List of works - Guanhua Du

3D-QSAR analysis of a new type of acetylcholinesterase inhibitors

scientific article published on 4 October 2007

A novel naturally occurring salicylic acid analogue acts as an anti-inflammatory agent by inhibiting nuclear factor-kappaB activity in RAW264.7 macrophages

scientific article published on 15 February 2012

A qualitative, and quantitative determination and pharmacokinetic study of four polyacetylenes from Radix Bupleuri by UPLC-PDA-MS

scientific article published on 09 April 2015

A sensitive method for determination of salvianolic acid A in rat plasma using liquid chromatography/tandem mass spectrometry

scientific article

A ¹H-NMR plasma metabonomic study of acute and chronic stress models of depression in rats

scientific article published on 3 December 2012

Advanced glycation end products serve as ligands for lectin-like oxidized low-density lipoprotein receptor-1(LOX-1): biochemical and binding characterizations assay

scientific article published in October 2008

Analysis of Polygala tenuifolia Transcriptome and Description of Secondary Metabolite Biosynthetic Pathways by Illumina Sequencing

scientific article

Anti-inflammation effect of methyl salicylate 2-O-β-D-lactoside on adjuvant induced-arthritis rats and lipopolysaccharide (LPS)-treated murine macrophages RAW264.7 cells.

scientific article

Antidiabetic Effect of Salvianolic Acid A on Diabetic Animal Models via AMPK Activation and Mitochondrial Regulation.

scientific article published on 7 May 2015

Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioacetamides derivatives as a novel class of potential antiviral agents

scientific article published on 30 June 2012

Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro

scientific article published on 25 March 2009

CREB is activated in smooth muscle cells isolated from atherosclerotic plaques and reduces smooth muscle cell proliferation via p21-dependent mechanism.

scientific article

Certification of a new certified reference material of honokiol.

scientific article published on 3 June 2015

Characterization and uncertainty evaluation of a new certified reference material of baicalein.

scientific article published in November 2013

Competing Endogenous RNA and Coexpression Network Analysis for Identification of Potential Biomarkers and Therapeutics in association with Metastasis Risk and Progression of Prostate Cancer

scientific article published on 05 August 2019

Design, synthesis, and biological activity of thiazole derivatives as novel influenza neuraminidase inhibitors

scientific article

Determination of salvianolic acid C in rat plasma using liquid chromatography-mass spectrometry and its application to pharmacokinetic study.

scientific article published on 14 July 2015

Development and validation of a high-performance liquid chromatographic method for determination of pinocembrin in rat plasma: application to pharmacokinetic study

scientific article

Development of a new chlorogenic acid certified reference material for food and drug analysis

scientific article published on 20 March 2017

Development of new reference material neohesperidin for quality control of dietary supplements

scientific article published on 6 October 2014

Discovery of dihydro-alkyloxy-benzyl-oxopyrimidines as promising anti-influenza virus agents

scientific article published on 25 August 2011

Edaravone Dexborneol Alleviates Cerebral Ischemic Injury via MKP-1-Mediated Inhibition of MAPKs and Activation of Nrf2

scientific article published in 2022

Effect of recombinant plasminogen activator timing on thrombolysis in a novel rat embolic stroke model.

scientific article

Effect of valsartan on the pathological progression of hepatic fibrosis in rats with type 2 diabetes

scientific article published on 21 April 2012

Evaluation and Identification of the Neuroprotective Compounds of Xiaoxuming Decoction by Machine Learning: A Novel Mode to Explore the Combination Rules in Traditional Chinese Medicine Prescription

scientific article published on 10 July 2019

Evaluation of hippocampal injury and cognitive function induced by embolization in the rat brain

scientific article published on June 2013

Evaluation of the new anti-inflammatory compound ethyl salicylate 2-O-β-D-glucoside and its possible mechanism of action

scientific article published on 4 December 2012

Expression of KL-6/MUC1 in pancreatic cancer tissues and its potential involvement in tumor metastasis

scientific article published on 23 May 2011

FOXC1 is associated with estrogen receptor alpha and affects sensitivity of tamoxifen treatment in breast cancer

scientific article published on 28 December 2016

FOXC1 promotes melanoma by activating MST1R/PI3K/AKT.

scientific article published on 11 August 2016

Fluorescence resonance energy transfer assay for high-throughput screening of ADAMTS1 inhibitors.

scientific article

Ginkgolide K protects the heart against endoplasmic reticulum stress injury by activating the inositol-requiring enzyme 1α/X box-binding protein-1 pathway

scientific article published on 17 May 2016

Goniolactone C, a styryl lactone derivative, inhibits PDGF-BB-induced vascular smooth muscle cell migration and proliferation via PDGFR/ERK signaling.

scientific article published on 26 November 2014

Identification of Cultured and Natural Astragalus Root Based on Monosaccharide Mapping.

scientific article published on 11 September 2015

Identification of Estrogen Receptor α Antagonists from Natural Products via In Vitro and In Silico Approaches.

scientific article published on 10 May 2018

Identification of a small molecular insulin receptor agonist with potent antidiabetes activity

scientific article

In vitro anti-influenza virus and anti-inflammatory activities of theaflavin derivatives

scientific article

Induction of apoptosis by cinobufacini preparation through mitochondria- and Fas-mediated caspase-dependent pathways in human hepatocellular carcinoma cells

scientific article published on 15 October 2011

Isolation and bioactivity of diterpenoids from the roots of Salvia grandifolia

scientific article published on 22 April 2015

Isostructurality among solvates of cabazitaxel: X-ray structures and new solvates preparation.

scientific article

Lack of dose dependent kinetics of methyl salicylate-2-O-β-D-lactoside in rhesus monkeys after oral administration

scientific article published on 5 January 2015

Lipopolysaccharide-induced serotonin transporter up-regulation involves PKG-I and p38MAPK activation partially through A3 adenosine receptor

scientific article published in January 2016

Luteolin isolated from the medicinal plant Elsholtzia rugulosa (Labiatae) prevents copper-mediated toxicity in β-amyloid precursor protein Swedish mutation overexpressing SH-SY5Y cells

Luteolin synergizes the antitumor effects of 5-fluorouracil against human hepatocellular carcinoma cells through apoptosis induction and metabolism.

scientific article published on 2 December 2015

Metabonomic study on chronic unpredictable mild stress and intervention effects of Xiaoyaosan in rats using gas chromatography coupled with mass spectrometry

scientific article published on 21 June 2011

Methyl salicylate 2-O-β-D-lactoside, a novel salicylic acid analogue, acts as an anti-inflammatory agent on microglia and astrocytes. ⬇️

scientific article

Methyl salicylate lactoside inhibits inflammatory response of fibroblast-like synoviocytes and joint destruction in collagen-induced arthritis in mice

scientific article

Microtubule-stabilizing agents: New drug discovery and cancer therapy

scientific article published on 16 December 2015

Multiple-Ascending-Dose Pharmacokinetics and Safety Evaluation of Baicalein Chewable Tablets in Healthy Chinese Volunteers.

scientific article published in September 2016

NMR-based metabonomic and quantitative real-time PCR in the profiling of metabolic changes in carbon tetrachloride-induced rat liver injury

scientific article published on 28 October 2013

NMR-based metabonomics and correlation analysis reveal potential biomarkers associated with chronic atrophic gastritis

scientific article published on 28 September 2016

Neuroprotective Effect of Salvianolic Acid A against Diabetic Peripheral Neuropathy through Modulation of Nrf2

scientific article published on 27 February 2020

Neuroprotective and Cytotoxic Phthalides from Angelicae Sinensis Radix

scientific article published on 26 April 2016

Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile

scientific article published on 10 June 2008

Oncological miR-182-3p, a Novel Smooth Muscle Cell Phenotype Modulator, Evidences From Model Rats and Patients

scientific article

Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer

scientific article

Pharmacokinetic study of baicalein after oral administration in monkeys

scientific article published on 08 January 2012

Pharmacokinetic study of gallocatechin-7-gallate from Pithecellobium clypearia Benth. in rats

scientific article

Pharmacokinetic study of salvianolic acid A in beagle dog after oral administration by a liquid chromatography-mass spectrometry method: a study on bioavailability and dose proportionality

scientific article

Pharmacokinetics and tissue distribution of coptisine in rats after oral administration by liquid chromatography-mass spectrometry

scientific article

Pharmacokinetics of 21 active components in focal cerebral ischemic rats after oral administration of the active fraction of Xiao-Xu-Ming decoction

scientific article

Pharmacokinetics of methyl salicylate-2-O-β-D-lactoside, a novel salicylic acid analog isolated from Gaultheria yunnanensis, in dogs.

scientific article

Pinocembrin Protects Blood-Brain Barrier Function and Expands the Therapeutic Time Window for Tissue-Type Plasminogen Activator Treatment in a Rat Thromboembolic Stroke Model.

scientific article

Pinocembrin alleviates memory impairment in transient global cerebral ischemic rats.

scientific article

Pinocembrin attenuates MPP(+)-induced neurotoxicity by the induction of heme oxygenase-1 through ERK1/2 pathway.

scientific article published on December 2015

Pinocembrin attenuates blood-brain barrier injury induced by global cerebral ischemia-reperfusion in rats.

scientific article

Pinocembrin protects the brain against ischemia-reperfusion injury and reverses the autophagy dysfunction in the penumbra area

scientific article published on 30 September 2014

Polymorphs and Versatile Solvates of 7-Hydroxyisoflavone

scientific article published on 28 February 2016

Potential quality evaluation method for Radix Astragali based on sweetness indicators.

scientific article published on 13 February 2015

Preclinical pharmacokinetic evaluation and metabolites identification of methyl salicylate-2-O-β-d-lactoside in rats using LC-MS/MS and Q-TOF-MS methods

scientific article published on 20 February 2015

Preclinical studies of YK-4-272, an inhibitor of class II histone deacetylases by disruption of nucleocytoplasmic shuttling.

scientific article

Prevention of Selenite-Induced Cataratogenesis by Ginkgo biloba Extract (Egb761) in Wistar Rats

scientific article published on 07 November 2014

Prevention of vascular smooth muscle cell proliferation and injury-induced neointimal hyperplasia by CREB-mediated p21 induction: An insight from a plant polyphenol

scientific article published on 22 January 2016

Puerarin Mitigates Diabetic Hepatic Steatosis and Fibrosis by Inhibiting TGF-β Signaling Pathway Activation in Type 2 Diabetic Rats

scientific article published on 02 July 2018

Role of the nicotinic acetylcholine receptor α3 subtype in vascular inflammation

scientific article published on 29 August 2016

Safety, tolerability, and pharmacokinetics of a single ascending dose of baicalein chewable tablets in healthy subjects

scientific article published on 8 September 2014

Salt screening and characterization of ciprofloxacin

scientific article published on 23 January 2016

Salvianolic Acid D Alleviates Cerebral Ischemia-Reperfusion Injury by Suppressing the Cytoplasmic Translocation and Release of HMGB1-Triggered NF-κB Activation to Inhibit Inflammatory Response

scientific article published on 22 January 2020

Salvianolic Acid a prevents the pathological progression of hepatic fibrosis in high-fat diet-fed and streptozotocin-induced diabetic rats

scientific article published on 3 September 2014

Salvianolic acid A alleviates renal injury in systemic lupus erythematosus induced by pristane in BALB/c mice.

scientific article published on 21 October 2016

Salvianolic acid A inhibits PDGF-BB induced vascular smooth muscle cell migration and proliferation while does not constrain endothelial cell proliferation and nitric oxide biosynthesis

scientific article published on 14 March 2012

Salvianolic acid A protects the peripheral nerve function in diabetic rats through regulation of the AMPK-PGC1α-Sirt3 axis

scientific article published on 20 September 2012

Scutellaria barbata D. Don extract synergizes the antitumor effects of low dose 5-fluorouracil through induction of apoptosis and metabolism

scientific article published on 18 May 2013

Selection and dynamic metabolic response of rat biomarkers by metabonomics and multivariate statistical analysis combined with GC-MS.

scientific article published on 16 December 2013

Structural and Computational Study of 4 New Solvatomorphs of Betulin: A Combined X-Ray, Hirshfeld Surface, and Thermal Analysis

scientific article published on 22 November 2016

Studies on solvatomorphism of betulinic acid

scientific article published on 13 January 2014

Study on antioxidant effect of Herba Lycopi and screening of active fractions

scientific article published on July 2010

Synthesis and biological activities of new halophenols

scientific article published in March 2013

Synthesis and preliminary evaluation of peptidomimetic inhibitors of human beta-secretase.

scientific article published on 28 January 2010

Tanshinone IIA triggers p53 responses and apoptosis by RNA polymerase II upon DNA minor groove binding

scientific article

The Bioinformatic Analysis of the Dysregulated Genes and MicroRNAs in Entorhinal Cortex, Hippocampus, and Blood for Alzheimer's Disease

scientific article

The Protective Effect of DL0805 Derivatives on Pulmonary Artery Cells and the Underlying Mechanisms Study

scientific article published in February 2017

The flavonoid apigenin protects brain neurovascular coupling against amyloid-β₂₅₋₃₅-induced toxicity in mice

scientific article published in January 2011

The natural product bergenin ameliorates lipopolysaccharide-induced acute lung injury by inhibiting NF-kappaB activition.

scientific article published on 9 February 2017

The obesity-induced transcriptional regulator TRIP-Br2 mediates visceral fat endoplasmic reticulum stress-induced inflammation

scientific article (publication date: 25 April 2016)

The vasorelaxant mechanisms of a Rho kinase inhibitor DL0805 in rat thoracic aorta.

scientific article published on 18 May 2012

Therapeutic effect of methyl salicylate 2-O-β-d-lactoside on LPS-induced acute lung injury by inhibiting TAK1/NF-kappaB phosphorylation and NLRP3 expression

scientific article published on 8 September 2016

UPLC/Q-TOF MS-based metabolomics and qRT-PCR in enzyme gene screening with key role in triterpenoid saponin biosynthesis of Polygala tenuifolia ⬇️

scientific article

Using the protein chip to screen agonists and antagonists of the androgen receptor

scientific article

Xiaoxuming Decoction Regulates Vascular Function by Modulating G Protein-Coupled Receptors: A Molecular Docking Study

scientific article published on 05 June 2021

Xuezhikang therapy increases miR-33 expression in patients with low HDL-C levels

scientific article published on 23 January 2014

synthesis and preliminary biologic evaluation of 5-substituted-2-(4-substituted phenyl)-1,3-benzoxazoles as a novel class of influenza virus A inhibitors

scientific article published on 20 February 2012

List of works by Guanhua Du

3D-QSAR analysis of a new type of acetylcholinesterase inhibitors

A novel naturally occurring salicylic acid analogue acts as an anti-inflammatory agent by inhibiting nuclear factor-kappaB activity in RAW264.7 macrophages

A qualitative, and quantitative determination and pharmacokinetic study of four polyacetylenes from Radix Bupleuri by UPLC-PDA-MS

A sensitive method for determination of salvianolic acid A in rat plasma using liquid chromatography/tandem mass spectrometry

A ¹H-NMR plasma metabonomic study of acute and chronic stress models of depression in rats

Advanced glycation end products serve as ligands for lectin-like oxidized low-density lipoprotein receptor-1(LOX-1): biochemical and binding characterizations assay

Analysis of Polygala tenuifolia Transcriptome and Description of Secondary Metabolite Biosynthetic Pathways by Illumina Sequencing

Anti-inflammation effect of methyl salicylate 2-O-β-D-lactoside on adjuvant induced-arthritis rats and lipopolysaccharide (LPS)-treated murine macrophages RAW264.7 cells.

Antidiabetic Effect of Salvianolic Acid A on Diabetic Animal Models via AMPK Activation and Mitochondrial Regulation.

Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioacetamides derivatives as a novel class of potential antiviral agents

Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro

CREB is activated in smooth muscle cells isolated from atherosclerotic plaques and reduces smooth muscle cell proliferation via p21-dependent mechanism.

Certification of a new certified reference material of honokiol.

Characterization and uncertainty evaluation of a new certified reference material of baicalein.

Competing Endogenous RNA and Coexpression Network Analysis for Identification of Potential Biomarkers and Therapeutics in association with Metastasis Risk and Progression of Prostate Cancer

Design, synthesis, and biological activity of thiazole derivatives as novel influenza neuraminidase inhibitors

Determination of salvianolic acid C in rat plasma using liquid chromatography-mass spectrometry and its application to pharmacokinetic study.

Development and validation of a high-performance liquid chromatographic method for determination of pinocembrin in rat plasma: application to pharmacokinetic study

Development of a new chlorogenic acid certified reference material for food and drug analysis

Development of new reference material neohesperidin for quality control of dietary supplements

Discovery of dihydro-alkyloxy-benzyl-oxopyrimidines as promising anti-influenza virus agents

Edaravone Dexborneol Alleviates Cerebral Ischemic Injury via MKP-1-Mediated Inhibition of MAPKs and Activation of Nrf2

Effect of recombinant plasminogen activator timing on thrombolysis in a novel rat embolic stroke model.

Effect of valsartan on the pathological progression of hepatic fibrosis in rats with type 2 diabetes

Evaluation and Identification of the Neuroprotective Compounds of Xiaoxuming Decoction by Machine Learning: A Novel Mode to Explore the Combination Rules in Traditional Chinese Medicine Prescription

Evaluation of hippocampal injury and cognitive function induced by embolization in the rat brain

Evaluation of the new anti-inflammatory compound ethyl salicylate 2-O-β-D-glucoside and its possible mechanism of action

Expression of KL-6/MUC1 in pancreatic cancer tissues and its potential involvement in tumor metastasis

FOXC1 is associated with estrogen receptor alpha and affects sensitivity of tamoxifen treatment in breast cancer

FOXC1 promotes melanoma by activating MST1R/PI3K/AKT.

Fluorescence resonance energy transfer assay for high-throughput screening of ADAMTS1 inhibitors.

Ginkgolide K protects the heart against endoplasmic reticulum stress injury by activating the inositol-requiring enzyme 1α/X box-binding protein-1 pathway

Goniolactone C, a styryl lactone derivative, inhibits PDGF-BB-induced vascular smooth muscle cell migration and proliferation via PDGFR/ERK signaling.

Identification of Cultured and Natural Astragalus Root Based on Monosaccharide Mapping.

Identification of Estrogen Receptor α Antagonists from Natural Products via In Vitro and In Silico Approaches.

Identification of a small molecular insulin receptor agonist with potent antidiabetes activity

In vitro anti-influenza virus and anti-inflammatory activities of theaflavin derivatives

Induction of apoptosis by cinobufacini preparation through mitochondria- and Fas-mediated caspase-dependent pathways in human hepatocellular carcinoma cells

Isolation and bioactivity of diterpenoids from the roots of Salvia grandifolia

Isostructurality among solvates of cabazitaxel: X-ray structures and new solvates preparation.

Lack of dose dependent kinetics of methyl salicylate-2-O-β-D-lactoside in rhesus monkeys after oral administration

Lipopolysaccharide-induced serotonin transporter up-regulation involves PKG-I and p38MAPK activation partially through A3 adenosine receptor

Luteolin isolated from the medicinal plant Elsholtzia rugulosa (Labiatae) prevents copper-mediated toxicity in β-amyloid precursor protein Swedish mutation overexpressing SH-SY5Y cells

Luteolin synergizes the antitumor effects of 5-fluorouracil against human hepatocellular carcinoma cells through apoptosis induction and metabolism.

Metabonomic study on chronic unpredictable mild stress and intervention effects of Xiaoyaosan in rats using gas chromatography coupled with mass spectrometry

Methyl salicylate 2-O-β-D-lactoside, a novel salicylic acid analogue, acts as an anti-inflammatory agent on microglia and astrocytes. ⬇️

Methyl salicylate lactoside inhibits inflammatory response of fibroblast-like synoviocytes and joint destruction in collagen-induced arthritis in mice

Microtubule-stabilizing agents: New drug discovery and cancer therapy

Multiple-Ascending-Dose Pharmacokinetics and Safety Evaluation of Baicalein Chewable Tablets in Healthy Chinese Volunteers.

NMR-based metabonomic and quantitative real-time PCR in the profiling of metabolic changes in carbon tetrachloride-induced rat liver injury

NMR-based metabonomics and correlation analysis reveal potential biomarkers associated with chronic atrophic gastritis

Neuroprotective Effect of Salvianolic Acid A against Diabetic Peripheral Neuropathy through Modulation of Nrf2

Neuroprotective and Cytotoxic Phthalides from Angelicae Sinensis Radix

Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile

Oncological miR-182-3p, a Novel Smooth Muscle Cell Phenotype Modulator, Evidences From Model Rats and Patients

Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer

Pharmacokinetic study of baicalein after oral administration in monkeys

Pharmacokinetic study of gallocatechin-7-gallate from Pithecellobium clypearia Benth. in rats

Pharmacokinetic study of salvianolic acid A in beagle dog after oral administration by a liquid chromatography-mass spectrometry method: a study on bioavailability and dose proportionality

Pharmacokinetics and tissue distribution of coptisine in rats after oral administration by liquid chromatography-mass spectrometry

Pharmacokinetics of 21 active components in focal cerebral ischemic rats after oral administration of the active fraction of Xiao-Xu-Ming decoction

Pharmacokinetics of methyl salicylate-2-O-β-D-lactoside, a novel salicylic acid analog isolated from Gaultheria yunnanensis, in dogs.

Pinocembrin Protects Blood-Brain Barrier Function and Expands the Therapeutic Time Window for Tissue-Type Plasminogen Activator Treatment in a Rat Thromboembolic Stroke Model.

Pinocembrin alleviates memory impairment in transient global cerebral ischemic rats.

Pinocembrin attenuates MPP(+)-induced neurotoxicity by the induction of heme oxygenase-1 through ERK1/2 pathway.

Pinocembrin attenuates blood-brain barrier injury induced by global cerebral ischemia-reperfusion in rats.

Pinocembrin protects the brain against ischemia-reperfusion injury and reverses the autophagy dysfunction in the penumbra area

Polymorphs and Versatile Solvates of 7-Hydroxyisoflavone

Potential quality evaluation method for Radix Astragali based on sweetness indicators.

Preclinical pharmacokinetic evaluation and metabolites identification of methyl salicylate-2-O-β-d-lactoside in rats using LC-MS/MS and Q-TOF-MS methods

Preclinical studies of YK-4-272, an inhibitor of class II histone deacetylases by disruption of nucleocytoplasmic shuttling.

Prevention of Selenite-Induced Cataratogenesis by Ginkgo biloba Extract (Egb761) in Wistar Rats

Prevention of vascular smooth muscle cell proliferation and injury-induced neointimal hyperplasia by CREB-mediated p21 induction: An insight from a plant polyphenol

Puerarin Mitigates Diabetic Hepatic Steatosis and Fibrosis by Inhibiting TGF-β Signaling Pathway Activation in Type 2 Diabetic Rats

Role of the nicotinic acetylcholine receptor α3 subtype in vascular inflammation

Safety, tolerability, and pharmacokinetics of a single ascending dose of baicalein chewable tablets in healthy subjects

Salt screening and characterization of ciprofloxacin

Salvianolic Acid D Alleviates Cerebral Ischemia-Reperfusion Injury by Suppressing the Cytoplasmic Translocation and Release of HMGB1-Triggered NF-κB Activation to Inhibit Inflammatory Response

Salvianolic Acid a prevents the pathological progression of hepatic fibrosis in high-fat diet-fed and streptozotocin-induced diabetic rats