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List of works by Kai Rothkamm

A comparison of six statistical distributions for analysis of chromosome aberration data for radiation biodosimetry.

scientific article

A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity

scientific article published on January 2004

A functional ex vivo assay to detect PARP1-EJ repair and radiosensitization by PARP-inhibitor in prostate cancer.

scientific article published on 5 January 2019

A new Bayesian model applied to cytogenetic partial body irradiation estimation

scientific article published on 11 June 2015

A new inverse regression model applied to radiation biodosimetry

scientific article published in 2015

A portable microfluidic fluorescence spectrometer device for γ-H2AX-based biological dosimetry

ATM acts downstream of ATR in the DNA damage response signaling of bystander cells

scientific article published on September 2008

ATR-dependent radiation-induced gamma H2AX foci in bystander primary human astrocytes and glioma cells

scientific article published on 7 August 2006

Analyzing expression and phosphorylation of the EGF receptor in HNSCC

scientific article published on 19 September 2019

Analyzing the influence of kinase inhibitors on DNA repair by differential proteomics of chromatin-interacting proteins and nuclear phospho-proteins.

scientific article published on 10 November 2017

Automatic scoring of dicentric chromosomes as a tool in large scale radiation accidents.

scientific article

BCL2-overexpressing prostate cancer cells rely on PARP1-dependent end-joining and are sensitive to combined PARP inhibitor and radiation therapy.

scientific article published on 8 March 2018

BRCA1, FANCD2 and Chk1 are potential molecular targets for the modulation of a radiation-induced DNA damage response in bystander cells.

scientific article published on 7 October 2014

Biomarkers of radiation exposure: can they predict normal tissue radiosensitivity?

scientific article published on 17 July 2013

Cohesin phosphorylation and mobility of SMC1 at ionizing radiation-induced DNA double-strand breaks in human cells

scientific article published on 4 November 2010

Cohesin promotes the repair of ionizing radiation-induced DNA double-strand breaks in replicated chromatin

scientific article

Combined analysis of gamma-H2AX/53BP1 foci and caspase activation in lymphocyte subsets detects recent and more remote radiation exposures

scientific article

Comparison of established and emerging biodosimetry assays

scientific article published on 17 July 2013

Correlation between DNA damage responses of skin to a test dose of radiation and late adverse effects of earlier breast radiotherapy

scientific article

Correlation between the radiation responses of fibroblasts cultured from individual patients and the risk of late reaction after breast radiotherapy.

scientific article published on 2 March 2016

CytoBayesJ: software tools for Bayesian analysis of cytogenetic radiation dosimetry data.

scientific article

DNA Repair.

scientific article published in January 2016

DNA and chromosomal damage in response to intermittent extremely low-frequency magnetic fields

scientific article

DNA damage foci: Meaning and significance.

scientific article published on 12 March 2015

DNA double-strand break repair and induction of apoptosis in ex vivo irradiated blood lymphocytes in relation to late normal tissue reactions following breast radiotherapy.

scientific article published on 13 March 2014

Deoxyribonucleic acid damage-associated biomarkers of ionising radiation: current status and future relevance for radiology and radiotherapy

scientific article

Development of a retrospective/fortuitous accident dosimetry service based on OSL of mobile phones

scientific article published on 01 April 2015

Direct involvement of retinoblastoma family proteins in DNA repair by non-homologous end-joining.

scientific article

EGFRvIII does not affect radiosensitivity with or without gefitinib treatment in glioblastoma cells.

scientific article

Effect of sorafenib on cisplatin-based chemoradiation in head and neck cancer cells

scientific article published on 22 March 2016

Erratum to "Correlation between the radiation responses of fibroblasts cultured from individual patients and the risk of late reaction after breast radiotherapy" [Cancer Lett. 374/2 (2016) 324-330]

scientific article published on 12 May 2016

Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice.

scientific article published on 23 November 2015

Gamma-H2AX biodosimetry for use in large scale radiation incidents: comparison of a rapid '96 well lyse/fix' protocol with a routine method.

scientific article

Gamma-H2AX foci counting: image processing and control software for high-content screening

scholarly article published 8 February 2007

Gamma-H2AX-based dose estimation for whole and partial body radiation exposure

scientific article

Homologous recombination mediates cellular resistance and fraction size sensitivity to radiation therapy

scientific article published on 5 June 2013

Impact of long-term exposure to sodium arsenite on cytogenetic radiation damage

scientific article published on 22 January 2014

In situ biological dose mapping estimates the radiation burden delivered to 'spared' tissue between synchrotron X-ray microbeam radiotherapy tracks

scientific article

Inter- and intra-laboratory comparison of a multibiodosimetric approach to triage in a simulated, large scale radiation emergency

Inter-individual and inter-cell type variation in residual DNA damage after in vivo irradiation of human skin

scientific article published on 26 May 2011

Interlaboratory variation in scoring dicentric chromosomes in a case of partial-body x-ray exposure: implications for biodosimetry networking and cytogenetic "triage mode" scoring

scientific article published in December 2009

Ionizing radiation-induced DNA strand breaks and γ-H2AXγ-H2AX foci in cells exposed to nitric oxide.

scientific article published in January 2011

Is a semi-automated approach indicated in the application of the automated micronucleus assay for triage purposes?

scientific article

Joining of correct and incorrect DNA double-strand break ends in normal human and ataxia telangiectasia fibroblasts

scientific article published on 01 January 2000

Laboratory intercomparison of gene expression assays

scientific article

Laboratory intercomparison of the cytokinesis-block micronucleus assay

scientific article published on 17 July 2013

Laboratory intercomparison of the dicentric chromosome analysis assay.

scientific article published on 17 July 2013

Laboratory intercomparison on the γ-H2AX foci assay

scientific article

Leukocyte DNA damage after multi-detector row CT: a quantitative biomarker of low-level radiation exposure.

scientific article published on January 2007

Loss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancer.

scientific article

Manual versus automated γ-H2AX foci analysis across five European laboratories: can this assay be used for rapid biodosimetry in a large scale radiation accident?

scientific article published on 3 May 2013

Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome

scientific article

Misrejoining of DNA double-strand breaks in primary and transformed human and rodent cells: a comparison between the HPRT region and other genomic locations

scientific article published on April 1999

Multibiodose radiation emergency triage categorization software

scientific article

Nonlinear ionizing radiation-induced changes in eye lens cell proliferation, cyclin D1 expression and lens shape.

scientific article published on April 2015

Operational guidance for radiation emergency response organisations in Europe for using biodosimetric tools developed in EU MULTIBIODOSE project.

scientific article published on October 2014

Pathways of DNA double-strand break repair during the mammalian cell cycle

scientific journal article

Physical and biological parameters affecting DNA double strand break misrejoining in mammalian cells

scientific article published on January 2002

Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer

scientific article published on 17 January 2020

Quantitative proteomics unveiled: Regulation of DNA double strand break repair by EGFR involves PARP1.

scientific article

Radiation Biomarkers in Large Scale Human Health Effects Studies

scientific article published on 03 October 2020

Radiation-induced HPRT mutations resulting from misrejoined DNA double-strand breaks

scientific article

Radiation-induced bystander and systemic effects serve as a unifying model system for genotoxic stress responses

scientific article published on 17 August 2018

Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks

scientific article published on May 2001

Radiation-induced transgenerational alterations in genome stability and DNA damage.

scientific article published on 05 June 2006

Radiosensitisation and enhanced tumour growth delay of colorectal cancer cells by sustained treatment with trifluridine/tipiracil and X-rays

scientific article published on 03 September 2020

Radiosensitization by nitric oxide at low radiation doses

scientific article published in April 2007

Radiotherapy fraction size sensitivity is modulated by DNA repair systems

scientific article published on 18 May 2010

Realising the European Network of Biodosimetry (RENEB).

scientific article

Realising the European network of biodosimetry: RENEB-status quo.

scientific article

Receptor tyrosine kinase MET as potential target of multi-kinase inhibitor and radiosensitizer sorafenib in HNSCC

scientific article published on 15 December 2018

Residual DNA and chromosomal damage in ex vivo irradiated blood lymphocytes correlated with late normal tissue response to breast radiotherapy

scientific article published on 23 June 2011

Review of Bayesian statistical analysis methods for cytogenetic radiation biodosimetry, with a practical example

scientific article

Review of retrospective dosimetry techniques for external ionising radiation exposures

scientific article published on 23 December 2010

Second-Generation Antiandrogen Therapy Radiosensitizes Prostate Cancer Regardless of Castration State through Inhibition of DNA Double Strand Break Repair

scientific article published on 31 August 2020

Similar cisplatin sensitivity of HPV-positive and -negative HNSCC cell lines

scientific article published on 26 April 2016

Targeted nanoparticles for tumour radiotherapy enhancement-the long dawn of a golden era?

scientific article published on December 2016

The first gamma-H2AX biodosimetry intercomparison exercise of the developing European biodosimetry network RENEB.

scientific article published on 12 August 2014

The inflammation-reducing compatible solute ectoine does not impair the cytotoxic effect of ionizing radiation on head and neck cancer cells

scientific article published on 29 April 2019

The lens of the eye: exposures in the UK medical sector and mechanistic studies of radiation effects

scientific article published on 10 March 2015

The relationship between homologous recombination repair and the sensitivity of human epidermis to the size of daily doses over a 5-week course of breast radiotherapy

scientific article

The shape of the radiation dose response for DNA double-strand break induction and repair.

scientific article published on 22 March 2013

Triage, monitoring and dose assessment for people exposed to ionising radiation following a malevolent act.

scientific article published on 08 December 2010

Tumor Cell Response to Synchrotron Microbeam Radiation Therapy Differs Markedly From Cells in Normal Tissues

article

Validation of semi-automatic scoring of dicentric chromosomes after simulation of three different irradiation scenarios

scientific article published in June 2014

Web-based scoring of the dicentric assay, a collaborative biodosimetric scoring strategy for population triage in large scale radiation accidents.

scientific article

What radiation dose does the FISH translocation assay measure in cases of incorporated radionuclides for the Southern Urals populations?

scientific article published on 15 April 2014

Where Do We Look for Markers of Radiotherapy Fraction Size Sensitivity?

scientific article published on 21 June 2015

Zero-inflated regression models for radiation-induced chromosome aberration data: A comparative study

scientific article

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