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List of works by Paul Elkington

A Bioengineered Three-Dimensional Cell Culture Platform Integrated with Microfluidics To Address Antimicrobial Resistance in Tuberculosis.

scientific article published on 07 February 2017

Advanced cellular systems to study tuberculosis treatment

scientific article published on 08 July 2018

Analysis of matrix metalloproteinase secretion by macrophages.

scientific article

Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α

scientific article published on 24 February 2020

Anti-Tuberculosis Activity of Three Carbapenems, Clofazimine and Nitazoxanide Using a Novel Ex Vivo Phenotypic Drug Susceptibility Model of Human Tuberculosis

scientific article published in 2022

Antimycobacterial drugs modulate immunopathogenic matrix metalloproteinases in a cellular model of pulmonary tuberculosis

scientific article

Bioelectrospray Methodology for Dissection of the Host-pathogen Interaction in Human Tuberculosis

scientific article published on July 2017

CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains.

scientific article published on 20 November 2017

Calcineurin Inhibitors and Variation in the Performance of Interferon-Gamma Release Assays Used to Detect TB Infection

scientific article published on 01 June 2019

Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis

scientific article

Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells.

scientific article published on 16 February 2016

Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis

scientific article (publication date: 7 February 2017)

Comprehensive plasma proteomic profiling reveals biomarkers for active tuberculosis

scientific article published on 11 August 2020

Controlled Generation of Microspheres Incorporating Extracellular Matrix Fibrils for Three-Dimensional Cell Culture

scientific article

Corticosteroids and infliximab impair the performance of interferon-γ release assays used for diagnosis of latent tuberculosis.

scientific article published on 3 February 2017

Cytokine diagnosis of pleural TB: will it stand the test of time?

scientific article published on 20 December 2017

Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model

scientific article

Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases

scientific article published on 26 July 2016

Doxycycline and HIV infection suppress tuberculosis-induced matrix metalloproteinases

scientific article

Early Secretory Antigenic Target-6 Drives Matrix Metalloproteinase-10 Gene Expression and Secretion in Tuberculosis

scientific article

Environmental temperature impacts on the performance of QuantiFERON-TB Gold In-Tube assays

scientific article published on 11 April 2015

Epigenetic Regulation of Matrix Metalloproteinase-1 and -3 Expression in Mycobacterium tuberculosis Infection.

scientific article

Ethnic variation in inflammatory profile in tuberculosis

scientific article

Extremes of age are associated with indeterminate QuantiFERON-TB gold assay results

scientific article

Filter sterilization of highly infectious samples to prevent false negative analysis of matrix metalloproteinase activity.

scientific article published on 20 December 2005

Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis.

scientific article

Gene Expression Signatures in Tuberculosis Have Greater Overlap with Autoimmune Diseases Than with Infectious Diseases

scientific article

HIV-1 infection of macrophages dysregulates innate immune responses to Mycobacterium tuberculosis by inhibition of interleukin-10.

scientific article

Hypoxia and tissue destruction in pulmonary TB

scientific article (publication date: 31 May 2016)

Hypoxia increases neutrophil-driven matrix destruction after exposure to Mycobacterium tuberculosis

scientific article published on 31 July 2018

IFNgamma synergizes with IL-1beta to up-regulate MMP-9 secretion in a cellular model of central nervous system tuberculosis

scientific article published on 11 December 2006

Implications of Tuberculosis Reactivation after Immune Checkpoint Inhibition

In Vitro Granuloma Models of Tuberculosis: Potential and Challenges

scientific article published on 01 May 2019

In an in vitro model of human tuberculosis, monocyte-microglial networks regulate matrix metalloproteinase-1 and -3 gene expression and secretion via a p38 mitogen activated protein kinase-dependent pathway

scientific article published on 26 August 2013

Induced sputum MMP-1, -3 & -8 concentrations during treatment of tuberculosis

scientific article

Induced sputum is safe and well-tolerated for TB diagnosis in a resource-poor primary healthcare setting

scientific article

Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets

scientific article published on 01 August 2021

Interleukin-17 regulates matrix metalloproteinase activity in human pulmonary tuberculosis.

scientific article

Invariant Natural Killer T-cell Dynamics in Human Immunodeficiency Virus-associated Tuberculosis

scientific article published on 01 April 2020

MMP-1 drives immunopathology in human tuberculosis and transgenic mice.

scientific article

MMP12, Lung Function, and COPD in High-Risk Populations

scientific article published on 01 April 2010

Matrix Metalloproteinase Inhibition in a Murine Model of Cavitary Tuberculosis Paradoxically Worsens Pathology

scientific article published on 01 January 2019

Matrix Metalloproteinases in Pulmonary and Central Nervous System Tuberculosis—A Review ⬇️

article

Matrix metalloproteinase-1 is regulated in tuberculosis by a p38 MAPK-dependent, p-aminosalicylic acid-sensitive signaling cascade.

scientific article published in May 2009

Matrix metalloproteinases in tuberculosis.

scientific article

Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis.

scientific article

Molecular Imaging in TB: From the Bench to the Clinic

scholarly article

Monocyte-Dependent Fibroblast CXCL8 Secretion Occurs in Tuberculosis and Limits Survival of Mycobacteria within Macrophages

scientific article published on 01 March 2007

Monocyte-astrocyte networks regulate matrix metalloproteinase gene expression and secretion in central nervous system tuberculosis in vitro and in vivo.

scientific article published in January 2007

Monocyte-dependent oncostatin M and TNF-alpha synergize to stimulate unopposed matrix metalloproteinase-1/3 secretion from human lung fibroblasts in tuberculosis

scientific article

Monocytes infected with Mycobacterium tuberculosis regulate MAP kinase-dependent astrocyte MMP-9 secretion

scientific article published on November 2006

Multifocal cortical myoclonus and cerebral amyloid beta-peptide angiopathy

scientific article published on December 1998

Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation

scientific article

Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology.

scientific article

Mycobacterium tuberculosis up-regulates matrix metalloproteinase-1 secretion from human airway epithelial cells via a p38 MAPK switch

scientific article published in October 2005

Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and Activator Protein-1-dependent monocyte networks

scientific article

Mycobacterium tuberculosis, but not vaccine BCG, specifically upregulates matrix metalloproteinase-1.

scientific article

Mycobacterium tuberculosis-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFα, NFκB, p38 and caspase 8 dependent pathways. ⬇️

scientific article published on 11 May 2011

Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis

scientific article published on 21 May 2015

Optimisation of bioluminescent reporters for use with mycobacteria

scientific article

Pathogenesis of ocular tuberculosis: New observations and future directions

scientific article published on 24 July 2020

Permutations of time and place in tuberculosis

scientific article

Personal respirators for population level control of the COVID19 pandemic

scientific article published on 23 April 2020

Personal respirators for population level control of the COVID19 pandemic

scientific article published on 05 May 2020

Procollagen III N-terminal propeptide and desmosine are released by matrix destruction in pulmonary tuberculosis

scientific article published on 06 August 2013

Quantitative and qualitative iNKT repertoire associations with disease susceptibility and outcome in macaque tuberculosis infection

scientific article published on 28 April 2017

Reconsidering the Optimal Immune Response to Mycobacterium tuberculosis

scientific article published on 01 February 2020

Regulation of matrix metalloproteinase-1, -3, and -9 in Mycobacterium tuberculosis-dependent respiratory networks by the rapamycin-sensitive PI3K/p70(S6K) cascade.

scientific article published on 27 September 2013

Relationship between pulmonary matrix metalloproteinases and quantitative CT markers of small airways disease and emphysema in COPD.

scientific article published on 8 December 2015

Repetitive Aerosol Exposure Promotes Cavitary Tuberculosis and Enables Screening for Targeted Inhibitors of Extensive Lung Destruction

scholarly article by Michael E Urbanowski et al published 5 June 2018 in Journal of Infectious Diseases

STAT3, p38 MAPK, and NF-kappaB drive unopposed monocyte-dependent fibroblast MMP-1 secretion in tuberculosis

scientific article

Seasonal variation in the performance of QuantiFERON-TB Gold In-Tube assays used for the diagnosis of tuberculosis infection.

scientific article

Spatz-Lindenberg disease: a rare cause of vascular dementia

scientific article published in March 1999

Structural and Functional Changes of the Invariant NKT Clonal Repertoire in Early Rheumatoid Arthritis

scientific article

Synergistic up-regulation of epithelial cell matrix metalloproteinase-9 secretion in tuberculosis.

scientific article published on 15 June 2007

The Extracellular Matrix Regulates Granuloma Necrosis in Tuberculosis.

scientific article

The effect of electromagnetic stimulation of the posterior parietal cortex on eye movements

scientific article

Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung

scientific article published on 13 April 2021

Towards host-directed therapies for tuberculosis

scientific article

Transcriptional profiling of innate and adaptive human immune responses to mycobacteria in the tuberculin skin test.

scientific article published on 30 August 2011

Tuberculosis and TNF-inhibitors: history of exposure should outweigh investigations

scientific article published on 5 May 2014

Tuberculosis associated with Triplet therapy for lung cancer

scientific article published on 14 May 2020

Tuberculosis immunopathology: the neglected role of extracellular matrix destruction.

scientific article published on February 2011

Tuberculosis, pulmonary cavitation, and matrix metalloproteinases.

scientific article

Tuberculosis: An Infection-Initiated Autoimmune Disease?

scientific article

Tuberculosis: Time for a new perspective? ⬇️

scientific article published on February 12, 2013

Update in Mycobacterium tuberculosis lung disease 2014.

scientific article

Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment

scientific article

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