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List of works by Makoto Ihara

A SNP in the ABCC11 gene is the determinant of human earwax type

scientific article

A dual-target molecular mechanism of pyrethrum repellency against mosquitoes

scientific article published on 05 May 2021

A hypothesis to account for the selective and diverse actions of neonicotinoid insecticides at their molecular targets, nicotinic acetylcholine receptors: catch and release in hydrogen bond networks

scientific article published on 30 January 2007

A single amino acid polymorphism in the Drosophila melanogaster Dα1 (ALS) subunit enhances neonicotinoid efficacy at Dα1-chicken β2 hybrid nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes

scientific article published on 30 May 2014

Action of nereistoxin on recombinant neuronal nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes

scientific article

Action of six pyrethrins purified from the botanical insecticide pyrethrum on cockroach sodium channels expressed in Xenopus oocytes

scientific article published on 03 May 2018

An L319F mutation in transmembrane region 3 (TM3) selectively reduces sensitivity to okaramine B of the Bombyx mori l-glutamate-gated chloride channel.

scientific article

Availability of NHS-biotin labeling to identify free protein lysine revealed by experiment and MD simulation

scientific article published on 17 July 2018

Biosynthesis and Structure-Activity Relationship Studies of Okaramines That Target Insect Glutamate-Gated Chloride Channels

scientific article published on 31 January 2018

Blocking actions of alkylene-tethered bis-neonicotinoids on nicotinic acetylcholine receptors expressed by terminal abdominal ganglion neurons of Periplaneta americana

scientific article published on 5 July 2007

Cofactor-enabled functional expression of fruit fly, honeybee, and bumblebee nicotinic receptors reveals picomolar neonicotinoid actions

scientific article published on 01 July 2020

Combined effects of mutations in loop C and the loop D-E-G triangle on neonicotinoid interactions with Drosophila Dα1/chicken β2 hybrid nAChRs

scientific article published on 27 March 2018

Comparative ecotoxicity of imidacloprid and dinotefuran to aquatic insects in rice mesocosms

scientific article published on 29 December 2016

Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin

scientific article

Cy3-3-acylcholine: a fluorescent analogue of acetylcholine for single molecule detection

scientific article published on 7 December 2007

Differential blocking actions of 4'-ethynyl-4-n-propylbicycloorthobenzoate (EBOB) and gamma-hexachlorocyclohexane (gamma-HCH) on gamma-aminobutyric acid- and glutamate-induced responses of American cockroach neurons

scientific article

Diverse actions of neonicotinoids on chicken alpha7, alpha4beta2 and Drosophila-chicken SADbeta2 and ALSbeta2 hybrid nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes

scientific article

Exon 3 splicing and mutagenesis identify residues influencing cell surface density of heterologously expressed silkworm (Bombyx mori) glutamate-gated chloride channels

scientific article published on 26 September 2014

Flupyrimin: A Novel Insecticide Acting at the Nicotinic Acetylcholine Receptors.

scientific article published on 18 August 2017

Functional characterization of Musca glutamate- and GABA-gated chloride channels expressed independently and coexpressed in Xenopus oocytes

scientific article published in December 2006

Functional impact of subunit composition and compensation on Drosophila melanogaster nicotinic receptors–targets of neonicotinoids

scientific article published in 2023

GFP-based evaluation system of recombinant expression through the secretory pathway in insect cells and its application to the extracellular domains of class C GPCRs

scientific article published on 12 September 2011

General flexible nature of the cytosolic regions of fungal transient receptor potential (TRP) channels, revealed by expression screening using GFP-fusion techniques.

scientific article

GluCl a target of indole alkaloid okaramines: a 25 year enigma solved.

scientific article

Heterozygous TGFBR2 mutations in Marfan syndrome

scientific article

High-resolution Native-PAGE for membrane proteins capable of fluorescence detection and hydrodynamic state evaluation.

scientific article published in February 2011

Insect-vertebrate chimeric nicotinic acetylcholine receptors identify a region, loop B to the N-terminus of the Drosophila Dalpha2 subunit, which contributes to neonicotinoid sensitivity

scientific article published in September 2005

Insecticidal and neural activities of candidate photoaffinity probes for neonicotinoid binding sites

scientific article published in July 2001

Ivermectin modulation of pH-sensitive chloride channels in the silkworm larvae of Bombyx mori

scientific article published on 28 August 2015

Loops D, E and G in the Drosophila Dα1 subunit contribute to high neonicotinoid sensitivity of Dα1-chicken β2 nicotinic acetylcholine receptor.

scientific article published on 14 June 2017

Mechanisms of action, resistance and toxicity of insecticides targeting GABA receptors.

scientific article published on 12 June 2017

Meroterpenoid Chrodrimanins Are Selective and Potent Blockers of Insect GABA-Gated Chloride Channels

scientific article published on 22 April 2015

Modes of action, resistance and toxicity of insecticides targeting nicotinic acetylcholine receptors.

scientific article

Molecular Bases of Multimodal Regulation of a Fungal Transient Receptor Potential (TRP) Channel

scientific article

Neonicotinoid Insecticides: Molecular Targets, Resistance, and Toxicity

scientific article published on 01 January 2020

Neonicotinoid insecticides display partial and super agonist actions on native insect nicotinic acetylcholine receptors

scientific article published on 8 August 2006

Neonicotinoids show selective and diverse actions on their nicotinic receptor targets: electrophysiology, molecular biology, and receptor modeling studies.

scientific article

Neonicotinoids: molecular mechanisms of action, insights into resistance and impact on pollinators

scientific article published on 27 September 2018

Okaramine insecticidal alkaloids show similar activity on both exon 3c and exon 3b variants of glutamate-gated chloride channels of the larval silkworm, Bombyx mori

scientific article published on 3 May 2016

Probing new components (loop G and the α-α interface) of neonicotinoid binding sites on nicotinic acetylcholine receptors.

scientific article published on 28 February 2015

Proinsecticide candidates N-(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl derivatives of imidacloprid and 1-chlorothiazolylmethyl-2-nitroimino-imidazolidine

scientific article published on 6 June 2007

Role in the selectivity of neonicotinoids of insect-specific basic residues in loop D of the nicotinic acetylcholine receptor agonist binding site

scientific article published on 25 July 2006

STAT3 inhibitory activity of naphthoquinones isolated from Tabebuia avellanedae

scientific article published on 28 January 2020

Selective regulation of pyrethrin biosynthesis by the specific blend of wound induced volatiles in Tanacetum cinerariifolium

scientific article published on 26 February 2016

Splice Variants of pH-Sensitive Chloride Channel Identify a Key Determinant of Ivermectin Sensitivity in the Larvae of the Silkworm Bombyx mori.

scientific article published on 24 July 2017

Studies on an acetylcholine binding protein identify a basic residue in loop G on the β1 strand as a new structural determinant of neonicotinoid actions

scientific article

Super agonist actions of clothianidin and related compounds on the SAD beta 2 nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes

scientific article published in March 2004

The fungal alkaloid Okaramine-B activates an L-glutamate-gated chloride channel from Ixodes scapularis, a tick vector of Lyme disease.

scientific article published on 4 June 2018