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List of works by Christine Desmedt

'In silico' oncology for clinical decision making in the context of nephroblastoma

scientific article published on 12 May 2009

A comparative study of survival models for breast cancer prognostication based on microarray data: does a single gene beat them all?

scientific article

A fuzzy gene expression-based computational approach improves breast cancer prognostication

scientific article

A gene signature to predict high tumor-infiltrating lymphocytes after neoadjuvant chemotherapy and outcome in patients with triple-negative breast cancer

scientific article published on 25 October 2017

A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling

scientific article published in 2023

A semantic grid infrastructure enabling integrated access and analysis of multilevel biomedical data in support of postgenomic clinical trials on cancer.

scientific article

A significant proportion of elderly patients develop hormone-dependant "luminal-B" tumours associated with aggressive characteristics

scientific article published on 3 March 2008

A three-gene model to robustly identify breast cancer molecular subtypes

scientific article published on 18 January 2012

Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer

scientific article

An advanced discrete state-discrete event multiscale simulation model of the response of a solid tumor to chemotherapy: Mimicking a clinical study

scientific article published on 31 May 2010

Assessment of an RNA interference screen-derived mitotic and ceramide pathway metagene as a predictor of response to neoadjuvant paclitaxel for primary triple-negative breast cancer: a retrospective analysis of five clinical trials

scientific article

Association between SPARC mRNA expression, prognosis and response to neoadjuvant chemotherapy in early breast cancer: a pooled in-silico analysis

scientific article

Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients

scientific article published on 18 December 2020

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences

scientific article published on 01 February 2019

Biological Processes Associated with Breast Cancer Clinical Outcome Depend on the Molecular Subtypes

article published in 2008

Biology of breast cancer during pregnancy using genomic profiling

scientific article published on 13 May 2014

Bortezomib (PS-341, Velcade) increases the efficacy of trastuzumab (Herceptin) in HER-2-positive breast cancer cells in a synergistic manner

scientific article published on 5 December 2006

Breast adipocyte size associates with ipsilateral invasive breast cancer risk after ductal carcinoma in situ

scientific article published on 22 March 2021

Breast cancer and melanoma cell line identification by FTIR imaging after formalin-fixation and paraffin-embedding

scientific article published on July 2013

Breast cancer gene expression profiling: clinical trial and practice implications

scientific article

Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration

scientific article published on 26 September 2016

CCR 20th Anniversary Commentary: Gene-Expression Signature in Breast Cancer--Where Did It Start and Where Are We Now?

scientific article

CD4⁺ follicular helper T cell infiltration predicts breast cancer survival

scientific article published on 17 June 2013

Catalog of genetic progression of human cancers: breast cancer

scientific article published on 8 March 2016

Change in the microenvironment of breast cancer studied by FTIR imaging

scientific article

Characterization and clinical evaluation of CD10+ stroma cells in the breast cancer microenvironment

scientific article published on 10 January 2012

Characterization of human breast cancer tissues by infrared imaging

scientific article published on 4 November 2015

Characterization of stromal tumor-infiltrating lymphocytes and genomic alterations in metastatic lobular breast cancer

scientific article published on 17 September 2020

Circulating tumor DNA in early response assessment and monitoring of advanced colorectal cancer treated with a multi-kinase inhibitor.

scientific article published on 3 April 2018

Clinico-pathological and transcriptomic determinants of SLFN11 expression in invasive breast carcinoma.

scientific article

Comparison of prognostic gene expression signatures for breast cancer

scientific article

Comprehensive evaluation of methods to assess overall and cell-specific immune infiltrates in breast cancer

scientific article published on 26 December 2019

Consistent metagenes from cancer expression profiles yield agent specific predictors of chemotherapy response

scientific article

Constitutive phosphorylated STAT3-associated gene signature is predictive for trastuzumab resistance in primary HER2-positive breast cancer

scientific article published on 3 August 2015

Correction for chromosome-17 is critical for the determination of true Her-2/neu gene amplification status in breast cancer.

scientific article

Correction: Association between SPARC mRNA Expression, Prognosis and Response to Neoadjuvant Chemotherapy in Early Breast Cancer: A Pooled in-silico Analysis

scientific article published on 16 December 2013

Corrigendum: Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells

scientific article published on May 2016

DNA methylation profiling reveals a predominant immune component in breast cancers.

scientific article

DNA methylation-based immune response signature improves patient diagnosis in multiple cancers

scientific article published on 17 July 2017

Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade

scientific article

Digital analysis of distant and cancer-associated mammary adipocytes

scientific article published on 16 October 2020

Doubling back on centromere 17 in early breast cancer

scientific article published in March 2010

Epstein-Barr Virus Infection of Mammary Epithelial Cells Promotes Malignant Transformation

scientific article published on 21 May 2016

Erratum: Corrigendum: Signatures of mutational processes in human cancer

scientific article published in Nature

Estrogens decrease gamma-ray-induced senescence and maintain cell cycle progression in breast cancer cells independently of p53

scientific article

Evolving paradigms in multifocal breast cancer.

scientific article

Frequent incidence of BARD1-truncating mutations in germline DNA from triple-negative breast cancer patients

scientific article

Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells

scientific article published on 11 May 2015

Gene Profiling Assay and Application: The Predictive Role in Primary Therapy

article

Gene expression profiling in breast cancer.

scientific article published on September 2006

Gene modules and response to neoadjuvant chemotherapy in breast cancer subtypes: a pooled analysis.

scientific article

Genome-wide gene expression profiling to predict resistance to anthracyclines in breast cancer patients

scientific article

Genomic Characterization of Primary Invasive Lobular Breast Cancer

scientific article

Genomic Evolution of Breast Cancer Metastasis and Relapse

scientific article published on August 2017

Genomic grade adds prognostic value in invasive lobular carcinoma.

scientific article published in October 2012

Genomic grade index is associated with response to chemotherapy in patients with breast cancer

scientific article published on 13 April 2009

Genomic index of sensitivity to endocrine therapy for breast cancer.

scientific article

Global microRNA expression profiling identifies MiR-210 associated with tumor proliferation, invasion and poor clinical outcome in breast cancer

scientific article

HER-2 as a target for breast cancer therapy

scientific article published in March 2009

HER2 and TOP2A as predictive markers for anthracycline-containing chemotherapy regimens as adjuvant treatment of breast cancer: a meta-analysis of individual patient data

scientific article

Immune Infiltration in Invasive Lobular Breast Cancer

scientific article published on 20 February 2018

Impact of cyclins E, neutrophil elastase and proteinase 3 expression levels on clinical outcome in primary breast cancer patients

scientific article

Impact of tumor sequencing on the use of anticancer drugs.

scientific article published on May 2014

Implication of tumor microenvironment in the resistance to chemotherapy in breast cancer patients ⬇️

scientific article published on November 1, 2010

Improvement of the clinical applicability of the Genomic Grade Index through a qRT-PCR test performed on frozen and formalin-fixed paraffin-embedded tissues

scientific article

Informed consent, biobank research, and locality: perceptions of breast cancer patients in three European countries

scientific article published on July 2014

Infrared imaging in breast cancer: automated tissue component recognition and spectral characterization of breast cancer cells as well as the tumor microenvironment

scientific article

Integrative proteomic and gene expression analysis identify potential biomarkers for adjuvant trastuzumab resistance: analysis from the Fin-her phase III randomized trial

scientific article published on 3 September 2015

International expert consensus on primary systemic therapy in the management of early breast cancer: highlights of the Fourth Symposium on Primary Systemic Therapy in the Management of Operable Breast Cancer, Cremona, Italy (2010).

scientific article published on January 2011

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

scientific article

Largest ever DNA methylation dataset for breast cancer completed.

scientific article

Loss of ARID1A Activates ANXA1, which Serves as a Predictive Biomarker for Trastuzumab Resistance.

scientific article

Low residual proliferation after short-term letrozole therapy is an early predictive marker of response in high proliferative ER-positive breast cancer.

scientific article published on 14 November 2011

Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures

scientific article published on 28 July 2008

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

scientific article

Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions

scientific article published on 5 December 2011

Molecular biology in breast cancer: should molecular classifiers be assessed by conventional tools or by gene expression arrays?

scientific article published on 07 September 2012

Multifactorial approach to predicting resistance to anthracyclines

scientific article published on 21 March 2011

Multiple-input multiple-output causal strategies for gene selection

scientific article

Next-generation sequencing in breast cancer: first take home messages

scientific article

Obesity and menopausal status impact the features and molecular phenotype of invasive lobular breast cancer

scientific article published on 24 November 2021

Observational study on the prognostic value of testosterone and adiposity in postmenopausal estrogen receptor positive breast cancer patients.

scientific article

Polysomy 17 in HER-2/neu Status Elaboration in Breast Cancer: Effect on Daily Practice

scientific article published on 01 June 2005

Potential Benefit of Intra-operative Administration of Ketorolac on Breast Cancer Recurrence According to the Patient’s Body Mass Index

scientific article published on 01 October 2018

Predicting Anthracycline Benefit: TOP2A and CEP17-Not Only but Also

scientific article published on 20 April 2015

Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen

scientific article

Predicting risk of breast cancer recurrence using gene-expression profiling.

scientific article published on January 2007

Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome.

scientific article published on 29 September 2015

Quantitation of HER2 expression or HER2:HER2 dimers and differential survival in a cohort of metastatic breast cancer patients carefully selected for trastuzumab treatment primarily by FISH.

scientific article published in March 2009

Recurrence dynamics of breast cancer according to baseline body mass index

scientific article published on 30 October 2017

Reliability of tumor-infiltrating lymphocyte and tertiary lymphoid structure assessment in human breast cancer

scientific article published on 16 June 2017

Results of a worldwide survey on the currently used histopathological diagnostic criteria for invasive lobular breast cancer

scientific article published in 2022

Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series

scientific article published in June 2007

Subclonal diversification of primary breast cancer revealed by multiregion sequencing

scientific article published on 22 June 2015

TOP2A protein by quantitative immunofluorescence as a predictor of response to epirubicin in the neoadjuvant treatment of breast cancer

scientific article

TP53 mutation-correlated genes predict the risk of tumor relapse and identify MPS1 as a potential therapeutic kinase in TP53-mutated breast cancers.

scientific article published on 5 January 2014

The "Oncosimulator": a multilevel, clinically oriented simulation system of tumor growth and organism response to therapeutic schemes. Towards the clinical evaluation of in silico oncology

scientific article published in January 2007

The AURORA pilot study for molecular screening of patients with advanced breast cancer-a study of the breast international group

scientific article

The Gene expression Grade Index: a potential predictor of relapse for endocrine-treated breast cancer patients in the BIG 1-98 trial

scientific article

The Genomic Grade Assay Compared With Ki67 to Determine Risk of Distant Breast Cancer Recurrence

scientific article published on 03 December 2015

The circular RNome of primary breast cancer

scientific article published on 28 January 2019

The technologically integrated oncosimulator: combining multiscale cancer modeling with information technology in the in silico oncology context

scientific article published on 2 October 2013

Time to move forward from “first-generation” prognostic gene signatures in early breast cancer

article

Transcriptomic and genomic features of invasive lobular breast cancer.

scientific article published on 8 April 2017

Transfer of clinically relevant gene expression signatures in breast cancer: from Affymetrix microarray to Illumina RNA-Sequencing technology

scientific article

Translational Genomics: Practical Applications of the Genomic Revolution in Breast Cancer

scientific article published in June 2017

Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial

scientific article

Tumor-Infiltrating Lymphocytes in Patients Receiving Trastuzumab/Pertuzumab-Based Chemotherapy: A TRYPHAENA Substudy

Uncovering the genomic heterogeneity of multifocal breast cancer

scientific article

Unraveling triple-negative breast cancer tumor microenvironment heterogeneity: towards an optimized treatment approach

scientific article published on 29 October 2019

p-53 gene mutations as a predictive marker in a population of advanced breast cancer patients randomly treated with doxorubicin or docetaxel in the context of a phase III clinical trial

article

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