Search filters

List of works by Francisco León

3'-Hydroxy-3,4'-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells

scientific article published on 3 October 2017

3'-Hydroxy-3,4'-dimethoxyflavone-induced cell death in human leukaemia cells is dependent on caspases and reactive oxygen species and attenuated by the inhibition of JNK/SAPK.

scientific article published on 6 April 2018

A chemotaxonomic study of endemic species of genus Tanacetum from the Canary Islands.

scientific article published on 25 May 2013

A homo-isoflavonoid and a cytotoxic saponin from Dracaena draco

scientific article published on January 2006

A new ceramide from Suillus luteus and its cytotoxic activity against human melanoma cells

scientific article

A new flavonoid and other constituents from Centaurea nicaeensis All. var. walliana M.

scientific article published on 4 August 2011

Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine

scientific article published on 27 June 2018

Antifungal metabolites from the roots of Diospyros virginiana by overpressure layer chromatography. ⬇️

scientific article

Antinociceptive activity of extracts and secondary metabolites from wild growing and micropropagated plants of Renealmia alpinia

scientific article published on 14 February 2015

Ayanin diacetate-induced cell death is amplified by TRAIL in human leukemia cells

scientific article published on 11 October 2012

Cell death triggered by synthetic flavonoids in human leukemia cells is amplified by the inhibition of extracellular signal-regulated kinase signaling

scientific article

Centaurea microcarpa Coss. & Dur. (Asteraceae) extracts: New cyanogenic glucoside and other constituents

scientific article published on 16 November 2018

Chemotaxonomy of Gonospermum and related genera

scientific article published on 22 January 2010

Chlorinated Guaiane-Type Sesquiterpene Lactones as Cytotoxic Agents against Human Tumor Cells

scientific article published on 21 December 2020

Cladocalol, a pentacyclic 28-nor-triterpene from Eucalyptus cladocalyx with cytotoxic activity

scientific article

Comparative Pharmacokinetics of Mitragynine after Oral Administration of Mitragyna speciosa (Kratom) Leaf Extracts in Rats

scientific article published on 16 November 2018

Computationally aided stereochemical assignment of undescribed bisabolenes from Calea urticifolia

scientific article published on 03 November 2018

Correction to Neocosmospora sp.-Derived Resorcylic Acid Lactones with in Vitro Binding Affinity for Human Opioid and Cannabinoid Receptors

scientific article published on 21 October 2013

Cytotoxic sesquiterpene lactones and other constituents of Centaurea omphalotricha

Effects of Nutrient Fertility on Growth and Alkaloidal Content in <i>Mitragyna speciosa</i> (Kratom)

scientific article published on 21 December 2020

Evaluation of Triazole and Isoxazole Derivatives as Potential Anti-infective Agents

scientific article published on 27 February 2018

Evaluation of the rewarding effects of mitragynine and 7-hydroxymitragynine in an intracranial self-stimulation procedure in male and female rats

scientific article published on 18 August 2020

Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids

scientific article published on 07 November 2019

Fatty acids with in vitro binding affinity for human opioid receptors from the fungus Emericella nidulans

scientific article published on 22 October 2013

Flavanones from Miconia prasina.

scientific article

Flavonoid aglycones and sterol from Chrysanthemum fontanesii

Flavonoids from Perovskia atriplicifolia and Their in Vitro Displacement of the Respective Radioligands for Human Opioid and Cannabinoid Receptors.

scientific article

Four flavonoids from the aerial part of Ononis angustissima species

article

Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco

scientific article published on August 2004

In vitro opioid receptor affinity and in vivo behavioral studies of Nelumbo nucifera flower

scientific article

Induction of G2-M phase arrest and apoptosis by alpha-methylene-gamma-butyrolactones in human leukemia cells.

scientific article published on 2 June 2008

Inhibition of human monoamine oxidase A and B by flavonoids isolated from two Algerian medicinal plants.

scientific article published on 27 December 2017

Interactions of Desmethoxyyangonin, a Secondary Metabolite from Renealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B.

scientific article published on 24 August 2017

Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids

scientific article published on 27 December 2019

Isolation from Eucalyptus occidentalis and identification of a new kaempferol derivative that induces apoptosis in human myeloid leukemia cells

scientific article

Isolation of Acacetin from Calea urticifolia with Inhibitory Properties against Human Monoamine Oxidase-A and -B.

scientific article published on 18 October 2016

Isolation, structure elucidation, total synthesis, and evaluation of new natural and synthetic ceramides on human SK-MEL-1 melanoma cells

scientific article published on September 2006

Lanostanoid triterpenes from Laetiporus sulphureus and apoptosis induction on HL-60 human myeloid leukemia cells

scientific article published in December 2004

Lyophilized Kratom Tea as a Therapeutic Option for Opioid Dependence

scientific article published on 22 September 2020

Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy

scientific article published on 31 July 2020

Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom)

scientific article published on 07 January 2019

Molecular Modeling Evaluation of the Enantiomers of a Novel Adenylyl Cyclase 2 Inhibitor

scientific article published on 9 January 2017

Motives for using Kratom (Mitragyna speciosa Korth.) among regular users in Malaysia

scientific article published on 28 December 2018

Mycophenolic derivatives from Eupenicillium parvum. ⬇️

scientific article

Neocosmospora sp.-derived resorcylic acid lactones with in vitro binding affinity for human opioid and cannabinoid receptors ⬇️

scientific article published on 09 May 2013

New lanostanoids from the fungus Ganoderma concinna.

scientific article published in March 2002

Perspective on the Therapeutics of Anti-Snake Venom

scientific article published on 09 September 2019

Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for Mu-Opioid Receptor and Opioid-Like Behavioral Effects in Rats

scientific article published on 31 December 2020

Phenolic compounds of Dragon's blood from Dracaena draco

scientific article published in September 2000

Revisiting the reaction between diaminomaleonitrile and aromatic aldehydes: a green chemistry approach.

scientific article

Secondary metabolites from Eupenicillium parvum and their in vitro binding affinity for human opioid and cannabinoid receptors.

scientific article published on 28 November 2013

Secondary metabolites from the aerial parts of Pourr

Secondary metabolites from two species of Pulicaria and their cytotoxic activity.

scientific article published in November 2011

Secondary metabolites from two species of Tolpis and their biological activities.

scientific article published in November 2012

Sesquiterpene lactones and other constituents from Matricaria chamomilla L

scientific article

Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities

scientific article

Sesquiterpenoid derivatives from Gonospermum elegans and their cytotoxic activity for HL-60 human promyelocytic cells.

scientific article published in July 2003

Sesquiterpenoids Isolated from Two Species of the Asteriscus Alliance

scientific article published on 4 May 2016

Sesquiterpenoids from Pulicaria canariensis and their cytotoxic activities.

scientific article

Simultaneous quantification of ten key Kratom alkaloids in Mitragyna speciosa leaf extracts and commercial products by ultra-performance liquid chromatography-tandem mass spectrometry

scientific article published on 15 May 2019

Synthesis and antiproliferative activity of a new compound containing an alpha-methylene-gamma-lactone group.

scientific article

Synthesis of novel spirostanic saponins and their cytotoxic activity

scientific article published on 4 November 2007

The effects of mitragynine and morphine on schedule-controlled responding and antinociception in rats

scientific article published on 17 May 2019

The presence of capsule in Cryptococcus neoformans influences the gene expression profile in dendritic cells during interaction with the fungus.

scientific article published on 4 February 2008

Total Phenolic and Flavonoid Content and Biological Activities of Extracts and Isolated Compounds of Cytisus villosus Pourr

scientific article published on 13 November 2019

Paulina is supported by:

About Paulina

Help