List of works - John Maclean

Biochemical and X-ray crystallographic studies on shikimate kinase: The important structural role of the P-loop lysine

scientific article

Crystallization and preliminary X-ray analysis of shikimate dehydrogenase from Escherichia coli

scientific article published on 01 April 2000

Design, synthesis and antibacterial properties of pyrimido[4,5-b]indol-8-amine inhibitors of DNA gyrase

scientific article published on 26 May 2018

Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors.

scientific article published on 28 July 2016

Discovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers

scientific article

Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4.

scientific article published on 20 April 2015

Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys

scientific article published on 7 April 2015

Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma

scientific article

Discovery of potent, soluble and orally active TRPV1 antagonists. Structure-activity relationships of a series of isoxazoles

scientific article published on 26 January 2011

Divergent kinetics differentiate the mechanism of action of two HDAC inhibitors

scientific article published on 22 January 2014

Estimating the affinity of protein-ligand complex from changes to the charge-state distribution of a protein in electrospray ionization mass spectrometry

scientific article published on 5 November 2010

Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy

scientific article

Identification of N-(1H-pyrazol-4-yl)carboxamide inhibitors of interleukin-1 receptor associated kinase 4: Bicyclic core modifications

scientific article

Identification of potent, soluble, and orally active TRPV1 antagonists

scientific article published on 31 January 2011

Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation

scientific article published on 18 April 2017

Imidazopyridyl compounds as aldosterone synthase inhibitors

scientific article published on 2 December 2016

Inhibitors of phosphopantetheine adenylyltransferase.

scientific article

Positive allosteric modulators of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor.

scientific article published on October 2010

Recent advances in positive allosteric modulators of the AMPA receptor.

scientific article published on September 2006

Structure based evolution of a novel series of positive modulators of the AMPA receptor

scientific article

Structure-activity studies of a novel series of isoxazole-3-carboxamide derivatives as TRPV1 antagonists

scientific article published on 23 December 2010

List of works by John Maclean

Biochemical and X-ray crystallographic studies on shikimate kinase: The important structural role of the P-loop lysine

Crystallization and preliminary X-ray analysis of shikimate dehydrogenase from Escherichia coli

Design, synthesis and antibacterial properties of pyrimido[4,5-b]indol-8-amine inhibitors of DNA gyrase

Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors.

Discovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers

Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4.

Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys

Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma

Discovery of potent, soluble and orally active TRPV1 antagonists. Structure-activity relationships of a series of isoxazoles

Divergent kinetics differentiate the mechanism of action of two HDAC inhibitors

Estimating the affinity of protein-ligand complex from changes to the charge-state distribution of a protein in electrospray ionization mass spectrometry

Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy

Identification of N-(1H-pyrazol-4-yl)carboxamide inhibitors of interleukin-1 receptor associated kinase 4: Bicyclic core modifications

Identification of potent, soluble, and orally active TRPV1 antagonists

Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation

Imidazopyridyl compounds as aldosterone synthase inhibitors

Inhibitors of phosphopantetheine adenylyltransferase.

Positive allosteric modulators of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor.

Recent advances in positive allosteric modulators of the AMPA receptor.

Structure based evolution of a novel series of positive modulators of the AMPA receptor

Structure-activity studies of a novel series of isoxazole-3-carboxamide derivatives as TRPV1 antagonists