendin-4 therapy in high fat fed mice

scientific article

Antidiabetic effects of sub-chronic administration of the cannabinoid receptor (CB1) antagonist, AM251, in obese diabetic (ob/ob) mice.

scientific article published on 14 December 2007

Antidiabetic potential of two novel fatty acid derivatised, N-terminally modified analogues of glucose-dependent insulinotropic polypeptide (GIP): N-AcGIP(LysPAL16) and N-AcGIP(LysPAL37).

scientific article published in July 2005

Antihyperglycaemic activity of Asparagus racemosus roots is partly mediated by inhibition of carbohydrate digestion and absorption, and enhancement of cellular insulin action.

scientific article published on 8 September 2011

Antihyperglycaemic effect of saccharin in diabetic ob/ob mice

scientific article published on January 1997

Aqueous extracts of husks of Plantago ovata reduce hyperglycaemia in type 1 and type 2 diabetes by inhibition of intestinal glucose absorption.

scientific article published on July 2006

Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity

scientific article published on February 2004

Asparagus adscendens (Shweta musali) stimulates insulin secretion, insulin action and inhibits starch digestion

scientific article published on March 2006

Beneficial effects of (pGlu-Gln)-CCK-8 on energy intake and metabolism in high fat fed mice are associated with alterations of hypothalamic gene expression

scientific article published on 11 January 2013

Beneficial effects of a N-terminally modified GIP agonist on tissue-level bone material properties

scientific article published on March 2014

Beneficial effects of parenteral GLP-1 delivery by cell therapy in insulin-deficient streptozotocin diabetic mice.

scientific article published on 20 June 2013

Beneficial effects of sub-chronic activation of glucagon-like peptide-1 (GLP-1) receptors on deterioration of glucose homeostasis and insulin secretion in aging mice

scientific article published on 20 December 2006

Beneficial effects of the novel cholecystokinin agonist (pGlu-Gln)-CCK-8 in mouse models of obesity/diabetes.

scientific article published on 20 July 2012

Beneficial long-term antidiabetic actions of N- and C-terminally modified analogues of apelin-13 in diet-induced obese diabetic mice.

scientific article published on 20 July 2017

Beneficial metabolic actions of a stable GIP agonist following pre-treatment with a SGLT2 inhibitor in high fat fed diabetic mice

scientific article published on 19 November 2015

Beneficial metabolic effects of dietary epigallocatechin gallate alone and in combination with exendin-4 in high fat diabetic mice

scientific article published on 25 July 2017

Biological Activity and Antidiabetic Potential of C-Terminal Octapeptide Fragments of the Gut-Derived Hormone Xenin.

scientific article

Biological activity and antidiabetic potential of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide, GIP(1-16) and (Pro3)GIP(1-16).

scientific article published on 03 May 2006

Brevinin-1 and multiple insulin-releasing peptides in the skin of the frog Rana palustris.

scientific article published on May 2004

Brevinin-2-related peptide and its [D4K] analogue stimulate insulin release in vitro and improve glucose tolerance in mice fed a high fat diet

scientific article published on 21 May 2010

C-terminal mini-PEGylation of glucose-dependent insulinotropic polypeptide exhibits metabolic stability and improved glucose homeostasis in dietary-induced diabetes

scientific article

Caerulein precursor fragment (CPF) peptides from the skin secretions of Xenopus laevis and Silurana epitropicalis are potent insulin-releasing agents

scientific article

Caerulein-and xenopsin-related peptides with insulin-releasing activities from skin secretions of the clawed frogs, Xenopus borealis and Xenopus amieti (Pipidae).

scientific article published on 31 March 2011

Cell-to-cell communication and cellular environment alter the somatostatin status of delta cells

scientific article published on 15 July 2010

Cellular responses of novel human pancreatic β-cell line, 1.1B4 to hyperglycemia

scientific article published on July 2013

Characterisation and biological activity of Glu3 amino acid substituted GIP receptor antagonists.

scientific article published on 28 March 2007

Characterisation and glucoregulatory actions of a novel acylated form of the (Pro3)GIP receptor antagonist in type 2 diabetes.

scientific article published on February 2007

Characterisation of the biological activity of xenin-25 degradation fragment peptides

scientific article published on 22 April 2014

Characterization of naturally occurring peptides in the skin secretion of Rana pipiens frog reveal pipinin-1 as the novel insulin-releasing agent

scientific article published on October 2005

Chemical cholecystokinin receptor activation protects against obesity-diabetes in high fat fed mice and has sustainable beneficial effects in genetic ob/ob mice.

scientific article

Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets.

scientific article published on 09 June 2007

Chronic exposure to tolbutamide and glibenclamide impairs insulin secretion but not transcription of K(ATP) channel components

scientific article published in July 2004

Co-culture of clonal beta cells with GLP-1 and glucagon-secreting cell line impacts on beta cell insulin secretion, proliferation and susceptibility to cytotoxins.

scientific article published on 22 March 2016

Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid.

scientific article

Comparison of independent and combined chronic metabolic effects of GIP and CB1 receptor blockade in high-fat fed mice

scientific article

Comparison of independent and combined metabolic effects of chronic treatment with (pGlu-Gln)-CCK-8 and long-acting GLP-1 and GIP mimetics in high fat-fed mice

scientific article published on 26 February 2013

Comparison of insulin release from MIN6 pseudoislets and pancreatic islets of Langerhans reveals importance of homotypic cell interactions

scientific article published in October 2010

Comparison of sub-chronic metabolic effects of stable forms of naturally occurring GIP(1-30) and GIP(1-42) in high-fat fed mice

scientific article published on 6 January 2011

Comparison of the anti-diabetic effects of GIP- and GLP-1-receptor activation in obese diabetic (ob/ob) mice: studies with DPP IV resistant N-AcGIP and exendin(1-39)amide.

scientific article published on October 2007

Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice

scientific article

Comparison of the independent and combined metabolic effects of subchronic modulation of CCK and GIP receptor action in obesity-related diabetes

scientific article published on 20 November 2012

Comparison of the metabolic effects of GIP receptor antagonism and PYY(3-36) receptor activation in high fat fed mice

scientific article published on 19 August 2007

Comparison of the metabolic effects of sustained CCK1 receptor activation alone and in combination with upregulated leptin signalling in high-fat-fed mice

scientific article published on 6 March 2013

Comparison of the secretory properties of four insulin-secreting cell lines

scientific article published on February 2002

Comparison of the subchronic antidiabetic effects of DPP IV-resistant GIP and GLP-1 analogues in obese diabetic (ob/ob) mice.

scientific article published on June 2007

Configuration of electrofusion-derived human insulin-secreting cell line as pseudoislets enhances functionality and therapeutic utility

scientific article

Conformational Analysis of the Host-Defense Peptides Pseudhymenochirin-1Pb and -2Pa and Design of Analogues with Insulin-Releasing Activities and Reduced Toxicities

scientific article published on 25 November 2015

Cooperative enhancement of insulinotropic action of GLP-1 by acetylcholine uncovers paradoxical inhibitory effect of beta cell muscarinic receptor activation on adenylate cyclase activity.

scientific article published on January 2003

Culture and function of electrofusion-derived clonal insulin-secreting cells immobilized on solid and macroporous microcarrier beads

scientific article

Cyclic AMP production and insulin releasing activity of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide.

scientific article published on October 2002

Cytochrome P-450-dependent mixed-function oxidase and glutathione S-transferase activities in spontaneous obesity-diabetes.

scientific article

Cytochrome P450 1A-like proteins expressed in the islets of Langerhans and altered pancreatic beta-cell secretory responsiveness

scientific article published on June 1997

Cytotoxic peptides with insulin-releasing activities from skin secretions of the Italian stream frog Rana italica (Ranidae).

scientific article

D-glucose metabolism in BRIN-BD11 islet cells

scientific article

DPP IV resistance and insulin releasing activity of a novel di-substituted analogue of glucose-dependent insulinotropic polypeptide, (Ser2-Asp13)GIP.

scientific article

Daily administration of the GIP-R antagonist (Pro3)GIP in streptozotocin-induced diabetes suggests that insulin-dependent mechanisms are critical to anti-obesity-diabetes actions of (Pro3)GIP.

scientific article

Decreased dipeptidyl peptidase-IV activity and glucagon-like peptide-1(7-36)amide degradation in type 2 diabetic subjects.

scientific article published on 29 September 2007

Defective expression of cytochrome P450 proteins in the liver of the genetically obese Zucker rat

scientific article published on 01 December 1995

Degradation and glycemic effects of His(7)-glucitol glucagon-like peptide-1(7-36)amide in obese diabetic ob/ob mice.

scientific article

Degradation, insulin secretion, and antihyperglycemic actions of two palmitate-derivitized N-terminal pyroglutamyl analogues of glucose-dependent insulinotropic polypeptide.

scientific article

Degradation, insulin secretion, glucose-lowering and GIP additive actions of a palmitate-derivatised analogue of xenin-25

scientific article published on April 26, 2012

Degradation, receptor binding, insulin secreting and antihyperglycaemic actions of palmitate-derivatised native and Ala8-substituted GLP-1 analogues.

scientific article

Deleterious effects of supplementation with dehydroepiandrosterone sulphate or dexamethasone on rat insulin-secreting cells under in vitro culture condition

scientific article published on February 2006

Demonstration of glycated insulin in human diabetic plasma and decreased biological activity assessed by euglycemic-hyperinsulinemic clamp technique in humans

scientific article published in February 2003

Desensitization of sulphonylurea- and nutrient-induced insulin secretion following prolonged treatment with glibenclamide

scientific article

Detection of glycated gastric inhibitory polypeptide within the intestines of diabetic obese (ob/ob) mice.

scientific article

Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion

scientific article

Development and functional characterization of insulin-releasing human pancreatic beta cell lines produced by electrofusion

scientific article

Differential expression of glucagon-like peptide-2 (GLP-2) is involved in pancreatic islet cell adaptations to stress and beta-cell survival

scientific article

Differential molecular and cellular responses of GLP-1 secreting L-cells and pancreatic alpha cells to glucotoxicity and lipotoxicity

scientific article published on 28 May 2015

Dipeptidyl peptidase IV (DPP IV) inhibitors: A newly emerging drug class for the treatment of type 2 diabetes.

scientific article

Direct and indirect effects of obestatin peptides on food intake and the regulation of glucose homeostasis and insulin secretion in mice

scientific article published on 12 February 2007

Dogfish glucagon analogues counter hyperglycaemia and enhance both insulin secretion and action in diet-induced obese diabetic mice

scientific article published on 30 June 2016

Dorothy Hodgkin Lecture 2008. Gastric inhibitory polypeptide (GIP) revisited: a new therapeutic target for obesity-diabetes?

scientific article published in July 2008

Double incretin receptor knock-out (DIRKO) mice present with alterations of trabecular and cortical micromorphology and bone strength

scientific article published on 16 August 2014

Drug-induced desensitization of insulinotropic actions of sulfonylureas

scientific article

Drugs inducing hypoglycemia.

scientific article published on January 1989

Dual modulation of GIP and glucagon action by the low molecular weight compound 4-hydroxybenzoic acid 2-bromobenzylidene hydrazide.

scientific article published in August 2011

Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro3)GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice.

scientific article published on 08 May 2007

Effect of RU486 on hepatic and adipocyte gene expression improves diabetes control in obesity-type 2 diabetes

scientific article published on 10 August 2009

Effect of a transplantable insulinoma upon serotonin concentrations in the intestine of the rat.

scientific article

Effect of repeated sodium pentobarbitone administration on glucose homeostasis in mice

scientific article published on 01 January 1980

Effect of vitamin C supplementation on hepatic cytochrome P450 mixed-function oxidase activity in streptozotocin-diabetic rats

scientific article published on 01 December 1996

Effective surgical treatment of obesity may be mediated by ablation of the lipogenic gut hormone gastric inhibitory polypeptide (GIP): evidence and clinical opportunity for development of new obesity-diabetes drugs?

scientific article published on 01 June 2007

Effects of Non-Glycated and Glycated Glucagon-Like Peptide-1(7-36) Amide on Glucose Metabolism in Isolated Mouse Abdominal Muscle

scientific article published in January 1997

Effects of a transplantable insulinoma upon regulatory peptide concentrations in the gastrointestinal tract of the rat

scientific article published on 01 May 1986

Effects of amino acids, hormones and drugs on insulin release and 45Ca uptake by transplantable rat insulinoma cells maintained in tissue culture

scientific article published in January 1988

Effects of anti-diabetic drugs on bone metabolism

scientific article published on 31 August 2015

Effects of cationic modification on 45Ca uptake and insulin release by transplantable rat insulinoma cells maintained in tissue culture

scientific article

Effects of chronic exposure of clonal β-cells to elevated glucose and free fatty acids on incretin receptor gene expression and secretory responses to GIP and GLP-1.

scientific article published on 20 November 2013

Effects of cytotoxic drugs and inhibitors of insulin secretion on a serially transplantable rat insulinoma and cultured rat insulinoma cells

scientific article published in January 1987

Effects of ephedrine and atenolol on the development of obesity and diabetes in ob/ob mice

scientific article published on 01 January 1986

Effects of gamma-glutamyl linker on DPP-IV resistance, duration of action and biological efficacy of acylated glucagon-like peptide-1.

scientific article published on 22 April 2010

Effects of glucose-dependent insulinotropic polypeptide receptor knockout and a high-fat diet on cognitive function and hippocampal gene expression in mice

scientific article

Effects of lipotoxicity on a novel insulin-secreting human pancreatic β-cell line, 1.1B4.

scientific article published on July 2013

Effects of long-term exposure to nicotinamide and sodium butyrate on growth, viability, and the function of clonal insulin secreting cells

scientific article published on February 2004

Effects of metformin on BRIN-BD11 beta-cell insulin secretory desensitization induced by prolonged exposure to sulphonylureas

scientific article published on December 2010

Effects of nateglinide on the secretion of glycated insulin and glucose tolerance in type 2 diabetes

scientific article published in September 2003

Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice.

scientific article published in September 2004

Effects of subchronic treatment with the long-acting glucose-dependent insulinotropic polypeptide receptor agonist, N-AcGIP, on glucose homeostasis in streptozotocin-induced diabetes

scientific article published on 01 July 2007

Effects of transplantation and resection of a radiation-induced rat insulinoma on glucose homeostasis and the endocrine pancreas

scientific article published on October 1986

Effects on glucose homeostasis and insulin secretion of long term activation of the glucose-dependent insulinotropic polypeptide (GIP) receptor by N-AcGIP(LysPAL37) in normal mice.

scientific article published on 21 September 2005

Emerging applications of metabolomic and genomic profiling in diabetic clinical medicine.

scientific article published on December 2011

Enhancement of homocysteine toxicity to insulin-secreting BRIN-BD11 cells in combination with alloxan

scientific article published on 11 May 2012

Enteroendocrine hormone mimetics for the treatment of obesity and diabetes

scientific article

Erratum. A Novel CCK-8/GLP-1 Hybrid Peptide Exhibiting Prominent Insulinotropic, Glucose-Lowering, and Satiety Actions With Significant Therapeutic Potential in High-Fat-Fed Mice. Diabetes 2015;64:2996-3009

scientific article published on 01 April 2016

Esculentin-2CHa(1-30) and its analogues: stability and mechanisms of insulinotropic action.

scientific article published on March 2017

Esculentin-2CHa-Related Peptides Modulate Islet Cell Function and Improve Glucose Tolerance in Mice with Diet-Induced Obesity and Insulin Resistance.

scientific article published on 29 October 2015

Evaluation of glycated glucagon-like peptide-1(7-36)amide in intestinal tissue of normal and diabetic animal models.

scientific article

Evaluation of glycated insulin in diabetic animals using immunocytochemistry and radioimmunoassay.

scientific article published in August 2001

Evaluation of the antidiabetic activity of DPP IV resistant N-terminally modified versus mid-chain acylated analogues of glucose-dependent insulinotropic polypeptide.

scientific article published on 20 July 2006

Evaluation of the degradation and metabolic effects of the gut peptide xenin on insulin secretion, glycaemic control and satiety

scientific article

Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta-cells, isolated pancreatic islets and mice

scientific article published on November 2013

Evaluation of the insulin-releasing and glucose-lowering effects of GPR120 activation in pancreatic β-cells.

scientific article

Evaluation of the long-term effects of gastric inhibitory polypeptide-ovalbumin conjugates on insulin resistance, metabolic dysfunction, energy balance and cognition in high-fat-fed mice

scientific article published on 20 January 2012

Evaluation of the role of N-methyl-D-aspartate (NMDA) receptors in insulin secreting beta-cells

scientific article published on 10 December 2015

Evaluation of the site(s) of glycation in human proinsulin by ion-trap LCQ electrospray ionization mass spectrometry

scientific article published in May 2003

Evaluation of traditional plant treatments for diabetes: studies in streptozotocin diabetic mice

scientific article published in January 1989

Evidence for a sustained increase in clonal beta-cell basal intracellular Ca2+ levels after incubation in the presence of newly diagnosed Type-1 diabetic patient sera. Possible role in serum-induced inhibition of insulin secretion.

scientific article published on April 2002

Evidence for beneficial effects of compromised gastric inhibitory polypeptide action in obesity-related diabetes and possible therapeutic implications.

scientific article published on 17 June 2009

Evidence for inhibitory autocrine effects of proinsulin C-peptide on pancreatic β-cell function and insulin secretion.

scientific article published on 27 April 2014

Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties.

scientific article

Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance

scientific article published on October 2010

Frog skin peptides (tigerinin-1R, magainin-AM1, -AM2, CPF-AM1, and PGla-AM1) stimulate secretion of glucagon-like peptide 1 (GLP-1) by GLUTag cells.

scientific article

Function of a long-term, GLP-1-treated, insulin-secreting cell line is improved by preventing DPP IV-mediated degradation of GLP-1

article published in 2005

Functional GIP receptors play a major role in islet compensatory response to high fat feeding in mice

scientific article published on 14 February 2015

Functional examination of microencapsulated bioengineered insulin-secreting beta-cells

scientific article published in January 2001

Functionality and antidiabetic utility of β- and L-cell containing pseudoislets

scientific article

G protein-coupled receptors: signalling and regulation by lipid agonists for improved glucose homoeostasis.

scientific article

GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet

scientific article published on 11 September 2007

GIP(Lys16PAL) and GIP(Lys37PAL): novel long-acting acylated analogues of glucose-dependent insulinotropic polypeptide with improved antidiabetic potential.

scientific article published in February 2006

GPR39 receptors and actions of trace metals on pancreatic beta cell function and glucose homoeostasis.

scientific article

Gastric inhibitory polypeptide and effects of glycation on glucose transport and metabolism in isolated mouse abdominal muscle.

scientific article published in February 1998

Glucagon-like peptide-1 and the entero-insular axis in obese hyperglycaemic (ob/ob) mice

scientific article published on 01 February 1987

Glucoregulatory, endocrine and morphological effects of [P5K]hymenochirin-1B in mice with diet-induced glucose intolerance and insulin resistance.

scientific article published on 12 April 2016

Glucose and insulin response to conditioned feeding in lean and genetically obese hyperglycemic (ob/ob) mice

scientific article published on 01 May 1983

Glucose and non-glucidic nutrients exert permissive effects on 2-keto acid regulation of pancreatic beta-cell function

scientific article published on 01 January 1999

Glucose-dependent insulinotropic polypeptide (GIP) dose-dependently reduces osteoclast differentiation and resorption

scientific article published on 19 July 2016

Glucose-dependent insulinotropic polypeptide (GIP) receptor deletion leads to reduced bone strength and quality.

scientific article

Glucose-dependent insulinotropic polypeptide (GIP): anti-diabetic and anti-obesity potential?

scientific article published on October 2003

Glucose-dependent insulinotropic polypeptide analogues and their therapeutic potential for the treatment of obesity-diabetes.

scientific article

Glucose-dependent insulinotropic polypeptide receptor deficiency leads to modifications of trabecular bone volume and quality in mice

scientific article

Glucose-mediated Ca(2+) signalling in single clonal insulin-secreting cells: evidence for a mixed model of cellular activation

scientific article published on 01 May 2000

Glutamine regulates expression of key transcription factor, signal transduction, metabolic gene, and protein expression in a clonal pancreatic beta-cell line

scientific article published on September 2006

Glycated cholecystokinin-8 has an enhanced satiating activity and is protected against enzymatic degradation

scientific article

Glycation of glucagon-like peptide-1(7-36)amide: characterization and impaired action on rat insulin secreting cells.

scientific article published on October 1998

Glycation of insulin results in reduced biological activity in mice

scientific article published on 01 December 1997

Hexose recognition by insulin-secreting BRIN-BD11 cells

scientific article published on June 1996

High fat-fed diabetic mice present with profound alterations of the osteocyte network

scientific article published on 13 June 2016

Histamine-releasing and antimicrobial peptides from the skin secretions of the dusky gopher frog, Rana sevosa

scientific article published on 28 December 2005

Homocysteine and other structurally-diverse amino thiols can alter pancreatic beta cell function without evoking cellular damage

scientific article

Homocysteine-induced impairment of insulin secretion from clonal pancreatic BRIN-BD11 beta-cells is not prevented by catalase

scientific article published on January 2007

Hormonal control of glucose homeostasis during development and ageing in mice

scientific article

Hyperinsulinaemia causes a preferential increase in hepatic P4501A2 activity

scientific article published on 01 March 1992

Hyperketonaemia markedly modulates the metabolic activation of chemical carcinogens

scientific article published on 01 January 1990

Identification of the site of glycation of human insulin

scientific article published on 01 January 1996

Impaired ability of glycated insulin to regulate plasma glucose and stimulate glucose transport and metabolism in mouse abdominal muscle

scientific article published on 01 September 2000

Implanting 1.1B4 human β-cell pseudoislets improves glycaemic control in diabetic severe combined immune deficient mice

scientific article

Improved antioxidative defence protects insulin-producing cells against homocysteine toxicity.

scientific article published on 15 June 2016

In vitro and in vivo insulinotropic properties of the multifunctional frog skin peptide hymenochirin-1B: a structure-activity study.

scientific article published on 6 October 2015

Increased responsiveness to glucoregulatory effect of opiates in obese-diabetic ob/ob mice.

scientific article

Incretin receptor null mice reveal key role of GLP-1 but not GIP in pancreatic beta cell adaptation to pregnancy

scientific article

Induction of hepatic microsomal P450 I and IIB proteins by hyperketonaemia

scientific article published on 01 July 1990

Induction of rat hepatic mixed-function oxidases by acetone and other physiological ketones: their role in diabetes-induced changes in cytochrome P450 proteins

scientific article published on 01 December 1992

Influence of a transplantable insulinoma on the pancreatic status of insulin and pancreatic polypeptide in the rat

scientific article published on 01 March 1985

Influence of neuropeptide Y and pancreatic polypeptide on islet function and beta-cell survival

scientific article published on 6 January 2017

Inhibition of dipeptidyl peptidase IV activity by oral metformin in Type 2 diabetes.

scientific article

Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1.

scientific article published on 27 July 2006

Insulin modulates glucose-dependent insulinotropic polypeptide (GIP) secretion from enteroendocrine K cells in rats

scientific article published in October 2011

Insulin releasing properties of the temporin family of antimicrobial peptides.

scientific article

Insulin secretory actions of extracts of Asparagus racemosus root in perfused pancreas, isolated islets and clonal pancreatic beta-cells.

scientific article published on January 2007

Insulin-releasing action of the novel antidiabetic agent BTS 67 582.

scientific article

Insulin-releasing and cytotoxic properties of the frog skin peptide, tigerinin-1R: a structure-activity study.

scientific article published on 12 February 2014

Insulin-releasing and insulin-like activity of Agaricus campestris (mushroom) ⬇️

scientific article published on May 1, 1998

Insulin-releasing and metabolic effects of small molecule GLP-1 receptor agonist 6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline

scientific article

Insulin-releasing properties of the frog skin peptide pseudin-2 and its [Lys18]-substituted analogue

scientific article

Insulinotropic actions of nateglinide in type 2 diabetic patients and effects on dipeptidyl peptidase-IV activity and glucose-dependent insulinotropic polypeptide degradation.

scientific article published on 15 September 2009

Insulinotropic actions of the frog skin host-defense peptide alyteserin-2a: a structure-activity study

scientific article published on 29 June 2013

Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism

scientific article published on 20 October 2006

Islet distribution of Peptide YY and its regulatory role in primary mouse islets and immortalised rodent and human beta-cell function and survival.

scientific article published on 24 July 2016

Isolation and characterisation of an unexpected class of insulinotropic peptides in the skin of the frog Agalychnis litodryas

scientific article

Isolation and characterisation of insulin-releasing compounds from Crotalus adamanteus, Crotalus vegrandis and Bitis nasicornis venom.

scientific article published on 7 May 2015

Isolation and structural characterisation of a novel 13-amino acid insulin-releasing peptide from the skin secretion of Agalychnis calcarifer.

scientific article published on June 2005

Isolation and structural characterization of novel Rugosin A-like insulinotropic peptide from the skin secretions of Rana saharica frog.

scientific article published on 14 April 2005

Iterative exposure of clonal BRIN-BD11 cells to ninhydrin enables selection of robust toxin-resistant cells but with decreased gene expression of insulin secretory function

scientific article

L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic beta-cell line and protects from pro-inflammatory cytokine-induced apoptosis

scientific article

L-arginine is essential for pancreatic β-cell functional integrity, metabolism and defense from inflammatory challenge

scientific article

Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice.

scientific article

Lixisenatide improves recognition memory and exerts neuroprotective actions in high-fat fed mice

scientific article published on 3 September 2014

Locally produced xenin and the neurotensinergic system in pancreatic islet function and β-cell survival

scientific article

Long-term administration of PACAP receptor antagonist, PACAP(6-27), impairs glucose tolerance and insulin sensitivity in obese diabetic ob/ob mice.

scientific article published on 24 May 2006

Long-term beneficial effects of vanadate, tungstate, and molybdate on insulin secretion and function of cultured beta cells

scientific article published on May 2004

Lys9 for Glu9 substitution in glucagon-like peptide-1(7-36)amide confers dipeptidylpeptidase IV resistance with cellular and metabolic actions similar to those of established antagonists glucagon-like peptide-1(9-36)amide and exendin (9-39).

scientific article published in February 2004

Magainin-AM2 improves glucose homeostasis and beta cell function in high-fat fed mice

scientific article published on 20 October 2014

Major contributions of comparative endocrinology to the development and exploitation of the incretin concept.

scientific article published on September 2006

Major metabolic homocysteine-derivative, homocysteine thiolactone, exerts changes in pancreatic beta-cell glucose-sensing, cellular signal transduction and integrity

scientific article published on 2 March 2007

Meal-dependent regulation of circulating glycated insulin in type 2 diabetic subjects.

scientific article published in February 2006

Meal-induced 24-hour profile of circulating glycated insulin in type 2 diabetic subjects measured by a novel radioimmunoassay.

scientific article published in May 2003

Mechanisms of toxicity by proinflammatory cytokines in a novel human pancreatic beta cell line, 1.1B4.

scientific article published on September 2013

Metabolic and K(ATP) channel-independent actions of keto acid initiators of insulin secretion

scientific article published on 01 January 2000

Metabolic and neuroprotective effects of dapagliflozin and liraglutide in diabetic mice

scientific article published on 13 June 2017

Metabolic and structural properties of human obestatin {1-23} and two fragment peptides

scientific article

Metabolic effects and secretory properties of a radiation-induced transplantable rat insulinoma

scientific article

Metabolic effects of activation of CCK receptor signaling pathways by twice-daily administration of the enzyme-resistant CCK-8 analog, (pGlu-Gln)-CCK-8, in normal mice

scientific article published on 02 January 2013

Metabolic effects of orally administered small-molecule agonists of GPR55 and GPR119 in multiple low-dose streptozotocin-induced diabetic and incretin-receptor-knockout mice

scientific article published on 27 September 2016

Metabolic effects of radiation induced rat insulinoma at pancreatic, hepatic and subscapular transplantation sites

scientific article published on 01 January 1986

Metabolic effects of sub-chronic ablation of the incretin receptors by daily administration of (Pro3)GIP and exendin(9-39)amide in obese diabetic (ob/ob) mice.

scientific article published on February 2007

Metabolic effects of sustained activation of the GLP-1 receptor alone and in combination with background GIP receptor antagonism in high fat-fed mice.

scientific article

Miniaturized technique for the rapid extraction of plasma glucagon for radioimmunoassay

scientific article published on 01 February 1981

Modulation of glucose-induced insulin secretion by cytosolic redox state in clonal beta-cells.

scientific article published on August 1999

Molecular Mechanisms of Toxicity and Cell Damage by Chemicals in a Human Pancreatic Beta Cell Line, 1.1B4.

scientific article published on 21 May 2016

Molecular mechanisms mediating the beneficial metabolic effects of [Arg4]tigerinin-1R in mice with diet-induced obesity and insulin resistance.

scientific article published on 11 March 2016

Muscarinic receptor subtypes mediate stimulatory and paradoxical inhibitory effects on an insulin-secreting beta cell line

scientific article published on January 2002

N-acetyl-GLP-1: a DPP IV-resistant analogue of glucagon-like peptide-1 (GLP-1) with improved effects on pancreatic beta-cell-associated gene expression.

scientific article published on January 2004

N-terminal His(7)-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity.

scientific article published on March 2004

N-terminal glycation of cholecystokinin-8 abolishes its insulinotropic action on clonal pancreatic B-cells

scientific article published on 01 October 1999

N-terminally modified glucagon-like peptide-1(7-36) amide exhibits resistance to enzymatic degradation while maintaining its antihyperglycaemic activity in vivo

scientific article published on 01 March 2000

Na+ cotransport by metabolizable and nonmetabolizable amino acids stimulates a glucose-regulated insulin-secretory response

scientific article published on August 1998

Novel dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1(7-36)amide have preserved biological activities in vitro conferring improved glucose-lowering action in vivo.

scientific article published on December 2003

Novel dual agonist peptide analogues derived from dogfish glucagon show promising in vitro insulin releasing actions and antihyperglycaemic activity in mice.

scientific article published on 11 May 2016

Novel glucagon-like peptide-1 (GLP-1) analog (Val8)GLP-1 results in significant improvements of glucose tolerance and pancreatic beta-cell function after 3-week daily administration in obese diabetic (ob/ob) mice.

scientific article published on 28 April 2006

Novel insulin-releasing peptides in the skin of Phyllomedusa trinitatis frog include 28 amino acid peptide from dermaseptin BIV precursor.

scientific article published on August 2004

Nutrient regulation of pancreatic beta-cell function in diabetes: problems and potential solutions

scientific article published on November 2006

Nutrient regulation of the enteroinsular axis and insulin secretion

scientific article published on 01 January 1988

Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic beta-cells.

scientific article published on April 2006

Optimal bone mechanical and material properties require a functional glucagon-like peptide-1 receptor

scientific article

Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism.

scientific article published on September 2009

Pancreatic and extra-pancreatic effects of the traditional anti-diabetic plant, Medicago sativa (lucerne).

scientific article published on August 1997

Pancreatic cancer cells selectively stimulate islet beta cells to secrete amylin

scientific article

Passport Initiative fosters applied science

scientific article published in August 2016

Peptide Tyrosine Arginine, a potent immunomodulatory peptide isolated and structurally characterized from the skin secretions of the dusky gopher frog, Rana sevosa.

scientific article

Peptides from frog skin with potential for development into agents for Type 2 diabetes therapy

scientific article published on 5 September 2017

Peptidomic analysis of skin secretions from the bullfrog Lithobates catesbeianus (Ranidae) identifies multiple peptides with potent insulin-releasing activity

scientific article published on 16 November 2010

Pharmacological characterization and antidiabetic activity of a long-acting glucagon-like peptide-1 analogue conjugated to an antithrombin III-binding pentasaccharide.

scientific article published on 30 April 2015

Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox status in a clonal pancreatic β-cell line and mouse islets.

scientific article

Pituitary adenylate cyclase-activating peptide (PACAP): assessment of dipeptidyl peptidase IV degradation, insulin-releasing activity and antidiabetic potential.

scientific article

Positive effects of GLP-1 receptor activation with liraglutide on pancreatic islet morphology and metabolic control in C57BL/KsJ db/db mice with degenerative diabetes

scientific article published on 18 November 2014

Potential therapeutic applications of multifunctional host-defense peptides from frog skin as anti-cancer, anti-viral, immunomodulatory, and anti-diabetic agents

scientific article published on 02 May 2014

Pro-inflammatory cytokines increase glucose, alanine and triacylglycerol utilization but inhibit insulin secretion in a clonal pancreatic beta-cell line

scientific article

Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice

scientific article published on 2 November 2010

Prolonged GIP receptor activation using stable mini-PEGylated GIP improves glucose homeostasis and beta-cell function in age-related glucose intolerance

scientific article

Prolonged L-alanine exposure induces changes in metabolism, Ca(2+) handling and desensitization of insulin secretion in clonal pancreatic beta-cells.

scientific article published on February 2009

Prolonged exposure to homocysteine results in diminished but reversible pancreatic beta-cell responsiveness to insulinotropic agents

scientific article published on May 2007

Pseudoislet formation enhances gene expression, insulin secretion and cytoprotective mechanisms of clonal human insulin-secreting 1.1B4 cells.

scientific article

Recent advances in antidiabetic drug therapies targeting the enteroinsular axis.

scientific article published on February 2009

Responses of GLP1-secreting L-cells to cytotoxicity resemble pancreatic β-cells but not α-cells

scientific article published on 19 December 2014

Reversal of diabetes by syngeneic transplantation of a radiation-induced rat insulinoma

scientific article published on 01 March 1987

Role of CYP2E1 in ketone-stimulated insulin release in pancreatic B-cells

scientific article published in March 2004

Role of endogenous GLP-1 and GIP in beta cell compensatory responses to insulin resistance and cellular stress

scientific article

Role of islet structure and cellular interactions in the control of insulin secretion.

scientific article published on March 2011

Role of ketone bodies in the diabetes-induced changes in hepatic mixed-function oxidase activities

scientific article published on 01 November 1988

Rotational co-culture of clonal β-cells with endothelial cells: effect of PPAR-γ agonism in vitro on insulin and VEGF secretion

scientific article published on July 2011

Schizandra arisanensis extract attenuates cytokine-mediated cytotoxicity in insulin-secreting cells

scientific article

Sequential induction of beta cell rest and stimulation using stable GIP inhibitor and GLP-1 mimetic peptides improves metabolic control in C57BL/KsJ db/db mice.

scientific article published on 6 June 2015

Sex differences in the diabetes-induced modulation of rat hepatic cytochrome P450 proteins

scientific article published on 01 January 1993

Sitagliptin, a dipeptidyl peptidase-4 inhibitor, improves recognition memory, oxidative stress and hippocampal neurogenesis and upregulates key genes involved in cognitive decline

scientific article published on 28 January 2015

Skin secretion of the toad Bombina variegata contains multiple insulin-releasing peptides including bombesin and entirely novel insulinotropic structures.

scientific article

Skin secretions of Rana saharica frogs reveal antimicrobial peptides esculentins-1 and -1B and brevinins-1E and -2EC with novel insulin releasing activity.

scientific article published on January 2006

Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action

scientific article published on 01 March 2007

Specific binding of the C-peptide of proinsulin to cultured B-cells from a transplantable rat islet cell tumor

scientific article published in February 1986

Specific desensitization of sulfonylurea- but not imidazoline-induced insulin release after prolonged tolbutamide exposure.

scientific article

Stable Incretin Mimetics Counter Rapid Deterioration of Bone Quality in Type 1 Diabetes Mellitus

scientific article

Stable agonist of glucose-dependent insulinotropic polypeptide (GIP) restores pancreatic beta cell glucose responsiveness but not glucose intolerance in aging mice.

scientific article published on 27 December 2005

Stable oxyntomodulin analogues exert positive effects on hippocampal neurogenesis and gene expression as well as improving glucose homeostasis in high fat fed mice

scientific article published on 3 June 2015

Stimulation of insulin secretion in clonal BRIN-BD11 cells by the imidazoline derivatives KU14r and RX801080.

scientific article

Streptozotocin-induced diabetes modulates the metabolic activation of chemical carcinogens

scientific article published on January 1988

Streptozotocin-resistant BRIN-BD11 cells possess wide spectrum of toxin tolerance and enhanced insulin-secretory capacity

scientific article published in August 2007

Structure, antihyperglycemic activity and cellular actions of a novel diglycated human insulin

scientific article published on 01 October 2000

Sub-chronic administration of the 11beta-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity

scientific article published in April 2008

Substance P, neurokinin A and calcitonin gene-related peptide during development of the rat gastrointestinal tract

scientific article published on 01 May 1991

Substance P, neurokinin A, vasoactive intestinal polypeptide and gastrin releasing peptide in the intestine and pancreas of spontaneously obese-diabetic mice.

scientific article

Sustained treatment with a stable long-acting oxyntomodulin analogue improves metabolic control and islet morphology in an experimental model of type 1 diabetes

scientific article

Synthesis and Evaluation of a Series of Long-Acting Glucagon-Like Peptide-1 (GLP-1) Pentasaccharide Conjugates for the Treatment of Type 2 Diabetes.

scientific article published on 09 June 2015

Terminalia bellirica stimulates the secretion and action of insulin and inhibits starch digestion and protein glycation in vitro.

scientific article

The frog skin host-defense peptide CPF-SE1 improves glucose tolerance, insulin sensitivity and islet function and decreases plasma lipids in high-fat fed mice

scientific article

The role of glucagon- and somatostatin-secreting cells in the regulation of insulin release and beta-cell function in heterotypic pseudoislets

scientific article published on October 2010

The role of the cyclic GMP-inhibited cyclic AMP-specific phosphodiesterase (PDE3) in regulating clonal BRIN-BD11 insulin secreting cell survival

scientific article published on 01 August 2000

Therapeutic potential for GIP receptor agonists and antagonists.

scientific article

Tigerinin-1R: a potent, non-toxic insulin-releasing peptide isolated from the skin of the Asian frog, Hoplobatrachus rugulosus.

scientific article

Time-correlation between membrane depolarization and intracellular calcium in insulin secreting BRIN-BD11 cells: studies using FLIPR.

scientific article published on July 2004

Toll-like receptor agonist induced changes in clonal rat BRIN-BD11 beta-cell insulin secretion and signal transduction

scientific article

Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice.

scientific article

Vitamin C supplementation decreases insulin glycation and improves glucose homeostasis in obese hyperglycemic (ob/ob) mice.

scientific article

Xenin-25[Lys13PAL]: a novel long-acting acylated analogue of xenin-25 with promising antidiabetic potential

scientific article published on 6 November 2014

[Erratum] Effects of glucose-dependent insulinotropic polypeptide receptor knockout and a high-fat diet on cognitive function and hippocampal gene expression in mice

scientific article published on 15 July 2015

[I10W]tigerinin-1R enhances both insulin sensitivity and pancreatic beta cell function and decreases adiposity and plasma triglycerides in high-fat mice.

scientific article published on 3 July 2015

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