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List of works by Shigeo Koyasu

70-75 kd molecules expressed on LGL and T cells recognized by a mitogenic monoclonal antibody YTA-1; co-modulation and functional association with the interleukin 2 receptor p75.

scientific article published on January 1990

A Mr = 190,000 glycoprotein phosphorylated on tyrosine residues in epidermal growth factor stimulated KB cells is the product of the c-erbB-2 gene

scientific article published on 01 April 1987

A mouse model of pemphigus vulgaris by adoptive transfer of naive splenocytes from desmoglein 3 knockout mice

scientific article published on 01 August 2004

A novel hydroxyapatite film coated with ionic silver via inositol hexaphosphate chelation prevents implant-associated infection.

scientific article published on 17 March 2016

A novel mouse model of soft-tissue infection using bioluminescence imaging allows noninvasive, real-time monitoring of bacterial growth

scientific article

A promoter-level mammalian expression atlas

scientific article

A proteomic approach for the elucidation of the specificity of ectodomain shedding

scientific article published on 20 January 2014

A soluble multimeric recombinant CD2 protein identifies CD48 as a low affinity ligand for human CD2: divergence of CD2 ligands during the evolution of humans and mice.

scientific article

Absence of memory B cells in patients with common variable immunodeficiency

scientific article published in April 2002

Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes

scientific article

Alteration in growth, cell morphology, and cytoskeletal structures of KB cells induced by epidermal growth factor and transforming growth factor-beta

scientific article published on 01 May 1988

An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers.

scientific article

Antigen-independent development of Foxp3+ regulatory T cells suppressing autoantibody production in experimental pemphigus vulgaris

scientific article published on 27 April 2011

Are ILC2s Jekyll and Hyde in airway inflammation?

scientific article published on July 2017

Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation

scientific article published on 11 December 2020

Auto-reactive B cells against peripheral antigen, desmoglein 3, escape from tolerance mechanism

scientific article published on 31 August 2004

Autoimmunity against M₂muscarinic acetylcholine receptor induces myocarditis and leads to a dilated cardiomyopathy-like phenotype

scientific article published on 01 May 2012

Autoreactive B-cell elimination by pathogenic IgG specific for the same antigen: implications for peripheral tolerance

scientific article published on 02 September 2008

BCR targets cyclin D2 via Btk and the p85alpha subunit of PI3-K to induce cell cycle progression in primary mouse B cells

scientific article published in April 2003

Basophil-Derived Interleukin-4 Controls the Function of Natural Helper Cells, a Member of ILC2s, in Lung Inflammation

scientific article published on 01 May 2014

Bordetella evades the host immune system by inducing IL-10 through a type III effector, BopN

scientific article

CD3+CD16+NK1.1+B220+ large granular lymphocytes arise from both alpha-beta TCR+CD4-CD8- and gamma-delta TCR+CD4-CD8- cells.

scientific article

Cancer Immunoediting by Innate Lymphoid Cells.

scientific article

Caulobacter crescentus flagellar filament has a right-handed helical form

scientific article published in February 1984

Characterization of thymus-derived lymphocytes expressing Ti alpha-beta CD3 gamma delta epsilon zeta-zeta, Ti alpha-beta CD3 gamma delta epsilon eta-eta or Ti alpha-beta CD3 gamma delta epsilon zeta-zeta/zeta-eta antigen receptor isoforms: analysis

scientific article published on 01 October 1990

Characterization of two flagella-related proteins from Caulobacter crescentus

scientific article published on 01 November 1978

Clarithromycin expands CD11b+Gr-1+ cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia.

scientific article published on 5 April 2018

Class I PI3K-mediated Akt and ERK signals play a critical role in FcεRI-induced degranulation in mast cells

scientific article published on 8 November 2012

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

scientific article

Complementary roles for CD2 and LFA-1 adhesion pathways during T cell activation

scientific article published on 01 March 1991

Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response

scientific article published on 01 December 2001

Critical role of NK but not NKT cells in acute rejection of parental bone marrow cells in F1 hybrid mice

scientific article published on 01 November 2001

Critical role of class IA PI3K for c-Rel expression in B lymphocytes

scientific article published on 16 October 2008

Critical role of dendritic cells in determining the Th1/Th2 balance upon Leishmania major infection

scientific article published on 14 January 2008

Critical roles of NK and CD8+ T cells in central nervous system listeriosis

scientific article published in May 2009

Cutting edge: mTORC1 in intestinal CD11c+ CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production

scientific article published on 13 April 2012

Delayed Propionibacterium acnes surgical site infections occur only in the presence of an implant

scientific article

Delineation of a T-cell activation motif required for binding of protein tyrosine kinases containing tandem SH2 domains

scientific article published on July 1994

Dendritic cells suppress IgE production in B cells.

scientific article

Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice

scientific article

Development of chimeric molecules for recognition and targeting of antigen-specific B cells in pemphigus vulgaris

scientific article

Development, differentiation, and diversity of innate lymphoid cells

scientific article

Differential effects on expression of IL-2 receptors (p55 and p70) by the HTLV-I pX DNA.

scientific article published in June 1988

Double-positive T cell receptor(high) thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection

scientific article published on 01 September 1997

Dynamic regulation of Th17 differentiation by oxygen concentrations.

scientific article

ERK and p38 MAPK, but not NF-kappaB, are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin II in cardiac fibroblasts

scientific article

ERK5 is involved in TCR-induced apoptosis through the modification of Nur77.

scientific article

Erratum: corrigendum: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

scientific article published in Nature

Essential requirement of an invariant V alpha 14 T cell antigen receptor expression in the development of natural killer T cells

scientific article published on October 1996

Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo

scientific article published on 11 September 2006

Establishment of a real-time, quantitative, and reproducible mouse model of Staphylococcus osteomyelitis using bioluminescence imaging

scientific article published on 21 November 2011

Exogenous antigens are processed through the endoplasmic reticulum-associated degradation (ERAD) in cross-presentation by dendritic cells.

scientific article

Expression of functional IL-2 receptors on mature splenic dendritic cells

scientific article published on 01 May 2000

FANTOM5 CAGE profiles of human and mouse samples

scientific article published on 29 August 2017

Functional analysis of immunoreceptor tyrosinebased activation motif (ITAM)-mediated signal transduction: the two YxxL segments within a single CD3ζITAM are functionally distinct

scientific article published on 01 August 1997

Functional phenotype of phosphoinositide 3-kinase p85alpha-null platelets characterized by an impaired response to GP VI stimulation

scientific article published on 20 March 2003

Group 2 innate lymphoid cells and asthma

scientific article

HIV-1 Nef impairs multiple T-cell functions in antigen-specific immune response in mice

scientific article published on 3 June 2011

Helicobacter pylori CagA phosphorylation-independent function in epithelial proliferation and inflammation

scientific article

Helicobacter pylori dampens gut epithelial self-renewal by inhibiting apoptosis, a bacterial strategy to enhance colonization of the stomach

scientific article published on October 2007

How Many Subsets of Innate Lymphoid Cells Do We Need?

scientific article

IFN-gamma and pro-inflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension

scientific article published in October 2002

IFN-gamma production by antigen-presenting cells: mechanisms emerge.

scientific article

IL-2 and IL-7 differentially induce CD4-CD8- alpha beta TCR+NK1.1+ large granular lymphocytes and IL-4-producing cells from CD4-CD8- alpha beta TCR+NK1.1- cells: implications for the regulation of Th1- and Th2-type responses

scientific article published on 01 August 1997

IL-2 enhancing factor(s) in B cell supernatants from patients with rheumatoid arthritis or systemic lupus erythematosus

scientific article published on 01 November 1989

Identification of a cell surface 105 kd protein (Aic-2 antigen) which binds interleukin-3.

scientific article published on January 1990

Immunologic and histopathologic characterization of an active disease mouse model for pemphigus vulgaris

scientific article published on 01 January 2002

Impaired B cell development and function in the absence of IkappaBNS

scientific article

Impairment of T cell interactions with antigen-presenting cells by immunosuppressive drugs reveals involvement of calcineurin and NF-κB in immunological synapse formation

article

In vivo role of IFN-gamma produced by antigen-presenting cells in early host defense against intracellular pathogens

scientific article published on 01 October 2003

Inflammatory cytokines and hypoxia contribute to 18F-FDG uptake by cells involved in pannus formation in rheumatoid arthritis

scientific article

Innate Lymphoid Cells: 10 Years On

scientific article published on 01 August 2018

Innate lymphoid cells in allergic and nonallergic inflammation

scientific article

Innate lymphoid cells, possible interaction with microbiota

scientific article

Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses.

scientific article

Introduction: Innate Lymphoid Cells Special Issue

scientific article published on 01 January 2016

Isolation and analysis of group 2 innate lymphoid cells in mice.

scientific article published on 30 April 2015

Langerhans cell antigen capture through tight junctions confers preemptive immunity in experimental staphylococcal scalded skin syndrome.

scientific article published on 5 December 2011

Listerial invasion protein internalin B promotes entry into ileal Peyer's patches in vivo

scientific article published on 01 February 2011

Mechanisms of action of cyclosporine.

scientific article published in May 2000

Milk fat globule epidermal growth factor-8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms

scientific article published on 11 May 2009

Molecular cloning of the CD3 eta subunit identifies a CD3 zeta-related product in thymus-derived cells

scientific article

Natural helper cells: a new player in the innate immune response against helminth infection

scientific article published on 01 January 2010

Natural “Helper” Cells in the Lung: Good or Bad Help? ⬇️

scientific article published on March 23, 2012

Negative feedback loop in T-cell activation through MAPK-catalyzed threonine phosphorylation of LAT.

scientific article published on 10 June 2004

Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation.

scientific article published on 8 October 2009

PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction

scientific article

PI3K and negative regulation of TLR signaling.

scientific article

PI3K is a negative regulator of IgE production

scientific article

PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ.

scientific article

PI3K-mediated negative feedback regulation of IL-12 production in DCs

scientific article published on 05 August 2002

Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris.

scientific article published on March 2002

Peripheral PDGFRα+gp38+ mesenchymal cells support the differentiation of fetal liver-derived ILC2

scientific article published on 04 May 2018

Phagocytic cells contribute to the antibody-mediated elimination of pulmonary-infected SARS coronavirus

scientific article published on 4 March 2014

Phosphoinositide 3-kinase in nitric oxide synthesis in macrophage: critical dimerization of inducible nitric-oxide synthase.

scientific article published on 24 April 2006

Positive selection of CD4+ T cells by TCR-specific antibodies requires low valency TCR cross-linking: implications for repertoire selection in the thymus

scientific article published in October 1998

Pre-TCR signaling components trigger transcriptional activation of a rearranged TCR alpha gene locus and silencing of the pre-TCR alpha locus: implications for intrathymic differentiation.

scientific article

Purification and characterization of the 90-kDa heat-shock protein from mammalian tissues

scientific article published on 01 October 1988

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.

scientific article

Rapid stimulation of fluid-phase endocytosis and exocytosis by insulin, insulin-like growth factor-I, and epidermal growth factor in KB cells

scientific article published on 01 September 1988

Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells

scientific article

Reduced T cell expansion by a superantigen as a result of impaired B cell development in mice deficient for the p85alpha regulatory subunit of PI3K.

scientific article published on 9 December 2009

Regulation by intracellular Ca2+ and cyclic AMP of the growth factor-induced ruffling membrane formation and stimulation of fluid-phase endocytosis and exocytosis

scientific article published on 01 April 1989

Regulatory role of dendritic cells in postinfarction healing and left ventricular remodeling

scientific article published on 3 February 2012

Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.

scientific article

Role of Innate Lymphocytes in Infection and Inflammation ⬇️

scientific article published on May 7, 2012

Role of PI3K/Akt and mTOR complexes in Th17 cell differentiation.

scientific article published on March 2013

Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis.

scholarly article

Role of interaction of CD2 molecules with lymphocyte function-associated antigen 3 in T-cell recognition of nominal antigen ⬇️

scientific article published on April 1, 1990

Role of phosphoinositide 3-kinase signaling in mast cells: new insights from knockout mouse studies.

scientific article

Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice

scientific article published on 19 February 2002

Sequential polymerization of flagellin A and flagellin B into Caulobacter flagella

scientific article published on 01 December 1981

Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression

scientific journal article

Suppression of the immune response against exogenous desmoglein 3 in desmoglein 3 knockout mice: an implication for gene therapy

scientific article published in April 2003

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

scientific article published on 01 May 2001

T cell receptor-independent CD2 signal transduction in FcR+ cells

scientific article

T lymphocyte activation signals for interleukin-2 production involve activation of MKK6-p38 and MKK7-SAPK/JNK signaling pathways sensitive to cyclosporin A

scientific article published on 01 May 1998

T lymphocyte development in the absence of Fc epsilon receptor I gamma subunit: analysis of thymic-dependent and independent alpha beta and gamma delta pathways

scientific article published in August 1996

T-cell receptor isoforms and signal transduction.

scientific article published on February 1991

TAK1-JNK axis mediates survival signal through Mcl1 stabilization in activated T cells.

scientific article published in April 2013

TGF-β-induced phosphorylation of Akt and Foxo transcription factors negatively regulates induced regulatory T cell differentiation

scientific article published on 30 September 2016

Temperature-sensitive ZAP70 mutants degrading through a proteasome-independent pathway. Restoration of a kinase domain mutant by Cdc37.

scientific article

The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells.

scientific article published on 14 December 2006

The group 2 innate lymphoid cell (ILC2) regulatory network and its underlying mechanisms

scientific article published on 01 November 2018

The prostaglandin E 2 receptor EP4 is integral to a positive feedback loop for prostaglandin E 2 production in human macrophages infected with Mycobacterium tuberculosis ⬇️

scientific article published on June 12, 2013

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells.

scientific article published on 19 January 2015

Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation.

scientific article published in January 2013

Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells

scientific article

Tolerance induction by the blockade of CD40/CD154 interaction in pemphigus vulgaris mouse model

scientific article published on 01 January 2006

Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris

scientific article published on 27 April 2011

Two YxxL segments of a single immunoreceptor tyrosine-based activation motif in the CD3zeta molecule differentially activate calcium mobilization and mitogen-activated protein kinase family pathways

scientific article published on 01 June 2000

Two distinct action mechanisms of immunophilin-ligand complexes for the blockade of T-cell activation

scientific article published on November 2000

Type 2 innate immune responses and the natural helper cell ⬇️

scientific article published on February 16, 2011

Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus

scientific article

VIP36 protein is a target of ectodomain shedding and regulates phagocytosis in macrophage Raw 264.7 cells

scientific article

VIP36 protein is a target of ectodomain shedding and regulates phagocytosis in macrophage Raw 264.7 cells.

scientific article published in June 2012

VIP36 protein is a target of ectodomain shedding and regulates phagocytosis in macrophage raw 264.7 cells

scientific article published in July 2014

Vanilloid flavor for a good appetite?

scientific article published on 01 March 2010

Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase

scientific article

c-Jun N-terminal kinase activation during warm hepatic ischemia/reperfusion injuries in a rat model

scientific article published in September 2002

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