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List of works by Remo Guerrini

A diastereoselective synthesis of Cebranopadol, a novel analgesic showing NOP/mu mixed agonism

scientific article

A new ligand for the urotensin II receptor

scientific article published on October 2002

A new selective antagonist of the nociceptin receptor.

scientific article published on January 1998

A novel and facile synthesis of tetra branched derivatives of nociceptin/orphanin FQ.

scientific article published on 13 May 2014

Activation of the nociceptin/orphanin FQ receptor reduces bronchoconstriction and microvascular leakage in a rabbit model of gastroesophageal reflux

scientific article

Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats

scholarly article by Laura Micheli et al published May 2015 in European Journal of Pharmacology

Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin-(1-13)-peptide amide.

scientific article published on June 1997

Antagonistic effects of [Nphe1]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor

scientific article published in January 2000

Anti-inflammatory and analgesic effects displayed by peptides derived from PKI55 protein, an endogenous protein kinase C inhibitor

scientific article published on 20 July 2010

Antidepressant-like effects of the nociceptin/orphanin FQ receptor antagonist UFP-101: new evidence from rats and mice

scientific article

Anxiolytic- and antidepressant-like activities of H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), a novel selective delta opioid receptor agonist.

scientific article

Anxiolytic- and panicolytic-like effects of Neuropeptide S in the mouse elevated T-maze

scientific article published on 29 August 2012

Anxiolytic-like effect of neuropeptide S in the rat defensive burying

scientific article

Assessment of the activity of a novel nociceptin/orphanin FQ analogue at recombinant human nociceptin/orphanin FQ receptors expressed in Chinese hamster ovary cells.

scientific article

Behavioural phenotypic characterization of CD-1 mice lacking the neuropeptide S receptor

scientific article published on 10 January 2012

Binding of the novel radioligand [(3)H]UFP-101 to recombinant human and native rat nociceptin/orphanin FQ receptors

scientific article published on 21 September 2008

Blockade of adenosine A2A receptor counteracts neuropeptide-S-induced hyperlocomotion in mice

scientific article published on 19 December 2009

Blockade of nociceptin/orphanin FQ receptor signaling in rat substantia nigra pars reticulata stimulates nigrostriatal dopaminergic transmission and motor behavior.

scientific article

Blockade of nociceptin/orphanin FQ receptor signaling reverses LPS-induced depressive-like behavior in mice

scientific article published on 28 May 2015

Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson's disease.

scientific article published in October 2005

Blockade of nociceptin/orphanin FQ transmission in rat substantia nigra reverses haloperidol-induced akinesia and normalizes nigral glutamate release

scientific article published in December 2004

Blockade of nociceptin/orphanin FQ-NOP receptor signalling produces antidepressant-like effects: pharmacological and genetic evidences from the mouse forced swimming test.

scientific article

Cationic liposomes as potential carriers for ocular administration of peptides with anti-herpetic activity

scientific article published on 05 April 2006

Cell and tissue responses of a range of Urotensin II analogs at cloned and native urotensin II receptors. Evidence for coupling promiscuity

scientific article published on 5 April 2006

Central adenosine A1 and A2A receptors mediate the antinociceptive effects of neuropeptide S in the mouse formalin test

Central and peripheral role of the nociceptinorphaninFQ system on normal and disturbed colonic motor function and faecal pellet output in the rat

scientific article published on 09 April 2008

Characterisation and comparison of novel ligands for the nociceptin/orphanin FQ receptor

scientific article

Characterization of the locomotor activity-inhibiting effect of nociceptin/orphanin FQ in mice.

scientific article

Chronic intracerebroventricular infusion of nociceptin/orphanin FQ increases food and ethanol intake in alcohol-preferring rats

scientific article published on 26 May 2006

Chronic treatment with the selective NOP receptor antagonist [Nphe 1, Arg 14, Lys 15]N/OFQ-NH 2 (UFP-101) reverses the behavioural and biochemical effects of unpredictable chronic mild stress in rats

scientific article published on 27 August 2009

Comparison of the effects of [Phe1psi(CH2-NH)Gly2]nociceptin(1-13)NH2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors

scientific article

Conformation-activity relationship of neuropeptide S and some structural mutants: helicity affects their interaction with the receptor

scientific article published on 15 August 2007

Conformational analysis of potent and very selective delta opioid dipeptide antagonists.

scientific article published on December 1995

Conformationally constrained amino acids: A concise route to a methionine analogue

article by Giancarlo Fantin et al published January 1994 in Tetrahedron

Conversion of enkephalin and dermorphin into delta-selective opioid antagonists by single-residue substitution.

scientific article published on August 1994

Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).

scientific article published on December 2005

Copper binding to the neurotoxic peptide PrP106-126: thermodynamic and structural studies

scientific article published in March 2004

Copper complexes of glycyl-histidyl-lysine and two of its synthetic analogues: chemical behaviour and biological activity

scientific article

Copper-ion interaction with the 106-113 domain of the prion protein: a solution-equilibria study on model peptides.

scientific article published on 18 July 2005

Crystal structures of dipeptides containing the Dmt-Tic pharmacophore

scientific article published in December 2002

CuII binding sites located at His-96 and His-111 of the human prion protein: thermodynamic and spectroscopic studies on model peptides

scientific article published on 13 August 2008

Daily Intravesical Instillation of 1 mg Nociceptin/Orphanin FQ for the Control of Neurogenic Detrusor Overactivity: A Multicenter, Placebo Controlled, Randomized Exploratory Study

article by Massimo Lazzeri et al published November 2006 in Journal of Urology

Desensitisation of native and recombinant human urotensin-II receptors

scientific article

Design and Synthesis of TcN-Labeled Dextran-Mannose Derivatives for Sentinel Lymph Node Detection

scholarly article by Alessandra Boschi et al published 16 July 2018 in Pharmaceuticals

Design and synthesis of 1-aminocycloalkane-1-carboxylic acid-substituted deltorphin analogues: unique delta and mu opioid activity in modified peptides

scientific article

Design of mu selective opioid dipeptide antagonists.

scientific article published in November 1997

Design of δ-opioid peptide antagonists for emerging drug applications

article by Lawrence H Lazarus et al published June 1998 in Drug Discovery Today

Design, Synthesis, and Biological Characterization of Novel Mitochondria Targeted Dichloroacetate-Loaded Compounds with Antileukemic Activity

scientific article published on 11 December 2015

Development and characterisation of novel fentanyl-delta opioid receptor antagonist based bivalent ligands.

scientific article published on 13 February 2015

Direct influence of C-terminally substituted amino acids in the Dmt-Tic pharmacophore on delta-opioid receptor selectivity and antagonism

scientific article published in July 2004

Effect of anchor residue modifications on the stability of HLA-A11/peptide complexes

scientific article published on January 1995

Effect of delta-opioid receptor agonist deltorphin on circulating concentrations of luteinizing hormone and follicle stimulating hormone in healthy fertile women.

scientific article published in May 1998

Effect of neuropeptide S receptor antagonists and partial agonists on palatable food consumption in the rat

scientific journal article

Effects of Ro 64-6198 in nociceptin/orphanin FQ-sensitive isolated tissues

scientific article published in May 2001

Effects of [(pF)Phe(4)]nociceptin/orphanin FQ-(1-13)NH(2) on GTPgamma(35)S binding and cAMP formation in Chinese hamster ovary cells expressing the human nociceptin/orphanin FQ receptor.

scientific article published in May 2002

Effects of chronic nociceptin/orphanin FQ exposure on cAMP accumulation and receptor density in Chinese hamster ovary cells expressing human nociceptin/orphanin FQ receptors.

scientific article published in August 2002

Effects of neuropeptide S on seizures and oxidative damage induced by pentylenetetrazole in mice

scientific article published on 7 September 2012

Effects of nociceptin and endomorphin 1 on the electrically stimulated human vas deferens

scientific article published on April 2001

Effects of nociceptin/orphanin FQ receptor ligands on blood pressure, heart rate, and plasma catecholamine concentrations in guinea pigs

scientific article published on 8 March 2003

Effects of nociceptinNH2 and [Nphe1]nociceptin(1-13)NH2 on rat brain noradrenaline release in vivo and in vitro.

scientific article published in May 2001

Endogenous neuropeptide S tone influences sleep-wake rhythm in rats

scientific article published on 23 August 2014

Endogenous nociceptin/orphanin FQ signalling produces opposite spinal antinociceptive and supraspinal pronociceptive effects in the mouse formalin test: Pharmacological and genetic evidences

article

Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties

scientific article published in January 2002

Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity

scientific article published in September 1997

Functional Selectivity of Nociceptin/Orphanin FQ Peptide Receptor Partial Agonists on Cardiovascular and Renal Function

scientific article published on 26 April 2005

Functional coupling of the nociceptin/orphanin FQ receptor in dog brain membranes.

scientific article published in April 2004

Further Studies on Nociceptin-Related Peptides: Discovery of a New Chemical Template with Antagonist Activity on the Nociceptin Receptor

scientific article published on 01 July 2000

Further studies at neuropeptide s position 5: discovery of novel neuropeptide S receptor antagonists

scientific article published on July 2009

Further studies on the Dmt-Tic pharmacophore: hydrophobic substituents at the C-terminus endow delta antagonists to manifest mu agonism or mu antagonism.

scientific article

Further studies on the pharmacological features of the nociceptin/orphanin FQ receptor ligand ZP120

scientific article published on 17 October 2008

Further studies on the pharmacological profile of the neuropeptide S receptor antagonist SHA 68.

scientific article

GABA(A) signalling is involved in N/OFQ anxiolytic-like effects but not in nocistatin anxiogenic-like action as evaluated in the mouse elevated plus maze

scientific article published on 21 May 2008

Gastrointestinal effects of intracerebroventricularly injected nociceptin/orphaninFQ in rats

scientific article

Helix-inducing alpha-aminoisobutyric acid in opioid mimetic deltorphin C analogues

scientific article published in August 1997

High structural side chain specificity required at the second position of immunogenic peptides to obtain stable MHC/peptide complexes

scientific article

Hypothalamic neuropeptide S receptor blockade decreases discriminative cue-induced reinstatement of cocaine seeking in the rat.

scientific article

Identification of a novel 45 kDa protein (JP-45) from rabbit sarcoplasmic-reticulum junctional-face membrane

scientific article published on October 2000

Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist.

scientific article published on 3 October 2005

Immunosensing by a Synthetic Ligand-Gated Ion Channel Financial support from the board of the Swiss Federal Institutes of Technology (SPP Minast, 7.06) is acknowledged. We thank G. Corradin for numerous discussions and J. Lakey for critical reading

scientific article published on 01 May 2001

In vitro activity of dermaseptin S1 derivatives against genital pathogens

scientific article

In vitro and in vivo pharmacological characterization of nociceptin/orphanin FQ tetrabranched derivatives.

scientific article

In vitro and in vivo pharmacological characterization of the neuropeptide s receptor antagonist [D-Cys(tBu)5]neuropeptide S

scientific article

In vitro and in vivo pharmacological characterization of the nociceptin/orphanin FQ receptor ligand Ac-RYYRIK-ol.

scientific article published on 5 April 2006

In vitro and in vivo pharmacological characterization of the novel UT receptor ligand [Pen5,DTrp7,Dab8]urotensin II(4-11) (UFP-803)

scientific article

In vitro and in vivo pharmacological characterization of the novel neuropeptide S receptor ligands QA1 and PI1.

scientific article published on 30 July 2013

In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptor

scientific article

In vitro characterization of J-113397, a non-peptide nociceptin/orphanin FQ receptor antagonist

scientific article published on 01 May 2000

In vitro pharmacological characterisation of a novel cyclic nociceptin/orphanin FQ analogue c[Cys(7,10)]N/OFQ(1-13)NH (2).

scientific article published on 28 June 2007

Inhibition of human multidrug resistance P-glycoprotein 1 by analogues of a potent delta-opioid antagonist

scientific article

Interaction of calmodulin with the phosphofructokinase target sequence

scientific article published in November 2004

Internalization and Stability of a Thymidylate Synthase Peptide Inhibitor in Ovarian Cancer Cells

article published in 2014

Intrathecal [Nphe1]nociceptin(1-13)NH2 selectively reduces the spinal inhibitory effect of nociceptin

scientific article published on 01 January 2002

Inverse agonism by Dmt-Tic analogues and HS 378, a naltrindole analogue.

scientific article

Ligands raise the constraint that limits constitutive activation in G protein-coupled opioid receptors.

scientific article published on 08 July 2013

Lithium attenuates behavioral and biochemical effects of neuropeptide S in mice.

scientific article published on 16 July 2009

Long-lasting antinociceptive spinal effects in primates of the novel nociceptin/orphanin FQ receptor agonist UFP-112.

scientific article

Mass spectrometric/bioinformatic identification of a protein subset that characterizes the cellular activity of anticancer peptides

scientific article published on 29 September 2014

Medicinal Chemistry, Pharmacology, and Biological Actions of Peptide Ligands Selective for the Nociceptin/Orphanin FQ Receptor

scholarly article by Girolamo Calo’ & Remo Guerrini published January 2013 in ACS Symposium Series

Modeling of overloaded gradient elution of nociceptin/orphanin FQ in reversed-phase liquid chromatography

scientific article published in June 2005

N- and C-terminal modifications of nociceptin/orphanin FQ generate highly potent NOP receptor ligands

scientific article published in March 2005

N-carbamidoyl-4-((3-ethyl-2,4,4-trimethylcyclohexyl)methyl)benzamide enhances staurosporine cytotoxic effects likely inhibiting the protective action of Magmas toward cell apoptosis

scientific article published on 14 May 2014

Neurobiology, pharmacology, and medicinal chemistry of neuropeptide S and its receptor

scientific article published on September 2010

Neuropeptide S counteracts 6-OHDA-induced motor deficits in mice

scientific article published on 11 March 2014

Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice

scientific article

Neuropeptide S produces hyperlocomotion and prevents oxidative stress damage in the mouse brain: a comparative study with amphetamine and diazepam.

scientific article published on 31 October 2008

Neuropeptide S reduces mouse aggressiveness in the resident/intruder test through selective activation of the neuropeptide S receptor.

scientific article

Neuropeptide S stimulates human monocyte chemotaxis via NPS receptor activation

scientific article

Neuropeptide S: a novel regulator of pain-related amygdala plasticity and behaviors

scientific article published on 24 July 2013

New approaches to high-throughput structure characterization of SH3 complexes: the example of Myosin-3 and Myosin-5 SH3 domains from S. cerevisiae

scientific article

Nociceptin binding sites in frog (Rana esculenta) brain membranes.

scientific article

Nociceptin modulates bronchoconstriction induced by sensory nerve activation in mouse lung.

scientific article published on 15 May 2009

Nociceptin receptor activation inhibits tachykinergic non adrenergic non cholinergic contraction of guinea pig isolated bronchus.

scientific article

Nociceptin/Orphanin FQ

Nociceptin/Orphanin FQ Receptor Agonists Attenuate L-DOPA-Induced Dyskinesias

scientific article published on 01 November 2012

Nociceptin/Orphanin FQ(1-13)NH2 analogues modified in the Phe1-Gly2 peptide bond

scientific article

Nociceptin/orphanin FQ and stress regulate synaptophysin expression in the rat fundic and colonic mucosa

scientific article published on 31 January 2015

Nociceptin/orphanin FQ induces simultaneously anxiolytic and amnesic effects in the mouse elevated T-maze task

scientific article

Nociceptin/orphanin FQ inhibits electrically induced contractions of the human bronchus via NOP receptor activation

scientific article published on 18 April 2005

Nociceptin/orphanin FQ modulates motor behavior and primary motor cortex output through receptors located in substantia nigra reticulata

scientific article

Nociceptin/orphanin FQ prevents ethanol-induced gastric lesions in the rat.

scientific article published in January 2005

Nociceptin/orphanin FQ prevents gastric damage induced by cold-restraint stress in the rat by acting in the periphery

Nociceptin/orphanin FQ receptor activation decreases the airway hyperresponsiveness induced by allergen in sensitized mice

scientific article published on 15 March 2013

Nociceptin/orphanin FQ receptor ligands.

scientific article

Nociceptin/orphanin FQ receptors modulate glutamate extracellular levels in the substantia nigra pars reticulata. A microdialysis study in the awake freely moving rat.

scientific article

Nociceptin/orphanin FQ stimulates human monocyte chemotaxis via NOP receptor activation

scientific article published in August 2005

Nonpeptide/peptide chimeric ligands for the nociceptin/orphanin FQ receptor: design, synthesis and in vitro pharmacological activity.

scientific article

Opioid pseudopeptides containing heteroaromatic or heteroaliphatic nuclei

scientific article published in November 2000

Opioid receptor selectivity alteration by single residue replacement: synthesis and activity profile of [Dmt1]deltorphin B.

scientific article

Optimization of peptides that target human thymidylate synthase to inhibit ovarian cancer cell growth

scientific article published on 12 February 2014

Pain peptides. Solution structure of orphanin FQ2.

scientific article

Parallel bioassay of 39 tachykinins on 11 smooth muscle preparations. Structure and receptor selectivity/affinity relationship.

scientific article

Peripheral mechanisms involved in gastric mucosal protection by intracerebroventricular and intraperitoneal nociceptin in rats

scientific article published on 26 May 2005

Perspectives of protein kinase C (PKC) inhibitors as anti-cancer agents.

scientific article published on April 2009

Pharmacological characterisation of [(pX)Phe 4 ]nociceptin(1-13)NH 2 analogues

scholarly article by Anna Rizzi et al published 1 June 2002 in Naunyn-Schmiedeberg's Archives of Pharmacology

Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 1. In vitro studies.

scientific article

Pharmacological characterization of nociceptin receptor: an in vitro study

scientific article

Pharmacological characterization of tachykinin tetrabranched derivatives

scientific article

Pharmacological characterization of the bifunctional opioid ligand H-Dmt-Tic-Gly-NH-Bzl (UFP-505).

scientific article published on 22 December 2011

Pharmacological characterization of the nociceptin receptor mediating hyperalgesia in the mouse tail withdrawal assay

scientific article published in September 1998

Pharmacological characterization of the nociceptin receptor which mediates reduction of alcohol drinking in rats

scientific article published in January 2002

Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist Compound 24.

scientific article published on 12 May 2009

Pharmacological profile of NOP receptors coupled with calcium signaling via the chimeric protein G alpha qi5.

scientific article published on 28 January 2009

Pharmacological profile of hemokinin 1: a novel member of the tachykinin family

scientific article published on 01 June 2002

Pharmacological profile of nociceptin/orphanin FQ receptors

scientific article

Pharmacological profile of the cyclic nociceptin/orphanin FQ analogues c[Cys10,14]N/OFQ(1-14)NH2 and c[Nphe1,Cys10,14]N/OFQ(1-14)NH2.

scientific article published on 4 November 2003

Pharmacological profiles of presynaptic nociceptin/orphanin FQ receptors modulating 5-hydroxytryptamine and noradrenaline release in the rat neocortex

scientific article

Pharmacology of [Tyr1]nociceptin analogs: receptor binding and bioassay studies

scientific article published on 01 September 1999

Physicochemical stability of cabazitaxel and docetaxel solutions

Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore

scientific article published in December 2002

Preparation and first biological evaluation of novel Re-188/Tc-99m peptide conjugates with substance-P.

scientific article

Prerequisite for His(4) in deltorphin A for highδ opioid receptor selectivity

scientific article

Proinflammatory and vasodilator effects of nociceptin/orphanin FQ in the rat mesenteric microcirculation are mediated by histamine.

scientific article published on 31 August 2007

Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase

scientific article

Proteinase-activated receptor-1 (PAR-1) activation contracts the isolated human renal artery in vitro

scientific article published in May 2003

Quantitative study of [(pF)Phe4,Arg14,Lys15]nociceptin/orphanin FQ-NH2 (UFP-102) at NOP receptors in rat periaqueductal gray slices

article by Chia-Ju Kuo et al published January 2008 in European Journal of Pharmacology

Rational design of dynorphin A analogues with δ-receptor selectivity and antagonism for δ- and κ-receptors

scientific article published on 01 January 1998

Role of nociceptin/orphanin FQ receptors in the decrease of mucosal mast cells caused by acute stress in the rat colon

Role of the ecto-nucleotidases in the cooperative effect of adenosine and neuropeptide-S on locomotor activity in mice

scientific article

Selective amino acid substitutions of a subdominant Epstein-Barr virus LMP2-derived epitope increase HLA/peptide complex stability and immunogenicity: implications for immunotherapy of Epstein-Barr virus-associated malignancies

scientific article published on August 1999

Selective breeding for high anxiety introduces a synonymous SNP that increases neuropeptide S receptor activity.

scientific article published on March 2015

Selective opioid dipeptides

scientific article

Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile

scientific article

Solution conformation of nociceptin.

scientific article published in April 1997

Solution structure of ZASP PDZ domain; implications for sarcomere ultrastructure and enigma family redundancy.

scientific article published in April 2004

Solution structure of amyloid beta-peptide (25-35) in different media

scientific article

Solution structure of nociceptin peptides

scientific article

Solution structure of the Alzheimer amyloid beta-peptide (1-42) in an apolar microenvironment. Similarity with a virus fusion domain

scientific article

Spinal antinociceptive effects of the novel NOP receptor agonist PWT2-nociceptin/orphanin FQ in mice and monkeys

scientific article published on 12 May 2015

Structural and Dynamic Characterization of Copper(II) Binding of the Human Prion Protein Outside the Octarepeat Region

scientific article published on 01 January 2007

Structure activity studies of nociceptin/orphanin FQ(1-13)-NH2 derivatives modified in position 5.

scientific article

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

scientific article

Structure-activity relationship study of position 4 in the urotensin-II receptor ligand U-II(4-11).

scientific article published on 31 July 2007

Structure-activity relationship study on Tyr9 of urotensin-II(4-11): identification of a partial agonist of the UT receptor

scientific article

Structure-activity relationship study on human urotensin II

scholarly article by Remo Guerrini published in January 2005

Structure-activity relationships of nociceptin and related peptides: comparison with dynorphin A.

scientific article

Structure-activity studies of the Phe(4) residue of nociceptin(1-13)-NH(2): identification of highly potent agonists of the nociceptin/orphanin FQ receptor

scientific article published in November 2001

Structure-activity studies on neuropeptide S: identification of the amino acid residues crucial for receptor activation

scientific article

Structure-activity studies on the nociceptin/orphanin FQ receptor antagonist 1-benzyl-N-{3-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl} pyrrolidine-2-carboxamide.

scientific article published on 2 June 2009

Structure-activity study at positions 3 and 4 of human neuropeptide S.

scientific article

Structure–activity relationship of [Nphe1]-NC-(1-13)-NH2, a pure and selective nociceptin/orphanin FQ receptor antagonist

Structure–activity studies on nociceptin/orphanin FQ: from full agonist, to partial agonist, to pure antagonist

scientific article published on 01 November 1999

Structure−Activity Study of the Nociceptin(1−13)-NH2N-Terminal Tetrapeptide and Discovery of a Nociceptin Receptor Antagonist

Studies of the cardiovascular effects of nociceptin and related peptides

scientific article

Studies on the antinociceptive effect of [Nphe1]nociceptin(1-13)NH2 in mice

scientific article published in December 2001

Study of synthetic peptides derived from the PKI55 protein, a protein kinase C modulator, in human neutrophils stimulated by the methyl ester derivative of the hydrophobic N-formyl tripeptide for-Met-Leu-Phe-OH.

scientific article published on 21 December 2007

Supraspinal and spinal effects of [Phe1psi(CH2-NH)Gly2]-nociceptin(1-13)-NH2 on nociception in the rat

Synthesis and antimicrobial activity of dermaseptin S1 analogues

scientific article published on 20 July 2008

Synthesis and biological activity of human neuropeptide S analogues modified in position 2.

scientific article

Synthesis and biological activity of human neuropeptide S analogues modified in position 5: identification of potent and pure neuropeptide S receptor antagonists

scientific article

Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with Calpha,alpha-dialkylated amino acids

scientific article published on 24 April 2007

Synthesis and opioid activity of N,N-dimethyl-Dmt-Tic-NH-CH(R)-R' analogues: acquisition of potent delta antagonism

scientific article

Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides.

scientific article published in August 1997

Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68).

scientific article

The SH3 domain of nebulin binds selectively to type II peptides: theoretical prediction and experimental validation

scientific article

The alpha-to-beta conformational transition of Alzheimer's Abeta-(1-42) peptide in aqueous media is reversible: a step by step conformational analysis suggests the location of beta conformation seeding

scientific article

The complex-formation behaviour of His residues in the fifth Cu2+ binding site of human prion protein: a close look

article published in 2009

The coordination of NiII and Cu(II) ions to the polyhistidyl motif of Hpn protein: is it as strong as we think?

scientific article published on 24 July 2012

The effects of [Arg14, Lys15] nociceptin/orphanin FQ, a highly potent agonist of the NOP receptor, on in vitro and in vivo gastrointestinal functions

scientific article published on 19 March 2005

The gastric effects of UFP-112, a new nociceptin/orphanin receptor agonist, in physiological and pathological conditions

scientific article published on 27 July 2007

The hypothalamus-pituitary-adrenal axis does not influence the protective effects of nociceptin/orphanin FQ on the rat gastric mucosa

scientific article

The interaction of highly helical structural mutants with the NOP receptor discloses the role of the address domain of nociceptin/orphanin FQ.

scientific article

The mouse vas deferens: a pharmacological preparation sensitive to nociceptin

scientific article published in September 1996

The nociceptin/orphanin FQ receptor antagonist UFP-101 reduces microvascular inflammation to lipopolysaccharide in vivo

scientific article

The nociceptin/orphanin FQ-NOP receptor antagonist effects on an animal model of sepsis

article

The paraventricular nucleus of the hypothalamus is a neuroanatomical substrate for the inhibition of palatable food intake by neuropeptide S

scientific journal article

Thermodynamic and spectroscopic investigation on the role of Met residues in Cu(II) binding to the non-octarepeat site of the human prion protein

scientific article published on 13 July 2012

Tryptophan replacement in the nociceptin/orphanin FQ receptor ligand Ac-RYYRWK-NH2.

scientific article published in July 2005

UFP-101 antagonizes the spinal antinociceptive effects of nociceptin/orphanin FQ: Behavioral and electrophysiological studies in mice

scientific article published on 11 December 2006

UFP-101, a high affinity antagonist for the nociceptin/orphanin FQ receptor: radioligand and GTPgamma(35)S binding studies.

scientific article published on 15 January 2003

UFP-112 a potent and long-lasting agonist selective for the Nociceptin/Orphanin FQ receptor

scientific article published on 18 May 2010

Ultraselective antagonists of the d-opioid receptor

Unexpected impact of the number of glutamine residues on metal complex stability.

scientific article published in March 2013

Urantide mimics urotensin-II induced calcium release in cells expressing recombinant UT receptors

scientific article published in September 2004

Urodynamic effects of intravesical nociceptin/orphanin FQ in neurogenic detrusor overactivity: a randomized, placebo-controlled, double-blind study

scientific article published in May 2003

Urotensin II evokes neurotransmitter release from rat cerebrocortical slices

scientific article

Urotensin II stimulates plasma extravasation in mice via UT receptor activation.

scientific article

[(pF)Phe4,Arg14,Lys15]N/OFQ-NH2 (UFP-102), a highly potent and selective agonist of the nociceptin/orphanin FQ receptor.

scientific article published on 27 October 2004

[Arg(14),Lys(15)]nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies

scientific article published in January 2002

[Dmt1]N/OFQ(1-13)-NH2: a potent nociceptin/orphanin FQ and opioid receptor universal agonist.

scientific article published on January 2013

[Nphe(1)]N/OFQ-(1-13)-NH(2) is a competitive and selective antagonist at nociceptin/orphanin FQ receptors mediating K(+) channel activation in rat periaqueductal gray slices

scientific article published in February 2002

[Nphe(1)]nociceptin-(1-13)-NH(2) antagonizes nociceptin effects in the mouse colon

scientific article published in December 1999

[Nphe(1)]nociceptin-(1-13)NH(2) selectively antagonizes nociceptin effects in the rabbit isolated ileum

scientific article published in June 2000

[Nphe1,Arg14,Lys15]N/OFQ-NH2 is a competitive antagonist of NOP receptors in the periaqueductal gray

article by Lih-Chu Chiou et al published May 2005 in European Journal of Pharmacology

[d-Pen(p- t BuBzl)5]NPS, a novel ligand for the neuropeptide S receptor: structure activity and pharmacological studies

scholarly article by Chiara Ruzza et al published 11 February 2014 in Medicinal Chemistry Research

[tBu-D-Gly5]NPS, a pure and potent antagonist of the neuropeptide S receptor: in vitro and in vivo studies

scientific article published on 9 February 2012

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